Nat Commun January 2020 PMID 31911652

U1 snRNP regulates cancer cell migration and invasion in vitro.

Jung-Min Oh, Christopher C Venters, Chao Di, Anna Maria Pinto, Lili Wan, Ihab Younis, Zhiqiang Cai, Chie Arai, Byung Ran So, Jingqi Duan, Gideon Dreyfuss

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Peak: 6 in Jan 2020

across 4 sources since Jan 2020

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The discussions show a focus on U1 snRNP’s role in regulating cancer cell migration and invasion, with mentions of techniques like morpholino to emphasize experimental significance. Words such as "regulates," "in vitro," and references to potential therapeutic angles reflect a solid understanding of the study’s importance and methodology, contributing to a generally positive and engaged perception.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, especially with repeated mentions highlighting U1 snRNP's role in cancer cell behavior.

InterestModerate interest

The discussions demonstrate curiosity about the biological mechanisms and potential therapeutic applications, though the tone remains somewhat technical.

EngagementModerate engagement

Comments include references to specific methods like morpholinos and discussions about the implications, indicating active engagement.

ImpactModerate impact

Participants seem to recognize the relevance of this research to cancer biology and therapy, suggesting perceived high impact.

Abstract in brief

U1 snRNP controls the length of mRNA 3' untranslated regions in cancer cells, and its inhibition leads to shorter mRNA isoforms, which is associated with increased cell migration and invasion.
Low doses of U1 AMO (antisense morpholino oligonucleotides) promote cancer cell migration and invasion in vitro, while overexpressing U1 has the opposite effect, reducing these processes.
Besides affecting 3'UTR length, changes in U1 levels also influence alternative splicing and gene expression of proto-oncogenes and tumor suppressors, highlighting U1's role in cancer cell behavior and its potential as a therapeutic target.]

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U1 snRNP's Role in Cancer Cell Migration and Invasion Mechanisms

U1 snRNP controls mRNA 3' untranslated regions in cancer cells. Its inhibition increases cell migration and invasion, while overexpression reduces these processes, affecting gene splicing and expression of oncogenes and…

STEM RTCL TV · Jun 22, 2023 92 views

bioRxiv Published

@biorxiv_pubd · X

U1 snRNP regulates cancer cell migration and invasion published as: https://t.co/m3jIAsa0GD @naturecomms #biorxiv

Aug 3, 2022 · 1 like · 2,905 followers View post →

Jorg Morf

@jorgmorf · X

RT @ShorterLab: U1 snRNP regulates cancer cell migration and invasion in vitro: https://t.co/ng4XKlds2I

Jan 17, 2020 · 1 share · 188 followers View post →

ShorterLab

@ShorterLab · X

U1 snRNP regulates cancer cell migration and invasion in vitro: https://t.co/ng4XKlds2I

Jan 16, 2020 · 4 likes · 1 share · 12,059 followers View post →

Europe PMC articles

@EuropePMC · X

New from #OfficialNIHR https://t.co/USpb2n7WTh U1 snRNP regulates cancer cell migration and invasion in vitro

Jan 14, 2020 · 1,553 followers View post →

Transcriptomes

@transcriptomes · X

U1 snRNP regulates cancer cell migration and invasion in vitro. https://t.co/julgbv7D3E

Jan 9, 2020 · 1,809 followers View post →

Gene Tools support

@GeneTools · X

RT @jonmoulton: U1 snRNP regulates cancer cell migration and invasion in vitro. https://t.co/qNOvWDVS2V #Morpholino

Jan 8, 2020 · 1 share · 253 followers View post →

Jon D. Moulton

@jonmoulton · X

U1 snRNP regulates cancer cell migration and invasion in vitro. https://t.co/qNOvWDVS2V #Morpholino

Jan 8, 2020 · 1 like · 1 share · 1,400 followers View post →