J Clin Invest May 2020 PMID 31961829

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans.

Brian S Finlin, Hasiyet Memetimin, Beibei Zhu, Amy L Confides, Hemendra J Vekaria, Riham H El Khouli, Zachary R Johnson, Philip M Westgate, Jianzhong Chen, Andrew J Morris, Patrick G Sullivan, Esther E Dupont-Versteegden, Philip A Kern

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Mentions

Peak: 12 in Jan 2020

across 4 sources since Jan 2020

Extended reach

209,709

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Total likes

189

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3,267

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Jan 2020 – Apr 2025

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The discussions are characterized by a mix of curiosity and cautious optimism, with phrases like 'looking into trials' and 'potential for weight loss' conveying strong interest and recognition of the article’s significance, supported by mentions of detailed mechanisms and ongoing studies that reflect deeper engagement.

AgreementModerate agreement

Most discussions acknowledge the positive findings of the research, with some expressing skepticism about its broader implications.

InterestHigh interest

Posts demonstrate high interest, especially with mentions of ongoing trials, potential applications, and specific human study outcomes.

EngagementHigh engagement

Several comments delve into mechanisms and clinical implications, indicating deep engagement with the topic and data.

ImpactModerate impact

While some see significant potential for improved treatments and understanding, others remain cautious about translating findings into practice.

Abstract in brief

Mirabegron, a 3-adrenergic receptor agonist, improves glucose regulation and insulin sensitivity in obese, insulin-resistant humans by promoting the conversion of white fat to energy-burning beige fat.
The treatment reduces fibrotic gene expression and enhances immune cell activity in white adipose tissue, leading to better metabolic function, with those showing the most fat "beiging" experiencing the greatest benefits.
In skeletal muscle, mirabegron decreases triglyceride accumulation, increases oxidative fiber types, and promotes gene expression associated with muscle energy production, suggesting improved muscle function indirectly benefits from beige fat formation.]

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Mirabegron Enhances Brown Fat and Metabolic Health in Humans

Chronic treatment with mirabegron can boost brown fat activity, HDL cholesterol, and insulin sensitivity, offering potential strategies for obesity and diabetes treatment. The study involved 14 healthy women taking 100…

VigorousClips · Apr 7, 2025 2,130 views

Mirabegron Enhances Brown Fat Activity and Metabolic Health

Chronic mirabegron treatment increases brown fat activity, HDL cholesterol, and insulin sensitivity. The study involving healthy women shows potential for treating metabolic diseases like obesity and diabetes through…

VigorousClips · Apr 7, 2025 1,137 views

JP, DO, MS ⚕️(He/him)

@TheDOctorJP · X

May 5, 2021 · 6 likes · 4,867 followers View post →

Spinal Cord Injury Research Publications Bot

@SCI_PubBot · X

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. https://t.co/HJPiySs5Cn https://t.co/2dcceqPOs1

Jan 27, 2021 · 1,085 followers View post →

Joni Lance

@JoniLance1 · X

RT @jclinicalinvest: Finlin, Memetimin, et al. @uk_healthcare reported that mirabegron treatment improved glucose homeostasis and produced…

Apr 8, 2020 · 2 shares · 201 followers View post →

john randall

@johnran28545123 · X

RT @jclinicalinvest: Finlin, Memetimin, et al. @uk_healthcare reported that mirabegron treatment improved glucose homeostasis and produced…

Mar 31, 2020 · 2 shares · 136 followers View post →

Journal of Clinical Investigation

@jclinicalinvest · X

Mar 31, 2020 · 5 likes · 2 shares · 50,970 followers View post →

James Wheeler Johnson, MD

@jameswjohnsonmd · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Feb 10, 2020 · 6 shares · 514 followers View post →

Dr. Luis A. Wadskier

@DrLuisWadskier · X

RT @michael_gorin: The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. - PubMed - NCBI https://t.co…

Feb 4, 2020 · 3 shares · 181 followers View post →

Heather Chalfin

@heather_chalfin · X

RT @michael_gorin: The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. - PubMed - NCBI https://t.co…

Feb 4, 2020 · 3 shares · 659 followers View post →

Rahul Janak Sinha

@rahuljanaksinha · X

RT @michael_gorin: The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. - PubMed - NCBI https://t.co…

Feb 4, 2020 · 3 shares · 208 followers View post →

Michael Gorin, M.D.

@michael_gorin · X

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. - PubMed - NCBI https://t.co/MR1RPMnTjw

Feb 4, 2020 · 10 likes · 3 shares · 7,770 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans https://t.co/SMrW9I73eX Visit https://t.co/X6HUOniPOB to find Bio-Medical/Pharma/Therapeutic/Clinical ideas that aid in understanding mechanism of diseases, identifying ..

Jan 25, 2020 · 887 followers View post →

Jamie Timmons

@metapredict · X

RT @ethanjweiss: I am skeptical about everything. This is not an exception. Chronically activating lipolysis to treat metabolic disease goe…

Jan 23, 2020 · 2 shares · 2,060 followers View post →

Katja

@Krapivner1 · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 23, 2020 · 6 shares · 6 followers View post →

Jocelyn J. Fitzgerald MD

@jjfitzgeraldMD · X

If this pans out, it could be a really great thing for many of our OAB patients. Better glucose control also leads to less diuresis

Jan 22, 2020 · 8 likes · 41,928 followers View post →

Cidiav

@cidiavas · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 6 shares · 2,507 followers View post →

Tom Varghese Jr. MD, MS, MBA, FACS, MAMSE

@TomVargheseJr · X

RT @ethanjweiss: I am skeptical about everything. This is not an exception. Chronically activating lipolysis to treat metabolic disease goe…

Jan 22, 2020 · 2 shares · 25,862 followers View post →

Journal of Clinical Investigation

@jclinicalinvest · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 6 shares · 50,970 followers View post →

Craig Porter

@bioblastgeek · X

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. https://t.co/0kYsVcurO9

Jan 22, 2020 · 3 likes · 1,254 followers View post →

Alessandro Bartolomucci Lab

@BartolomucciLab · X

RT @BarteltLab: Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 6 shares · 1,519 followers View post →

Adipose Papers

@adipose_papers · X

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. https://t.co/fiyU3CvBkF

Jan 22, 2020 · 2,457 followers View post →

Alexander Bartelt

@BarteltLab · X

Two important human studies out now in @jclinicalinvest - #brownfat activation with mirabegron

Jan 22, 2020 · 37 likes · 6 shares · 9,062 followers View post →

Yu-Hua Tseng

@tsengyuhua · X

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans https://t.co/boeDNIJfYi

Jan 21, 2020 · 2 likes · 1,223 followers View post →

The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans.

Mentions per month

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Abstract in brief

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All mentions

Mirabegron Enhances Brown Fat and Metabolic Health in Humans

Mirabegron Enhances Brown Fat Activity and Metabolic Health