Nature February 2020 PMID 32025018

The repertoire of mutational signatures in human cancer.

Ludmil B Alexandrov, Jaegil Kim, Nicholas J Haradhvala, Mi Ni Huang, Alvin Wei Tian Ng, Yang Wu, Arnoud Boot, Kyle R Covington, Dmitry A Gordenin, Erik N Bergstrom, S M Ashiqul Islam, Nuria Lopez-Bigas, Leszek J Klimczak, John R McPherson, Sandro Morganella

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Peak: 14 in Feb 2020

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Several discussions praise the publication as a monumental contribution to cancer genomics, with remarks like 'truly world-class scientists' and calls to explore the open access article. The tone varies from admiration to curiosity, and terms like 'game-changing' and 'solid foundation' underscore the perceived high impact of the study’s findings, especially given its large dataset and comprehensive analysis.

AgreementModerate agreement

Many discussions acknowledge the significance of the publication, with some posts referencing the scientific rigor and the importance of the research for advancing cancer understanding.

InterestHigh interest

Posts frequently highlight curiosity about the detailed mutational analyses and express motivation to explore further, as seen in phrases like 'truly world-class scientists' and 'seminal research.'

EngagementModerate engagement

There is some deep engagement with mentions of methodologies, such as whole-genome sequencing, and the significance of linking mutations to causes, although much of the discourse remains high-level rather than technical deep dives.

ImpactHigh impact

Posts suggest the research is viewed as impactful, emphasized by comments calling it 'groundbreaking' and referencing its potential to influence future studies and cancer treatments.

Abstract in brief

The study analyzed a large dataset of nearly 85 million somatic mutations from thousands of cancer genomes to identify specific mutational signatures associated with different cancer-causing processes.
They discovered 49 single-base, 11 double-base, 4 clustered-base substitution, and 17 small insertion-deletion signatures, some of which were new and helped distinguish overlapping signatures.
By examining how these signatures vary across individual cancers, the researchers linked certain signatures to environmental exposures or DNA repair defects, although many signatures remain of unknown origin, providing insight into cancer development mechanisms.]

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Environmental Mutagens and Cancer: Linking Exposure to Mutational Signatures

This video explores the connection between environmental exposure and cancer, focusing on the role of environmental mutagens. It discusses how mutational signatures in cancer genomes reveal insights into carcinogenesis…

Tanima Saha · Apr 2, 2025 101 views

Environmental Exposure to Metals and Their Role in Cancer Mutagenesis

This video discusses the mutagenic mechanisms of metals as classical carcinogens and their role in environmental exposure and cancer development, referencing recent research on mutational signatures in human cancer.

Tanima Saha · Jun 4, 2025 98 views

Dr. Gennadi Glinsky, MD, Ph.D.

@gglinskii · X

The repertoire of mutational signatures in human cancer https://t.co/xMZOdVxRCh

Oct 8, 2025 · 2,067 followers View post →

mutational signatures twitbot

@mutSignatures · X

RT @the_paper_link: Trend up+7: Alexandrov LB, ..., Pcawg Consortium (Nature) __Author Correction: The repertoire of mutational signatures…

Mar 15, 2023 · 1 share · 251 followers View post →

the paper link

@the_paper_link · X

Trend up+7: Alexandrov LB, ..., Pcawg Consortium (Nature) __Author Correction: The repertoire of mutational signatures in human cancer__ https://t.co/rg5NKjor35

Mar 15, 2023 · 1 share · 137 followers View post →

mutational signatures twitbot

@mutSignatures · X

RT @StevOmics: Author Correction: The repertoire of mutational signatures in human cancer https://t.co/WCjcTznBns #science

Jan 28, 2023 · 1 share · 251 followers View post →

Steve, PhD

@StevOmics · X

Author Correction: The repertoire of mutational signatures in human cancer https://t.co/WCjcTznBns #science

Jan 28, 2023 · 1 share · 272 followers View post →

mutational signatures twitbot

@mutSignatures · X

RT @ucl_discovery: Open Access UCL Research: The repertoire of mutational signatures in human cancer https://t.co/XdiezafdsR

May 9, 2022 · 1 share · 251 followers View post →

UCL Discovery

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Open Access UCL Research: The repertoire of mutational signatures in human cancer https://t.co/XdiezafdsR

May 9, 2022 · 1 share · 2,521 followers View post →

Kirk Hartley

@kirklsp · X

@melissabjacoby @alahav Also see this open access article by truly world class scientists who use whole genome sequencing (and more) to find signature mutations in cancers to show causes of cancer. To build good solutions, lawyers have to work with real science. https://t.co/zJBnpLWWpR

Oct 15, 2021 · 455 followers View post →

mutational signatures twitbot

@mutSignatures · X

The repertoire of mutational signatures in human cancer. https://t.co/rG7IyhNiz9

Nov 2, 2020 · 251 followers View post →

mutational signatures twitbot

@mutSignatures · X

The repertoire of mutational signatures in human cancer. https://t.co/rG7IyhNiz9

Jul 24, 2020 · 251 followers View post →

mutational signatures twitbot

@mutSignatures · X

The repertoire of mutational signatures in human cancer. https://t.co/rG7IyhNiz9

Jun 28, 2020 · 251 followers View post →

Europe PMC articles

@EuropePMC · X

New from #wellcometrust https://t.co/XPD4XdBqKL The repertoire of mutational signatures in human cancer

Mar 13, 2020 · 1,553 followers View post →

Europe PMC articles

@EuropePMC · X

New from #ERC_Research https://t.co/XPD4XdBqKL The repertoire of mutational signatures in human cancer

Mar 11, 2020 · 1,553 followers View post →

Hilana Hatoum MD

@hilana_hatoum · X

RT @ckesserwan: The repertoire of mutational signatures in human cancer https://t.co/Sq5QpuE9UT

Mar 3, 2020 · 1 share · 245 followers View post →

Chimene Kesserwan

@ckesserwan · X

The repertoire of mutational signatures in human cancer https://t.co/Sq5QpuE9UT

Feb 10, 2020 · 1 like · 1 share · 289 followers View post →

Anna Hagström Lab

@HagstromLab · X

The repertoire of mutational signatures in human cancer appears in the same issue from the same consortium.https://t.co/PI2xC2zl7h

Feb 8, 2020 · 53 followers View post →

Krishan Maggon

@kkmaggon · X

The repertoire of mutational signatures in human cancer https://t.co/FzmfcV9zD8 https://t.co/ExZNxpCaXk

Feb 7, 2020 · 1 like · 1,002 followers View post →

LordGenome

@LordGenome · X

The repertoire of mutational signatures in human cancer | Nature https://t.co/GPUZNPGBO1

Feb 7, 2020 · 1 like · 1 share · 742 followers View post →

DTHSTR

@CDADeathStar · X

The repertoire of mutational signatures in human cancer null https://t.co/hSJddkEKVy #DTHSTR

Feb 7, 2020 · 113 followers View post →

Safia Danovi

@SafiaDanovi · X

The repertoire of mutational signatures in human cancer | Nature #PCAWG https://t.co/8MD6iuSRSI

Feb 6, 2020 · 9 likes · 2,006 followers View post →

Wafik S. El-Deiry, MD, PhD, FACP

@weldeiry · X

The repertoire of mutational signatures in human cancer | Nature https://t.co/QyEMwoNhPa

Feb 5, 2020 · 4 likes · 1 share · 18,502 followers View post →

Steven G. Rozen

@steverozen · X

Author of "The Repertoire of Mutational Signatures in Human Cancer" in Nature. Read here: https://t.co/Pljzp9dhlu

Feb 5, 2020 · 10 likes · 1 share · 56 followers View post →

No1 Doctor

@no1_doctor · X

The repertoire of mutational signatures in human cancer – https://t.co/xDZXjk2XJj https://t.co/RCX4wyXsfH https://t.co/hYNzkpSnNz

Feb 5, 2020 · 1,504 followers View post →

Dr.ATEF AHMED(Surgeon)

@DrATEFAHMED · X

The repertoire of mutational signatures in human cancer – https://t.co/LecTG0tEN2 https://t.co/y7YIX2QTkt https://t.co/5K0PR5YUc2

Feb 5, 2020 · 1,770 followers View post →

VIPortal INC

@VIPortalINC · X

The repertoire of mutational signatures in human cancer – https://t.co/qQsDphAXeW https://t.co/B7EJps3VIC https://t.co/4AYu6JLsEq

Feb 5, 2020 · 1,524 followers View post →

Javier Santoyo

@jsantoyo · X

The repertoire of mutational signatures in human cancer. https://t.co/fQVdpyDNgh

Feb 5, 2020 · 6,217 followers View post →

Biosíntesis podcast

@bio_sintesis · X

RT @emulenews: @leviaingenia The repertoire of mutational signatures in human cancer. 84,729,690 somatic mutations from 4,645 whole-genome…

Feb 5, 2020 · 1 share · 1,250 followers View post →

Francis Villatoro

@emulenews · X

Feb 5, 2020 · 2 likes · 1 share · 45,152 followers View post →

UCL Cancer Institute

@uclcancer · X

TODAY at 12:00 Prof Ludmil Alexandrov @ucsdbe is with us to present #SeminarSeries 'The Repertoire of Mutational Signatures in Human Cancer' All welcome. Hosted by @NischalanP https://t.co/mswiFCiHeJ

Jan 28, 2020 · 2 likes · 4,636 followers View post →

Early Cancer Institute, University of Cambridge

@EarlyCancerCam · X

Jan 27, 2020 · 9 likes · 2,342 followers View post →

Takeya Kasukawa

@kasukawa · X

Ludmill B Alexandrov et al., The Repertoire of Mutational Signatures in Human Cancer, bioRxiv, 2018 https://t.co/DnQjbUPDOF

Nov 9, 2019 · 380 followers View post →

Emre Kocakavuk, MD, PhD

@ekocakavuk · X

The Repertoire of Mutational Signatures in Human Cancer https://t.co/dtXxHRdtUX

Jul 8, 2019 · 1 like · 937 followers View post →

Craig Anderson

@craigandersn · X

If I tweet it, then maybe I'll actually read it... The Repertoire of Mutational Signatures in Human Cancer https://t.co/zScEiBZFro

Mar 4, 2019 · 407 followers View post →

The repertoire of mutational signatures in human cancer.

Mentions per month

Where it's discussed

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Abstract in brief

Top posts

All mentions

Environmental Mutagens and Cancer: Linking Exposure to Mutational Signatures

Environmental Exposure to Metals and Their Role in Cancer Mutagenesis