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Biochem Biophys Res Commun February 2020 PMID 32081428

Structure analysis of the receptor binding of 2019-nCoV.

Yun Chen, Yao Guo, Yihang Pan, Zhizhuang Joe Zhao

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Mentions

15
Peak: 5 in Feb 2020
across 4 sources since Feb 2020

Extended reach

135,029
potential audience

Total likes

22

Video views

2,189

Mentions per month

Feb 2020 – Dec 2021

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos
  • News2 articles
  • Facebook1 posts

AI synopsis

What people are saying

The discussions revolve around detailed molecular insights, such as the conserved glycosylation site N343 and the stronger binding of the virus to the ACE2 receptor. The tone reflects curiosity and scientific curiosity, with examples like references to structural comparisons between SARS-CoV and 2019-nCoV, emphasizing the relevance of the research for understanding viral transmission and potential treatments.

AgreementModerate agreement

Most discussions support the findings of the structural analysis, emphasizing the importance of the receptor binding details and its implications.

InterestHigh interest

The conversations demonstrate high interest, with many users engaging deeply through technical details and scientific references.

EngagementModerate engagement

Participants reference specific amino acid residues, molecular modeling, and broader implications, showing moderate but meaningful engagement.

ImpactModerate impact

The discussions highlight the significance of the study in understanding virus-host interactions and potential transmission routes, indicating a moderate impact.

Abstract in brief

  • The study analyzes how the COVID-19 virus (2019nCoV) binds to human cells, focusing on its spike protein's receptor binding domain (RBD), which is similar but slightly different from the SARS virus, especially in a flexible loop with a key phenylalanine residue that enhances binding to the ACE2 receptor.
  • Molecular modeling shows that 2019nCoV's RBD binds more strongly to ACE2, which is found in many animals, suggesting that animals could be natural hosts for the virus and that it might infect a wide range of species.
  • The primary transmission is through respiratory droplets, but since ACE2 is also present in the intestines, testis, and kidneys, other routes like fecal-oral transmission are possible; developing antibodies or inhibitors to block the virus-ACE2 interaction is a potential strategy to fight the virus.]
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Top posts

Most liked on X and Bluesky
Amir باش
@Amirbio2 · X

@mohammadsarmast @sabaazarpeik خیلی دوست داری مقاله علمی بخونی این رو بخون بعد برام تعریف کن ببینم چی به چی شد!! https://t.co/scLEx2yOdg

Mar 18, 2020 · 2 likes · 1 share · 763 followers View post →
Saba Azarpeik
@sabaazarpeik · X

RT @Amirbio2: @mohammadsarmast @sabaazarpeik خیلی دوست داری مقاله علمی بخونی این رو بخون بعد برام تعریف کن ببینم چی به چی شد!! https://t.c…

Mar 18, 2020 · 1 share · 130,909 followers View post →
NFTdose
@PaperbirdsH · X

New article: Structure analysis of the receptor binding of 2019-nCoV. https://t.co/sM4Iz8DBD4 #coronavirus #wuhan #2019ncov

Feb 22, 2020 · 300 followers View post →
Afi Ghazouani
@pharmad_281 · X

Structure analysis of the receptor binding of 2019-nCoV - ScienceDirect https://t.co/Z0Y6X0cZgD

May 15, 2020 · 264 followers View post →
the paper link
@the_paper_link · X

Trend up+1: *Chen Y* et al (Biochem Biophys Res Commun) __Structure analysis of the receptor binding of 2019-nCoV__ https://t.co/CrmgfeR0tc

Feb 24, 2020 · 136 followers View post →
the paper link
@the_paper_link · X

Trend new: *Chen Y* et al (Biochem Biophys Res Commun) __Structure analysis of the receptor binding of 2019-nCoV__ https://t.co/CrmgfeR0tc

Feb 23, 2020 · 136 followers View post →

All mentions

Leek a Week
@leekaweek · X

https://t.co/EGC9V7ThEA A structural analysis of the #SARSCoV2 virus confirms that "N330 corresponds to N343 in the spike glycoprotein of 2019-nCoV [SARS-CoV-2] and is a conserved glycosylation site" - so what was called N330 on SARS-CoV is still around, now called N343. 10/n

Dec 27, 2021 · 4 followers View post →
Afi Ghazouani
@pharmad_281 · X

Structure analysis of the receptor binding of 2019-nCoV - ScienceDirect https://t.co/Z0Y6X0cZgD

May 15, 2020 · 264 followers View post →
airi.clip
@AiriClip · X

TERAPIA SPERIMENTALE (DOI:10.1016/j.bbrc.2020.02.071) https://t.co/X3tvV6XAqG #Coronavirus #COVID19 #ACE2 #ACE1 #RBD #RBDReceptorBindingDomain #Spike #SpikeProtein

Mar 31, 2020 · 23 followers View post →
Saba Azarpeik
@sabaazarpeik · X

RT @Amirbio2: @mohammadsarmast @sabaazarpeik خیلی دوست داری مقاله علمی بخونی این رو بخون بعد برام تعریف کن ببینم چی به چی شد!! https://t.c…

Mar 18, 2020 · 1 share · 130,909 followers View post →
Amir باش
@Amirbio2 · X

@mohammadsarmast @sabaazarpeik خیلی دوست داری مقاله علمی بخونی این رو بخون بعد برام تعریف کن ببینم چی به چی شد!! https://t.co/scLEx2yOdg

Mar 18, 2020 · 2 likes · 1 share · 763 followers View post →
the paper link
@the_paper_link · X

Trend up+1: *Chen Y* et al (Biochem Biophys Res Commun) __Structure analysis of the receptor binding of 2019-nCoV__ https://t.co/CrmgfeR0tc

Feb 24, 2020 · 136 followers View post →
the paper link
@the_paper_link · X

Trend up+1: *Chen Y* et al (Biochem Biophys Res Commun) __Structure analysis of the receptor binding of 2019-nCoV__ https://t.co/CrmgfeR0tc

Feb 23, 2020 · 136 followers View post →
the paper link
@the_paper_link · X

Trend up+6: *Chen Y* et al (Biochem Biophys Res Commun) __Structure analysis of the receptor binding of 2019-nCoV__ https://t.co/CrmgfeR0tc

Feb 23, 2020 · 136 followers View post →
the paper link
@the_paper_link · X

Trend new: *Chen Y* et al (Biochem Biophys Res Commun) __Structure analysis of the receptor binding of 2019-nCoV__ https://t.co/CrmgfeR0tc

Feb 23, 2020 · 136 followers View post →
NFTdose
@PaperbirdsH · X

New article: Structure analysis of the receptor binding of 2019-nCoV. https://t.co/sM4Iz8DBD4 #coronavirus #wuhan #2019ncov

Feb 22, 2020 · 300 followers View post →
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