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Overall, these discussions reflect a high level of interest and engagement, with many emphasizing the importance of the study’s findings on LDL and ApoB, questioning outdated concepts about HDL, and analyzing the methodologies behind the research, which demonstrates their deep engagement and recognition of the study’s potential impact on medical understanding.
Many discussions affirm the study’s findings, emphasizing that lipid measurements like LDL are closely linked to heart disease risk, with some posts dismissing older misconceptions about HDL and ratios.
The posts demonstrate high interest by referencing specific research methods, such as Mendelian randomization, and debating complex topics like lipoproteins' causal roles.
Users actively analyze, criticize, and discuss various aspects, including the validity of biomarkers and study interpretations, indicating deep engagement.
The widespread focus on the study’s implications for understanding lipid-related cardiovascular risk underscores its significant influence on current scientific debates and public perception.
Do you mean to say high LDL cholesterol causes and is directly linked to heart diseases? Not really. The leading cause is the "Bus", the LDL. (the paper: https://t.co/6WpMyNvPYg) https://t.co/OqTPGeiipL
Don't be fooled by RATIOS like Triglycerides:HDL-C https://t.co/iu5nujCh3d via @YouTube Great work @NutritionMadeS3
Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol isn't the main problem - LDL isn't 'bad' per se - HDL isn't 'good cholesterol' (short thread) full video: https://t.co/tafpR4TlVb
LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD risk almost never survives adjustment for LDL-P/ApoB in multivariable adjustment models.
2/8 Mendelian randomization analyses consistently fail to show statistically significant associations between ApoA-1 and CHD risk. Particularly after adjustments for LDL-C. This raises serious doubts regarding ApoA-1's causal role. https://t.co/EE9l68MMFh https://t.co/J4GSR9Zn9j https://t.co/Vx5Y216lA7
@DrHirschfield @DavidDel86 @PeterAttiaMD @Drlipid coincidentally we just published a video going over this FAQ of the ratios https://t.co/VdPY6sEmCt
This video explains LDL cholesterol levels, exploring their physiological significance and the distinction between LDL and HDL. We discuss how specific genetic variations in the PCSK9 gene can lead to reduced LDL…
Are ratios like triglyceridesHDLC or total cholesterolHDLC reliable measures of heart disease risk? This video discusses the strengths and limitations of cholesterol ratios and explores recent genetic research on…
This video discusses pemafibrate, a drug that lowers high triglyceride levels and improves lipids. A trial with nearly 10,500 patients showed that while it significantly reduced triglycerides, it did not lead to fewer…
Higher dietary fiber intake is linked to a lower risk of cardiovascular disease (CVD) and can improve blood pressure and health factors. This video explores the impact of fiber consumption on overall mortality…
@sjak87x @VirtuePostMort @williawa @sibaburck There is a great video explaining why this is not true, I really hope you watch it and let me know what you think. Great risk factor, but it doesn't make sense to specifically alter it. https://t.co/e7itfdQxFn
@CTolsoy You may find this channel helpful, he's a PhD who tries to be clear, unbiased, cites evidence and interviews cardiologists. https://t.co/jSDsLw2JzF
@YouthStudyCPC @uncle23atom 记不住 看这个md讲的https://t.co/fAp8rc9Yox
@ThelastStyleb16 @Birdgirl_22 @grok @MasalaFry69 @Special_Cactus And here is an actual person explaining this because as I showed you many times, LLMs should not be used for absolute reference. https://t.co/e7itfdPZPP
LDL Cholesterol level: Your lab results explained https://t.co/TxiHmxdBD5 via @YouTube
RT @YLyashchuk: @TheBladeRunner4 @Drlipid This a very good explanation, of why measuring ratios like TG/HDL is pointless for accessing indi…
@TheBladeRunner4 @Drlipid This a very good explanation, of why measuring ratios like TG/HDL is pointless for accessing individual risks. https://t.co/Q1le6Y9dSj
LDL Cholesterol level: Your lab results explained https://t.co/cVrUC9OdOd via @YouTube … a Must to Watch.
@tiras_corner Science is pretty clear. Higher cholesterol correlates with heart disease. But sure push your own agenda. Unbiased information https://t.co/TtaqjzC2FT
@InquizitiveOne @SBakerMD HDL and Triglycerides are not causative risk factors. They are only markers. https://t.co/1pEa7zeATZ ApoB is the main causative cause of concern. https://t.co/KYHrVjdw55 DISCLAIMER: BOTH VIDEOS LINK DATA IN DESCRIPTION.
@susanwoledge Enjoy them while you can. https://t.co/bQ0ZdKuQuB
@arunkumar3112 Huh? https://t.co/ZUQWKzk6cG
@healthieRx Thoughts? https://t.co/jMcUJcL5om
@DoctorTro Sure thing. https://t.co/YGT8YFSHSO. https://t.co/CM8XlvnZJj https://t.co/46fDF6yeZO https://t.co/hmwRVqROIJ https://t.co/F1mk00HVZC https://t.co/hylnO1ntaZ https://t.co/oygiA2yjJ3 https://t.co/1eJWOtTVIk
@BoaterOwl @Aybayapp @SBakerMD Great video to check out. https://t.co/rerGlbHj5k
@luxbriant @fleroy1974 This is the science denialism you foster as of a result of sharing the nonsense you do @fleroy1974 https://t.co/h5m0Q1ZxAc
@JeniusStern @gildone84 @ifixhearts https://t.co/QCm7qvSgZ8
RT @theproof: Don't be fooled by RATIOS like Triglycerides:HDL-C https://t.co/iu5nujCh3d via @YouTube Great work @NutritionMadeS3
Don't be fooled by RATIOS like Triglycerides:HDL-C https://t.co/iu5nujCh3d via @YouTube Great work @NutritionMadeS3
@en_tarpan @DoctorTro https://t.co/PL9ikRu1ll
@OMC1986 @goddeketal (1) U.S.'s 1920s CVD rate was already high (2) From high baseline, meat consumption per-capita ↑ a lot since 1920s (up 65 pounds/person just since 1960). Cheese/person up 4x since 1960. Yes veg oils went up too, in parallel not inversely. On ratios: https://t.co/Zw3FJDlcJ1
LDL Cholesterol level: Your lab results explained https://t.co/ni5LqAF95h via @YouTube
Don't be fooled by RATIOS like Triglycerides:HDL-C https://t.co/nJxmqZg15G via @YouTube
@DrHirschfield @DavidDel86 @PeterAttiaMD @Drlipid coincidentally we just published a video going over this FAQ of the ratios https://t.co/VdPY6sEmCt
Don't be fooled by RATIOS like Triglycerides:HDL-C https://t.co/nJxmqZg15G via @YouTube @NutritionMadeS3
@KenDBerryMD another video I feel you should take a look at! Basically saying we shouldn't go by hdl-c/tg ratios. Research articles from Pubmed and the likes are in the video description. https://t.co/rj2kzUpkN5
RT @MasalaFry69: Pure propaganda from Carvalho again. The video is false. 1. Lipoproteins do not cause CVD. 2. ApoB does NOT modulate r…
Pure propaganda from Carvalho again. The video is false. 1. Lipoproteins do not cause CVD. 2. ApoB does NOT modulate risk of CVD https://t.co/QJbpZsAVsx Slyly slipping in the ApoB is causal hoax.
@roderickfromzf @NutritionMadeS3 Just to add the video is false. Lipoproteins do not cause CVD https://t.co/QJbpZsAVsx
RT @NutritionMadeS3: https://t.co/VdPY6sDOMV
https://t.co/VdPY6sDOMV
RT @chiragbarjatyaa: Do you mean to say high LDL cholesterol causes and is directly linked to heart diseases? Not really. The leading cause…
Do you mean to say high LDL cholesterol causes and is directly linked to heart diseases? Not really. The leading cause is the "Bus", the LDL. (the paper: https://t.co/6WpMyNvPYg) https://t.co/OqTPGeiipL
@Tellit007 @NutritionMadeS3 @DanClintonRN https://t.co/xQgBRnokaV You mean this study?
@Andysmalls13 @ZackStrength This is not a meta-analysis. This is a very poor, low level literature review. https://t.co/FRKgRhaysg https://t.co/D3gMt343Cn https://t.co/D3JQgU7fmS https://t.co/zr0tYpjGi9 https://t.co/zPFKqugLvj https://t.co/giNVjzzZD9 https://t.co/ds4XZXrkWv https://t.co/BlvjOiutJQ
Focus on LDL-C . There is no such thing as good HDL-C
@Yo_soy_JulyR Aquí algunas referencias para consultar: https://t.co/Dk8AsmW6fk https://t.co/gcZxOkAPtm https://t.co/zrcgbrfgt0 https://t.co/L4d4u4H1kT https://t.co/qTo82NAl0w https://t.co/BY2b2ksF7i https://t.co/xZTN7ZXUvw Su tweet es un despropósito y si es por parte de un médico más.
@NickBivens4 @kevinstock12 I believe in nuance and understand that it's too simplistic to say "cholesterol is bad". But yeah, generally speaking you will be better off with lower LDL and lower trigs (not so with HDL). If you want to check out a great video on cholesterol: https://t.co/nfNw3IaJCa
@gAlecsyBrain @NutritionMadeS3 @BobbyAxelrod_ @SkyZer0_ @TheNutrivore @Regenarian @theproof @mhd25112 @KenDBerryMD @LipidDNP24 @TheCarnivoreKid @MrDiefenbach @SBakerMD @drjamesdinic @Mangan150 @TuckerGoodrich @ck_eternity_ @realDaveFeldman yes I was just replying to him. To answer you I have to analyze the new study and I haven't had time yet. I think you r not aware of other studies so I'll leave one of the main ones in case you wanna check the methodological differences by yourself: https://t.co/FaF3zHGBpZ
2/8 Mendelian randomization analyses consistently fail to show statistically significant associations between ApoA-1 and CHD risk. Particularly after adjustments for LDL-C. This raises serious doubts regarding ApoA-1's causal role. https://t.co/EE9l68MMFh https://t.co/J4GSR9Zn9j https://t.co/Vx5Y216lA7
@Lpa_Doc I find multivariable MR studies to be convincing that apoB captures risk of LDL-C and TG. As I understand it, Lp(a) associated SNPs not included. https://t.co/VuriViSXkN https://t.co/Qt2dEycFkh
@TheSGEM @DBelardoMD Ference slide from #ESC2021 shows meta analysis of lipid lowering RCTs and apoB in 285k individuals. Mendelian randomization study in 180k individuals points to apoB specifically as causal. Animal models consistent - see prior post. https://t.co/VuriViSXkN https://t.co/GPEwbsg7TP
@jason_howerton https://t.co/i732yuyCXv
LDL Cholesterol level: Your lab results explained https://t.co/pUR8qIKgZB via @YouTube oh here this one is better .. dont eat lots of saturated fats ..
@TheDagda__ ASCVD risk is a function of ApoB. The inverse associations between HDL and ApoA-1 and ASCVD do not survive adjustment for ApoB: https://t.co/EE9l693PHh Mendelian randomization doesn't support a causal role for HDL either: https://t.co/J4GSRagqbj
@Move101Pod @DrNadolsky Check @NutritionMadeS3's channel tons of videos on the topic but you can start here. There's always sources in the description so you can read for yourself https://t.co/OxL11TGYIa
For those who prefer a video explanation: https://t.co/sAH9JtHEUV
RT @NutritionMadeS3: @muralijnu1 @FusionProgGuy standard lipid panel = LDL-c this covers the basics: https://t.co/tafpR5aXjL
@muralijnu1 @FusionProgGuy standard lipid panel = LDL-c this covers the basics: https://t.co/tafpR5aXjL
This cholesterol information could save your life. Our @lifemedWP partner and friend @NutritionMadeS3 illustrates how!
RT @The_Nutrivore: LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD…
RT @The_Nutrivore: LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD…
RT @The_Nutrivore: LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD…
LDL-C or LDL-P/ApoB? A high TG/HDL ratio is a correlate for elevated LDL-P/ApoB, and LDL-C's effects on increasing CVD risk almost never survives adjustment for LDL-P/ApoB in multivariable adjustment models.
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
RT @The_Nutrivore: @AviBittMD @NutritionMadeS3 @DaveKeto @TheBhupiThakur @RobertLustigMD @LDLSkeptic @MyNutritionSci https://t.co/EE9l68MePJ
RT @The_Nutrivore: @ondrej_sibl @RChrisCC @zerohedge https://t.co/PPxuvOhoDU https://t.co/EE9l693PHh The association between CVD and LDL-C…
RT @The_Nutrivore: @AviBittMD @NutritionMadeS3 @DaveKeto @TheBhupiThakur @RobertLustigMD @LDLSkeptic @MyNutritionSci https://t.co/EE9l68MePJ
RT @dylanarmbruste3: https://t.co/POSs7Z3QKY https://t.co/3NkexQ5xLx
https://t.co/POSs7Z3QKY https://t.co/3NkexQ5xLx
RT @NutritionMadeS3: @SteveTiger999 @Eric_OGrey @EAllen0417 I covered it here, references in description (but tbh in my experience no poi…
RT @NutritionMadeS3: so LDL-cholest causes heart disease? kinda main factor are the lipoproteins themselves. especially LDL “it is the n…
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
RT @The_Nutrivore: @ondrej_sibl @RChrisCC @zerohedge https://t.co/PPxuvOhoDU https://t.co/EE9l693PHh The association between CVD and LDL-C…
@ondrej_sibl @RChrisCC @zerohedge https://t.co/PPxuvOhoDU https://t.co/EE9l693PHh The association between CVD and LDL-C is null after adjusting for ApoB. https://t.co/EULPjoPsPJ
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
@AviBittMD @NutritionMadeS3 @DaveKeto @TheBhupiThakur @RobertLustigMD @LDLSkeptic @MyNutritionSci https://t.co/EE9l68MePJ
RT @NutritionMadeS3: PS. some will say 'sure, dietary cholesterol/SFA raises LDL-C/apoB, that's established. but do those markers translate…
And rounding out the top 10 is the ever popular GCKR which is associated with nearly every circulating metabolite and is responsible for at least 450 associations in the @gwascatalog, the strongest being triglycerides, p=1e-526 https://t.co/YmzIqUqGNX GCKR regulates glucokinase.
Returning to lipids, #8 with 482 associations belongs to LIPC, the strongest being HDL with p=2E-166. LIPC encodes hepatic triglyceride lipase which hydrolyses triglycerides. The enzyme plays a key role in regulating levels of HDL. https://t.co/YmzIqUqGNX
Coming in with over 500 associations is the cholesterol ester transfer protein, CETP, the strongest being HDL with a p-value of 1e-1211 https://t.co/YmzIqUqGNX Once upon a time it was believed that raising HDL (good cholesterol) would be beneficial: https://t.co/1bnIWRLEfH
PS. some will say 'sure, dietary cholesterol/SFA raises LDL-C/apoB, that's established. but do those markers translate to higher risk of CVD? that's the question' and yes, preponderance of evidence overwhelmingly says they do. covered it here: https://t.co/tafpR5aXjL
@SteveTiger999 @Eric_OGrey @EAllen0417 I covered it here, references in description (but tbh in my experience no point sharing with dissenters, they'll reflexively dismiss) https://t.co/tafpR5aXjL
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
LDL Cholesterol level: Your lab results explained https://t.co/xseCkTbSun via @YouTube
RT @NutritionMadeS3: Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol…
so LDL-cholest causes heart disease? kinda main factor are the lipoproteins themselves. especially LDL “it is the number of lipoproteins rather than the amount of cholesterol or triglycerides per se that is the important driver of heart disease” https://t.co/nXwxjHAaTt
Your Cholesterol Lab results explained (a primer on LDL and blood lipids) - LDL vs LDL-cholesterol - why cholesterol isn't the main problem - LDL isn't 'bad' per se - HDL isn't 'good cholesterol' (short thread) full video: https://t.co/tafpR4TlVb
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis https://t.co/ilZI1YALlg https://t.co/hYZNgSJY1W
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. https://t.co/HRWCAF9ooz
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. https://t.co/GrW1UnQoJ0
I just posted "Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. - March 2020" on Reddit https://t.co/Ypp6xAKWno
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis. https://t.co/7uFjdu5Jv7
#PlosMedicine Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis https://t.co/WH9LeLYdxG