April 2020 PMID 32219282

The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials.

Xiaotong Kuang, Chunxiao Liu, Xiaofei Guo, Kelei Li, Qingxue Deng, Duo Li

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Mentions

42
Peak: 7 in Mar 2020
across 5 sources since Mar 2020

Extended reach

355,793
potential audience

Total likes

2,953

Video views

88,650

Mentions per month

Mar 2020 – Apr 2025

Where it's discussed

  • X / Twitter25 posts
  • News8 articles
  • YouTube4 videos
  • Facebook3 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions convey support for the article's findings with phrases like 'Vitamin D toxicity is a real problem' contrasted with recommendations to take K2 with D3, showing a concern for safe supplement use. Mentions of nutrient synergy, like 'K2 is relevant' alongside vitamin D, reflect deeper engagement, while references to practical health benefits emphasize the article's potential impact on health practices.

AgreementModerate agreement

Most discussions express support or acknowledgment of the benefits of combining vitamins K2 and D for bone health, indicating general agreement with the article's findings.

InterestModerate interest

There is moderate interest shown, with posts emphasizing the importance of these vitamins and highlighting the relevance to health, though some are more factual than passionate.

EngagementModerate engagement

Posts include references to related nutrients like magnesium and multidisciplinary considerations, demonstrating a decent level of engagement beyond superficial comments.

ImpactModerate impact

The discussions suggest recognition of practical implications for health, such as immune support and bone density improvements, indicating a perceived meaningful impact.

Abstract in brief

  • The meta-analysis of eight randomized controlled trials involving 971 subjects found that combining vitamin K (particularly K2) with vitamin D significantly improves bone mineral density (BMD) and reduces undercarboxylated osteocalcin, a marker of bone health.
  • The results showed a pooled increase in BMD with a confidence interval of 0.0031 to 0.0601 and a notable decrease in osteocalcin levels, indicating enhanced bone quality.
  • The study suggests that vitamin K2 or unspecified vitamin K supplements at doses below 500 μg/day, when combined with vitamin D, offer the most beneficial effects on bone health compared to no treatment or normal diet controls.

Top posts

Most liked on X and Bluesky
Ferran Roca
@roca_ferran · X

La combinación de #vitK2 y #vitD puede aumentar significativamente la DMO total ... @canciotrujillo @LeonorCuadra @rmtorresa @SolerMorera @FontsSerra @FormigaFrancesc @Sabater71 @lexmarcasvila https://t.co/ZJvHKVuspm

Mar 26, 2022 · 8 likes · 4 shares · 2,186 followers View post →
J P Fanton
@HealthyFellow · X

The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials Attn: ⁦@_atanas_⁩ ⁦@_INPST⁩ ⁦@TheAgingField⁩ ⁦@bonehealthfdn⁩ ⁦@OsteoporosisNOF⁩ ⁦@RoyalOsteoSoc⁩ https://t.co/xOTESBsTPF

Mar 27, 2020 · 6 likes · 7 shares · 26,025 followers View post →
Abhishek
@OneAbhishekJain · X

https://t.co/U0e00BORo9

Dec 19, 2023 · 2 likes · 14,084 followers View post →
Pilgrim
@villagerssn · X

@eric_krauss17 @dylanarmbruste3 @DailyBlend2 @IanCopeland5 Magnesium is important in the overall metabolism and function of Vitamin D. /2 https://t.co/RxfZ0Arshl

Feb 5, 2023 · 2 likes · 2,631 followers View post →
Abhishek
@OneAbhishekJain · X

https://t.co/U0e00BORo9

May 20, 2023 · 1 like · 14,084 followers View post →
Abhishek
@OneAbhishekJain · X

https://t.co/U0e00BORo9

Apr 20, 2022 · 1 like · 14,084 followers View post →

All mentions

Lera
@lerabell · X

@_HRH_Victoria_ @graceandaplomb1 @WallStreetMav https://t.co/Kmci7lbUr2

Dec 2, 2024 · 789 followers View post →
ErinA
@AErinalex · X

Vitamin D deficiency is a real problem. Vitamin D toxicity is a real problem. If Dr. Winter was a 1/2 decent doctor they would tell you to take K2 w/D3 (plus a little fat) instead of mega doses of D. (If your D lvls are low.) https://t.co/cZETfsjUlh https://t.co/QxPimGuqtQ

Mar 2, 2024 · 1 like · 595 followers View post →
Abhishek
@OneAbhishekJain · X

https://t.co/U0e00BORo9

Dec 19, 2023 · 2 likes · 14,084 followers View post →
Abhishek
@OneAbhishekJain · X

https://t.co/U0e00BORo9

May 20, 2023 · 1 like · 14,084 followers View post →
Ben Hoffman
@bhoff36 · X

• Vitamin D3/K2 - In a perfect world we would all be getting our Vitamin D from being outside in the sun. WFH and/or sitting at a desk working all day has a lot of people deficient in this vitamin. Insurance policy for bone and immune health. https://t.co/S7Qob4pox0

May 5, 2023 · 103 followers View post →
walter joseph kovacs
@normski2000 · X

@goddeketal I believe vitamin K2 helps alongside vitamin D https://t.co/jKqvNe9nCS.

Feb 9, 2023 · 1 like · 1,548 followers View post →
Pilgrim
@villagerssn · X

@eric_krauss17 @dylanarmbruste3 @DailyBlend2 @IanCopeland5 Magnesium is important in the overall metabolism and function of Vitamin D. /2 https://t.co/RxfZ0Arshl

Feb 5, 2023 · 2 likes · 2,631 followers View post →
Pilgrim
@villagerssn · X

@eric_krauss17 @dylanarmbruste3 @DailyBlend2 @IanCopeland5 Not sure that it possible on twitter, but both Vitamin K and Magnesium are important in the function of Vitamin D. Vitamin K and Vitamin D are important for bone density. /1 https://t.co/RxfZ0Arshl

Feb 5, 2023 · 1 like · 2,631 followers View post →
Earl Killian
@EarlKillian2 · X

@PeterAttiaMD Another consideration is that many nutrient studies are done in isolation, and something nutrient synergy is a factor. For Vitamin D, it might be that K2 is relevant: https://t.co/kLRq0K6RS0

Aug 16, 2022 · 2 followers View post →
Earl Killian
@EarlKillian2 · X

@DanielJDrucker Also what about studies that show that you need Vitamin K to see benefits from D? Did VITAL suffer from studying only D in insolation (OK with fish oil). Example: https://t.co/kLRq0K6RS0

Jul 29, 2022 · 2 followers View post →
Abhishek
@OneAbhishekJain · X

https://t.co/U0e00BORo9

Apr 20, 2022 · 1 like · 14,084 followers View post →
cristina carbonell
@cristicarbo · X

RT @roca_ferran: La combinación de #vitK2 y #vitD puede aumentar significativamente la DMO total ... @canciotrujillo @LeonorCuadra @rmtorre…

Mar 27, 2022 · 4 shares · 834 followers View post →
Paco Tarazona
@Sabater71 · X

RT @roca_ferran: La combinación de #vitK2 y #vitD puede aumentar significativamente la DMO total ... @canciotrujillo @LeonorCuadra @rmtorre…

Mar 27, 2022 · 4 shares · 1,218 followers View post →
Carlos
@MarvinHarris76 · X

RT @roca_ferran: La combinación de #vitK2 y #vitD puede aumentar significativamente la DMO total ... @canciotrujillo @LeonorCuadra @rmtorre…

Mar 26, 2022 · 4 shares · 4,517 followers View post →
Ferran Roca
@roca_ferran · X

La combinación de #vitK2 y #vitD puede aumentar significativamente la DMO total ... @canciotrujillo @LeonorCuadra @rmtorresa @SolerMorera @FontsSerra @FormigaFrancesc @Sabater71 @lexmarcasvila https://t.co/ZJvHKVuspm

Mar 26, 2022 · 8 likes · 4 shares · 2,186 followers View post →
GKLA-Scientific
@GklaSci · X

Great vitamin D-K interplay article: 'Dream team- Improving hearts and bones with vitamins D and K. Journal. https://t.co/m66INU4P0Z Also a very recent quick pickle article #dailymail https://t.co/yqaurA1Bab https://t.co/qCo7R38osa

Feb 20, 2021 · 374 followers View post →
Santa Cruz Nutrition
@CruzNutrition · X

"The combination of vitamin K and D can significantly increase the total BMD and significantly decrease undercarboxylated osteocalcin, and a more favorable effect is expected when vitamin K2 is used." https://t.co/n8DrQDDM5E

Oct 5, 2020 View post →
Science Updates
@cpa61 · X

RT @HealthyFellow: The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials…

Apr 8, 2020 · 7 shares · 35,964 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @HealthyFellow: The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials…

Mar 28, 2020 · 7 shares · 3,166 followers View post →
Lynne Evans
@levaly2 · X

RT @HealthyFellow: The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials…

Mar 28, 2020 · 7 shares · 932 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @HealthyFellow: The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials…

Mar 28, 2020 · 7 shares · 123,722 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @HealthyFellow: The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials…

Mar 28, 2020 · 7 shares · 10,276 followers View post →
Best Health 4 You
@besthealthyou · X

RT @HealthyFellow: The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials…

Mar 27, 2020 · 7 shares · 522 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @HealthyFellow: The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials…

Mar 27, 2020 · 7 shares · 6,711 followers View post →
J P Fanton
@HealthyFellow · X

The combination effect of #vitamin K & vitamin D on human #bone quality: A meta-analysis of randomized controlled trials Attn: ⁦@_atanas_⁩ ⁦@_INPST⁩ ⁦@TheAgingField⁩ ⁦@bonehealthfdn⁩ ⁦@OsteoporosisNOF⁩ ⁦@RoyalOsteoSoc⁩ https://t.co/xOTESBsTPF

Mar 27, 2020 · 6 likes · 7 shares · 26,025 followers View post →