March 2020 PMID 32223745

Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment.

Phong Duong, Mavis A A Tenkorang, Jenny Trieu, Clayton McCuiston, Nataliya Rybalchenko, Rebecca L Cunningham

Mentions

16
Peak: 7 in Apr 2020
across 2 sources since Apr 2020

Extended reach

14,333
potential audience

Total likes

57

Video views

1,113

Mentions per month

Apr 2020 – Jan 2025

Where it's discussed

  • X / Twitter14 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a balanced appreciation of the study's nuanced insights, with posts mentioning the protective versus harmful effects of sex hormones in different cell types and their relevance to disorders like Parkinson’s. The tone combines scientific detail with relevance to health, emphasizing both methodological rigor, as seen in the praise for RRID inclusion, and broader implications, such as how this research could influence future treatments.

AgreementModerate agreement

Most discussions acknowledge the nuanced effects of sex hormones on oxidative stress, showing general support for the study's findings.

InterestModerate interest

Comments demonstrate moderate curiosity, referencing specific cell types and implications for diseases like Parkinson's, indicating engagement beyond surface-level.

EngagementModerate engagement

Posts discuss methodological details, such as the inclusion of RRIDs and the study's relevance to disease mechanisms, reflecting active participation.

ImpactModerate impact

Several discussions highlight the importance of this research for understanding neurodegenerative diseases and potential therapies, suggesting notable significance.

Abstract in brief

  • The study explores how sex hormones like androgens and estrogens can either protect or harm nerve cells in conditions of oxidative stress, finding that their effects depend on cell type and timing of hormone exposure.
  • In neuronal cells, sex hormones generally showed protective effects via estrogen receptors, but in glial cells, they did not prevent damage from oxidative stress; applying hormones after stress could worsen cell loss.
  • The research also examined brain tissue from men and women, finding that a specific androgen receptor variant (AR45) is present in the human brain, which may influence how hormones affect brain cell survival under stress.

Top posts

Most liked on X and Bluesky
Biology of Sex Differences
@BiologySexDiff · X

New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress insults, but in unhealthy cells, sex hormones have negative effects on cell viability by exacerbating oxidative stress-induced cell loss. https://t.co/2zfaroCAJe

Apr 1, 2020 · 19 likes · 4 shares · 1,918 followers View post →
Biology of Sex Differences
@BiologySexDiff · X

This BSD study examines the relationship between #sexhormones and oxidative stress on cell viability—noting that #sexdifferences have been observed in multiple oxidative stress-associated CNS disorders, including #Parkinsons disease: https://t.co/8MK5C9UK0Q #WorldParkinsonsDay

Apr 11, 2022 · 8 likes · 4 shares · 1,918 followers View post →
brenda lynn pehrsson potter
@lynnpotter11 · X

RT @BiologySexDiff: New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress ins…

Apr 19, 2020 · 4 shares · 2,750 followers View post →
OSSD
@OSSDtweets · X

RT @BiologySexDiff: New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress ins…

Apr 1, 2020 · 4 shares · 1,870 followers View post →
Dianna H. Nguyen, DO, PhD
@DiannaHNguyen1 · X

RT @BiologySexDiff: This BSD study examines the relationship between #sexhormones and oxidative stress on cell viability—noting that #sexdi…

Apr 11, 2022 · 4 shares · 1,367 followers View post →
SexGenomics
@sexgenomics · X

Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment. https://t.co/xojDrqADLs

Apr 1, 2020 · 813 followers View post →

All mentions

Simon Breidert
@SimonBreidert · X

@JoshpBerta Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment https://t.co/tOVFdLuicm

Jul 27, 2022 · 742 followers View post →
Dianna H. Nguyen, DO, PhD
@DiannaHNguyen1 · X

RT @BiologySexDiff: This BSD study examines the relationship between #sexhormones and oxidative stress on cell viability—noting that #sexdi…

Apr 11, 2022 · 4 shares · 1,367 followers View post →
Licy Yanes Cardozo
@LicyYanes · X

RT @BiologySexDiff: This BSD study examines the relationship between #sexhormones and oxidative stress on cell viability—noting that #sexdi…

Apr 11, 2022 · 4 shares · 329 followers View post →
Houng-Wei Tsai
@TsaiLab_CSULB · X

RT @BiologySexDiff: This BSD study examines the relationship between #sexhormones and oxidative stress on cell viability—noting that #sexdi…

Apr 11, 2022 · 4 shares · 46 followers View post →
Delaney
@PhDelaney6 · X

RT @BiologySexDiff: This BSD study examines the relationship between #sexhormones and oxidative stress on cell viability—noting that #sexdi…

Apr 11, 2022 · 4 shares · 200 followers View post →
Biology of Sex Differences
@BiologySexDiff · X

This BSD study examines the relationship between #sexhormones and oxidative stress on cell viability—noting that #sexdifferences have been observed in multiple oxidative stress-associated CNS disorders, including #Parkinsons disease: https://t.co/8MK5C9UK0Q #WorldParkinsonsDay

Apr 11, 2022 · 8 likes · 4 shares · 1,918 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Neuroprotective and neurotoxic outcomes of androge…" (https://t.co/rRAsvLFhyz) included RRIDs in their paper! Thank you for making your #methodsmatter. #reproducibility

Mar 1, 2021 · 161 followers View post →
brenda lynn pehrsson potter
@lynnpotter11 · X

RT @BiologySexDiff: New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress ins…

Apr 19, 2020 · 4 shares · 2,750 followers View post →
Simone Nardin Weis
@simonenardin · X

RT @BiologySexDiff: New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress ins…

Apr 1, 2020 · 4 shares · 181 followers View post →
OSSD
@OSSDtweets · X

RT @BiologySexDiff: New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress ins…

Apr 1, 2020 · 4 shares · 1,870 followers View post →
Rachael E. Hokenson, PhD
@NeuroHoke · X

RT @BiologySexDiff: New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress ins…

Apr 1, 2020 · 4 shares · 446 followers View post →
Biology of Sex Differences
@BiologySexDiff · X

New research finds that in healthy neuronal cells, androgens & estrogens appear protective against oxidative stress insults, but in unhealthy cells, sex hormones have negative effects on cell viability by exacerbating oxidative stress-induced cell loss. https://t.co/2zfaroCAJe

Apr 1, 2020 · 19 likes · 4 shares · 1,918 followers View post →
SexGenomics
@sexgenomics · X

Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment. https://t.co/xojDrqADLs

Apr 1, 2020 · 813 followers View post →
sexchrpapers
@sexChr_papers · X

Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment. https://t.co/Fq321rDlqR

Apr 1, 2020 · 399 followers View post →