Overall, the discussions reflect a strong alignment with the article's emphasis on genetic variations affecting virus binding, exemplified by posts mentioning specific ACE2 variants like S19P, and the potential protective role of vitamin D. The tone varies from factual referencing of the research to advocacy for public health measures, indicating both understanding and motivation to act based on the findings.
AgreementModerate agreement
Most discussions support the idea that genetic variations like those in ACE2 could influence COVID-19 susceptibility.
InterestHigh interest
Posts show high interest, especially with references to implications for different populations and potential protective effects of variants.
EngagementHigh engagement
Many posts cite specific details from the publication, discuss the role of vitamin D, and share links, indicating deep engagement.
ImpactModerate impact
There is awareness of the potential significance of genetic and biological factors in COVID-19 outcomes, but some posts focus more on supplementary measures.
Abstract in brief
This study investigates how different genetic variations in the human ACE2 receptor might affect its ability to bind with the SARS-CoV-2 spike protein, which is key to viral entry and infection.
Researchers modeled various ACE2 variants to see structural differences and how these might influence binding to the virus, finding that most variants have similar binding affinity to the wild type, but some, like S19P and E329G, show notable differences.
The findings suggest that certain ACE2 genetic variants could potentially influence individual susceptibility or resistance to COVID-19 by altering how effectively the virus attaches to human cells.
For anyone looking for rational, measured analysis of all things corona-virus follow this gentleman's Youtube channel. I have been watching it since the beginning of March and he's been spot on. It's really refreshing to listen to actually.
https://t.co/rfVD6PfLT0
This update covers the COVID-19 situation as of April 8th, including rising cases in Africa and the UK, the impact of ACE2 receptor genetic variations on virus binding, and ongoing efforts including donations to Johns…
This study explores how different genetic variations in the human ACE2 receptor may influence its ability to bind with the SARS-CoV-2 spike protein, potentially affecting individual susceptibility to COVID-19. Variants…
"Most ACE2 variants showed a similar binding affinity for SARS-CoV-2 spike protein [...] However, ACE2 alleles, rs73635825 (S19P) and rs143936283 (E329G) showed noticeable variations in their intermolecular interactions with the viral spike protein."
https://t.co/T0HgLZdwIR https://t.co/iJlW36XEhf
@CarlosdelRio7 @tal7291 As sad and true-are there factors other than racism? IE genetic variations in ACE2 Receptor? (J Med Virol. 2020 Apr 15 : 10.1002/jmv.25832. https://t.co/KcYreUxuTY) Regardless, when vaccine ready, early use in at risk populations must be a standard of care.
Şu iki makaleyi kabaca özet geçiyorum:
https://t.co/VUsm8ZzjER
https://t.co/uCVdTXkMwc
Denen şey şu, eğer belirli mutasyonları genetiğinizde taşıyor iseniz, ya hastalığı ağır, ya da daha hafif atlatacaksınız, açalım+++
@KizzyPhD "genetic variations in the host receptor ACE2 may _ contribute to the _**susceptibility**_ and/or resistance "
our data provide a structural basis of potential resistance against SARS‐CoV‐2 infection driven by ACE2 allelic variants
https://t.co/nzoDEQPE2O
@Mugiwara_79 @elmundoes Individuos infectados asintomáticos por SARS-CoV-2 -> Pueden existir personas resistentes a la infección -> Una explicación potencial -> Las variaciones estructurales en ACE2 humano pueden influir en su unión con la proteína espicular del SARS-CoV-2 https://t.co/YOkj4nNp1j
@hemofelo @GuyDistance Also, the research papers from our biomedicine department are already published in US based University journal after which they have requested permission to share it WHO as it has a breakthrough results.
https://t.co/qaPkHRj5UP
Apr 14, 2020 · 1 like · 5,021 followersView post →
CG
Carol Anne Grayson
@Quickieleaks · X
RT @QuraishySaeed: @Quickieleaks No such relationship exist as HIV and SARsCovV2 bind to different receptors. Thereby encoded by different…
@cboyz_j @DrEricDing Yes, I think Vitamin D blood levels are a worthy consideration. See cued up clip from Dr. John Campbell's comments on it:
https://t.co/uuNxmxjn83
@Cat_MarqueeLV @davidfrum Also see Dr John Campbell on YT, ahead of everyone else in January... he has posited vitamin D deficiency links. https://t.co/7UYp57f1Qg Here also a Spanish sub : https://t.co/DoILEFWNgJ
@EricDJuly @YouTube Eric, please watch this from about 5 minutes on. The creator is not on our side, (he's pro shutdown) but he makes an incredibly important "demographic" point about skin color and Covid-19. https://t.co/RYPVsAXQ8y
Mutations in ACE2 affect its binding to SARS-CoV-2 spike protein. Worst binding was rs73635825 (S19P in UniProt accession Q9BYF1). Not known yet if this mutation provides immunity, but it's interesting! Paper just accepted: https://t.co/8jzhSO5IH2
Watch "Thursday 9th April Global Update" on YouTube https://t.co/7Z9kk81Kx4 @SecAzar @Mike_Pence @IU_Health @MayoClinic @ClevelandClinic ....teams worldwide working on vaccines....
@PabloFuente muy buenas noche me sorprende este Doctor del Reino Unido el Dr John Campbell https://t.co/RmMqehOXdV
Le sigo cada día por la información que nos comparte
Un saludo y enhorabuena por el programa La reunión secreta
Latest update from Dr. Campbell.
"It's a population level measure"
"I have to take rsponsibility for YOUR health"
So true.
&Disapointing news from the antibody-test front. :-(
https://t.co/jUXuHcb1bx
You have to follow Dr. John Campbell (@DrJohnCampbell)
His videos are more informative and less dramatic than the news, and full of positive information, and he's really a great guy.
LINK TO FULL VIDEO:
https://t.co/XmLtYOfuQv https://t.co/lYstLjJZaD
Coronavirus Update 112 By Doctor John Campbell #COVID19 #coronavirus #pandemic #GlobalEmergency #HealthEmergency #JohnCampbell https://t.co/qSnhTet6pU https://t.co/0eHhvGCNRU
@Eyaaaad ذكر د. جون كامبل أن فيتامين د يتم صنعه في البشرة البيضاء أسرع من البشرة السمراء وهو من الفيتامينات التي تقوي المناعة
يمكن عشان هذا السبب هم أكثر عرضة للعدوى
المصدر :
https://t.co/oiidJlTMVN
من الدقيقة 6:26 أبدأ الفيديو
@narendramodi, @ArvindKejriwal, @PMOIndia ,@RubikaLiyaquat, @sudhirchaudhary listen to this video. Dr. John is talking about surveillance measures in China and Saudi Arabia like apps and drone checking body temperature: https://t.co/bQhk8uMI8E
India use them as well.
@NYGovCuomo greetings sir. Watched you saying you find it ‘sick’ observing black and latino ppl are likely being hit by #covid19 more than white ppl, ‘due to their poverty situation’. You may want to have a look into this on ‘#vitD’ off 7:00
Stay safe https://t.co/dBUL21qua8
@McKTerese Thank you, Terese! Earlier today I posted a vlog link to a doctor who is very knowledgable about Vitamin D and how it may be impacting the high numbers of POC deaths. Here is that link again: https://t.co/oQslStimgu
https://t.co/HWgkjrqoP4 Dr. Campbell says everyone should take Vitamin D to help immunity during #COVID19Pandemic -- but particularly African Americans since skin color affects natural Vitamin D uptake.
For anyone looking for rational, measured analysis of all things corona-virus follow this gentleman's Youtube channel. I have been watching it since the beginning of March and he's been spot on. It's really refreshing to listen to actually.
https://t.co/rfVD6PfLT0
Watch "Wednesday 8th April Global Update" on YouTube https://t.co/Cjfo9z0QyO
Today's update. Of particular relevance to anybody with dark skin. #coronavirus #COVID-19 #pandemic
@BreeNewsome Agree 100%. And, I heard a hypothesis that sounds very valid from Dr. John Campbell today, about the disproportionate amount of deaths, being possibly related to Vit-D deficiencies in African Americans. Starts at 4:30. The whole thing is worth a listen. https://t.co/5g0cDFo5Sq
@AyannaPressley Agree 100%. And, I heard a hypothesis that sounds very valid from Dr. John Campbell today, about the disproportionate amount of deaths, being possibly related to Vit-D deficiencies in African Americans. Starts at 4:30. The whole thing is worth a listen.
https://t.co/5g0cDFo5Sq
@MaajidNawaz Of the many factors, one not yet mentioned: White skin produces more Vit D which is protective against respiratory infection. We need to check Vit D levels. see:https://t.co/gfgBf6dIcR
at 7:18
Update April 8
“These are the experts [WH☠️] who are paid to monitor this very thing and they got it wrong...” — J. Campbell
WH☠️ got it wrong and they knew. I watched this unfold in January. No excuses.
#WHOLied #WHO #COVID19 #coronavirus #Wuhan
https://t.co/4W6M5ykxV1
@Constantguide @Smahezn You know that’s I am not doctor , sorry I can’t answer in correct way, but
see videos of this doctor you may find a your specific questions & answer
I remember this doctor he has mail may help
https://t.co/iR38QDoISS
Apr 8, 2020 · 1 like · 10,444 followersView post →
MA
Michael Argiroudis
@MikeArgi · X
Wednesday 8th April Global Update #COVID19 https://t.co/9OCBr2B9c2 μέσω του χρήστη @YouTube
Wednesday 8th April Global Update https://t.co/MVPk8V8UjQ via @YouTube Dr John Campbell daily update on COVID 19 interesting theory on the role of Vit D and increased impact of the virus on African Americans
@AOC Dear Alexandria, Evidence suggests that lack of Vit D may linked to how ill people get from this virus. Please take a look and judge for yourself. Dr John Campbell vid https://t.co/WtVMOxDfeS
If you want to hear/follow a factual global #COVID19 #coronavirus global update, check out @DrJohnCampbell’s feed or @YouTube channel. Clear, concise information and explanations.
Wednesday 8th April Global Update https://t.co/e5rI9i9mUN
@ScottAdamsSays you have to get the message to African American population to take vitamin D , the dr explains why there is a higher % of deaths in them > check 7:20 https://t.co/rc3dShLvs2
Making the case for providing more vitamin D generally, especially for Africans and African Americans who's skin colour makes it harder for them to produce this vitamin.
https://t.co/FUO0daGT5Z
Wednesday 8th April Global Update https://t.co/iR38QDoISS via @YouTube
يأكد ان منظمة الصحة العالمية اخطاءت باجراءات الوباء وان ترامب صادق بما طرحة وكنا نتحدث بذلك من بداية فبراير
hi friends, if you're not already taking vitamin d supplements, now that we're constantly inside it's the time to start taking them! here's a video theorizing some reasons why we should https://t.co/9sFdh6q6Q3 as vitamin d production has had an effect on covid-19 outcomes!!!
I was watching this interesting video going over #covid19 worldwide, interesting thoughts about Vitamin D. Worth the watch. Also potentially Australia is doing so well because of peak summer vitamin D time when it hit the west.
https://t.co/QIZA0kUlko
Coronavirus Update 111 By Doctor John Campbell #COVID19 #coronavirus #pandemic #GlobalEmergency #HealthEmergency #JohnCampbell https://t.co/NuDFWjtFG0 https://t.co/oza4bivdJS
For all of my black, hispanic and Asian followers or any follower with non-white skin color, I highly, highly recommend you watch this video today. Also, if you are Vitamin D deficient! https://t.co/oQslStimgu
Vitamin D suppliments and better natural cultural/dietary habits needed.
Leftist media got mad at tesla for sending CPAPs vs ventilators and this makes them look more the overpaid fools they are.
Real numbers are inaccurate.
The peak should be near.
https://t.co/sjrBnSfEeg
@DrJohnCampbell agreed with @POTUS the @WHO WAS LATE in calling #coronavirus what is was and is.
Wednesday 8th April Global Update https://t.co/LzxjySfk7V via @YouTube
New article: Structural Variations in Human ACE2 may Influence its Binding with SARS-CoV-2 Spike Protein. https://t.co/VErd8GSZDC #coronavirus #COVID19 #2019ncov
Structural Models of Human Ace2 Variants With Sars-Cov-2 Spike ...
News
https://doi.org/10.1002/jmv.25832 (2020). 14. Chen, Y. Y. et al. Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its ...