J Med Virol July 2020 PMID 32253759

Tocilizumab treatment in COVID-19: A single center experience.

Pan Luo, Yi Liu, Lin Qiu, Xiulan Liu, Dong Liu, Juan Li

Mentions

77
Peak: 55 in Apr 2020
across 4 sources since Apr 2020

Extended reach

272,638
potential audience

Total likes

152

Video views

695

Mentions per month

Apr 2020 – Jul 2023

Where it's discussed

  • X / Twitter70 posts
  • News4 articles
  • YouTube2 videos
  • Facebook1 posts

AI synopsis

What people are saying

Several discussions highlight the promising yet cautious nature of the study, with references to specific results such as the reduction of inflammatory markers and the need for repeated dosing in critically ill patients. The tone varies from clinical curiosity to skepticism, with phrases like 'hard to interpret this data' and 'seems at least as good as...' illustrating the ongoing debate about the treatment's real-world effectiveness.

AgreementNeither agree nor disagree

Discussions show mixed opinions about the article's findings, with some emphasizing the potential of tocilizumab and others questioning its effectiveness. There is no clear consensus supporting or opposing the publication.

InterestModerate interest

Many posts express curiosity by referencing specific data points like IL-6 levels and mentioning ongoing trials or multiple studies. The discussion reflects a moderate level of engagement with the research details.

EngagementModerate engagement

The discussions include references to multiple studies, clinical observations, and methodological considerations, indicating active engagement, though mostly at a surface level.

ImpactModerate impact

Participants recognize the research's significance in the context of COVID-19 treatment options, but noting limitations like small sample sizes and lack of controls reduces the perception of high impact.

Abstract in brief

  • The study reviews the use of Tocilizumab (TCZ), an antibody targeting IL6, as a treatment for COVID-19 patients experiencing cytokine storms, showing mixed results depending on illness severity and treatment dosage.
  • In 15 patients, TCZ generally reduced CRP levels quickly, but related outcomes varied; critically ill patients who received only a single dose often did not survive, and IL6 levels initially spiked before decreasing in most cases.
  • The findings suggest that TCZ can be effective, especially if administered repeatedly to critically ill patients with high IL6 levels, but some patients did not respond favorably, indicating the need for tailored treatment approaches.

Top posts

Most liked on X and Bluesky
Kelly Echevarria
@kelechevarria · X

Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tell me what you make of this... It seems at least as good as the non-peer reviewed abstract that got us all jumping off the IL-6 cliff...

Apr 9, 2020 · 54 likes · 18 shares · 529 followers View post →
Saman Nematollahi
@TxID_Edu · X

Tocilizumab treatment in #COVID19: a single center experience 15 patients - 13 very ill - 8/15 received steroids too - inflammatory markers improved - some got single dose Toci It is very hard to interpret this data https://t.co/Q9TxREryK8 https://t.co/GC5onap1pN

Apr 10, 2020 · 21 likes · 5 shares · 4,215 followers View post →
Neil Floch MD
@NeilFlochMD · X

Several other reports that the effectiveness of this drug is best as the cytokines storm begins with increasing oxygen requirements -#Tocilizumab treatment in COVID‐19: A single center experience - Luo - - Journal of Medical Virology - Wiley Online Library https://t.co/6qTK3UQ9qA

Apr 15, 2020 · 8 likes · 4 shares · 130,200 followers View post →
Cristian Merchan
@ColombianpharmD · X

Tocilizumab treatment in COVID‐19: a single center experience - Luo - - Journal of Medical Virology - Wiley Online Library https://t.co/5T3wlnEEBp

Apr 10, 2020 · 6 likes · 2 shares · 269 followers View post →
Julien Potet
@julienpotet · X

Another small cohort study of #tocilizumab (TCZ) for #COVID19 (n=15). Results look favourable, but no control group. Authors recommend repeated dose for critically ill patients with elevated IL‐6. https://t.co/LyAV3X85f1

Apr 14, 2020 · 5 likes · 3 shares · 4,217 followers View post →
CetiCov
@CetiCov · X

tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relativement encourageants quant au potentiel thérapeutique https://t.co/u4G5fQs3mz https://t.co/WkLX9K0LmR https://t.co/onSwV16qq5

Jun 7, 2021 · 4 likes · 5 shares · 866 followers View post →

All mentions

François ex citoyen Francais
@Francois_libre · X

RT @CetiCov: tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relative…

Jul 26, 2023 · 5 shares · 2,272 followers View post →
Weasel FR
@FrWeasel · X

RT @CetiCov: tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relative…

Mar 27, 2022 · 5 shares · 2,525 followers View post →
Maria rossi
@Mariaro18921044 · X

RT @CetiCov: tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relative…

Jun 8, 2021 · 5 shares · 4 followers View post →
zyzy Torres
@TorresZyzy · X

RT @CetiCov: tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relative…

Jun 8, 2021 · 5 shares · 277 followers View post →
CLAUDINE GAUTIER
@vicmahec · X

RT @CetiCov: tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relative…

Jun 7, 2021 · 5 shares · 1,588 followers View post →
Weasel FR
@FrWeasel · X

RT @CetiCov: tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relative…

Jun 7, 2021 · 5 shares · 2,525 followers View post →
CetiCov
@CetiCov · X

tocilizumab certains espoirs thérapeutiques ont été placé dans cet inhibiteur monoclonal de l’IL6 avec des résultats relativement encourageants quant au potentiel thérapeutique https://t.co/u4G5fQs3mz https://t.co/WkLX9K0LmR https://t.co/onSwV16qq5

Jun 7, 2021 · 4 likes · 5 shares · 866 followers View post →
Ronald M. Chavin
@rmchavin · X

4-6-2020: China has 2 pro-Actemra meta-analyses (Jie Zhao, Meng Zhao) and 4 pro-Actemra studies (Jianbo Tian, Xiaoling Xu, Jia Zeng, Kai-Lian Zheng). I made Pan Luo my 5th head researcher of Chinese pro-Actemra studies, he's the world's 70th on my list: https://t.co/MVQaTYVILb

Dec 27, 2020 · 210 followers View post →
Almansour
@malmansour81 · X

RT @drsubramanians: #tocilizumab is being tried in critically ill patients with #covid_19 15 patients with severe #covid19 & ⬆️ #IL6 lev…

Jul 21, 2020 · 2 shares · 214 followers View post →
健康大臣くらら
@uCvAEFxGGZvhzyc · X

RT @hichachu: https://t.co/2sK29YJPpr TCZは、COVID-19患者の炎症活動を緩和するのに役立つ。 重症のCOVID-19患者には、TCZの反復投与が推奨される。 TCZの影響をさらに検証するには、さらにケースが必要。

Jun 4, 2020 · 2 shares · 74 followers View post →
JunSky 自民党・原発 全廃、野党共闘
@Jun_Sky_0610 · X

RT @hichachu: https://t.co/2sK29YJPpr TCZは、COVID-19患者の炎症活動を緩和するのに役立つ。 重症のCOVID-19患者には、TCZの反復投与が推奨される。 TCZの影響をさらに検証するには、さらにケースが必要。

Jun 3, 2020 · 2 shares · 1,567 followers View post →
ニューロドクター乱夢
@hichachu · X

https://t.co/2sK29YJPpr TCZは、COVID-19患者の炎症活動を緩和するのに役立つ。 重症のCOVID-19患者には、TCZの反復投与が推奨される。 TCZの影響をさらに検証するには、さらにケースが必要。

Jun 3, 2020 · 1 like · 2 shares · 4,264 followers View post →
Dr Khalid
@rauf_khalid · X

@abbasmaj This drug is globally used to manage leukotrienes storms in all critically ill patients of COVID 19. A COMMENDABLE AND BOLD STEP. Early View RESEARCH ARTICLE Free Access Tocilizumab treatment in COVID‐19: A single center experience

May 28, 2020 · 2,491 followers View post →
Dr Khalid
@rauf_khalid · X

https://t.co/cwwKEUESKO

May 28, 2020 · 3 likes · 2,491 followers View post →
dr•malvika
@dactarnee · X

@Sulci_Gyri https://t.co/yhBOYTG3sP Maybe you will find this helpful.

May 20, 2020 · 2,327 followers View post →
Cesar Silva Santisteban
@cssantisteban · X

Tocilizumab treatment in COVID‐19: A single center experience https://t.co/WHqua9cAmd

Apr 30, 2020 · 193 followers View post →
nori
@kana17plus · X

@karimero77 @b_t_n_s_ Lou P, et. al. Tocilizumab treatment in COVID-19: A single center experience. J Med Virol. 2020;1-5

Apr 28, 2020 · 268 followers View post →
JPR PRODUCTION
@DrPavanKGanga · X

Tocilizumab treatment in COVID‐19: A single center experience https://t.co/xhXMLj8I1G

Apr 28, 2020 · 1 like · 436 followers View post →
Dr Andy
@AndieforIndie · X

@stokofano @Noahpinion https://t.co/UeTpSJWlEa

Apr 28, 2020 · 1 like · 1,527 followers View post →
へへへのヘビーメタロウ
@Metallaw666 · X

RT @Metallaw666: この論文見てると、トシリズマブで解決はするわけではないかなと。 さっきのリツイを考慮すると、高血圧がハイリスクなのは確かにと思ってしまうね。 https://t.co/f24ZCJ2cYR

Apr 27, 2020 · 1 share · 129 followers View post →
Victor Yosef Melt Campos
@DrJxFL · X

Tocilizumab treatment in COVID‐19: A single center experience https://t.co/N5S4TfgXEV

Apr 26, 2020 · 928 followers View post →
alison sander
@alison_sander · X

Tocilizumab treatment in COVID-19: A single center experience. - PubMed - NCBI https://t.co/LueYXuXEz6

Apr 23, 2020 · 1,047 followers View post →
ibrahim khan
@ibrahimlicoln · X

Antibody to interleukin 6 is possible treatment of #covid19 #ARDS We need to keep looking for as many new treatment possibilities to this #pandemic its funny how the #TrumpSupporters are only obsessed with that old arthritis drug #hydroxychloroquine https://t.co/HQD4YxfzEV

Apr 22, 2020 · 21 followers View post →
へへへのヘビーメタロウ
@Metallaw666 · X

この論文見てると、トシリズマブで解決はするわけではないかなと。 さっきのリツイを考慮すると、高血圧がハイリスクなのは確かにと思ってしまうね。 https://t.co/f24ZCJ2cYR

Apr 22, 2020 · 1 like · 1 share · 129 followers View post →
a_ssann
@a_ssann · X

RT @tango_ballet: COVIDに対するトシリズマブ(= TCZ =アクテムラ)のことを集中的に調べています. 本論文は ・計15例 (中等症2, 重症6, 重篤 7) ・8例はmPSLも併用 ・inclusionと同時に投与開始 ・5例でTCZ 2回以上投与…

Apr 18, 2020 · 2 shares · 2,163 followers View post →
Sangeeta Motiani
@sangmotiani · X

RT @julienpotet: Another small cohort study of #tocilizumab (TCZ) for #COVID19 (n=15). Results look favourable, but no control group. Aut…

Apr 17, 2020 · 3 shares · 283 followers View post →
mimi--(納豆)
@mimi534 · X

RT @NeilFlochMD: Several other reports that the effectiveness of this drug is best as the cytokines storm begins with increasing oxygen req…

Apr 17, 2020 · 4 shares · 97 followers View post →
Jason Smith
@GoodHealthBlog · X

RT @NeilFlochMD: Several other reports that the effectiveness of this drug is best as the cytokines storm begins with increasing oxygen req…

Apr 16, 2020 · 4 shares · 154 followers View post →
Dr Abdullah Sultan
@Dr_sultan1974 · X

RT @NeilFlochMD: Several other reports that the effectiveness of this drug is best as the cytokines storm begins with increasing oxygen req…

Apr 16, 2020 · 4 shares · 481 followers View post →
Larry O
@larryo99 · X

RT @NeilFlochMD: Several other reports that the effectiveness of this drug is best as the cytokines storm begins with increasing oxygen req…

Apr 15, 2020 · 4 shares · 184 followers View post →
Neil Floch MD
@NeilFlochMD · X

Several other reports that the effectiveness of this drug is best as the cytokines storm begins with increasing oxygen requirements -#Tocilizumab treatment in COVID‐19: A single center experience - Luo - - Journal of Medical Virology - Wiley Online Library https://t.co/6qTK3UQ9qA

Apr 15, 2020 · 8 likes · 4 shares · 130,200 followers View post →
呼吸器内科医K
@ifitwasnt1 · X

RT @tango_ballet: COVIDに対するトシリズマブ(= TCZ =アクテムラ)のことを集中的に調べています. 本論文は ・計15例 (中等症2, 重症6, 重篤 7) ・8例はmPSLも併用 ・inclusionと同時に投与開始 ・5例でTCZ 2回以上投与…

Apr 15, 2020 · 2 shares · 642 followers View post →
Florin-Dan
@florindanpopesq · X

RT @florindanpopesq: IL-6 is one of the most important #cytokines involved in COVID-19-induced #CytokineStorm [Luo P et al. J Med Virol. 20…

Apr 15, 2020 · 1 share · 4,076 followers View post →
Florin-Dan
@florindanpopesq · X

RT @florindanpopesq: #Tocilizumab, humanized monoclonal antibody against IL-6 receptor, appears to be effective treatment option in COVID-1…

Apr 15, 2020 · 2 shares · 4,076 followers View post →
We are all Charlie Kirk
@ManOnDaNet · X

RT @florindanpopesq: #Tocilizumab, humanized monoclonal antibody against IL-6 receptor, appears to be effective treatment option in COVID-1…

Apr 15, 2020 · 2 shares · 1,043 followers View post →
Sarah Roberts
@orangetree100 · X

RT @julienpotet: Another small cohort study of #tocilizumab (TCZ) for #COVID19 (n=15). Results look favourable, but no control group. Aut…

Apr 15, 2020 · 3 shares · 55 followers View post →
武田孝一
@tango_ballet · X

COVIDに対するトシリズマブ(= TCZ =アクテムラ)のことを集中的に調べています. 本論文は ・計15例 (中等症2, 重症6, 重篤 7) ・8例はmPSLも併用 ・inclusionと同時に投与開始 ・5例でTCZ 2回以上投与 ・10例は臨床的に改善・安定 https://t.co/sKyin8QIvp

Apr 15, 2020 · 1 like · 2 shares · 1,408 followers View post →
Medico Peruano
@MedicoPeruano · X

RT @julienpotet: Another small cohort study of #tocilizumab (TCZ) for #COVID19 (n=15). Results look favourable, but no control group. Aut…

Apr 14, 2020 · 3 shares · 4,640 followers View post →
Julien Potet
@julienpotet · X

Another small cohort study of #tocilizumab (TCZ) for #COVID19 (n=15). Results look favourable, but no control group. Authors recommend repeated dose for critically ill patients with elevated IL‐6. https://t.co/LyAV3X85f1

Apr 14, 2020 · 5 likes · 3 shares · 4,217 followers View post →
Florin-Dan
@florindanpopesq · X

#Tocilizumab, humanized monoclonal antibody against IL-6 receptor, appears to be effective treatment option in COVID-19 patients w/ risk of #CytokineStorm. For critically ill patients w/ elevated IL-6, a repeated dose may be recommended [Luo P et al. 2020] https://t.co/2IAceBu3oo

Apr 14, 2020 · 2 likes · 2 shares · 4,076 followers View post →
Florin-Dan
@florindanpopesq · X

IL-6 is one of the most important #cytokines involved in COVID-19-induced #CytokineStorm [Luo P et al. J Med Virol. 2020] https://t.co/2IAceBu3oo

Apr 14, 2020 · 1 like · 1 share · 4,076 followers View post →
nur 'izzati ahmad za
@anurizzati · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 12, 2020 · 18 shares · 42 followers View post →
Jason Yee, PharmD, BCIDP
@JYeeIDPharmD · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 11, 2020 · 18 shares · 66 followers View post →
InfectoPed
@InfectoPe · X

RT @TxID_Edu: Tocilizumab treatment in #COVID19: a single center experience 15 patients - 13 very ill - 8/15 received steroids too - infl…

Apr 10, 2020 · 5 shares · 948 followers View post →
Almansour
@malmansour81 · X

RT @TxID_Edu: Tocilizumab treatment in #COVID19: a single center experience 15 patients - 13 very ill - 8/15 received steroids too - infl…

Apr 10, 2020 · 5 shares · 214 followers View post →
أحمد محمد
@MeedoTheLibyan · X

RT @TxID_Edu: Tocilizumab treatment in #COVID19: a single center experience 15 patients - 13 very ill - 8/15 received steroids too - infl…

Apr 10, 2020 · 5 shares · 949 followers View post →
Bartako
@galimarsot · X

RT @TxID_Edu: Tocilizumab treatment in #COVID19: a single center experience 15 patients - 13 very ill - 8/15 received steroids too - infl…

Apr 10, 2020 · 5 shares · 862 followers View post →
Almansour
@malmansour81 · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 214 followers View post →
Saman Nematollahi
@TxID_Edu · X

Tocilizumab treatment in #COVID19: a single center experience 15 patients - 13 very ill - 8/15 received steroids too - inflammatory markers improved - some got single dose Toci It is very hard to interpret this data https://t.co/Q9TxREryK8 https://t.co/GC5onap1pN

Apr 10, 2020 · 21 likes · 5 shares · 4,215 followers View post →
RXKEVING
@KNRXRX · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 354 followers View post →
Rodrigo Nunes Cal
@CalZole · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 3,378 followers View post →
Wes Pierce
@ICUapothecary · X

RT @ColombianpharmD: Tocilizumab treatment in COVID‐19: a single center experience - Luo - - Journal of Medical Virology - Wiley Online Lib…

Apr 10, 2020 · 2 shares · 490 followers View post →
JUSTADUDE
@mookiemanboi · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 891 followers View post →
Bug Pharmacist
@IDstewardship · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 39,335 followers View post →
Erica K. Little
@CefidErica · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 433 followers View post →
Abdulrahman Alshaya | عبدالرحمن الشايع
@_aalshaya · X

RT @ColombianpharmD: Tocilizumab treatment in COVID‐19: a single center experience - Luo - - Journal of Medical Virology - Wiley Online Lib…

Apr 10, 2020 · 2 shares · 3,316 followers View post →
Muhammad Effendi
@FND_pharmacy · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 967 followers View post →
Cristian Merchan
@ColombianpharmD · X

Tocilizumab treatment in COVID‐19: a single center experience - Luo - - Journal of Medical Virology - Wiley Online Library https://t.co/5T3wlnEEBp

Apr 10, 2020 · 6 likes · 2 shares · 269 followers View post →
Ana Ayestarán
@AnaAyestaran · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 289 followers View post →
Brent C. Beckner PharmD, BCPS, BCCCP
@BCB_PharmD · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 10, 2020 · 18 shares · 849 followers View post →
Antibiotic Tweets
@khalideljaaly · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 9, 2020 · 18 shares · 15,505 followers View post →
VirologyToday
@VirologyToday · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 9, 2020 · 18 shares · 569 followers View post →
Rebecca Cofsky
@Rebeccacillin · X

Tocilizumab treatment in COVID‐19: a single center experience https://t.co/npa7FvfS7O

Apr 9, 2020 · 1 like · 1 share · 87 followers View post →
J Arancibia
@pollistico77 · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 9, 2020 · 18 shares · 638 followers View post →
Jamie Kisgen
@KisgenUF · X

RT @kelechevarria: Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tel…

Apr 9, 2020 · 18 shares · 3,685 followers View post →
Kelly Echevarria
@kelechevarria · X

Tocilizumab treatment in COVID‐19: a single center experience https://t.co/Y1UcpmQz57 OK my really smart ID friends- tell me what you make of this... It seems at least as good as the non-peer reviewed abstract that got us all jumping off the IL-6 cliff...

Apr 9, 2020 · 54 likes · 18 shares · 529 followers View post →
Amanda Barner
@BarnerIDpharmD · X

I don't agree with the author's conclusions that this case series demonstrated the effectiveness of toci

Apr 9, 2020 · 1 like · 660 followers View post →
Bryson Crushers Fan
@crushergolf · X

RT @drsubramanians: #tocilizumab is being tried in critically ill patients with #covid_19 15 patients with severe #covid19 & ⬆️ #IL6 lev…

Apr 8, 2020 · 2 shares · 811 followers View post →
SubramanianMD
@drsubramanians · X

#tocilizumab is being tried in critically ill patients with #covid_19 15 patients with severe #covid19 & ⬆️ #IL6 levels (2X - 90X normal) 10 of 15 improved 3 of 4 that received only single dose died https://t.co/NGdCTrIoGK #covidclinicalpearls /42

Apr 8, 2020 · 2 likes · 2 shares · 190 followers View post →
Médecine & actualités
@medecineactu · X

Apr 8, 2020 · 65 followers View post →
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