May 2020 PMID 32350928

Rethinking the role of hydroxychloroquine in the treatment of COVID-19.

Eric A Meyerowitz, Augustin G L Vannier, Morgan G N Friesen, Sara Schoenfeld, Jeffrey A Gelfand, Michael V Callahan, Arthur Y Kim, Patrick M Reeves, Mark C Poznansky

Mentions

43
Peak: 24 in May 2020
across 4 sources since Apr 2020

Extended reach

100,019
potential audience

Total likes

68

Video views

776

Mentions per month

Apr 2020 – Jan 2024

Where it's discussed

  • X / Twitter36 posts
  • News4 articles
  • YouTube2 videos
  • Facebook1 posts

AI synopsis

What people are saying

The overall tone includes technical references to mechanisms like endosomal pH changes, and critical comments about study validity, which demonstrates a moderate level of engagement and interest. Some discussions mention the risks of combining HCQ with other drugs, highlighting concerns over safety and scientific rigor, while others seek to understand the complex mechanisms involved, reflecting a balanced and analytical exchange.

AgreementNeither agree nor disagree

The discussions seem divided, with some posts questioning or criticizing the publication, while others acknowledge its scientific focus without outright agreement or disagreement.

InterestModerate interest

Many posts reference detailed scientific mechanisms and studies, indicating a moderate level of curiosity or engagement with the topic, though not with high enthusiasm.

EngagementModerate engagement

Participants quote and critique specific research points, such as mechanisms of HCQ action and study limitations, showing active involvement rather than superficial mentions.

ImpactNeutral impact

The discussions seem more academic and informational, with some posts sharing links to full studies, but there's no clear consensus on altering practices or policies, leading to a neutral impact score.

Abstract in brief

  • Currently, there are no proven treatments for COVID-19, and initial hopes for hydroxychloroquine (HCQ) were based on limited and not high-quality data.
  • The use of HCQ and chloroquine can cause serious side effects, especially heart-related issues, and their immunomodulatory effects might actually hinder the body's natural immune response to the virus.
  • Given the uncertain benefits and potential risks, more well-designed clinical trials are needed to determine whether these drugs should be used for COVID-19 treatment.

Top posts

Most liked on X and Bluesky
Harvard's Defeating Malaria Initiative
@HarvardMalaria · X

May 1, 2020 · 5 likes · 3 shares · 4,713 followers View post →
Dr Conrad Goodwin
@ConradGoodwin · X

@GallaherCaren @DrJenGunter But hey, here’s an open access review article that summarizes the early trials. https://t.co/d6ePRUcQr2 The fact that when I say “clinically unproven”, you jump to “so you say it’s not true and you’ll never believe it”, says more about your biases than mine.

May 18, 2020 · 3 likes · 3,019 followers View post →
Meghan May
@DrMay5 · X

Here is the link to the Poznansky Lab's review of #Hydroxychloroquine studies as mentioned on @SIRIUSXM @NYUDocs. Happy reading! https://t.co/cPboYDQLOm

Jul 28, 2020 · 2 likes · 2,541 followers View post →
Patrick Reeves
@pmreeves · X

Our article exploring the potential, concerns, and risks of chloroquine and hydroxychloroquine for COVID19 is now available. #COVID19 #HCQ https://t.co/2d43JYCEEg https://t.co/A8WHB9QuSq

May 1, 2020 · 2 likes · 412 followers View post →
Rolando Garcia
@RatioScientiae · X

https://t.co/tU4Kp4xqsG

May 14, 2020 · 1 like · 1 share · 30,169 followers View post →
Galder Gonzalez
@theklaneh · X

@jasoneiroz @raoult_didier Hidroxiklorikina ere enpresa farmazeutiko batek egiten du. Eta, momentuz, datuak ez daude bere alde: https://t.co/aimKjqpqEE https://t.co/dqSGoHPla7 https://t.co/CxWNBsUx7J https://t.co/ULcsm53X9K

Jul 16, 2020 · 1 like · 9,410 followers View post →

All mentions

freethinker✝️☀️
@freethi52378078 · X

https://t.co/rhyCtZCA5N

Jan 6, 2024 · 1,012 followers View post →
SprkJoy4BtrDays
@SprkJoy4BtrDays · X

RT @renesugar: Rethinking the role of hydroxychloroquine in the treatment of #COVID19 https://t.co/qNA4nRYdR0 "By increasing endosomal pH…

Nov 1, 2022 · 1 share · 1,889 followers View post →
Rene Sugar
@renesugar · X

Rethinking the role of hydroxychloroquine in the treatment of #COVID19 https://t.co/qNA4nRYdR0 "thereby diminishing the induction of cytokines which may play a role in viral control including type I interferon, IL-6, and IL-12."

Jul 23, 2022 · 3,971 followers View post →
Rene Sugar
@renesugar · X

Rethinking the role of hydroxychloroquine in the treatment of #COVID19 https://t.co/qNA4nRYdR0 "By increasing endosomal pH, HCQ reduces TLR 7 and TLR 9 affinity for viral RNA,"

Jul 23, 2022 · 1 share · 3,971 followers View post →
Très Désappointé
@tresdesappointe · X

@FreeMIN24465256 @Twittos_567 @JoelleRobinet @libe Mais je peux vous en fournir, même récentes... Si vous avez toujours la flemme de lire : ça ne fait rien, et c'est dangereux. https://t.co/wZ8ER1AwOj https://t.co/dNQL52OnKa https://t.co/riHAMrAj91 https://t.co/STqYAy92Pb

Jul 6, 2022 · 72 followers View post →
5EyesInsider
@5Eyes_insider · X

@Agrant3595Grant Weird how you midssed this paper https://t.co/oQY5e4IdZr I guess your 'research' is best described here

Aug 19, 2021 · 611 followers View post →
5EyesInsider
@5Eyes_insider · X

@USBornNRaised @Agrant3595Grant @GrizzlyJoeShow @forcemultipler https://t.co/oQY5e4IdZr

Aug 19, 2021 · 611 followers View post →
The Tomahawk
@TheRealTomahawk · X

@Marco_030881 @ronan_glynn Oh good, you know what peer reviewed papers are. Here are some published papers I've found in the subject: https://t.co/mjrk4TDcpF https://t.co/8frA6StRVu https://t.co/AcAXe6GqIr https://t.co/Xh8bQKNeI5 Let me know if you want any more.

Feb 12, 2021 · 15 followers View post →
Marleen Dingenouts
@marmor40d · X

RT @sandoly: @marmor40d @Camel19759961 Hydroxychloroquine (HCQ) and chloroquine (CQ) are known to raise intracellular pH, bringing back th…

Jan 14, 2021 · 1 share · 498 followers View post →
Szabolcs Sandoly
@sandoly · X

@marmor40d @Camel19759961 Hydroxychloroquine (HCQ) and chloroquine (CQ) are known to raise intracellular pH, bringing back the blood pH to the healthy 7.3-7.35 range. https://t.co/NYFBwyQgUw

Jan 14, 2021 · 1 like · 1 share · 2,408 followers View post →
Bombadil Brin
@bjorn_daporn · X

@Noahpinion @netripy Here's a full negative review from May: https://t.co/8tgcsXxz2R Note: it turns out to be theoretical concerns along w/"the growing uncertainty about these agents for the treatment of COVID-19" --not their data-- that drive their conclusion. I'm allergic to the passive voice...

Oct 8, 2020 · 1,113 followers View post →
Meghan May
@DrMay5 · X

Here is the link to the Poznansky Lab's review of #Hydroxychloroquine studies as mentioned on @SIRIUSXM @NYUDocs. Happy reading! https://t.co/cPboYDQLOm

Jul 28, 2020 · 2 likes · 2,541 followers View post →
Galder Gonzalez
@theklaneh · X

@jasoneiroz @raoult_didier Hidroxiklorikina ere enpresa farmazeutiko batek egiten du. Eta, momentuz, datuak ez daude bere alde: https://t.co/aimKjqpqEE https://t.co/dqSGoHPla7 https://t.co/CxWNBsUx7J https://t.co/ULcsm53X9K

Jul 16, 2020 · 1 like · 9,410 followers View post →
Charles Wood
@Mare_Indicum · X

@bodhibrian And it's much more dangerous when given in conjunction with azithromycin - a doubling of death rates from heart effects. https://t.co/GxBaeMQAf8

May 25, 2020 · 881 followers View post →
Gaspard Baltazar
@BaltazarGaspard · X

@dr_l_alexandre @raoult_didier Encore une fois quelles sont vos ref? DOI: 10.1096/fj.202000919 celle là est plutot mesurée. DOI: 10.1093/ofid/ofaa130 celle là prudente DOI: 10.5582/bst.2020.03072 et encore une autre Dans cette histoire on trouve de tout dans pubMed. Un peu de prudence serait utile.

May 23, 2020 · 153 followers View post →
Craig Williams
@Craigohbryn · X

@TheBigG71 @JuliaHB1 @talkRADIO Done! https://t.co/iDQQFJajQu

May 21, 2020 · 588 followers View post →
polit
@mplesalt · X

@itche2 This article very informative. I don’t know if you’ve used pubmed for academia before but the link will take you to the abstract. Click the Wiley link in top right corner for full text. This article has been fully referenced and reviewed. https://t.co/ehNg2PT49J

May 19, 2020 · 4 followers View post →
Dr Conrad Goodwin
@ConradGoodwin · X

@GallaherCaren @DrJenGunter But hey, here’s an open access review article that summarizes the early trials. https://t.co/d6ePRUcQr2 The fact that when I say “clinically unproven”, you jump to “so you say it’s not true and you’ll never believe it”, says more about your biases than mine.

May 18, 2020 · 3 likes · 3,019 followers View post →
maycodrogas
@maycon_d_oliver · X

@italorochaaa @jujubaba61 @oatila https://t.co/Aj5ytwM3pd https://t.co/ImaUiiOJtS

May 16, 2020 · 2 followers View post →
randel saunders
@saundu22 · X

RT @RatioScientiae: https://t.co/tU4Kp4xqsG

May 14, 2020 · 1 share · 826 followers View post →
Rolando Garcia
@RatioScientiae · X

https://t.co/tU4Kp4xqsG

May 14, 2020 · 1 like · 1 share · 30,169 followers View post →
Christine Carson
@Chris_F_Carson · X

@caoimhinoceall @SorchaMcNally1 @ta19132140 @gemmaod1 HCQ was suggested for its antiVIRAL properties... https://t.co/HaQ1Mb3vtp (Hydroxy)chloroquine may do more harm than good Read for yourself https://t.co/KJmp5QA1d2 https://t.co/XpkazVtYcM

May 11, 2020 · 603 followers View post →
Hat Maul
@Xerxesheimdal · X

@NewCabal @BryanJFischer Rethinking the role of hydroxychloroquine in the treatment of COVID-19. Meyerowitz EA, Vannier AGL, Friesen MGN, Schoenfeld S, Gelfand JA, Callahan MV, Kim AY, Reeves PM, Poznansky MC. FASEB J. 2020 May;34(5):6027-6037. doi: 10.1096/fj.202000919. Epub 2020 Apr 29. PMID: 32350928

May 10, 2020 · 65 followers View post →
Christine Carson
@Chris_F_Carson · X

@wolverines_dad Couple of Tweets ago the "scientific community has never actually isolated a virus" Now you say there IS a #COVID19 viral infection (correct!) caused by a virus a cheap simple drug treats So there is a virus (Hydroxy)chloroquine may do more harm than good https://t.co/KJmp5QipOs https://t.co/oJUiH78eIA

May 7, 2020 · 603 followers View post →
Chris Bullock
@cmb04051983 · X

@NThrithm @david83799119 @business https://t.co/t2GnfAwTnS - a good summary paper that also cites the Brazilian study. You may not need a subscription.

May 6, 2020 · 14 followers View post →
Dr Conrad Goodwin
@ConradGoodwin · X

@NellESDouglas @NathanSlaman @DaveWilliamsUSA @DrDenaGrayson @FT @jburnmurdoch No there are no clinically and statistically significant results that support the use of hydroxychloroquine as a treatment. See an open-access paper from mere days ago, have a read: https://t.co/G949SeRiPT Table 1 nicely summaries the issues.

May 4, 2020 · 3,019 followers View post →
Scott
@scott1849 · X

@barbj2000 @thornhillgd @dapplegraypony @bessbell https://t.co/HIAQ6cYTEf

May 3, 2020 · 40 followers View post →
Larry O
@larryo99 · X

Rethinking the role of #hydroxychloroquine in the treatment of #COVID‐19 https://t.co/4XPxDcAgZu

May 3, 2020 · 184 followers View post →
Birdie
@birdielovesdogs · X

@JacuzziJoeQ @rich_prayer @maddow Because it is used to treat diseases like rheumatoid arthritis. Perhaps you’ve overlooked that in your research. https://t.co/1qyvX6DCOX

May 3, 2020 · 278 followers View post →
FASEB
@FASEBorg · X

Researchers present mechanistic reasons why chloroquine and hydroxychloroquine may fail for #COVID19. Explore their research in @FASEBJournal: https://t.co/rjKgvNimry #coronavirus #science #research https://t.co/R9t5oktqPv

May 1, 2020 · 10,487 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @HarvardMalaria:

May 1, 2020 · 3 shares · 1,822 followers View post →
Harvard's Defeating Malaria Initiative
@HarvardMalaria · X

May 1, 2020 · 5 likes · 3 shares · 4,713 followers View post →
James V. Kohl
@microRNApro · X

https://t.co/RsYzvXM1C2 Every so-called scientist who missed the connection from God's Creation of UV light and water to biophysically constrained viral latency across kingdoms must try to convince you that not enough is known to treat stress-linked reactivation of HERVs.

May 1, 2020 · 2,573 followers View post →
Patrick Reeves
@pmreeves · X

Our article exploring the potential, concerns, and risks of chloroquine and hydroxychloroquine for COVID19 is now available. #COVID19 #HCQ https://t.co/2d43JYCEEg https://t.co/A8WHB9QuSq

May 1, 2020 · 2 likes · 412 followers View post →
Rostyslav Bubnov
@RostBubnov · X

https://t.co/EopY8K2qoP

May 1, 2020 · 104 followers View post →
FASEB
@FASEBorg · X

Researchers present mechanistic reasons why chloroquine and hydroxychloroquine may fail for #COVID19. Explore their research in @FASEBJournal: https://t.co/HtyWK0fRwM #coronavirus #science #research https://t.co/FNlQJXmFdd

Apr 30, 2020 · 1 share · 10,487 followers View post →
Chloroquine | PDF | Medical Specialties | Clinical Medicine
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FASEB Journal. 34 (5): 6027–6037. doi:10.1096/fj.202000919 (https://doi.org/10.1096%2Ffj.202000919).

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doi:10.1096/fj.202000919 . PMC 7267640 . PMID 32350928 . 4. Juurlink DN (April 2020). "Safety considerations with chloroquine, hydroxychloroquine and ...

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