FASEB Journal. 34 (5): 6027–6037. doi:10.1096/fj.202000919 (https://doi.org/10.1096%2Ffj.202000919).
Rethinking the role of hydroxychloroquine in the treatment of COVID-19.
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Apr 2020 – Jan 2024Where it's discussed
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X / Twitter36 posts
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News4 articles
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YouTube2 videos
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Facebook1 posts
AI synopsis
What people are saying
The overall tone includes technical references to mechanisms like endosomal pH changes, and critical comments about study validity, which demonstrates a moderate level of engagement and interest. Some discussions mention the risks of combining HCQ with other drugs, highlighting concerns over safety and scientific rigor, while others seek to understand the complex mechanisms involved, reflecting a balanced and analytical exchange.
The discussions seem divided, with some posts questioning or criticizing the publication, while others acknowledge its scientific focus without outright agreement or disagreement.
Many posts reference detailed scientific mechanisms and studies, indicating a moderate level of curiosity or engagement with the topic, though not with high enthusiasm.
Participants quote and critique specific research points, such as mechanisms of HCQ action and study limitations, showing active involvement rather than superficial mentions.
The discussions seem more academic and informational, with some posts sharing links to full studies, but there's no clear consensus on altering practices or policies, leading to a neutral impact score.
Abstract in brief
- Currently, there are no proven treatments for COVID-19, and initial hopes for hydroxychloroquine (HCQ) were based on limited and not high-quality data.
- The use of HCQ and chloroquine can cause serious side effects, especially heart-related issues, and their immunomodulatory effects might actually hinder the body's natural immune response to the virus.
- Given the uncertain benefits and potential risks, more well-designed clinical trials are needed to determine whether these drugs should be used for COVID-19 treatment.
Top posts
Most liked on X and Bluesky@GallaherCaren @DrJenGunter But hey, here’s an open access review article that summarizes the early trials. https://t.co/d6ePRUcQr2 The fact that when I say “clinically unproven”, you jump to “so you say it’s not true and you’ll never believe it”, says more about your biases than mine.
Here is the link to the Poznansky Lab's review of #Hydroxychloroquine studies as mentioned on @SIRIUSXM @NYUDocs. Happy reading! https://t.co/cPboYDQLOm
Our article exploring the potential, concerns, and risks of chloroquine and hydroxychloroquine for COVID19 is now available. #COVID19 #HCQ https://t.co/2d43JYCEEg https://t.co/A8WHB9QuSq
https://t.co/tU4Kp4xqsG
@jasoneiroz @raoult_didier Hidroxiklorikina ere enpresa farmazeutiko batek egiten du. Eta, momentuz, datuak ez daude bere alde: https://t.co/aimKjqpqEE https://t.co/dqSGoHPla7 https://t.co/CxWNBsUx7J https://t.co/ULcsm53X9K
All mentions
Understanding Chloroquine: Mechanisms and Controversies
Do you really know how chloroquine works? This video explains its effects in the body and why its efficacy is debated. Join Professor Elizabeth Igne Ferreira from the Faculty of Pharmaceutical Sciences for an informed…
Chloroquine vs Hydroxychloroquine: Key Differences Explained
In this video, we discuss the interruption of clinical trials for chloroquine to treat COVID-19 by the WHO. A significant study in The Lancet suggested no benefits and possible risks associated with chloroquine and…
https://t.co/rhyCtZCA5N
RT @renesugar: Rethinking the role of hydroxychloroquine in the treatment of #COVID19 https://t.co/qNA4nRYdR0 "By increasing endosomal pH…
Rethinking the role of hydroxychloroquine in the treatment of #COVID19 https://t.co/qNA4nRYdR0 "thereby diminishing the induction of cytokines which may play a role in viral control including type I interferon, IL-6, and IL-12."
Rethinking the role of hydroxychloroquine in the treatment of #COVID19 https://t.co/qNA4nRYdR0 "By increasing endosomal pH, HCQ reduces TLR 7 and TLR 9 affinity for viral RNA,"
@FreeMIN24465256 @Twittos_567 @JoelleRobinet @libe Mais je peux vous en fournir, même récentes... Si vous avez toujours la flemme de lire : ça ne fait rien, et c'est dangereux. https://t.co/wZ8ER1AwOj https://t.co/dNQL52OnKa https://t.co/riHAMrAj91 https://t.co/STqYAy92Pb
@Agrant3595Grant Weird how you midssed this paper https://t.co/oQY5e4IdZr I guess your 'research' is best described here
@USBornNRaised @Agrant3595Grant @GrizzlyJoeShow @forcemultipler https://t.co/oQY5e4IdZr
@Marco_030881 @ronan_glynn Oh good, you know what peer reviewed papers are. Here are some published papers I've found in the subject: https://t.co/mjrk4TDcpF https://t.co/8frA6StRVu https://t.co/AcAXe6GqIr https://t.co/Xh8bQKNeI5 Let me know if you want any more.
RT @sandoly: @marmor40d @Camel19759961 Hydroxychloroquine (HCQ) and chloroquine (CQ) are known to raise intracellular pH, bringing back th…
@marmor40d @Camel19759961 Hydroxychloroquine (HCQ) and chloroquine (CQ) are known to raise intracellular pH, bringing back the blood pH to the healthy 7.3-7.35 range. https://t.co/NYFBwyQgUw
@Noahpinion @netripy Here's a full negative review from May: https://t.co/8tgcsXxz2R Note: it turns out to be theoretical concerns along w/"the growing uncertainty about these agents for the treatment of COVID-19" --not their data-- that drive their conclusion. I'm allergic to the passive voice...
Here is the link to the Poznansky Lab's review of #Hydroxychloroquine studies as mentioned on @SIRIUSXM @NYUDocs. Happy reading! https://t.co/cPboYDQLOm
@jasoneiroz @raoult_didier Hidroxiklorikina ere enpresa farmazeutiko batek egiten du. Eta, momentuz, datuak ez daude bere alde: https://t.co/aimKjqpqEE https://t.co/dqSGoHPla7 https://t.co/CxWNBsUx7J https://t.co/ULcsm53X9K
@bodhibrian And it's much more dangerous when given in conjunction with azithromycin - a doubling of death rates from heart effects. https://t.co/GxBaeMQAf8
@dr_l_alexandre @raoult_didier Encore une fois quelles sont vos ref? DOI: 10.1096/fj.202000919 celle là est plutot mesurée. DOI: 10.1093/ofid/ofaa130 celle là prudente DOI: 10.5582/bst.2020.03072 et encore une autre Dans cette histoire on trouve de tout dans pubMed. Un peu de prudence serait utile.
@TheBigG71 @JuliaHB1 @talkRADIO Done! https://t.co/iDQQFJajQu
@itche2 This article very informative. I don’t know if you’ve used pubmed for academia before but the link will take you to the abstract. Click the Wiley link in top right corner for full text. This article has been fully referenced and reviewed. https://t.co/ehNg2PT49J
@GallaherCaren @DrJenGunter But hey, here’s an open access review article that summarizes the early trials. https://t.co/d6ePRUcQr2 The fact that when I say “clinically unproven”, you jump to “so you say it’s not true and you’ll never believe it”, says more about your biases than mine.
@italorochaaa @jujubaba61 @oatila https://t.co/Aj5ytwM3pd https://t.co/ImaUiiOJtS
RT @RatioScientiae: https://t.co/tU4Kp4xqsG
https://t.co/tU4Kp4xqsG
@caoimhinoceall @SorchaMcNally1 @ta19132140 @gemmaod1 HCQ was suggested for its antiVIRAL properties... https://t.co/HaQ1Mb3vtp (Hydroxy)chloroquine may do more harm than good Read for yourself https://t.co/KJmp5QA1d2 https://t.co/XpkazVtYcM
@NewCabal @BryanJFischer Rethinking the role of hydroxychloroquine in the treatment of COVID-19. Meyerowitz EA, Vannier AGL, Friesen MGN, Schoenfeld S, Gelfand JA, Callahan MV, Kim AY, Reeves PM, Poznansky MC. FASEB J. 2020 May;34(5):6027-6037. doi: 10.1096/fj.202000919. Epub 2020 Apr 29. PMID: 32350928
@wolverines_dad Couple of Tweets ago the "scientific community has never actually isolated a virus" Now you say there IS a #COVID19 viral infection (correct!) caused by a virus a cheap simple drug treats So there is a virus (Hydroxy)chloroquine may do more harm than good https://t.co/KJmp5QipOs https://t.co/oJUiH78eIA
@NThrithm @david83799119 @business https://t.co/t2GnfAwTnS - a good summary paper that also cites the Brazilian study. You may not need a subscription.
@NellESDouglas @NathanSlaman @DaveWilliamsUSA @DrDenaGrayson @FT @jburnmurdoch No there are no clinically and statistically significant results that support the use of hydroxychloroquine as a treatment. See an open-access paper from mere days ago, have a read: https://t.co/G949SeRiPT Table 1 nicely summaries the issues.
@barbj2000 @thornhillgd @dapplegraypony @bessbell https://t.co/HIAQ6cYTEf
Rethinking the role of #hydroxychloroquine in the treatment of #COVID‐19 https://t.co/4XPxDcAgZu
@JacuzziJoeQ @rich_prayer @maddow Because it is used to treat diseases like rheumatoid arthritis. Perhaps you’ve overlooked that in your research. https://t.co/1qyvX6DCOX
Researchers present mechanistic reasons why chloroquine and hydroxychloroquine may fail for #COVID19. Explore their research in @FASEBJournal: https://t.co/rjKgvNimry #coronavirus #science #research https://t.co/R9t5oktqPv
RT @HarvardMalaria:
https://t.co/RsYzvXM1C2 Every so-called scientist who missed the connection from God's Creation of UV light and water to biophysically constrained viral latency across kingdoms must try to convince you that not enough is known to treat stress-linked reactivation of HERVs.
Our article exploring the potential, concerns, and risks of chloroquine and hydroxychloroquine for COVID19 is now available. #COVID19 #HCQ https://t.co/2d43JYCEEg https://t.co/A8WHB9QuSq
https://t.co/EopY8K2qoP
Researchers present mechanistic reasons why chloroquine and hydroxychloroquine may fail for #COVID19. Explore their research in @FASEBJournal: https://t.co/HtyWK0fRwM #coronavirus #science #research https://t.co/FNlQJXmFdd
FASEB Journal. 34 (5): 6027–6037. doi:10.1096/fj.202000919 (https://doi.org/10.1096%2Ffj.202000919).
doi:10.1096/fj.202000919 . PMC 7267640 . PMID 32350928 . 4. Juurlink DN (April 2020). "Safety considerations with chloroquine, hydroxychloroquine and ...
2020;doi:10.1096/fj.202000919. For more information: Mark C. Poznansky, MD, PhD, can be reached at The Vaccine and Immunotherapy Center, MGH ...
com/doi/full/10.1096/fj.202000919. faseb.onlinelibrary.wiley.com. Rethinking the role of hydroxychloroquine in the. 5 yrs. Alexandre da Silva.
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