May 2020 PMID 32423490

Polygenic risk scores: from research tools to clinical instruments.

Cathryn M Lewis, Evangelos Vassos

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Mentions

103

Peak: 55 in May 2020

across 4 sources since May 2020

Extended reach

508,375

potential audience

Total likes

201

Video views

447

Mentions per month

May 2020 – Oct 2024

Where it's discussed

X / Twitter69 posts
News22 articles
YouTube6 videos
Blogs6 articles

AI synopsis

What people are saying

The discussions demonstrate a balanced interest, with some posters emphasizing the scientific progress and review articles on polygenic risk scores, like mentions of their potential in disease prediction and limitations in current models, while others express skepticism about resources and practical applications. The tone varies from professional and informative to cautious, capturing the ongoing debates within the field.

AgreementNeither agree nor disagree

The discussions show a mix of support and skepticism, with some recognizing the potential of polygenic risk scores, while others question their practical utility and limitations.

InterestModerate interest

Most posts display curiosity about the research, especially referencing the review papers and discussions about future applications, indicating a moderate level of interest.

EngagementModerate engagement

Several users are actively engaging with the topic by referencing studies, sharing their research, and asking questions about clinical utility, reflecting a meaningful but not deeply technical engagement.

ImpactNeutral impact

The overall influence of these discussions appears moderate, as they highlight ongoing debates and research developments but lack evidence of wide-scale policy or clinical adoption yet.

Abstract in brief

Polygenic risk scores (PRS) are tools that combine genetic variants to estimate an individual's likelihood of developing complex diseases, but their usefulness in clinical settings is still limited due to low accuracy in the general population.
PRS are more promising for specific groups with higher disease risk, such as early-stage patients, where they can aid in diagnosis and treatment decisions; however, challenges include less reliable results for non-European populations and difficulties translating PRS into straightforward lifetime risk estimates.
The review discusses how PRS could be useful at different stages of disease development, highlights current progress, and emphasizes the need to overcome obstacles before these scores can be widely adopted in healthcare.]

Read the full abstract

All mentions

Applying Polygenic Scores at Scale for Disease Prediction in Biobanks

Chris Gignoux discusses the application of polygenic scores at large-scale biobank levels. The talk covers current research, challenges in clinical adoption, and how PRS can aid in disease diagnosis and treatment…

Computational Genomics Summer Institute CGSI · Nov 21, 2022 332 views

Transforming Polygenic Risk Scores from Research to Clinical Practice

Polygenic risk scores estimate the likelihood of developing complex diseases using genetic variants, but their clinical usefulness is still evolving. This video discusses current progress, challenges, and potential…

Medicine RTCL TV · May 9, 2024 32 views

Converting Polygenic Risk Scores from Research to Clinical Use

Polygenic risk scores estimate an individual's likelihood of developing complex diseases, but their clinical usefulness faces challenges like low accuracy in general populations. This video reviews progress and…

Medicine RTCL TV · Mar 6, 2024 30 views

Converting Polygenic Risk Scores from Research Tools to Clinical Applications

Polygenic risk scores estimate individual disease risk using genetic variants. While promising, their clinical use faces challenges like accuracy and population differences, emphasizing need for further development…

Medicine RTCL TV · Sep 24, 2024 23 views

Evaluating Polygenic Risk Scores for Clinical Use and Disease Prediction

Polygenic risk scores estimate individual disease likelihood based on genetic variants, offering potential in clinical settings, especially for high-risk groups. Challenges include limited accuracy in diverse…

Medicine RTCL TV · Oct 25, 2024 21 views

Advancing Polygenic Risk Scores from Research to Clinical Practice

Polygenic risk scores estimate disease likelihood by combining genetic variants. While promising for high-risk groups, challenges remain in accuracy and broad clinical application, especially for non-European…

Medicine RTCL TV · Nov 25, 2023 11 views

Paras Chopra

@paraschopra · X

But these tests will give scores on hundreds of diseases. I doubt any single company has sufficient resources to model genetically-determined risk of hundreds of diseases in a statistically significant way. And that is why there are no studies cited. https://t.co/ARVkotKtK2

May 10, 2022 · 4 likes · 220,544 followers View post →

Janitza Montalvo-Ortiz

@JanitzaMontalvo · X

RT @cathrynlewis: #Kings25 Science Much of my recent research has been on #polygenic risk scores. Two review papers with @VangelisVassos…

Sep 17, 2021 · 1 share · 1,230 followers View post →

Dr Cathryn Lewis

@cathrynlewis · X

Sep 17, 2021 · 5 likes · 1 share · 8,018 followers View post →

Usama.P

@Usama_Polani · X

@Andrew___Baker https://t.co/ZM66ttuLJT And so is this, especially given the role it can play it trying to explain differences in educational attainment across groups(including racial and national groups). Like until that coverage improves, skeptical of the whole thing https://t.co/qFKsCLijE5

Sep 11, 2021 · 623 followers View post →

AMPdr™

@AMPdrInnovation · X

RT @GenomeMedicine: Read one of Genome Medicine's most popular articles of 2020, Polygenic risk scores: from research tools to clinical ins…

May 13, 2021 · 5 shares · 879 followers View post →

Prof Angelica Ronald

@Gelironald · X

The ADHD PRS cannot yet accurately predict individual outcomes.ADHD PRS may in the future be one of these characteristics that is used in combination with other factors to identify individuals who are likely to develop ADHD. See https://t.co/sPt0D6eFx9 https://t.co/Iw4VjnwKYS 6/n

Apr 15, 2021 · 1 like · 1,462 followers View post →

Professor Zoe Winters

@drzoewinters · X

RT @GenomeMedicine: Read one of Genome Medicine's most popular articles of 2020, Polygenic risk scores: from research tools to clinical ins…

Apr 9, 2021 · 5 shares · 667 followers View post →

Simon Mead

@smead2 · X

RT @GenomeMedicine: Read one of Genome Medicine's most popular articles of 2020, Polygenic risk scores: from research tools to clinical ins…

Mar 24, 2021 · 5 shares · 3,270 followers View post →

evasanchezrodriguez

@evisaro · X

RT @GenomeMedicine: Read one of Genome Medicine's most popular articles of 2020, Polygenic risk scores: from research tools to clinical ins…

Mar 8, 2021 · 5 shares · 624 followers View post →

Genome Medicine

@GenomeMedicine · X

Read one of Genome Medicine's most popular articles of 2020, Polygenic risk scores: from research tools to clinical instruments

Mar 3, 2021 · 34 likes · 5 shares · 24,733 followers View post →

Dr Cathryn Lewis

@cathrynlewis · X

Jan 28, 2021 · 8 likes · 8,018 followers View post →

Shai Carmi

@ShaiCarmi · X

This was confusing: Genome Medicine published reviews on the clinical utility of polygenic scores in both 2020 and 2021. Both Lewis et al. But diff authors! https://t.co/dM5iX5EAY9 https://t.co/xCK2JLDsAQ

Jan 28, 2021 · 4 likes · 3,823 followers View post →

Alberto Lira

@AlbeLira · X

La implementación clínica de Puntuaciones de Riesgo Poligénico será util el cohortes con alta probabilidad pre-prueba. Excelente revisión sobre el uso de estos scores en la practica clínica. Lewis C; et al. BMC 2020. https://t.co/2u531xjaxa https://t.co/jXljasaVA9

Dec 2, 2020 · 3 likes · 1,694 followers View post →

Charles Campbell Roberts

@CCRobertsARK · X

Sep 2, 2020 · 5 likes · 2 shares · 59,788 followers View post →

Andy Latchford

@AndyLatchford · X

RT @MuinJKhoury: An informative @GenomeMedicine review by @cathrynlewis & E. Vassos on the potential clinical applications of polygenic ris…

May 22, 2020 · 6 shares · 242 followers View post →

Yin-Hung Lin

@yinhunglin · X

RT @MuinJKhoury: An informative @GenomeMedicine review by @cathrynlewis & E. Vassos on the potential clinical applications of polygenic ris…

May 21, 2020 · 6 shares · 32 followers View post →

Philippe Froguel

@philippefroguel · X

RT @MuinJKhoury: An informative @GenomeMedicine review by @cathrynlewis & E. Vassos on the potential clinical applications of polygenic ris…

May 21, 2020 · 6 shares · 5,023 followers View post →

Benjamin Garcia-Bloj

@BGarciaBloj · X

RT @MuinJKhoury: An informative @GenomeMedicine review by @cathrynlewis & E. Vassos on the potential clinical applications of polygenic ris…

May 21, 2020 · 6 shares · 165 followers View post →

Christian LLC

@lacks22 · X

RT @MuinJKhoury: An informative @GenomeMedicine review by @cathrynlewis & E. Vassos on the potential clinical applications of polygenic ris…

May 21, 2020 · 6 shares · 420 followers View post →

WeiTing Lin(GR15

@weitinglin66 · X

RT @MuinJKhoury: An informative @GenomeMedicine review by @cathrynlewis & E. Vassos on the potential clinical applications of polygenic ris…

May 21, 2020 · 6 shares · 1,289 followers View post →

Muin J. Khoury

@MuinJKhoury · X

May 21, 2020 · 18 likes · 6 shares · 4,018 followers View post →

Topher Hübel

@topherhuebel · X