The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians, and functional work in flies and mice, to support ALK via central nervous system https://t.co/gI81Driol4 @penningerlab @ubclifesciences @CellCellPress https://t.co/fza7HZjEmE
Identification of ALK in Thinness.
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May 2020 – Aug 2025Where it's discussed
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What people are saying
Numerous discussions highlight the identification of ALK as a thinness gene, emphasizing its potential role in metabolism and weight management. Phrases like 'thinness gene conferring resistance against weight gain' and 'groundbreaking work' convey excitement and curiosity about the findings. The tone is predominantly positive, suggesting a strong consensus on the importance of this research in addressing obesity.
There is general support for the findings in the discussions, with many acknowledging the relevance of ALK as a thinness gene.
Participants demonstrate high interest in the topic, frequently referencing the implications of genetic factors influencing obesity.
While some posts reflect deeper engagement, such as discussions on the mechanisms of ALK, others are more superficial, merely sharing the article.
Many contributors believe that the research could significantly contribute to understanding thinness and potential obesity interventions.
Abstract in brief
- There is significant variability among individuals in gaining weight, even in similar environments, prompting research into genetic factors influencing obesity.
- A genome-wide association study (GWAS) identified anaplastic lymphoma kinase (ALK) as a potential gene linked to thinness in a specific group of metabolically healthy individuals with low BMI.
- Experiments in fruit flies and mice revealed that reducing ALK leads to lower fat storage and a resistance to obesity, suggesting that ALK plays a key role in regulating energy expenditure and fat breakdown.
Top posts
Most liked on X and Bluesky食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoing research that focuses on people who are particularly thin rather than particularly fat. h/t @deirdre_tobias https://t.co/SEeBJztAid
How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT
https://t.co/Y01JCEyqvy https://t.co/fxXrkWE3Ht https://t.co/vNo4yvryQR
Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipose tissue. https://t.co/SEeBJztAid
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Секрет худых людей
Genetic Insights on Thinness and Severe Obesity
This video presents findings from a study that examined the heritability of thinness, revealing it to be similar to severe obesity. It explores genetic factors affecting body weight extremes, offering insights that may…
RT @whsource: Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipos…
RT @whsource: Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipos…
RT @whsource: Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipos…
Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipose tissue. https://t.co/SEeBJztAid
RRIDs were included in the Cell paper "Identification of ALK in Thinness" (https://t.co/HG5wjHHvNG). Thank you for making your #methodsmatter. #STMpublishing
https://t.co/Y01JCEyqvy https://t.co/fxXrkWE3Ht https://t.co/vNo4yvryQR
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
Identification of ALK in Thinness https://t.co/8c37ttn1nM
@JohnSpeakman4 @KevinH_PhD If ALK, for instance, is a thinness gene, per Orthofer et al, promoting resistance to weight gain via "sympathetic control of adipose tissue lipolysis," then wouldn't a variant that doesn't stimulate lipolysis be a fatness gene? A direct mechanism? https://t.co/m5MlUu8JqI
Identification of ALK in Thinness https://t.co/YJ5zpWTFUf
RT @interactivefly: Orthofer, M., Valsesia, A., ..., Gheldof, N. and Penninger, J. M. (2020). Identification of ALK in Thinness. Cell 181(6…
Orthofer, M., Valsesia, A., ..., Gheldof, N. and Penninger, J. M. (2020). Identification of ALK in Thinness. Cell 181(6): 1246-1262 https://t.co/txIvFdR4JU
Our on-line journal club by KI. Identification of ALK in Thinness. From Josef Penninger's lab, IMBA, Austria. https://t.co/Fvio4pp8kE
Article in this issue of Cell: Identification of ALK in Thinness - https://t.co/mcTFV00F4T
RT @NatureRevEndo: Identification of ALK in Thinness https://t.co/9p8klSmx4a
RT @ConscienHealth: Featured in the #OEO this week: ►Identification of ALK in Thinness ►RCT: High-intensity Training in Normobaric Hypoxia…
Featured in the #OEO this week: ►Identification of ALK in Thinness ►RCT: High-intensity Training in Normobaric Hypoxia ►Effects of Carb-Restricted Dietary Patterns & PA Much more at: https://t.co/4qRgZlR5Li
Interesting paper, ALK has been identified as a thinness gene conferring resistance against weight gain. https://t.co/gAZy4lEYGq
Very nice to see more candidate lean, or thinness genes popping out of GWA! Identification of ALK in Thinness https://t.co/j7YV124B9J
Targeting ALK to fight obesity? Identification of ALK in Thinness https://t.co/VLCNXdT29j
RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T
Identification of ALK in Thinness https://t.co/nNzWWOsQLI
Identification of ALK in Thinness https://t.co/CuufvmsdGd
RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
Genome-wide Association Study in the EGCUT biobank identifies ALK as a candidate thinness gene. In mice, genetic deletion of Alk resulted in thin animals with marked resistance to diet- and leptin-mutation-induced obesity. https://t.co/bQRgXtrPAu #obesity #Genetics https://t.co/B86ONkpS3F
Identification of ALK in Thinness: Cell https://t.co/HoqXsUD2zl
RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt
https://t.co/sZsvvPQZfU
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…
Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoing research that focuses on people who are particularly thin rather than particularly fat. h/t @deirdre_tobias https://t.co/SEeBJztAid
La comparación de muestras de ADN de personas delgadas sanas con personas de peso normal detectó variantes genéticas únicas del gen ALK en las personas delgadas. ALK pudiese funcionar como gen de la delgadez involucrado en la resistencia al aumento de peso https://t.co/ZLtNMIANJF
RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T
Identification of ALK in Thinness: Cell https://t.co/8dgpmQdNJy
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
“We discovered anaplastic lymphoma kinase ( ALK) as a candidate thinness gene” https://t.co/qz3iwoKxXk. Big money.
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…
The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians, and functional work in flies and mice, to support ALK via central nervous system https://t.co/gI81Driol4 @penningerlab @ubclifesciences @CellCellPress https://t.co/fza7HZjEmE
Thinness is in the brain! Beautiful work. Identification of ALK in Thinness https://t.co/3AwUbQHTOO
RT @the_paper_link: Trend up+4: *Orthofer M* et al (Cell) __Identification of ALK in Thinness__ https://t.co/4jMN2aTF71
Identification of ALK in Thinness. #lymphoma #lymsm https://t.co/Rqdiv6G6Fz
Trend up+4: *Orthofer M* et al (Cell) __Identification of ALK in Thinness__ https://t.co/4jMN2aTF71
Identification of ALK in Thinness. https://t.co/oRBwIP1gZ7 https://t.co/0aETo3uG3a
Identification of ALK in Thinness 痩せさせない遺伝子ALKを発見 https://t.co/MgNGgA6Tmg
RT @bensolomon1: How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT
RT @bensolomon1: How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT
Gene for "thinness"? Identification of ALK in Thinness https://t.co/8RVcOrWyCK
Awesome new paper! Identification of ALK in Thinness - https://t.co/xYikG3a3uy
Identification of ALK in Thinness https://t.co/QxpQsiBMGi https://t.co/Rn4F92S0rn
Very interesting study...! Identification of ALK in Thinness: Cell https://t.co/T44IE5AI2P
RT @bensolomon1: How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT
How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT
Identification of ALK in thinness https://t.co/hvAMuLbnPV
Groundbreaking work from our campus: "Identification of ALK in thinness" https://t.co/XTVZ3X2vQM @viennabiocenter #obesity
RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T
RT @NatureRevEndo: Identification of ALK in Thinness https://t.co/9p8klSmx4a
Identification of ALK in Thinness https://t.co/9p8klSmx4a
RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T
New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T
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