Cell June 2020 PMID 32442405

Identification of ALK in Thinness.

Michael Orthofer, Armand Valsesia, Reedik Mägi, Qiao-Ping Wang, Joanna Kaczanowska, Ivona Kozieradzki, Alexandra Leopoldi, Domagoj Cikes, Lydia M Zopf, Evgenii O Tretiakov, Egon Demetz, Richard Hilbe, Anna Boehm, Melita Ticevic, Margit Nõukas

Mentions

191
Peak: 58 in May 2020
across 6 sources since May 2020

Extended reach

1,739,655
potential audience

Total likes

919

Video views

48,470

Mentions per month

May 2020 – Aug 2025

Where it's discussed

  • News88 articles
  • X / Twitter80 posts
  • Blogs14 articles
  • Reddit5 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Numerous discussions highlight the identification of ALK as a thinness gene, emphasizing its potential role in metabolism and weight management. Phrases like 'thinness gene conferring resistance against weight gain' and 'groundbreaking work' convey excitement and curiosity about the findings. The tone is predominantly positive, suggesting a strong consensus on the importance of this research in addressing obesity.

AgreementModerate agreement

There is general support for the findings in the discussions, with many acknowledging the relevance of ALK as a thinness gene.

InterestHigh interest

Participants demonstrate high interest in the topic, frequently referencing the implications of genetic factors influencing obesity.

EngagementModerate engagement

While some posts reflect deeper engagement, such as discussions on the mechanisms of ALK, others are more superficial, merely sharing the article.

ImpactHigh impact

Many contributors believe that the research could significantly contribute to understanding thinness and potential obesity interventions.

Abstract in brief

  • There is significant variability among individuals in gaining weight, even in similar environments, prompting research into genetic factors influencing obesity.
  • A genome-wide association study (GWAS) identified anaplastic lymphoma kinase (ALK) as a potential gene linked to thinness in a specific group of metabolically healthy individuals with low BMI.
  • Experiments in fruit flies and mice revealed that reducing ALK leads to lower fat storage and a resistance to obesity, suggesting that ALK plays a key role in regulating energy expenditure and fat breakdown.

Top posts

Most liked on X and Bluesky
Eric Topol
@EricTopol · X

The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians, and functional work in flies and mice, to support ALK via central nervous system https://t.co/gI81Driol4 @penningerlab @ubclifesciences @CellCellPress https://t.co/fza7HZjEmE

May 24, 2020 · 70 likes · 17 shares · 679,520 followers View post →
新Mmの憂鬱
@miyatamitsuru · X

食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 59 likes · 8 shares · 36,059 followers View post →
Stephan J. Guyenet
@sguyenet · X

Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoing research that focuses on people who are particularly thin rather than particularly fat. h/t @deirdre_tobias https://t.co/SEeBJztAid

May 28, 2020 · 34 likes · 8 shares · 48,957 followers View post →
Ben Solomon
@bensolomon1 · X

How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT

May 22, 2020 · 17 likes · 4 shares · 5,241 followers View post →
JT | Jerry Teixeira
@jerryteixeira · X

https://t.co/Y01JCEyqvy https://t.co/fxXrkWE3Ht https://t.co/vNo4yvryQR

Apr 18, 2021 · 10 likes · 79,153 followers View post →
Stephan J. Guyenet
@sguyenet · X

Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipose tissue. https://t.co/SEeBJztAid

May 29, 2021 · 8 likes · 3 shares · 48,957 followers View post →

All mentions

NutritionYum
@nutritionyum · X

RT @whsource: Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipos…

Jun 19, 2021 · 3 shares · 2 followers View post →
Pere Joan Sala
@Fradbius · X

RT @whsource: Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipos…

May 29, 2021 · 3 shares · 252 followers View post →
Eve Beavers is espacetimeCO
@espacetimeCO · X

RT @whsource: Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipos…

May 29, 2021 · 3 shares · 902 followers View post →
Stephan J. Guyenet
@sguyenet · X

Identification of anaplastic lymphoma kinase (ALK) as a "thinness gene". Impacts brain control of sympathetic tone to adipose tissue. https://t.co/SEeBJztAid

May 29, 2021 · 8 likes · 3 shares · 48,957 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Cell paper "Identification of ALK in Thinness" (https://t.co/HG5wjHHvNG). Thank you for making your #methodsmatter. #STMpublishing

Apr 24, 2021 · 161 followers View post →
JT | Jerry Teixeira
@jerryteixeira · X

https://t.co/Y01JCEyqvy https://t.co/fxXrkWE3Ht https://t.co/vNo4yvryQR

Apr 18, 2021 · 10 likes · 79,153 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

Jan 21, 2021 · 8 shares · 1,367 followers View post →
noorbahadar
@noorbahadarpk · X

Identification of ALK in Thinness https://t.co/8c37ttn1nM

Jan 17, 2021 · 2 likes · 155 followers View post →
gary taubes
@garytaubes · X

@JohnSpeakman4 @KevinH_PhD If ALK, for instance, is a thinness gene, per Orthofer et al, promoting resistance to weight gain via "sympathetic control of adipose tissue lipolysis," then wouldn't a variant that doesn't stimulate lipolysis be a fatness gene? A direct mechanism? https://t.co/m5MlUu8JqI

Jan 6, 2021 · 1 like · 119,872 followers View post →
Nikola
@nikolaivica · X

Identification of ALK in Thinness https://t.co/YJ5zpWTFUf

Dec 29, 2020 · 534 followers View post →
Drosophilosopher
@HammedBadmos · X

RT @interactivefly: Orthofer, M., Valsesia, A., ..., Gheldof, N. and Penninger, J. M. (2020). Identification of ALK in Thinness. Cell 181(6…

Jul 15, 2020 · 1 share · 1,363 followers View post →
Thomas Brody
@interactivefly · X

Orthofer, M., Valsesia, A., ..., Gheldof, N. and Penninger, J. M. (2020). Identification of ALK in Thinness. Cell 181(6): 1246-1262 https://t.co/txIvFdR4JU

Jul 15, 2020 · 2 likes · 1 share · 2,024 followers View post →
Ryusuke Niwa
@TsukubaNiwaLab · X

Our on-line journal club by KI. Identification of ALK in Thinness. From Josef Penninger's lab, IMBA, Austria. https://t.co/Fvio4pp8kE

Jun 29, 2020 · 1,037 followers View post →
Cell
@CellCellPress · X

Article in this issue of Cell: Identification of ALK in Thinness - https://t.co/mcTFV00F4T

Jun 11, 2020 · 1 like · 263,911 followers View post →
Álvaro Otero Campos
@otero_86 · X

RT @NatureRevEndo: Identification of ALK in Thinness https://t.co/9p8klSmx4a

Jun 9, 2020 · 2 shares · 333 followers View post →
#obsm chat
@obsmchat · X

RT @ConscienHealth: Featured in the #OEO this week: ►Identification of ALK in Thinness ►RCT: High-intensity Training in Normobaric Hypoxia…

Jun 6, 2020 · 2 shares · 3,575 followers View post →
Ted Kyle
@ConscienHealth · X

Featured in the #OEO this week: ►Identification of ALK in Thinness ►RCT: High-intensity Training in Normobaric Hypoxia ►Effects of Carb-Restricted Dietary Patterns & PA Much more at: https://t.co/4qRgZlR5Li

Jun 5, 2020 · 5 likes · 2 shares · 11,457 followers View post →
Ali Aldibbiat
@Aldibbiat · X

Interesting paper, ALK has been identified as a thinness gene conferring resistance against weight gain. https://t.co/gAZy4lEYGq

Jun 2, 2020 · 1 like · 507 followers View post →
EdinUniMetabolism
@EdinUniMetabol · X

Very nice to see more candidate lean, or thinness genes popping out of GWA! Identification of ALK in Thinness https://t.co/j7YV124B9J

Jun 2, 2020 · 1 like · 698 followers View post →
Gorba Ambroise
@AmbroiseGorba · X

Targeting ALK to fight obesity? Identification of ALK in Thinness https://t.co/VLCNXdT29j

Jun 2, 2020 · 166 followers View post →
Marc Bejarano
@beej69 · X

RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T

Jun 2, 2020 · 5 shares · 345 followers View post →
Luis Díaz-Batalla
@DiazDeBatalla · X

Identification of ALK in Thinness https://t.co/nNzWWOsQLI

Jun 1, 2020 · 759 followers View post →
ChimericChenl
@ChimericChenl · X

Identification of ALK in Thinness https://t.co/CuufvmsdGd

May 31, 2020 · 22 followers View post →
AKI
@akira_h3 · X

RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 31, 2020 · 8 shares · 1,128 followers View post →
VK Ulaganathan
@VK_Ulaganathan · X

Genome-wide Association Study in the EGCUT biobank identifies ALK as a candidate thinness gene. In mice, genetic deletion of Alk resulted in thin animals with marked resistance to diet- and leptin-mutation-induced obesity. https://t.co/bQRgXtrPAu #obesity #Genetics https://t.co/B86ONkpS3F

May 31, 2020 · 1 like · 942 followers View post →
#
@freelancer1a2b · X

Identification of ALK in Thinness: Cell https://t.co/HoqXsUD2zl

May 30, 2020 · 437 followers View post →
トク_テル
@otfk039 · X

RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 8 shares · 548 followers View post →
Scienterest
@cxaraya · X

RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 8 shares · 135 followers View post →
Hiroshi Fujisaki
@hiro2fuji · X

RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 8 shares · 549 followers View post →
Tadashi Nishida
@tadd229 · X

RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 8 shares · 9 followers View post →
かがみ
@n_kagami · X

RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 8 shares · 812 followers View post →
Δt
@zimei_no_ri · X

RT @miyatamitsuru: 食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 8 shares · 3,630 followers View post →
新Mmの憂鬱
@miyatamitsuru · X

食生活に依らず、肥満にならないスリム遺伝子が発見された! なんと肺がんの抗癌剤の標的、ALK遺伝子 だった。 Identification of ALK in Thinness: Cell https://t.co/q0yaO8agJt

May 30, 2020 · 59 likes · 8 shares · 36,059 followers View post →
Lex
@realXandre · X

https://t.co/sZsvvPQZfU

May 30, 2020 · 85 followers View post →
EJPNutrition
@EjpNutrition · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

May 29, 2020 · 8 shares · 9 followers View post →
PT_Thunem
@PT_Thunem · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

May 29, 2020 · 8 shares · 80 followers View post →
Miguel López Moreno
@nutreconciencia · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

May 29, 2020 · 8 shares · 770 followers View post →
Harmless Frog
@FrogHarmless · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

May 29, 2020 · 8 shares · 503 followers View post →
Pere Joan Sala
@Fradbius · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

May 29, 2020 · 8 shares · 252 followers View post →
Shah Fahad
@shahnutrition · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

May 29, 2020 · 8 shares · 1,097 followers View post →
Deirdre Tobias, ScD
@deirdre_tobias · X

RT @whsource: Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoi…

May 28, 2020 · 8 shares · 9,610 followers View post →
Stephan J. Guyenet
@sguyenet · X

Genome-wide study identifies a "thinness gene" that may influence metabolic rate via the hypothalamus. This is part of ongoing research that focuses on people who are particularly thin rather than particularly fat. h/t @deirdre_tobias https://t.co/SEeBJztAid

May 28, 2020 · 34 likes · 8 shares · 48,957 followers View post →
Sociedad Química de Panamá
@SOQUIPA_507 · X

La comparación de muestras de ADN de personas delgadas sanas con personas de peso normal detectó variantes genéticas únicas del gen ALK en las personas delgadas. ALK pudiese funcionar como gen de la delgadez involucrado en la resistencia al aumento de peso https://t.co/ZLtNMIANJF

May 27, 2020 · 1 like · 398 followers View post →
Ann Aro
@ann_aro93 · X

RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T

May 27, 2020 · 5 shares · 45 followers View post →
Yaron Einhorn
@yaronoox · X

Identification of ALK in Thinness: Cell https://t.co/8dgpmQdNJy

May 26, 2020 · 22 followers View post →
Frantz Fanon
@waweru · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 25, 2020 · 17 shares · 8,072 followers View post →
UBC Life Sciences Institute
@ubclifesciences · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 25, 2020 · 17 shares · 4,033 followers View post →
Dr. Biswapriya Misra
@BiswapriyaMisra · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 25, 2020 · 17 shares · 5,769 followers View post →
April Pawluk
@AprilPawluk · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 4,411 followers View post →
John Gordon (@jgordon@appdot.net)
@jgordonshare · X

“We discovered anaplastic lymphoma kinase ( ALK) as a candidate thinness gene” https://t.co/qz3iwoKxXk. Big money.

May 24, 2020 · 418 followers View post →
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 2,054 followers View post →
luis hernan graffe
@hernangraffe · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 3,148 followers View post →
Sheila Shin
@scshinyahoo · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 3,560 followers View post →
Charbel C Khoury
@Charbel_Khoury · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 1,542 followers View post →
Abdelrahman Abushouk, MD, FESC
@AbushoukMD · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 5,536 followers View post →
COVID-19 HQ
@covid19hq1 · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 12 followers View post →
marypg keating aka Mary-the-Cat
@marypgkeating · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 3,251 followers View post →
Guanlin Wang 王冠琳
@guanlin2016 · X

RT @EricTopol: The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians,…

May 24, 2020 · 17 shares · 340 followers View post →
Eric Topol
@EricTopol · X

The (understudied) genomics of thinness. Not to be covid-centric lost is this impressive study of 6% of thinnest Estonians, and functional work in flies and mice, to support ALK via central nervous system https://t.co/gI81Driol4 @penningerlab @ubclifesciences @CellCellPress https://t.co/fza7HZjEmE

May 24, 2020 · 70 likes · 17 shares · 679,520 followers View post →
Random
@RandomChaos8 · X

Thinness is in the brain! Beautiful work. Identification of ALK in Thinness https://t.co/3AwUbQHTOO

May 24, 2020 · 48 followers View post →
the paper link
@the_paper_link · X

RT @the_paper_link: Trend up+4: *Orthofer M* et al (Cell) __Identification of ALK in Thinness__ https://t.co/4jMN2aTF71

May 24, 2020 · 1 share · 137 followers View post →
Lymphoma Papers
@Lymphoma_Papers · X

Identification of ALK in Thinness. #lymphoma #lymsm https://t.co/Rqdiv6G6Fz

May 24, 2020 · 2,449 followers View post →
the paper link
@the_paper_link · X

Trend up+4: *Orthofer M* et al (Cell) __Identification of ALK in Thinness__ https://t.co/4jMN2aTF71

May 24, 2020 · 1 share · 137 followers View post →
Adipose Papers
@adipose_papers · X

Identification of ALK in Thinness. https://t.co/oRBwIP1gZ7 https://t.co/0aETo3uG3a

May 23, 2020 · 1 like · 2,457 followers View post →
biotoday
@BioTodaySuppl · X

Identification of ALK in Thinness 痩せさせない遺伝子ALKを発見 https://t.co/MgNGgA6Tmg

May 23, 2020 · 704 followers View post →
Roberto Ferrara
@RobertoFerrara_ · X

RT @bensolomon1: How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT

May 22, 2020 · 4 shares · 1,465 followers View post →
Pasquale Pisapia
@PasqualePisapia · X

RT @bensolomon1: How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT

May 22, 2020 · 4 shares · 959 followers View post →
Joseph Takahashi
@CircadianClocks · X

Gene for "thinness"? Identification of ALK in Thinness https://t.co/8RVcOrWyCK

May 22, 2020 · 2 likes · 5,082 followers View post →
Paul Humphries
@PaulHumpa · X

Awesome new paper! Identification of ALK in Thinness - https://t.co/xYikG3a3uy

May 22, 2020 · 2,606 followers View post →
jenniferwalters
@susanstorm62 · X

Identification of ALK in Thinness https://t.co/QxpQsiBMGi https://t.co/Rn4F92S0rn

May 22, 2020 · 514 followers View post →
Anette Duensing
@A_Duensing · X

Very interesting study...! Identification of ALK in Thinness: Cell https://t.co/T44IE5AI2P

May 22, 2020 · 951 followers View post →
Sakis Paliouras
@sakispalbio · X

RT @bensolomon1: How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT

May 22, 2020 · 4 shares · 142 followers View post →
Ben Solomon
@bensolomon1 · X

How curious ... anaplastic lymphoma kinase ( ALK) as a candidate thinness gene... https://t.co/zgMg6R5paT

May 22, 2020 · 17 likes · 4 shares · 5,241 followers View post →
Matthias Schewe
@Matthias_Schewe · X

Identification of ALK in thinness https://t.co/hvAMuLbnPV

May 22, 2020 · 486 followers View post →
Sebastian Burgstaller
@sebotic · X

Groundbreaking work from our campus: "Identification of ALK in thinness" https://t.co/XTVZ3X2vQM @viennabiocenter #obesity

May 21, 2020 · 470 followers View post →
AleorSK, MD
@KoliciRoela · X

RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T

May 21, 2020 · 5 shares · 28 followers View post →
Jing
@CaATiER_Chop_ER · X

RT @NatureRevEndo: Identification of ALK in Thinness https://t.co/9p8klSmx4a

May 21, 2020 · 2 shares · 323 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

Identification of ALK in Thinness https://t.co/9p8klSmx4a

May 21, 2020 · 3 likes · 2 shares · 35,523 followers View post →
Anjan Barman
@anjbth · X

RT @CellCellPress: New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T

May 21, 2020 · 5 shares · 1,410 followers View post →
Cell
@CellCellPress · X

New Article online now at Cell: Identification of ALK in Thinness https://t.co/mcTFV00F4T

May 21, 2020 · 7 likes · 5 shares · 263,911 followers View post →