May 2020 PMID 32443810

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping.

Maria Romano, Alessia Ruggiero, Flavia Squeglia, Giovanni Maga, Rita Berisio

Mentions

15
Peak: 2 in Sep 2020
across 4 sources since May 2020

Extended reach

49,349
potential audience

Total likes

957

Video views

29,306

Mentions per month

May 2020 – Oct 2025

Where it's discussed

  • X / Twitter8 posts
  • News4 articles
  • YouTube2 videos
  • Reddit1 posts

AI synopsis

What people are saying

The discussions reveal a balanced mix of technical curiosity and skepticism; for example, users debate the fidelity of the replication machinery and its components like RdRp, while others question the credibility of the publication based on its source. The tone varies from analytical to dismissive, reflecting differing levels of engagement and perceived relevance.

AgreementNeither agree nor disagree

The discussions reflect mixed opinions, with some questioning the reliability of claims about replication fidelity while others accept the structural insights.

InterestModerate interest

Most comments show moderate interest, particularly in understanding the machinery involved in viral replication, though some posts dismiss or downplay the study's significance.

EngagementModerate engagement

There is some depth in engagement, as users discuss technical components like RdRp and proofreading enzymes, but overall participation remains relatively surface-level.

ImpactModerate impact

The conversations suggest that the article influences some users' perceptions of viral replication, yet many remain skeptical or dismissive, indicating a moderate perceived impact.

Abstract in brief

  • The article focuses on how SARS-CoV-2 replicates its RNA inside infected cells, involving complex interactions between viral and host proteins for functions like RNA synthesis, proofreading, and capping.
  • It highlights recent structural and functional data on key components of the viral replication machinery, mainly obtained through modeling and literature review, to better understand their roles and interactions.
  • Cofactors such as Nsp8 and Nsp10 are emphasized as crucial players that activate and stabilize the replication complex, improving the virus's ability to efficiently replicate its RNA.]

Top posts

Most liked on X and Bluesky
MotleySlate
@MotleySlate · X

@Kevin_McKernan @SynaptekLabs @NotJason666 @AnneliseBocquet @PinsolleT @PlanZip @dr_SDRK @TheJikky @denisrancourt @extemporea @BretWeinstein @ProfTimNoakes @delbigtree @FatEmperor @ArtemisiaBurge1 @pathocratie I question his low fidelity replication claim for this complex ~30k bp genome. Sure, there are errors, but isn't the replication machinery better than what he claims? RdRp nsp12, Helicase nsp13, RNA proofreader nsp14, and other nsp's are quite amazing.1/2 https://t.co/LN5wB022fu

Nov 25, 2022 · 3 likes · 1 share · 3,654 followers View post →
Cells MDPI
@Cells_MDPI · X

"A Structural View of #SARS-CoV-2 #RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping" from Romano et al. #cellsmdpi #molecularbiology #cellbiology #COVID19 #RNAreplication #proteinstructure Full text: https://t.co/aLBpLVYxNv https://t.co/kimZqREkLi

Jan 14, 2022 · 2 likes · 1 share · 3,041 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/EnccwfB16r

Apr 28, 2021 · 1 like · 49 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @Cells_MDPI: "A Structural View of #SARS-CoV-2 #RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping" from Romano et…

Jan 14, 2022 · 1 share · 8,184 followers View post →
Maples the Syrup Frog
@Maples46014332 · X

RT @MotleySlate: @Kevin_McKernan @SynaptekLabs @NotJason666 @AnneliseBocquet @PinsolleT @PlanZip @dr_SDRK @TheJikky @denisrancourt @extempo…

Nov 25, 2022 · 1 share · 2,793 followers View post →
LIgirl82
@longisland82 · X

@kvwatchtay7 @viralvideovlogs Reference Romano, M., Ruggiero, A., Squeglia, F., Maga, G., & Berisio, R. (2020). A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping. Cells, 9(5), 1267. https://t.co/izhKQ5H4ok

Apr 14, 2021 · 1,927 followers View post →

All mentions

Maples the Syrup Frog
@Maples46014332 · X

RT @MotleySlate: @Kevin_McKernan @SynaptekLabs @NotJason666 @AnneliseBocquet @PinsolleT @PlanZip @dr_SDRK @TheJikky @denisrancourt @extempo…

Nov 25, 2022 · 1 share · 2,793 followers View post →
MotleySlate
@MotleySlate · X

@Kevin_McKernan @SynaptekLabs @NotJason666 @AnneliseBocquet @PinsolleT @PlanZip @dr_SDRK @TheJikky @denisrancourt @extemporea @BretWeinstein @ProfTimNoakes @delbigtree @FatEmperor @ArtemisiaBurge1 @pathocratie I question his low fidelity replication claim for this complex ~30k bp genome. Sure, there are errors, but isn't the replication machinery better than what he claims? RdRp nsp12, Helicase nsp13, RNA proofreader nsp14, and other nsp's are quite amazing.1/2 https://t.co/LN5wB022fu

Nov 25, 2022 · 3 likes · 1 share · 3,654 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @Cells_MDPI: "A Structural View of #SARS-CoV-2 #RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping" from Romano et…

Jan 14, 2022 · 1 share · 8,184 followers View post →
Cells MDPI
@Cells_MDPI · X

"A Structural View of #SARS-CoV-2 #RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping" from Romano et al. #cellsmdpi #molecularbiology #cellbiology #COVID19 #RNAreplication #proteinstructure Full text: https://t.co/aLBpLVYxNv https://t.co/kimZqREkLi

Jan 14, 2022 · 2 likes · 1 share · 3,041 followers View post →
Cristian Pérez
@CristianFPerezP · X

@Autoformato @LexQDev @e_crisanto @Swanros Ya entiendo el porque cree en cualquier video que ve por internet. Si supiera leer se daría cuanta que es una publicación de la revista Cells. Esa es solo una copia en NCBI https://t.co/3da7kphJby Además, artículos con el código genetico existen miles.

Sep 24, 2021 · 37 followers View post →
Isatou Sarr
@IsatouSarr4 · X

https://t.co/EnccwfB16r

Apr 28, 2021 · 1 like · 49 followers View post →
LIgirl82
@longisland82 · X

@kvwatchtay7 @viralvideovlogs Reference Romano, M., Ruggiero, A., Squeglia, F., Maga, G., & Berisio, R. (2020). A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping. Cells, 9(5), 1267. https://t.co/izhKQ5H4ok

Apr 14, 2021 · 1,927 followers View post →
NFTdose
@PaperbirdsH · X

New article: A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping. https://t.co/0AW8j48ZJK #coronavirus #COVID19 #2019ncov https://t.co/07IbAzsjs6

May 24, 2020 · 301 followers View post →
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