June 2020 PMID 32463582

Altered glucocorticoid metabolism represents a feature of macroph-aging.

Jenny Vanessa Valbuena Perez, Rebecca Linnenberger, Anna Dembek, Stefano Bruscoli, Carlo Riccardi, Marcel H Schulz, Markus R Meyer, Alexandra K Kiemer, Jessica Hoppstädter

Mentions

31
Peak: 5 in Feb 2025
across 4 sources since May 2020

Extended reach

7,757
potential audience

Total likes

10

Video views

65

Mentions per month

May 2020 – Feb 2025

Where it's discussed

  • News15 articles
  • X / Twitter9 posts
  • YouTube5 videos
  • Blogs2 articles

AI synopsis

What people are saying

The comments reflect a moderate level of interest, with mentions of how cortisol levels influence inflammation and aging, illustrated by phrases like 'poor lifestyle choices' and 'low cortisol as a key factor,' showing concern and curiosity. The tone is mostly explanatory, and the choice of words indicates recognition of the research's relevance to aging and health, contributing to a generally supportive and intrigued overall sentiment.

AgreementModerate agreement

Most discussions acknowledge the importance of altered glucocorticoid metabolism in macrophage aging, with some emphasizing low cortisol's role in inflammation and aging, showing general support for the findings.

InterestModerate interest

Participants show moderate curiosity, referencing the role of cortisol and inflammation, but the tone is mostly informational without deep curiosity or controversy.

EngagementModerate engagement

Comments engage with the research by mentioning lifestyle factors and physiological mechanisms, indicating a basic but not very deep engagement with the topic.

ImpactModerate impact

The discussions highlight the potential significance of glucocorticoid alterations in aging, suggesting possible implications for health management, though they stop short of extensive application or critique.

Abstract in brief

  • The study explores how aging affects immune cells called macrophages, showing that older mice have reduced levels of active glucocorticoids like corticosterone, which are hormones that help regulate inflammation.
  • This decrease is linked to impaired activity of an enzyme called 11HSD1, leading to less activation of glucocorticoids, and results in reduced expression of GILZ, a gene important for controlling macrophage activation.
  • The findings suggest that loss of GILZ and disrupted glucocorticoid metabolism contribute to the increased inflammation seen in aging, helping us better understand how immune regulation changes over time.

Top posts

Most liked on X and Bluesky
Sean Hurley
@Age_Wisely · X

@mike_lustgarten @Mangan150 It seems like poor lifestyle choices play a huge role in depleted cortisol as we age (adrenal fatigue & macrophage impairments) Meaning, low cortisol levels may be one of many negative side effects from living a life full of destructive pleasures https://t.co/gOPYLNm7AI

Aug 11, 2022 · 3 likes · 1,158 followers View post →
AgeingUK
@AgeingUK · X

Altered glucocorticoid metabolism represents a feature of macroph‐aging https://t.co/aQpgTUy9Ep https://t.co/VYW9d3hXIH

May 29, 2020 · 1 like · 1 share · 3,029 followers View post →
Paul Humphries
@PaulHumpa · X

Altered glucocorticoid metabolism represents a feature of macroph‐aging - https://t.co/O5HzTQQPKZ

Jul 1, 2020 · 1 like · 2,600 followers View post →
The Aegean Society
@aegeansociety · X

seviyelerinin vücutta kronik inflamatuar yanıtlarını tetikleyerek yaşlanma sürecine katkıda bulunabileceğini göstermektedir. https://t.co/gLAjtxsPyN

Jul 2, 2020 · 1 like · 462 followers View post →
PANDEY LAB
@Pandeylab · X

Role of cortisol in ageing. https://t.co/SGKVWxkdwn

Jul 2, 2020 · 236 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Age research: A low level of the stress hormone cortisol contributes to the ageing process https://t.co/n4hbCx313S https://t.co/BDqsUDFQJV https://t.co/sMQ1ANqIoR

Jul 6, 2020 · 94 followers View post →

All mentions

Sean Hurley
@Age_Wisely · X

@mike_lustgarten @Mangan150 It seems like poor lifestyle choices play a huge role in depleted cortisol as we age (adrenal fatigue & macrophage impairments) Meaning, low cortisol levels may be one of many negative side effects from living a life full of destructive pleasures https://t.co/gOPYLNm7AI

Aug 11, 2022 · 3 likes · 1,158 followers View post →
hectordietentrena
@hectorllorenc · X

...por lo que los macrófagos continuan liberando moléculas de señalización inflamatoria. Por lo que tanto los niveles altos como los bajos niveles de la hormona cortisol pueden desencadenar respuestas inflamatorias crónicas en el cuerpo. https://t.co/7ew09VOYSk

Sep 11, 2020 · 47 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Age research: A low level of the stress hormone cortisol contributes to the ageing process https://t.co/n4hbCx313S https://t.co/BDqsUDFQJV https://t.co/sMQ1ANqIoR

Jul 6, 2020 · 94 followers View post →
The Aegean Society
@aegeansociety · X

seviyelerinin vücutta kronik inflamatuar yanıtlarını tetikleyerek yaşlanma sürecine katkıda bulunabileceğini göstermektedir. https://t.co/gLAjtxsPyN

Jul 2, 2020 · 1 like · 462 followers View post →
PANDEY LAB
@Pandeylab · X

Role of cortisol in ageing. https://t.co/SGKVWxkdwn

Jul 2, 2020 · 236 followers View post →
Paul Humphries
@PaulHumpa · X

Altered glucocorticoid metabolism represents a feature of macroph‐aging - https://t.co/O5HzTQQPKZ

Jul 1, 2020 · 1 like · 2,600 followers View post →
Science
@Long_life_sci · X

RT @AgeingUK: Altered glucocorticoid metabolism represents a feature of macroph‐aging https://t.co/aQpgTUy9Ep https://t.co/VYW9d3hXIH

Jun 1, 2020 · 1 share · 33 followers View post →
Aging UK
@AgingUK · X

RT @AgeingUK: Altered glucocorticoid metabolism represents a feature of macroph‐aging https://t.co/p8xezsEKMH https://t.co/bKrCOnczNa

May 29, 2020 · 31 followers View post →
AgeingUK
@AgeingUK · X

Altered glucocorticoid metabolism represents a feature of macroph‐aging https://t.co/aQpgTUy9Ep https://t.co/VYW9d3hXIH

May 29, 2020 · 1 like · 1 share · 3,029 followers View post →