The overall discussions express optimism about progress in the field, mentioning promising drugs and frameworks, such as lithium as a 'Tier 1 geroprotector' and analysis of preclinical results. Words like 'progress,' 'potential,' and references to authoritative reviews highlight the high interest and perceived impact, though some posts call for more human data, indicating cautious optimism.
AgreementModerate agreement
Most discussions recognize the importance and promise of the research, with some emphasizing the need for better human data.
InterestHigh interest
Participants show high curiosity, referencing recent reviews and potential treatments like lithium, indicating strong engagement with the topic.
EngagementModerate engagement
Many posts include specific references to advances in drug discovery and discussion of frameworks, suggesting moderate depth in their engagement.
ImpactModerate impact
The general tone reflects a belief that this research could significantly influence aging treatments, though some mention existing gaps in evidence.
Abstract in brief
The article discusses how scientific research is exploring drugs like rapamycin, senolytics, and metformin to slow down aging by targeting biological systems such as nutrient sensing and cellular aging, which could reduce age-related diseases.
These interventions are categorized into two tiers based on how strong the evidence is; the top tier includes promising drugs that have shown positive results in animal and early human studies, aiming to extend healthy lifespan.
The focus is on understanding the potential of these drugs and the challenges in conducting clinical trials to enable longer, healthier lives before inevitable aging-related decline and death.
The quest to slow ageing through drug discovery (2020)
https://t.co/IixLfCxsql @MPIAGE https://t.co/AIfsFCHqHS
Jun 14, 2023 · 64 likes · 15 shares · 43,743 followersView post →
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Aging Science News
@AgingBiology · X
The quest to slow ageing through drug discovery
https://t.co/fm267nn8mi
May 29, 2020 · 47 likes · 27 shares · 31,452 followersView post →
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Nature Reviews Drug Discovery
@NatRevDrugDisc · X
The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising potential interventions with a framework based on the robustness of the preclinical and clinical results so far https://t.co/q6LsJYBqVh
May 28, 2020 · 26 likes · 17 shares · 43,017 followersView post →
JC
John F. Cryan
@jfcryan · X
The quest to slow ageing through drug discovery https://t.co/395haKJgIa https://t.co/9O4eam77Sw
Jun 2, 2020 · 18 likes · 5 shares · 22,439 followersView post →
ND
Nature Reviews Drug Discovery
@NatRevDrugDisc · X
Our August issue is live! https://t.co/3P20LLibqH Featuring articles on the progress in targeting the 'undruggable' cancer targets RAS and p53, the quest to slow ageing through drug discovery and the kinase RIPK1 as a therapeutic target https://t.co/3P20LLibqH https://t.co/mMnwQmDG5r
This video reviews over 200 geroprotective compounds, focusing on the top 5 most promising for healthspan improvement, highlighting their availability, clinical trials, and FDA approval. It emphasizes ongoing research…
This video updates my list of the most promising anti-aging compounds, focusing on healthspan extension. It highlights drugs like rapamycin, senolytics, and metformin, exploring their potential based on animal and early…
Spermidine is a natural polyamine in many foods that activates autophagy, a cell recycling process. This has implications for potential anti-aging benefits and disease prevention, including heart disease…
@Blagosklonny @CastilloQuan_JI @foundmyfitness We need better human data to have confidence in persons, however given the high safety (as opposed to definitive efficacy data) profile @ low/micro dose, even @BKennedy_aging and Linda have now dubbed lithium as a potential Tier 1 geroprotector:
https://t.co/IOZcGFOxSm ...4/N...
Aug 13, 2020 · 1 like · 43,743 followersView post →
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PPBI
@PPBIOConsWW · X
RT @NatRevDrugDisc: Our August issue is live! https://t.co/3P20LLibqH Featuring articles on the progress in targeting the 'undruggable' can…
Our August issue is live! https://t.co/3P20LLibqH Featuring articles on the progress in targeting the 'undruggable' cancer targets RAS and p53, the quest to slow ageing through drug discovery and the kinase RIPK1 as a therapeutic target https://t.co/3P20LLibqH https://t.co/mMnwQmDG5r
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 217 followersView post →
JP
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 2,050 followersView post →
IP
Ilmari Parkkinen
@IParkkinen · X
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 302 followersView post →
MI
Mochammad Ichsan
@ichsanomics · X
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 689 followersView post →
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Diego Baiano
@DiegoBaiano90 · X
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 21 followersView post →
GR
Gareth Richards
@G_O_Richards · X
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 227 followersView post →
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Mike
@michaelscally · X
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 888 followersView post →
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C. Brandon Ogbunu
@big_data_kane · X
RT @NatRevDrugDisc: The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising p…
May 28, 2020 · 17 shares · 8,471 followersView post →
ND
Nature Reviews Drug Discovery
@NatRevDrugDisc · X
The quest to slow ageing through drug discovery https://t.co/3bkMNVfYMG A new review that analyses the most promising potential interventions with a framework based on the robustness of the preclinical and clinical results so far https://t.co/q6LsJYBqVh
May 28, 2020 · 26 likes · 17 shares · 43,017 followersView post →
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fragi-05-1334261 | PDF | Senescence | Ageing
News
doi:10.1038/s41573-020-0067-7 emerging yet understudied hallmark of aging and longevity. Aging Dis. 14, 670–693. doi:10.14336/AD.2022.1116. Pascual-Torner, M ...