This collection reflects a highly positive and engaged attitude toward the research, with posts praising the technique's novelty and potential, such as mentions of 'extending survival in mice' and 'out of the box approach', suggesting broad optimism about the influence of these findings on aging and disease treatment.
AgreementStrong agreement
Most discussions praise the research, emphasizing its promising results and potential applications in anti-aging therapies.
InterestHigh interest
The posts indicate high curiosity about the innovative approach, mentioning terms like 'super interesting', 'wow', and expressing excitement about the future possibilities.
EngagementHigh engagement
Many users reference specific methods, such as CAR T cells targeting uPAR, and discuss implications for disease treatment and aging, showing deep involvement.
ImpactHigh impact
The discussions highlight potential high-impact changes in medicine and aging, with phrases like 'reversing pathologies' and 'extending lifespan' emphasizing significant influence.
Abstract in brief
The article explains how cellular senescence, which normally prevents tumor growth and aids wound healing, can cause chronic tissue damage and diseases like fibrosis, diabetes, and osteoarthritis when these cells accumulate abnormally.
Researchers developed special immune cells called CAR T cells that target a protein called uPAR, which appears on the surface of many senescent cells, enabling these engineered cells to specifically remove senescent cells.
In experiments, these uPAR-targeting CAR T cells successfully cleared senescent cells in mice, improved tissue health, extended survival in cancer models, and suggest a promising approach for treating diseases related to cellular aging.
wow! || Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/i83Qjm2b5K
Jun 18, 2020 · 49 likes · 18 shares · 17,195 followersView post →
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kat
@katclone · X
Very excited for tomorrow’s ‘aging’ themed journal club!
Traditional figure walkthrough followed by Q&A
Nov 13, 2021 · 29 likes · 7 shares · 11,343 followersView post →
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Marcel van den Brink
@DrMvandenBrink · X
Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/E0fvo1lVOi
Jun 19, 2020 · 28 likes · 6 shares · 8,724 followersView post →
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Jonathan Kipnis
@jonykipnis · X
Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/mmIWDOxpX9
Jun 19, 2020 · 27 likes · 8 shares · 26,180 followersView post →
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AntonioPérezMartínez
@antonioper_mar · X
Incredible!! Inspiring!!! Corina Amor, la científica española que triunfa en EEUU: "En 10 años no será ciencia ficción hablar de vivir 130 o 140 años" | Actualidad https://t.co/1T3afWWOAm https://t.co/vr2g519GK8 https://t.co/VbL0DDOyym
Feb 5, 2023 · 13 likes · 3 shares · 3,562 followersView post →
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Ashton C Trotman-Grant
@ATrotmanGrant · X
Jun 17, 2020 · 13 likes · 1 share · 2,765 followersView post →
Every year I compile what I think were some important contributions to longevity research. Here is my list for 2025. Find me on Twitter httpstwittercomEleanorSheekey Support through PayPal…
This video summarizes the role of senescent cells in cancer and age-related diseases. It discusses how cellular senescence can prevent tumor growth but also cause chronic tissue damage. The video highlights the…
@thanhtulhpl Yes—and we already have proof it works! uPAR CAR T cells selectively killed senescent cells in mice, extending survival in cancer models (DOI: 10.1038/s41586-020-2403-9). A safer vaccine approach using CD153 peptides triggered antibodies that cleared senescent T cells via
@Salome96394602 @BioProtocol CAR T cells targeting senescence actually work better than I expected. uPAR-directed CAR T cells synergized with senescence induction to clear tumors (DOI: 10.1038/s41586-020-2403-9). NK cells also act as natural senolytics, clearing senescent T cells in humans (DOI:
@TammyWr82770870 @BioProtocol uPAR-CAR T cells already demonstrate precision senolytic activity - they cleared senescent cells across tissues and extended survival in mice (DOI: 10.1038/s41586-020-2403-9). NK cells enhanced with dopamine also achieved multi-tissue senescent cell clearance (DOI:
@AlexisA17842209 @BioProtocol Senolytic vaccines are closer than you think—we're already weaponizing immunity against senescent cells. CAR T cells targeting uPAR cleared senescent cells and reversed fibrosis in mice (DOI: 10.1038/s41586-020-2403-9), while B2M-targeted antibody-drug conjugates selectively
@AsiaLovett9 @BioProtocol Engineered T cells targeting senescent cells are proving remarkably effective. uPAR-CAR T cells selectively killed senescent cells across tissues and extended survival in cancer therapy models (DOI: 10.1038/s41586-020-2403-9).
Safety concerns are real—high doses trigger cytokine
Nature, Published online: 21 February 2024; doi:10.1038/s41586-024-07197-3Author Correction: Senolytic CAR T cells reverse senescence-associated pathologies
https://t.co/7yUtIn6ljy
RT @antonioper_mar: Incredible!! Inspiring!!! Corina Amor, la científica española que triunfa en EEUU: "En 10 años no será ciencia ficción…
Feb 5, 2023 · 3 shares · 38,431 followersView post →
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AntonioPérezMartínez
@antonioper_mar · X
Incredible!! Inspiring!!! Corina Amor, la científica española que triunfa en EEUU: "En 10 años no será ciencia ficción hablar de vivir 130 o 140 años" | Actualidad https://t.co/1T3afWWOAm https://t.co/vr2g519GK8 https://t.co/VbL0DDOyym
Feb 5, 2023 · 13 likes · 3 shares · 3,562 followersView post →
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QuantumAI+Crispr3D=QuInCy=QAI&C3D=LA
@1LEOOEL1 · X
RT @1LEOOEL1: ‘
#Senolytic CAR T cells reverse senescence-associated pathologies
[#SenescentCells are believed to be deleterious to Human…
Recent achievements in CAR-T cell therapy. Review in Cancer Cell
https://t.co/7BxkKBWGch
And the application of this approach to senolytic therapies of senescent cell in diseases and in ageing
https://t.co/8HoDtLYgnc
‘
#Senolytic CAR T cells reverse senescence-associated pathologies
[#SenescentCells are believed to be deleterious to Human health & lifespan; especially in t elderly
T removal of senescent cells has now been verified in mice
"Senolytic CAR T cells reverse senescence-associated pathologies" ("CAR T cells that target uPAR extend the survival of mice with lung adenocarcinoma that are treated with a senescence-inducing combination of drugs, and restore tissue homeostasis in mice") https://t.co/zgns9mhlly
Jul 7, 2020 · 1 like · 30,724 followersView post →
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Jason T Maynes
@DrDrJTMaynes · X
Selective elimination of senescent cells, amazing. First cancer, then selective organ fibrosis?
https://t.co/bWp6OkAlem
CAR-Tでの老化細胞の排除。肝炎(薬剤性とNASH)の治療モデルで結果を出してる。
Commentsのところに書き連ねられた指摘も面白い。
Senolytic CAR T cells reverse senescence-associated pathologies https://t.co/UwsvdCZtNJ
Jul 2, 2020 · 1 like · 1 share · 781 followersView post →
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Eiichiro Mori
@MoriEiichiro · X
Senolytic CAR T cells reverse senescence-associated pathologies
https://t.co/48QOlSjU83
Trending on PubMed: Senolytic CAR T cells reverse senescence-associated pathologies. https://t.co/xgUG5slN2w
Jun 26, 2020 · 1 like · 1 share · 5,167 followersView post →
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Pedro Teixeira MD PhD
@Vote_ForPedro · X
The future could be so cool.
Jun 25, 2020 · 1 like · 2,450 followersView post →
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MSKHemOncTrials
@MSKHemOncTrials · X
RT @DrMvandenBrink: Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/E0fvo1lVOi
Jun 24, 2020 · 6 shares · 1,601 followersView post →
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Jessica Lancaster
@jnlancast · X
RT @DrMvandenBrink: Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/E0fvo1lVOi
Jun 23, 2020 · 6 shares · 678 followersView post →
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Markus Riessland
@RiesslandLab · X
Super interesting feasibility study! Targeting senescent cells using CAR T technology!
Senolytic CAR T cells reverse senescence-associated pathologies https://t.co/FlkR1DrnAz
RT @IdoAmitLab: wow! || Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/i83Qjm2b5K
Jun 18, 2020 · 18 shares · 946 followersView post →
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AnnaEsteveCodina
@AEsteveCodina · X
RT @IdoAmitLab: wow! || Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/i83Qjm2b5K
Jun 18, 2020 · 18 shares · 300 followersView post →
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Mathieu Laplante
@LaplanteMathieu · X
Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/G0vmWBZFn8
Jun 18, 2020 · 2 likes · 2,662 followersView post →
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Elvira Forte
@ElviraForte1 · X
RT @IdoAmitLab: wow! || Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/i83Qjm2b5K
Jun 18, 2020 · 18 shares · 551 followersView post →
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Kai Song, PhD
@song_kk · X
RT @IdoAmitLab: wow! || Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/i83Qjm2b5K
Jun 18, 2020 · 18 shares · 348 followersView post →
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Jerome Staal
@NeuroStaal · X
RT @IdoAmitLab: wow! || Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/i83Qjm2b5K
Jun 18, 2020 · 18 shares · 577 followersView post →
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IdoAmitLab
@IdoAmitLab · X
wow! || Senolytic CAR T cells reverse senescence-associated pathologies | Nature https://t.co/i83Qjm2b5K
Jun 18, 2020 · 49 likes · 18 shares · 17,195 followersView post →
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Paul Humphries
@PaulHumpa · X
Senolytic CAR T cells reverse senescence-associated pathologies - https://t.co/S2nWgsDywm
Jun 18, 2020 · 1 like · 2,613 followersView post →
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Zihai Li, MD, PhD
@Zihai · X
#Senolytic #CAR_T cells targeting urokinase-type plasminogen activator receptor (#uPAR) for treatment of cancer. Yup. Great work by @corina_amor_MD @LoweLabMSKCC Michel Sadelain et al. https://t.co/tPSoxPoPB8 https://t.co/Q1yWJZHGVW
Jun 18, 2020 · 6 likes · 3,235 followersView post →
Jun 17, 2020 · 13 likes · 1 share · 2,765 followersView post →
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Senescence 1st Paper | PDF | Glioma | P53
News
Nature 583:127–132. lar mechanisms of arginine deiminase-based therapy—compara- https://doi.org/10.1038/s41586-020-2403-9 tive response analysis in paired ...
https://doi.org/10.1038/s41586-020-2403-9. B. (2022). Ra-223 induces clustered DNA damage and inhibits cell sur vival in several prostate cancer cell lines ...
0 Merged 1728546547 | PDF | Carcinogenesis | Cancer
News
https://doi.org:10.1038/s41586-020-2403-9 288 Birch, J. & Gil, J. Senescence and the SASP: many therapeutic avenues. Genes Dev 34, 1565-1576 (2020). https ...