Am J Psychiatry February 2021 PMID 32600153

Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology.

Adrienne L Romer, Maxwell L Elliott, Annchen R Knodt, Maria L Sison, David Ireland, Renate Houts, Sandhya Ramrakha, Richie Poulton, Ross Keenan, Tracy R Melzer, Terrie E Moffitt, Avshalom Caspi, Ahmad R Hariri

Mentions

33
Peak: 13 in Jun 2020
across 3 sources since Jun 2020

Extended reach

111,782
potential audience

Total likes

57

Video views

302

Mentions per month

Jun 2020 – Dec 2024

Where it's discussed

  • X / Twitter29 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Multiple discussions highlight the importance of the study, with users sharing enthusiasm about its findings and implications, like one user referring to the 'transdiagnostic feature' and others mentioning potential therapeutic methods such as rTMS. The tone combines curiosity, support, and some recognition of broader impacts, reflecting a balanced perception of the research's significance.

AgreementModerate agreement

Most discussions acknowledge the validity and significance of the findings, with some explicitly supporting the idea that cortical thinning is a common feature across disorders.

InterestModerate interest

The discussions reflect a moderate level of curiosity, with some users sharing excitement about the research and its implications for understanding mental health.

EngagementModerate engagement

Participants demonstrate active engagement by referencing specific aspects of the study, such as brain regions involved and potential therapies, indicating thoughtful consideration.

ImpactModerate impact

The conversations suggest that the article influences ongoing discussions about psychiatric research, treatment approaches, and the broader understanding of mental illnesses.

Abstract in brief

  • Structural brain changes, specifically thinner neocortex, are common across many mental disorders rather than being specific to just one, reflecting a general underlying mental health factor.
  • The study found that individuals with high levels of generalized psychopathology showed widespread reductions in neocortical thickness, similar to patterns seen in various diagnostic categories like externalizing, internalizing, and thought disorders.
  • The findings suggest that a thinner neocortex might be a universal brain feature related to mental health issues, indicating that focusing on brain structure diversity might be less helpful than understanding shared features across disorders for better diagnosis and treatment.]

Top posts

Most liked on X and Bluesky
HaririLab Duke
@NeurogenDuke · X

Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdVh0iGU6 https://t.co/nLBpiYlWnO

Jun 30, 2020 · 31 likes · 16 shares · 332 followers View post →
Adrienne Romer
@adrienne_romer · X

Pretty cool full circle moment today. Danny Pine made a video summary of my paper (exciting on its own). He also was my RA mentor @NIMH SDAN 8+ yrs ago. I know he’s the AJP editor and I’m sure he does this for a lot of papers but it kinda made my day

Feb 1, 2021 · 8 likes · 394 followers View post →
NINET Lab
@NinetLab · X

Abnormalities in the frontal lobes across multiple psychiatric conditions. Not surprising that #rTMS is a transdiagnostic therapy aiming at frontal lobes? "Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology | AJP https://t.co/i0DUnqkuOc

Jun 30, 2020 · 5 likes · 3 shares · 1,270 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

Pervasively Thinner Neocortex as a #Transdiagnostic Feature of General Psychopathology #mri https://t.co/Z5fMojmXnJ

Jul 2, 2020 · 3 likes · 2 shares · 2,279 followers View post →
Juan Ramos-Cejudo, Ph.D.
@RamosCejudo · X

Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology | new cool findings looking for a p factor... | American Journal of Psychiatry https://t.co/tP6I76Kvty

Jul 22, 2020 · 3 likes · 2,046 followers View post →
wiemeyer
@mentalfundalist · X

@CathLouisa1976 @Jeremy61966 onze hersenstam of 'reptielenbrein' functioneert gewetenloos, dus wanneer de humane frontale cortex uitgeschakeld is, wordt met psychopaat. deze geestesstoornis komt vaker voor bij machthebbers. de logica van icke is dus dezelfde als de hersenwetenschap. https://t.co/S7byJEoiNr

Oct 20, 2022 · 2 likes · 718 followers View post →

All mentions

wiemeyer
@mentalfundalist · X

@CathLouisa1976 @Jeremy61966 onze hersenstam of 'reptielenbrein' functioneert gewetenloos, dus wanneer de humane frontale cortex uitgeschakeld is, wordt met psychopaat. deze geestesstoornis komt vaker voor bij machthebbers. de logica van icke is dus dezelfde als de hersenwetenschap. https://t.co/S7byJEoiNr

Oct 20, 2022 · 2 likes · 718 followers View post →
ROBERTO COLOM
@ROBERTO_COLOM · X

AJP Editor Spotlight: A Thinner Neocortex as a Feature of ... https://t.co/bcCDC0gElx a través de @YouTube

Sep 12, 2022 · 3,168 followers View post →
Hannah R. Snyder
@Hannah_R_Snyder · X

@R__INDEX @aidangcw @drl4567 @JMill_er https://t.co/2HyKTURDgk

Jul 24, 2022 · 1 like · 1,472 followers View post →
Adrienne Romer
@adrienne_romer · X

Pretty cool full circle moment today. Danny Pine made a video summary of my paper (exciting on its own). He also was my RA mentor @NIMH SDAN 8+ yrs ago. I know he’s the AJP editor and I’m sure he does this for a lot of papers but it kinda made my day

Feb 1, 2021 · 8 likes · 394 followers View post →
HaririLab Duke
@NeurogenDuke · X

The AJP February issue includes an editor spotlight on our findings of cortical thinning with general psychopathology: https://t.co/W8pa6FidC7 https://t.co/0qXZE27Xbf

Feb 1, 2021 · 1 like · 332 followers View post →
Juan Ramos-Cejudo, Ph.D.
@RamosCejudo · X

Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology | new cool findings looking for a p factor... | American Journal of Psychiatry https://t.co/tP6I76Kvty

Jul 22, 2020 · 3 likes · 2,046 followers View post →
Wei Cheng
@WeiFDU · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jul 3, 2020 · 16 shares · 442 followers View post →
Leonhard Schilbach
@leoschilbach · X

RT @Luke_629: Pervasively Thinner Neocortex as a #Transdiagnostic Feature of General Psychopathology #mri https://t.co/Z5fMojmXnJ

Jul 3, 2020 · 2 shares · 6,748 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jul 2, 2020 · 16 shares · 10,957 followers View post →
tor wager
@torwager · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jul 2, 2020 · 16 shares · 9,545 followers View post →
CLaE
@leafs_s · X

RT @Luke_629: Pervasively Thinner Neocortex as a #Transdiagnostic Feature of General Psychopathology #mri https://t.co/Z5fMojmXnJ

Jul 2, 2020 · 2 shares · 28,697 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

Pervasively Thinner Neocortex as a #Transdiagnostic Feature of General Psychopathology #mri https://t.co/Z5fMojmXnJ

Jul 2, 2020 · 3 likes · 2 shares · 2,279 followers View post →
SCAN Lab
@SCAN_Lab · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jul 2, 2020 · 16 shares · 856 followers View post →
Divyangana Rakesh
@Divyanganar · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jul 2, 2020 · 16 shares · 899 followers View post →
Ted Satterthwaite
@sattertt · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jul 2, 2020 · 16 shares · 4,223 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jul 1, 2020 · 16 shares · 2,279 followers View post →
Jamie Hanson (@jamielarsh.bsky.social)
@JamieLarsH · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 9,676 followers View post →
Renata Menezes
@renata_bmenezes · X

RT @NinetLab: Abnormalities in the frontal lobes across multiple psychiatric conditions. Not surprising that #rTMS is a transdiagnostic the…

Jun 30, 2020 · 3 shares · 59 followers View post →
Taylor J. Keding
@tjkeding · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 347 followers View post →
Sarah Whittle
@SarahLWhittle · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 804 followers View post →
Associate Professor Amy Finlay-Jones
@amyfinlayjones · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 2,253 followers View post →
Christian K. Tamnes
@cktamnes · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 1,106 followers View post →
Assaf Oshri (אסף אושרי)
@AssafOshri · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 853 followers View post →
Reut Avinun, PhD
@AvinunReut · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 284 followers View post →
Michael Fox
@foxmdphd · X

RT @NinetLab: Abnormalities in the frontal lobes across multiple psychiatric conditions. Not surprising that #rTMS is a transdiagnostic the…

Jun 30, 2020 · 3 shares · 6,685 followers View post →
Maxwell Elliott
@max12elliott · X

RT @NeurogenDuke: Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdV…

Jun 30, 2020 · 16 shares · 589 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Data from the Dunedin Study show that measures of brain structure exhibit broad associations with psychopathology, raising questions about specificity of structural correlates in particular psychiatric disorders. Learn More: https://t.co/nATdFdxf6U https://t.co/wGWHQ158GV

Jun 30, 2020 · 11,606 followers View post →
HaririLab Duke
@NeurogenDuke · X

Out in AJP today: Pervasively Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology https://t.co/OcdVh0iGU6 https://t.co/nLBpiYlWnO

Jun 30, 2020 · 31 likes · 16 shares · 332 followers View post →
NINET Lab
@NinetLab · X

Abnormalities in the frontal lobes across multiple psychiatric conditions. Not surprising that #rTMS is a transdiagnostic therapy aiming at frontal lobes? "Thinner Neocortex as a Transdiagnostic Feature of General Psychopathology | AJP https://t.co/i0DUnqkuOc

Jun 30, 2020 · 5 likes · 3 shares · 1,270 followers View post →
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