PubHawk
September 2020 PMID 32661021

Attenuation of cGAS/STING activity during mitosis.

Brittany L Uhlorn, Eduardo R Gamez, Shuaizhi Li, Samuel K Campos

Full text PDF Download social card

Mentions

12
Peak: 4 in Dec 2019
across 2 sources since Dec 2019

Extended reach

164,110
potential audience

Total likes

33

Video views

261

Mentions per month

Dec 2019 – Jun 2024

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions primarily consist of congratulatory messages and references to the publication, such as mentions of mechanisms like Golgi vesiculation affecting STING activity, indicating moderate engagement. The tone reflects acknowledgment rather than critical analysis, emphasizing the biological importance without exploring wider impacts.

AgreementModerate agreement

Most discussions acknowledge the importance of the findings, especially the biological mechanism of Golgi vesiculation reducing STING activity during mitosis.

InterestModerate interest

Participants show moderate interest, primarily recognizing the significance of immune regulation during cell division without deep curiosity.

EngagementNeutral engagement

The discussions are somewhat superficial, mostly congratulating the authors or referencing the publication without detailed analysis.

ImpactModerate impact

The consensus recognizes the research as relevant but stops short of discussing broader implications like clinical applications or future research.

Abstract in brief

  • During mitosis, the cGAS-STING pathway, which normally helps the immune system detect DNA from microbes or cellular stress, becomes less active to prevent attacking the cell's own DNA.
  • The study found that while cGAS enzyme activity remains largely unaffected by Golgi vesiculation, the activation of STING is significantly impaired if the Golgi is vesiculated, especially during mitosis.
  • Overall, the research suggests that cells naturally reduce cGAS-STING immune responses during mitosis through Golgi vesiculation, serving as a protective mechanism to prevent harmful immune activation against self-DNA.]
Read the full abstract

Top posts

Most liked on X and Bluesky
LifeScienceAlliance
@LSAjournal · X

Dampening of both cGAS and STING Activity During Mitosis @ImmunobiologyUA @UAZBIO5 Congratulations to @BrittanyUhlorn, @Eduardozemag, Li & @SciVirusGuy on your nice work! https://t.co/OX9otXkaE6 https://t.co/VSBTA189cN

Jul 14, 2020 · 7 likes · 4 shares · 2,641 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

Attenuation of cGAS/STING Activity During Mitosis https://t.co/2kS1JyhTjV #biorxiv_immuno

Dec 20, 2019 · 2 likes · 10,691 followers View post →
bioRxiv
@biorxivpreprint · X

Attenuation of cGAS/STING Activity During Mitosis https://t.co/4ETtCdodcY #bioRxiv

Dec 20, 2019 · 1 like · 1 share · 137,597 followers View post →
bioRxiv Published
@biorxiv_pubd · X

Attenuation of cGAS/STING Activity During Mitosis published as: https://t.co/2biEUTpcor @LSAjournal #biorxiv

May 1, 2023 · 1 like · 2,909 followers View post →
bxv_imm
@bxv_imm · X

Attenuation of cGAS/STING Activity During Mitosis https://t.co/qqltnrWtKP

Dec 20, 2019 · 1 like · 440 followers View post →
BIO5 Institute
@UAZBIO5 · X

RT @LSAjournal: Dampening of both cGAS and STING Activity During Mitosis @ImmunobiologyUA @UAZBIO5 Congratulations to @BrittanyUhlorn,…

Jul 14, 2020 · 4 shares · 4,566 followers View post →

All mentions

bioRxiv Published
@biorxiv_pubd · X

Attenuation of cGAS/STING Activity During Mitosis published as: https://t.co/2biEUTpcor @LSAjournal #biorxiv

May 1, 2023 · 1 like · 2,909 followers View post →
Kimberly Luddy
@luddyka · X

Attenuation of cGAS/STING Activity During Mitosis https://t.co/GrLerVnkxD

Dec 14, 2020 · 1,466 followers View post →
Katerina Strati
@katerina_strati · X

RT @LSAjournal: Dampening of both cGAS and STING Activity During Mitosis @ImmunobiologyUA @UAZBIO5 Congratulations to @BrittanyUhlorn,…

Jul 15, 2020 · 4 shares · 429 followers View post →
UAZImmunobiology
@ImmunobiologyUA · X

RT @LSAjournal: Dampening of both cGAS and STING Activity During Mitosis @ImmunobiologyUA @UAZBIO5 Congratulations to @BrittanyUhlorn,…

Jul 14, 2020 · 4 shares · 731 followers View post →
BIO5 Institute
@UAZBIO5 · X

RT @LSAjournal: Dampening of both cGAS and STING Activity During Mitosis @ImmunobiologyUA @UAZBIO5 Congratulations to @BrittanyUhlorn,…

Jul 14, 2020 · 4 shares · 4,566 followers View post →
LifeScienceAlliance
@LSAjournal · X

Dampening of both cGAS and STING Activity During Mitosis @ImmunobiologyUA @UAZBIO5 Congratulations to @BrittanyUhlorn, @Eduardozemag, Li & @SciVirusGuy on your nice work! https://t.co/OX9otXkaE6 https://t.co/VSBTA189cN

Jul 14, 2020 · 7 likes · 4 shares · 2,641 followers View post →
bxv_imm
@bxv_imm · X

Attenuation of cGAS/STING Activity During Mitosis https://t.co/qqltnrWtKP

Dec 20, 2019 · 1 like · 440 followers View post →
Sedge
@LSedger · X

RT @biorxivpreprint: Attenuation of cGAS/STING Activity During Mitosis https://t.co/4ETtCdodcY #bioRxiv

Dec 20, 2019 · 1 share · 2,343 followers View post →
bioRxiv Immunology
@biorxiv_immuno · X

Attenuation of cGAS/STING Activity During Mitosis https://t.co/2kS1JyhTjV #biorxiv_immuno

Dec 20, 2019 · 2 likes · 10,691 followers View post →
bioRxiv
@biorxivpreprint · X

Attenuation of cGAS/STING Activity During Mitosis https://t.co/4ETtCdodcY #bioRxiv

Dec 20, 2019 · 1 like · 1 share · 137,597 followers View post →