The collective discussions demonstrate a moderate level of interest through references to mechanisms like Tregs and immune privilege, while many posts emphasize the potential for new treatments, using words like 'comprehensive,' 'counteract,' and 'important,' which reflect a recognition of the article's significance and depth of engagement.
AgreementModerate agreement
Most discussions acknowledge the importance of the research, emphasizing mechanisms and potential treatments, indicating overall agreement with the significance of the findings.
InterestModerate interest
Participants show moderate interest, with some posts referencing detailed mechanisms and potential interventions, but few express high enthusiasm or skepticism.
EngagementModerate engagement
Comments include specific questions about immune mechanisms and potential therapies, suggesting active engagement with the research details.
ImpactModerate impact
Discussions highlight the potential clinical implications, such as treatments for alopecia areata and understanding immune privilege, pointing to perceived moderate impact.
Abstract in brief
Hair follicles have a special immune privilege (IP) that protects them from immune attacks during the anagen (growth) phase, primarily by reducing antigen presentation and creating an immunosuppressive environment.
When this immune privilege collapses, especially at the hair bulb, it triggers alopecia areata (AA), where immune cells like CD8 T cells and NK cells attack the hair follicle, leading to hair loss.
Studies show that restoring immune privilege around hair follicles could be a key strategy in treating AA, as it might prevent or reverse the immune attack and reduce disease relapse.]
Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible. Includes mechanisms of collapse in AA pathogenesis, and considers possible methods to counteract immune privilege collapse. #openaccess
https://t.co/WJqkiLQuus
Hair follicles are repositories for #Tregs. Q: What % of patients with one T1D autoantibody show dysfunctional folliclular Tregs? What % of all T1D pts show it? @BUMedical @EmKSims @cevansmo @marina_basina @AliceTomei79 @CaladriusBio
https://t.co/de0aE6CIJo
Mar 23, 2021 · 1 like · 2,243 followersView post →
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NK papers
@NK_papers · X
Hair follicle immune privilege and its collapse in alopecia areata. by Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R https://t.co/QuXC6deQrH
Jul 19, 2020 · 1 like · 1,285 followersView post →
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Dr. Sergio Vañó
@SergioVanoG · X
RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…
Hair follicles have a unique immune privilege that protects them during growth. Its failure, especially at the hair bulb, triggers alopecia areata by immune cells attacking the follicle. Restoring this privilege may…
Hidradenitis suppurativa HS is a chronic inflammatory skin condition involving abscesses, sinus tracts, and scarring, predominantly affecting females. The sex bias is likely due to hormones, genetics, microbiome, and…
Hair follicles have a special immune privilege during the growth phase to prevent immune attacks. Collapse of this privilege can trigger alopecia areata, leading to hair loss. Restoring immune privilege may be key to…
Hair follicles are repositories for #Tregs. Q: What % of patients with one T1D autoantibody show dysfunctional folliclular Tregs? What % of all T1D pts show it? @BUMedical @EmKSims @cevansmo @marina_basina @AliceTomei79 @CaladriusBio
https://t.co/de0aE6CIJo
Mar 23, 2021 · 1 like · 2,243 followersView post →
E
ExpDermatol
@ExpDermatol · X
Hair follicle immune privilege and its collapse in alopecia areata https://t.co/se7CCbgeHS
Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible. Includes mechanisms of collapse in AA pathogenesis, and considers possible methods to counteract immune privilege collapse. #openaccess
https://t.co/WJqkiLQuus
Hair follicle immune privilege and its collapse in alopecia areata. by Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R https://t.co/QuXC6deQrH
Jul 19, 2020 · 1 like · 1,285 followersView post →
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