Exp Dermatol August 2020 PMID 32682334

Hair follicle immune privilege and its collapse in alopecia areata.

Marta Bertolini, Kevin McElwee, Amos Gilhar, Silvia Bulfone-Paus, Ralf Paus

Mentions

23
Peak: 11 in Jul 2020
across 3 sources since Jul 2020

Extended reach

64,078
potential audience

Total likes

65

Video views

2,627

Mentions per month

Jul 2020 – Apr 2025

Where it's discussed

  • X / Twitter14 posts
  • News6 articles
  • YouTube3 videos

AI synopsis

What people are saying

The collective discussions demonstrate a moderate level of interest through references to mechanisms like Tregs and immune privilege, while many posts emphasize the potential for new treatments, using words like 'comprehensive,' 'counteract,' and 'important,' which reflect a recognition of the article's significance and depth of engagement.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, emphasizing mechanisms and potential treatments, indicating overall agreement with the significance of the findings.

InterestModerate interest

Participants show moderate interest, with some posts referencing detailed mechanisms and potential interventions, but few express high enthusiasm or skepticism.

EngagementModerate engagement

Comments include specific questions about immune mechanisms and potential therapies, suggesting active engagement with the research details.

ImpactModerate impact

Discussions highlight the potential clinical implications, such as treatments for alopecia areata and understanding immune privilege, pointing to perceived moderate impact.

Abstract in brief

  • Hair follicles have a special immune privilege (IP) that protects them from immune attacks during the anagen (growth) phase, primarily by reducing antigen presentation and creating an immunosuppressive environment.
  • When this immune privilege collapses, especially at the hair bulb, it triggers alopecia areata (AA), where immune cells like CD8 T cells and NK cells attack the hair follicle, leading to hair loss.
  • Studies show that restoring immune privilege around hair follicles could be a key strategy in treating AA, as it might prevent or reverse the immune attack and reduce disease relapse.]

Top posts

Most liked on X and Bluesky
Kevin McElwee
@ResearchHair · X

Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible. Includes mechanisms of collapse in AA pathogenesis, and considers possible methods to counteract immune privilege collapse. #openaccess https://t.co/WJqkiLQuus

Jul 20, 2020 · 23 likes · 8 shares · 892 followers View post →
the(sugar)science
@thesugarscience · X

Hair follicles are repositories for #Tregs. Q: What % of patients with one T1D autoantibody show dysfunctional folliclular Tregs? What % of all T1D pts show it? @BUMedical @EmKSims @cevansmo @marina_basina @AliceTomei79 @CaladriusBio https://t.co/de0aE6CIJo

Mar 23, 2021 · 1 like · 2,243 followers View post →
NK papers
@NK_papers · X

Hair follicle immune privilege and its collapse in alopecia areata. by Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R https://t.co/QuXC6deQrH

Jul 19, 2020 · 1 like · 1,285 followers View post →
Dr. Sergio Vañó
@SergioVanoG · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 21, 2020 · 8 shares · 35,208 followers View post →
Jorge Tovilla
@jorgetovilla_ · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 21, 2020 · 8 shares · 17,343 followers View post →
Dmitri Wall
@DmitriWall · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 20, 2020 · 8 shares · 1,253 followers View post →

All mentions

Derma Immunology Prof. Naglaa ElMongy
@nnradw1 · X

my newest video https://t.co/AtTTH19syr

Sep 20, 2023 · 8 followers View post →
Derma Immunology Prof. Naglaa ElMongy
@nnradw1 · X

hair follicle immune privilege https://t.co/E3gwexCQZ9

Sep 14, 2023 · 8 followers View post →
the(sugar)science
@thesugarscience · X

Hair follicles are repositories for #Tregs. Q: What % of patients with one T1D autoantibody show dysfunctional folliclular Tregs? What % of all T1D pts show it? @BUMedical @EmKSims @cevansmo @marina_basina @AliceTomei79 @CaladriusBio https://t.co/de0aE6CIJo

Mar 23, 2021 · 1 like · 2,243 followers View post →
ExpDermatol
@ExpDermatol · X

Hair follicle immune privilege and its collapse in alopecia areata https://t.co/se7CCbgeHS

Jul 29, 2020 · 1,077 followers View post →
StephTs
@STurcios_Sa · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 21, 2020 · 8 shares · 258 followers View post →
Cindy Mariel
@CindyCMGG · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 21, 2020 · 8 shares · 26 followers View post →
Jorge Tovilla
@jorgetovilla_ · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 21, 2020 · 8 shares · 17,343 followers View post →
Dr. Sergio Vañó
@SergioVanoG · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 21, 2020 · 8 shares · 35,208 followers View post →
Dmitri Wall
@DmitriWall · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 20, 2020 · 8 shares · 1,253 followers View post →
MARTA • trichologist/dermatology nurse
@clinihair · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 20, 2020 · 8 shares · 309 followers View post →
Nekma Meah
@NekiMeah · X

RT @ResearchHair: Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible.…

Jul 20, 2020 · 8 shares · 127 followers View post →
Kevin McElwee
@ResearchHair · X

Review: Hair follicle immune privilege and its collapse in alopecia areata. We tried to be as comprehensive as possible. Includes mechanisms of collapse in AA pathogenesis, and considers possible methods to counteract immune privilege collapse. #openaccess https://t.co/WJqkiLQuus

Jul 20, 2020 · 23 likes · 8 shares · 892 followers View post →
NK cell Biology
@NKcellBiology · X

Hair follicle immune privilege and its collapse in alopecia areata. https://t.co/pQ0nXuvkmi

Jul 19, 2020 · 1,227 followers View post →
NK papers
@NK_papers · X

Hair follicle immune privilege and its collapse in alopecia areata. by Bertolini M, McElwee K, Gilhar A, Bulfone-Paus S, Paus R https://t.co/QuXC6deQrH

Jul 19, 2020 · 1 like · 1,285 followers View post →
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