July 2020 PMID 32694791

The small intestine shields the liver from fructose-induced steatosis.

Cholsoon Jang, Shogo Wada, Steven Yang, Bridget Gosis, Xianfeng Zeng, Zhaoyue Zhang, Yihui Shen, Gina Lee, Zoltan Arany, Joshua D Rabinowitz

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Mentions

102
Peak: 33 in Jun 2020
across 6 sources since Jun 2020

Extended reach

5,313,302
potential audience

Total likes

94,488

Video views

4,513,460

Mentions per month

Jun 2020 – Sep 2022

Where it's discussed

  • X / Twitter69 posts
  • News17 articles
  • Facebook8 posts
  • YouTube3 videos
  • Blogs3 articles
  • Reddit2 posts

AI synopsis

What people are saying

Many discussions highlight specific points from the article, like the critical role of the small intestine in metabolizing fructose and preventing liver damage. Phrases such as 'the same amount of fructose is more strongly lipogenic when drunk than eaten' indicate a nuanced understanding of the research. The tone is often enthusiastic and thoughtful, with users conveying excitement about the potential for dietary awareness using phrases such as 'important to understand' and 'wow,' underscoring both the significance and the engaging nature of the findings.

AgreementStrong agreement

The majority of discussions express strong support for the article's findings regarding the protective role of the small intestine against liver damage from fructose.

InterestHigh interest

There is high interest reflected in the number of users engaging with the topic, showcasing its relevance to contemporary health debates.

EngagementHigh engagement

Discussions delve deeply into the implications of the research, often referencing specific metabolic mechanisms and dietary habits.

ImpactHigh impact

Participants perceive the findings as having significant implications for public health, especially concerning dietary changes.

Abstract in brief

  • The small intestine plays a critical role in preventing liver damage from excessive fructose consumption, especially in the context of increased intake over the last century.
  • Excessive fructose, particularly from sweet beverages, is linked to various health issues, including obesity and nonalcoholic fatty liver disease, and is metabolized primarily by the enzyme ketohexokinase (KHK) in both the liver and small intestine.
  • Research indicates that intestinal metabolism of fructose can protect against liver fat accumulation; when specific KHKC activity is increased in the intestine, it enhances fructose clearance and reduces the harmful impacts of fructose on the liver, suggesting that how quickly fructose is consumed matters for liver health.

Top posts

Most liked on X and Bluesky
Nature Metabolism
@NatMetabolism · X

Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/gLrroJF9Fh

Jun 22, 2020 · 55 likes · 21 shares · 79,111 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogenic when drunk than eaten, or when administered as a single dose, as opposed to multiple doses spread over 45 min. https://t.co/aP94lQ1XHw

Jul 23, 2020 · 45 likes · 7 shares · 291,308 followers View post →
Nature Metabolism
@NatMetabolism · X

#BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinowitz (@Princeton), @AranyLab (@PennMedicine), @cholsoon_jang (@UCIrvine), & Shogo Wada https://t.co/4KYgNMS3L3

Dec 28, 2020 · 37 likes · 6 shares · 79,111 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Nov 26, 2020 · 14 likes · 1 share · 6,434 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Jun 22, 2020 · 13 likes · 3 shares · 6,434 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

The small intestine shields the liver from fructose-induced steatosis until it is overwhelmed by high dietary fructose intake of sugary drinks and other sources. https://t.co/ZBQW0lSQ7G https://t.co/qHzn4Uv4Dm

Jan 7, 2021 · 5 likes · 2 shares · 144,957 followers View post →

All mentions

ibrahim botros
@ibrahimkadis · X

Complete apple : OK Apple Juice : NO https://t.co/3HO7yicK0L

Sep 6, 2022 · 151 followers View post →
Gentle Mutt
@GentleMutt · X

RT @endalaclinic: The small intestine shields the liver from fructose-induced steatosis - PMC Per capita fructose consumption has increase…

Sep 5, 2022 · 1 share · 793 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

The small intestine shields the liver from fructose-induced steatosis - PMC Per capita fructose consumption has increased 100-fold over the last century…. https://t.co/M0iu5wvr23

Sep 5, 2022 · 1 share · 254 followers View post →
1naturalhormone
@1naturalhormone · X

続報も読んでほしい。 本当に原因は果糖ですか?https://t.co/9JA89lkZ6h

Feb 19, 2021 · 201 followers View post →
Andrew
@Andrew__Lima · X

RT @robertlufkinmd: The small intestine shields the liver from fructose-induced steatosis until it is overwhelmed by high dietary fructose…

Jan 7, 2021 · 2 shares · 7 followers View post →
Gary Schroth
@Genomics_Guy · X

RT @robertlufkinmd: The small intestine shields the liver from fructose-induced steatosis until it is overwhelmed by high dietary fructose…

Jan 7, 2021 · 2 shares · 3,934 followers View post →
Robert Lufkin MD
@robertlufkinmd · X

The small intestine shields the liver from fructose-induced steatosis until it is overwhelmed by high dietary fructose intake of sugary drinks and other sources. https://t.co/ZBQW0lSQ7G https://t.co/qHzn4Uv4Dm

Jan 7, 2021 · 5 likes · 2 shares · 144,957 followers View post →
愛してやまない栄養管理を
@nutrimemo1024 · X

『世界はまだ果糖の代謝も知らなかった③』 実際のところ、小腸によって肝臓は果糖から守られてたんやな。 参考文献 https://t.co/P3BpxKDvyN https://t.co/hllHoJIYBy

Jan 5, 2021 · 2 likes · 788 followers View post →
metagen human papers
@metagen_human · X

The small intestine shields the liver from fructose-induced steatosis. https://t.co/zASQzlk7M0

Jan 4, 2021 · 75 followers View post →
CogniSphere
@jorgensenmc1 · X

“Collectively, these data demonstrate that fructose induces lipogenesis when its dietary intake rate exceeds the intestinal clearance capacity. In the modern context of ready food availability, the resulting fructose spillover drives metabolic syndrome. “ https://t.co/yVi0p7CXXP

Jan 1, 2021 · 816 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: The small intestine shields the liver from fructose-induced steatosis. https://t.co/yIiHUUm65F #livercancer #oncology https://t.co/Bv5CBWkoTs

Jan 1, 2021 · 892 followers View post →
The Arany lab
@AranyLab · X

RT @NatMetabolism: #BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinow…

Dec 30, 2020 · 6 shares · 1,384 followers View post →
りっくる
@rikkururikkuru · X

RT @NatMetabolism: #BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinow…

Dec 30, 2020 · 6 shares · 1 followers View post →
Mimi_ Cardio
@mimi_cardio · X

RT @NatMetabolism: #BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinow…

Dec 28, 2020 · 6 shares · 188 followers View post →
Battsetseg Batchuluun (Tseegii)
@batchuluun_b · X

RT @NatMetabolism: #BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinow…

Dec 28, 2020 · 6 shares · 717 followers View post →
lbgbox
@lbgbox · X

RT @NatMetabolism: #BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinow…

Dec 28, 2020 · 6 shares · 51 followers View post →
Updates ⊛ Actualités scientifiques
@UpdateSciences · X

RT @NatMetabolism: #BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinow…

Dec 28, 2020 · 6 shares · 103 followers View post →
Nature Metabolism
@NatMetabolism · X

#BestofNatMetab2020 | # 10 - CITED The small intestine shields the liver from fructose-induced steatosis | Josh Rabinowitz (@Princeton), @AranyLab (@PennMedicine), @cholsoon_jang (@UCIrvine), & Shogo Wada https://t.co/4KYgNMS3L3

Dec 28, 2020 · 37 likes · 6 shares · 79,111 followers View post →
Mark Turner
@MarkC_Turner · X

RT @Brunorm84: The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Nov 26, 2020 · 1 share · 1,374 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Nov 26, 2020 · 14 likes · 1 share · 6,434 followers View post →
Gabor Erdosi
@gerdosi · X

@GeorgiaEdeMD @DrPaulMason The extra-splanchnic fructose escape after ingestion of a fructose–glucose drink… https://t.co/nfEeMECyEM The small intestine shields the liver from fructose-induced steatosis https://t.co/kfRJsmuUwi Also https://t.co/7WRRu02la3 @DrPaulMason

Aug 18, 2020 · 1 like · 25,914 followers View post →
Meteor0905
@meteor_0905 · X

RT @KalsotraLab: Alternative splicing in the intestine protects against fatty liver disease Wow! The small intestine shields the liver from…

Jul 26, 2020 · 2 shares · 39 followers View post →
Dr. Carolyn Cummins
@CarolynLCummins · X

RT @KalsotraLab: Alternative splicing in the intestine protects against fatty liver disease Wow! The small intestine shields the liver from…

Jul 25, 2020 · 2 shares · 801 followers View post →
Kalsotra Lab
@KalsotraLab · X

Alternative splicing in the intestine protects against fatty liver disease Wow! The small intestine shields the liver from fructose-induced steatosis - PubMed https://t.co/4XhOjpUtMJ

Jul 25, 2020 · 1 like · 2 shares · 550 followers View post →
nyp
@ny_poppa · X

RT @Mangan150: The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogeni…

Jul 24, 2020 · 7 shares · 783 followers View post →
Ankit Kumar
@ankit_helios · X

RT @Mangan150: The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogeni…

Jul 24, 2020 · 7 shares · 125 followers View post →
PostPaleocon
@PostPaleocon · X

RT @Mangan150: The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogeni…

Jul 23, 2020 · 7 shares · 1,153 followers View post →
Symbiosis papers
@Symbiosispapers · X

The small intestine shields the liver from fructose-induced steatosis. https://t.co/2BbW6kDrlh

Jul 23, 2020 · 1,114 followers View post →
Michael_J_Koss
@Michael_J_Koss · X

RT @Mangan150: The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogeni…

Jul 23, 2020 · 7 shares · 629 followers View post →
Rodrigo Rondón
@rjrondonleon · X

RT @Mangan150: The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogeni…

Jul 23, 2020 · 7 shares · 155 followers View post →
Bow Hunter
@HunterGirlSoul · X

RT @Mangan150: The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogeni…

Jul 23, 2020 · 7 shares · 1,914 followers View post →
bubucea90
@bubucea90 · X

RT @Mangan150: The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogeni…

Jul 23, 2020 · 7 shares · 170 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

The small intestine shields the liver from fructose-induced steatosis The same amount of fructose is more strongly lipogenic when drunk than eaten, or when administered as a single dose, as opposed to multiple doses spread over 45 min. https://t.co/aP94lQ1XHw

Jul 23, 2020 · 45 likes · 7 shares · 291,308 followers View post →
tm
@norippie_5 · X

@sosotakei 武井さんは気になされないと思いますが、果糖を1度に取り過ぎると脂肪になりますよー。 Nature Metabolism. Letter Published: 22 June 2020 The small intestine shields the liver from fructose-induced steatosis

Jul 14, 2020 · 1 like · 8 followers View post →
Gabor Erdosi
@gerdosi · X

@vision_quality @DrSarahHallberg @MichaelMindrum Only an issue when there’s a failure in…? The small intestine shields the liver from fructose-induced steatosis https://t.co/kfRJsmuUwi

Jul 13, 2020 · 1 like · 25,914 followers View post →
Salvatore Papa, PhD
@salpapa_lab · X

Nice work @NatMetabolism showing fructose induces lipogenesis when its dietary intake rate exceeds the intestinal clearance capacity | The small intestine shields the liver from fructose-induced steatosis | Article https://t.co/v8L4zSGiWk & Commentary https://t.co/BJMjfzdJB4

Jul 7, 2020 · 1 like · 236 followers View post →
DIFM DPG
@integrativerdn · X

GO WITH YOUR GUT TUESDAY New research in mice helps to understand how the gut may help to prevent the liver from fructose intake. See the full article here: 10.1038/s42255-020-0222-9 https://t.co/kQ9GGTpEho #RDchat #guthealth #highfructosecornsyrup #liverhealth

Jun 30, 2020 · 2,607 followers View post →
Maurício Lima
@dj_surfista · X

O intestino protege o fígado dos danos induzidos pela #frutose. #Fructose https://t.co/jGjb4JJ5gK https://t.co/2IzvcUS4EL

Jun 30, 2020 · 4 likes · 741 followers View post →
Paul Humphries
@PaulHumpa · X

The small intestine shields the liver from fructose-induced steatosis - https://t.co/l5CmHcgY24

Jun 29, 2020 · 3 likes · 2,602 followers View post →
Aida Habib Lab. Beirut
@AubHabibLab · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 25, 2020 · 21 shares · 21 followers View post →
Uhlenhaut Lab
@UhlenhautLab · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 23, 2020 · 21 shares · 1,051 followers View post →
Hon. Muhammad Usman
@Mohd_Usman2012 · X

RT @LiverSaver: When considering diet it is important to understand how the small intestine shields the liver from fructose-induced steatos…

Jun 23, 2020 · 2 shares · 1,040 followers View post →
Lafiya Wealth Initiative
@LafiyaWealthNG · X

RT @LiverSaver: When considering diet it is important to understand how the small intestine shields the liver from fructose-induced steatos…

Jun 23, 2020 · 2 shares · 105 followers View post →
Zoe Hall
@zoehall_ICL · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 23, 2020 · 21 shares · 259 followers View post →
Vargas-Vazquez A
@VargasVazquezA1 · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 23, 2020 · 21 shares · 63 followers View post →
Ullas Kolthur
@UllasKolthur · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 23, 2020 · 21 shares · 3,447 followers View post →
Marouan Zarrouk, Ph.D.
@Marozar82 · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 23, 2020 · 21 shares · 195 followers View post →
Dataemia
@Dataemia · X

The small intestine shields the liver from fructose-induced steatosis - https://t.co/6hJS9cR2XS https://t.co/Bp1K0GLyd4

Jun 23, 2020 · 969 followers View post →
Russell Jones
@DrRGJonesLab · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 2,530 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @Brunorm84: The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Jun 22, 2020 · 3 shares · 32,527 followers View post →
M Shafi Kuchay
@drshafikuchay · X

RT @Brunorm84: The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Jun 22, 2020 · 3 shares · 19,870 followers View post →
tshedizacks
@tshedizacks · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 643 followers View post →
Warwick Dunn
@rickdunnblade · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 2,505 followers View post →
Miguel Reina-Campos
@MReinaCampos · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 764 followers View post →
shalev itzkovitz
@SItzkovitz · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 2,143 followers View post →
Paul Humphries
@PaulHumpa · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 2,602 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 4,771 followers View post →
Ilaria Croci
@Ilaria_Croci · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 468 followers View post →
Mauro Corrado
@MauroCorradoBio · X

The small intestine shields the liver from fructose-induced steatosis | Nature Metabolism https://t.co/6oEA7Wwrxc

Jun 22, 2020 · 2,006 followers View post →
gaelennequin
@EnnequinGael · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 198 followers View post →
Gavin Bewick
@GavBew · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 1,254 followers View post →
Fatty Liver Foundation
@LiverSaver · X

When considering diet it is important to understand how the small intestine shields the liver from fructose-induced steatosis | @scoopit https://t.co/og3Ta4fnjU

Jun 22, 2020 · 2 likes · 2 shares · 3,622 followers View post →
FrezzaLab
@FrezzaLab · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 26,995 followers View post →
Jonathan Schertzer (SchertzerLab)
@SchertzerLab · X

RT @Brunorm84: The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Jun 22, 2020 · 3 shares · 1,480 followers View post →
Bhavani Shankar Sahu.
@urssahu · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 1,360 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

The small intestine shields the liver from fructose-induced steatosis @NatMetabolism https://t.co/jZzRENmoEo

Jun 22, 2020 · 13 likes · 3 shares · 6,434 followers View post →
Cholsoon Jang
@cholsoon_jang · X

RT @NatMetabolism: Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/g…

Jun 22, 2020 · 21 shares · 1,035 followers View post →
Nature Metabolism
@NatMetabolism · X

Online now! The small intestine shields the liver from fructose-induced steatosis https://t.co/9sMEQDOZEG https://t.co/gLrroJF9Fh

Jun 22, 2020 · 55 likes · 21 shares · 79,111 followers View post →
NwokeAgulu
@AguluNwoke · X

The small intestine shields the liver from fructose-induced steatosis https://t.co/waA9ra3eiG

Jun 22, 2020 · 277 followers View post →