Nat Metab June 2019 PMID 32694802

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.

Pénélope A Andreux, William Blanco-Bose, Dongryeol Ryu, Frédéric Burdet, Mark Ibberson, Patrick Aebischer, Johan Auwerx, Anurag Singh, Chris Rinsch

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Mentions

207
Peak: 22 in Jun 2019
across 6 sources since Jun 2019

Extended reach

608,275
potential audience

Total likes

2,963

Video views

124,812

Mentions per month

Jun 2019 – May 2025

Where it's discussed

  • News116 articles
  • X / Twitter62 posts
  • Blogs9 articles
  • Facebook8 posts
  • Reddit8 posts
  • YouTube4 videos

AI synopsis

What people are saying

The overall discussions reflect high interest and engagement, with many posts highlighting the safety and promising benefits of Urolithin A, such as its ability to improve cellular and mitochondrial health, and comparing it favorably to other anti-aging methods like metformin or rapamycin. The tone is excited and speculative, emphasizing its potential to shape future health interventions.

AgreementStrong agreement

Most discussions are highly supportive, emphasizing the safety and potential benefits of Urolithin A for mitochondrial health.

InterestHigh interest

Posts express strong fascination and curiosity about the research, with words like 'fascinating,' 'revolutionary,' and 'game changer.'

EngagementHigh engagement

Participants cite specific details from the study, compare it to existing treatments, and mention potential applications, indicating deep engagement.

ImpactHigh impact

The discussions suggest this research could significantly influence future anti-aging and mitochondrial health strategies, termed as 'revolutionary' and 'potential game changer.'

Abstract in brief

  • Urolithin A (UA) is a natural compound derived from the gut microbiome that can stimulate mitophagy, which is the process of clearing out damaged mitochondria, thereby potentially improving muscle and cellular health.
  • A clinical trial found that UA is safe for humans and is absorbed into the bloodstream, with treatment over four weeks at doses of 500mg and 1000mg leading to positive changes in mitochondrial function, as shown by changes in plasma markers and gene expression in muscle cells.
  • These results suggest that regular oral intake of UA could promote mitochondrial health and cellular vitality in elderly individuals, supporting its potential as a safe supplement for age-related health benefits.

Top posts

Most liked on X and Bluesky
Aging Science News
@AgingBiology · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans https://t.co/61eqxBk8Kk

Jun 17, 2019 · 19 likes · 10 shares · 30,529 followers View post →
Lifespan News
@LifespanNews · X

The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 8, 2020 · 10 likes · 3 shares · 22,333 followers View post →
Lifespan News
@LifespanNews · X

The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 6, 2020 · 8 likes · 3 shares · 22,333 followers View post →
Lifespan News
@LifespanNews · X

What happens when your #mitochondria break down? #aging #lifeextension #X1 https://t.co/sZkZXE8imN

Aug 20, 2020 · 8 likes · 2 shares · 22,333 followers View post →
Lifespan News
@LifespanNews · X

In case you missed #X10's episode on #mitochondria... #biology #aging https://t.co/sZkZXE8imN

May 27, 2020 · 7 likes · 1 share · 22,333 followers View post →
Lifespan News
@LifespanNews · X

Did you miss X10's latest episode on #mitochondria? #aging #biology https://t.co/sZkZXE8imN

May 19, 2020 · 5 likes · 22,333 followers View post →

All mentions

Baryalai Sultani
@BaryalaiSu61765 · X

https://t.co/bx7iN6YLxn

May 22, 2025 · 3 followers View post →
YoSean.DeSAI
@ywang01 · X

@Pepecoinmeme Maybe you should read the reference papers first. https://t.co/fvjFB1thaQ https://t.co/sxJllx1WhF

Dec 26, 2024 · 1,052 followers View post →
Jeff Robinson, CEO and Chairman of $MRES and $RLAB
@contrariansmind · X

Urolithin A for Mitochondrial Health, Autophagy, and More: Is it worth i... https://t.co/bk7QovJVok via @YouTube

Sep 26, 2024 · 56,316 followers View post →
Imelda
@BadCompany02 · X

https://t.co/tdeWLDScQL

Mar 26, 2024 · 41 followers View post →
Dale
@healthspanfans · X

Dec 14, 2023 · 347 followers View post →
Yuji Marutani Planning Director
@YujiMarutani · X

Urolithin A for Mitochondrial Health, Autophagy, and More: Is it worth it? https://t.co/cKYgpw9zfh via @YouTube

Dec 11, 2023 · 1,583 followers View post →
blubber_bones
@blubber_bones · X

Urolithin A for Mitochondrial Health, Autophagy, and More: Is it worth it? https://t.co/rR4lDhEwaE

Dec 11, 2023 · 1,079 followers View post →
Citizen of EU
@wavetossed · X

RT @schachin: "The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health…

Mar 6, 2023 · 1 share · 9,493 followers View post →
Kristine (@schachin on Threads)
@schachin · X

"The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans" From Nature. https://t.co/HQr1qVAH9i 2/ https://t.co/jfxuBC1axH

Mar 6, 2023 · 1 like · 1 share · 22,058 followers View post →
ComunidadLongevidad
@Com_longevidad · X

RT @agingdoc1: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health…

Sep 28, 2022 · 2 shares · 16 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health…

Sep 27, 2022 · 2 shares · 133 followers View post →
Agingdoc
@agingdoc1 · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans (2019) https://t.co/b2957vTSPQ

Sep 27, 2022 · 2 likes · 2 shares · 41,316 followers View post →
Mikhail Batin
@MikhailBatin · X

Urolithin A might be useful for our cocktail https://t.co/Ua7DiiUhAg

Mar 28, 2022 · 2,195 followers View post →
Rene Sugar
@renesugar · X

RT @AutophagyPapers: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular h…

Apr 7, 2021 · 2 shares · 3,951 followers View post →
Niranjana Prabhakar Bandaru
@metallicat6 · X

RT @AutophagyPapers: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular h…

Jan 20, 2021 · 2 shares · 95 followers View post →
Autophagy Papers
@AutophagyPapers · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. https://t.co/D50fx5UN6K https://t.co/TSOUk0EdkR

Jan 7, 2021 · 1 like · 2 shares · 1,701 followers View post →
David
@David77692706 · X

RT @sunray120: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health…

Jan 6, 2021 · 1 share · 26,722 followers View post →
Lady Ray ☀️❤️
@LadyRay120 · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans, it helps older people build muscle->it is in pomegranate https://t.co/Q8yBBTfZ8m https://t.co/AmZtGcQU5g

Jan 6, 2021 · 5 likes · 1,213 followers View post →
Lady Ray ☀️❤️
@LadyRay120 · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans | Nature Metabolism https://t.co/XD3SScXwuC

Jan 6, 2021 · 1 like · 1 share · 1,213 followers View post →
Tucker Goodrich
@TuckerGoodrich · X

@_martinsip_ @maximumcharacte I have to say, this is beyond interesting, it's fascinating, maybe revolutionary. Compare to metformin or rapamycin. "The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans" https://t.co/XimLEgP5kQ

Dec 10, 2020 · 2 likes · 28,260 followers View post →
OccuWorld
@OccuWorld · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. https://t.co/C7JiNHKkaV

Oct 27, 2020 · 8,760 followers View post →
Chris Rabane
@ChrisRabane · X

RT @LifespanIO: What happens when your #mitochondria break down? #aging #lifeextension #X1 https://t.co/sZkZXE8imN

Aug 20, 2020 · 2 shares · 11,127 followers View post →
TheRedDragon
@TheDreamSphere · X

RT @LifespanIO: What happens when your #mitochondria break down? #aging #lifeextension #X1 https://t.co/sZkZXE8imN

Aug 20, 2020 · 2 shares · 411 followers View post →
Lifespan News
@LifespanNews · X

What happens when your #mitochondria break down? #aging #lifeextension #X1 https://t.co/sZkZXE8imN

Aug 20, 2020 · 8 likes · 2 shares · 22,333 followers View post →
Lifespan News
@LifespanNews · X

Check out X10's previous episode on mitochondrial dysfunction: https://t.co/sZkZXE8imN #aging #biology #molecularbiology #lifextenshow

Jun 3, 2020 · 22,333 followers View post →
Chris Rabane
@ChrisRabane · X

RT @LifespanIO: In case you missed #X10's episode on #mitochondria... #biology #aging https://t.co/sZkZXE8imN

May 27, 2020 · 1 share · 11,127 followers View post →
Lifespan News
@LifespanNews · X

In case you missed #X10's episode on #mitochondria... #biology #aging https://t.co/sZkZXE8imN

May 27, 2020 · 7 likes · 1 share · 22,333 followers View post →
Lifespan News
@LifespanNews · X

Did you miss X10's latest episode on #mitochondria? #aging #biology https://t.co/sZkZXE8imN

May 19, 2020 · 5 likes · 22,333 followers View post →
Eternal Youth Advocate | Gerascophobic
@EnthusiastYouth · X

RT @LifespanIO: With #aging, the powerhouse of the #cell goes south on you! This episode of LifeXtenShow is all about the #biology of mitoc…

May 17, 2020 · 2 shares · 35 followers View post →
Jonathan
@schwartzworld · X

RT @LifespanIO: With #aging, the powerhouse of the #cell goes south on you! This episode of LifeXtenShow is all about the #biology of mitoc…

May 12, 2020 · 2 shares · 204 followers View post →
Lifespan News
@LifespanNews · X

With #aging, the powerhouse of the #cell goes south on you! This episode of LifeXtenShow is all about the #biology of mitochondria and how #science may keep them #young. https://t.co/sZkZXEpTel

May 12, 2020 · 4 likes · 2 shares · 22,333 followers View post →
Chris Rabane
@ChrisRabane · X

RT @LifespanIO: The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 9, 2020 · 3 shares · 11,127 followers View post →
Ljubomir Josifovski
@ljupc0 · X

RT @LifespanIO: The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 8, 2020 · 3 shares · 5,572 followers View post →
Lifespan News
@LifespanNews · X

The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 8, 2020 · 10 likes · 3 shares · 22,333 followers View post →
Valerie Kemp
@VK_ValerieKemp · X

RT @LifespanIO: The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 7, 2020 · 3 shares · 902 followers View post →
Adi
@Adrian06661136 · X

RT @LifespanIO: The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 6, 2020 · 3 shares · 505 followers View post →
Chris Rabane
@ChrisRabane · X

RT @LifespanIO: The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 6, 2020 · 3 shares · 11,127 followers View post →
Lifespan News
@LifespanNews · X

The Hallmarks of Aging: Mitochondrial dysfunction | LifeXtenShow https://t.co/9J69AaI2v6

May 6, 2020 · 8 likes · 3 shares · 22,333 followers View post →
OptimOZ.com.au
@OptimOZ · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans https://t.co/BHm9I1dtgt strawberries, raspberries, walnuts https://t.co/wNn9OMV30h https://t.co/n3cqXGf2PZ

Sep 20, 2019 · 474 followers View post →
てぃきでぃー
@Chicadee_PhD · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans https://t.co/lWrOvrpHIQ

Jul 16, 2019 · 1,136 followers View post →
Nikolay Novitskiy
@novitskiynic · X

More information: Pénélope A. Andreux et al. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans, Nature Metabolism (2019) @nresearchnews

Jun 30, 2019 · 3 likes · 2,432 followers View post →
Soph
@sophiatseliem · X

ANTI-AGING: The mitophagy activator urolithin A is safe and induces a molecular signature of improv… https://t.co/URsoxtohn6

Jun 23, 2019 · 556 followers View post →
MESD
@PolycarpJ01 · X

RT @erlesen: Urolithin https://t.co/UlFAyMDrRE The mitophagy activator urolithin A is safe and induces a molecular signature of improved mi…

Jun 23, 2019 · 3 shares · 53 followers View post →
Die Mim 
@kulturbolschewi · X

RT @erlesen: Urolithin https://t.co/UlFAyMDrRE The mitophagy activator urolithin A is safe and induces a molecular signature of improved mi…

Jun 22, 2019 · 3 shares · 17,154 followers View post →
Reiner 
@erlesen · X

Urolithin https://t.co/UlFAyMDrRE The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans https://t.co/OFuaNAzbtr Granatapfel-Komponente zeigt Anti-Aging-Wirkung beim Menschen https://t.co/Um3pnSSemc

Jun 22, 2019 · 4 likes · 3 shares · 7,849 followers View post →
Verdean Mtichell
@verdeanmitchell · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans https://t.co/aO9Tibpk4U

Jun 21, 2019 · 495 followers View post →
KronoDeus
@DrKronoDeus · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 18, 2019 · 10 shares · 53 followers View post →
Theptat
@Theptat5 · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 18, 2019 · 10 shares · 15 followers View post →
Halimaha2709
@Halimaha2709 · X

Urolithin A, a metabolite of biomolecules found in pomegranates, may attenuate the process of sarcopenia by improving the functioning of mitochondria. Researchers found that UA can slow down the mitochondrial aging process. https://t.co/KzHeDL9K54 https://t.co/kX5h8EN6Lt https://t.co/n0ZmjhaPw5

Jun 18, 2019 · 228 followers View post →
Andri García
@AndriGarciaOfic · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 18, 2019 · 10 shares · 640 followers View post →
Urolithin A
@UrolithinA · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 18, 2019 · 10 shares · 881 followers View post →
Ageing Research KCL
@ARK_KCL · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 18, 2019 · 10 shares · 1,645 followers View post →
annibal_ms
@AnnibalMs · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 18, 2019 · 10 shares · 304 followers View post →
SNZK
@shinopp · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 17, 2019 · 10 shares · 726 followers View post →
Punkmando (dr house's evil twin)
@Punkmando1 · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 17, 2019 · 10 shares · 274 followers View post →
Jake
@Jake_dd_snake · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 17, 2019 · 10 shares · 57 followers View post →
Rocío Villena
@rochi_villena · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 17, 2019 · 10 shares · 282 followers View post →
cmilina27
@cmilina27 · X

RT @AgingBiology: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular heal…

Jun 17, 2019 · 10 shares · 202 followers View post →
Aging Science News
@AgingBiology · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans https://t.co/61eqxBk8Kk

Jun 17, 2019 · 19 likes · 10 shares · 30,529 followers View post →
Chuck Tierney
@IrishIslands4us · X

@davidasinclair Have you come across this recent study. I would be interested in your take. “The mitophagy activator Urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans” (doi: 10.1038/s42255-019-0073-4).

Jun 16, 2019 · 198 followers View post →
Surojit Sural
@surojitsural · X

RT @ClinConnection: The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular he…

Jun 14, 2019 · 1 share · 872 followers View post →
Clinical Connection
@ClinConnection · X

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans https://t.co/aK0q4l8KIB #clinicaltrials https://t.co/ap63GepWoy

Jun 14, 2019 · 1 like · 1 share · 30 followers View post →