Discussions emphasize the scientific consensus that chloroquine does not inhibit SARS-CoV-2 in human lung cells, citing peer-reviewed research from sources like Nature, with posts highlighting that this evidence may end the long-standing debate about its efficacy. The tone is analytical and conclusive, reflecting the importance of these findings for public health and treatment strategies.
AgreementStrong agreement
Most discussions reinforce the findings that chloroquine is ineffective against human lung cells with SARS-CoV-2, indicating strong consensus.
InterestHigh interest
Posts demonstrate high engagement with the topic, citing peer-reviewed studies, implications for treatment debates, and scientific explanations.
EngagementModerate engagement
There is active referencing of scientific literature, calls to settle controversies, and discussions about the drug’s pathways, showing thoughtful engagement.
ImpactHigh impact
The collective tone suggests the findings could significantly influence ongoing debates, clinical practices, and future research directions.
Abstract in brief
Chloroquine was initially thought to inhibit SARS-CoV-2 infection based on studies in African green monkey kidney cells, but it does not effectively block infection in human lung cells.
The presence of the cellular protease TMPRSS2 in human lung cells activates the virus in a way that makes chloroquine ineffective, suggesting it targets a pathway not active in lung tissue.
Overall, these findings imply that chloroquine is unlikely to protect against COVID-19 spread in humans, especially in lung tissue where the virus primarily infects.
Furthermore, the presence of the TMPRSS2 protease favors a plasma membrane entry route whereas its absence favors cathepsin-mediated endosomal entry in vitro, as shown by @c_drosten & @snpoehlm
This may also impact apparent neutralization.
10/19
https://t.co/XcYrxrDQN7
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. "Chloroquine failed to efficiently block Calu-3 (lung) cell infection with SARS-2-S-bearing pseudotypes and authentic #SARSCoV2" https://t.co/w6abUxcJpz via @nature
Here’s more evidence, in addition to lack of activity both as prophylaxis and Rx in NHPs, why HCQ/CQ may not work....Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 | Nature https://t.co/hoJFR3MLYM
Scientists of the German Primate Center in Göttingen, together with colleagues at the @ChariteBerlin, were able to show that the malaria drug chloroquine does not inhibit #SARSCoV2 infection of lung cells: https://t.co/kqEDkZmLxk
https://t.co/wImmK96bZn
Scientist Dr Susan Oliver and Julie discuss science mistakes made by ivermectin supporters, including misinterpretation of data and faulty comparisons to antivirals. The video emphasizes the importance of understanding…
This was the first video I ever made for my channel Unfortunately YouTube removed it after 6 hours After over a year and thanks to the efforts of my supporters they relooked at it and realised they had made a mistake…
Dude. Take a walk before you post. Your initial point was reactionary "slippery slope" nonsense mixed with the emptiest and snarkiest "c'mon bro!" I've seen in a while. This is not worth being that defensive about. Nobody thinks you're "bad" because you speed. They're just fed up with speeding.
That was the argument you were allowed to make BEFORE you lost lmao. After we found out it lost way more votes and that Israel collided with trump while harris sent Ritchie Torres and rapey bill to scold Muslims as their families were killed.
Sir के खिलाफ कांग्रेस का हल्ला बोल:दिल्ली के रामलीला मैदान में विशाल रैली, ‘वोट चोरी’ को लेकर प्रदर्शन – Congress Holds A Maharally At Delhi’s Ramlila Maidan Against Alleged Vote Chori
दिल्ली के रामलीला मैदान में आज कांग्रेस की महारैली है। महारैली की तैयारियां पूरी कर ली गई हैं। दिल्ली प्रदेश…
I think it'd result in more deaths than expected.
But i think you have a point, speeding would almost certainly account for more deaths and injuries.
That said, apparently the limiter idea needs work so it doesn't kill people.
Maybe instead of a hard limit, it forces you into lower and lower gears.
sperrung berlin, alt-köpenick bis grünstraße zwischen kirchstraße und kietzer straße über alt-köpenick|gesperrt, veranstaltung
#Berlin #Verkehr #Baustelle #Sperrung #Störung #Straße
we had to pee in a cup for the privilege of working at the company that sent the email marketing campaigns for Bank of America, meanwhile these guys are high as a kite and in charge of the global economy and all our personal information. it’s a cool system, really, no notes.
But have they backfilled the university and research cuts? Are there Canadian researchers who haven been able to access opportunities? What about equity accommodations and services for grad students, currently weak. At the time of the budget announcement I read several comments to that effect.
Researchers found that chloroquine protects NORMAL cells from viruses but ALLOWS viruses to attack CANCER cells.
Oct 8, 2025 · 3 likes · 2,840 followersView post →
FF
Fab Frank
@LockedFab · X
@YanConstantin @joelgarcin @laurenceide69 @nicolasberrod @Sonic_urticant @lonnibesancon @AlexSamTG In vitro sur cellules sans récepteur TMPRSS2, mais même pas sur cellules de poumon humains où la voie TMPRSS2 n'était pas inhibé par la chloroquine.
https://t.co/nW0u0EEyLS
May 21, 2025 · 4 likes · 3,258 followersView post →
Furthermore, the presence of the TMPRSS2 protease favors a plasma membrane entry route whereas its absence favors cathepsin-mediated endosomal entry in vitro, as shown by @c_drosten & @snpoehlm
This may also impact apparent neutralization.
10/19
https://t.co/XcYrxrDQN7
May 26, 2022 · 5 likes · 4,504 followersView post →
JO
Jason Ozolins
@JasonOzolins · X
@SCH451 @pwafork Blocked, but she then tweeted some ad hominems about the VIC CHO and Fauci, and some quotes about HCQ being good for treating SARS-COV.
That was in a *kidney cell line*.
'Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2'
https://t.co/z7wDuDe9oo https://t.co/ZMnvgDHlUS
@Bidenhuffsgas @KollockShepard @Wsg20210525 @RonFilipkowski @NIH Right, so this is an experiment that tried to replicate those results with covid-19. It failed. They wanted it to work. It would have been great. The evidence isn’t there though https://t.co/RV94SGudak
@SenadorHeinze nunca leu um artigo científico na vida e vem falar que "não há pesquisa que evidência ser inútil o tratamento precoce"
Para ajudar o senador:
https://t.co/uk6gMWrCoj
https://t.co/TpnybRTESR
https://t.co/F3kmfejb58
@RobsonDias80 @donizetearruda7 @nature Hoffmann, M., Mösbauer, K., Hofmann-Winkler, H. et al. Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. Nature 585, 588–590 (2020). https://t.co/Xex7LE8kA7
@nathanpsmad In (cellules) vero non est veritas. Déjà vu hélas avec l'HCQ, https://t.co/hRQljGpGJz
On m'a envoyé ce lien mais les titres donnent ... le tournis. Comme dirait un footeux j'ai peur d'avoir mal à ma science. La flemme de m'y plonger. Quelqu'un l'a fait ?
https://t.co/SWgevzNozz
Nature : Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
Expression of TMPRSS2—a protease that activates SARS-CoV-2 for entry into cells—renders SARS-CoV-2 insensitive to chloroquine.
Markus Hoffmann, Kirstin Mösbauer, Heike Hofmann-Winkler et al.
"..chloroquine targets a pathway for viral activation that is not operative in lung cells and is unlikely to protect against SARS-CoV-2 spread"
Hoffmann, M.,et al. Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. Nature (2020). https://t.co/uHqLTYDlig
Aug 1, 2020 · 7 likes · 3 shares · 7,823 followersView post →
AA
Angel Azpeitia
@AngelAzpeitia · X
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 | Nature https://t.co/c2KrsGCx2k, see more https://t.co/DYNr6PCqHI
Aug 1, 2020 · 1 like · 1 share · 1,475 followersView post →
JT
Jose Torres
@jtorresales · X
Demasiada data para los que aún piensan que es la solución mágica al #COVID-19
#Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 | Nature https://t.co/GUzncRwm1N
In @nature last week: "Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2" "Results indicate that chloroquine targets a pathway for viral activation that is not operative in lung cells." https://t.co/JjwHSecihr
Jul 31, 2020 · 1 like · 1 share · 2,761 followersView post →
EC
European Virus Bioinformatics Center
@EVirusBioinfC · X
#Chloroquine does not block #SARSCoV2 infection of human lung cells and is unlikely to protect against spread in and between patients. Paper co-authored by EVBC member @c_drosten https://t.co/GvqwAftkj7
@J0sephMcN4bb @1ofakndLizzy @globalnews Hoffmann, M., Mösbauer, K., Hofmann-Winkler, H. et al. Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. Nature (2020). https://t.co/aSSz6TPngu
Here’s more evidence, in addition to lack of activity both as prophylaxis and Rx in NHPs, why HCQ/CQ may not work....Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 | Nature https://t.co/hoJFR3MLYM
NATURE: "Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2"
I think finally the chloroquine debate may be over? #COVID19
https://t.co/la34lmb1tW
Cuando usas una célula en cultivo y extrapolas a humanos. El caso de cloroquina que funciona inhibiendo entrada virus en celulas Vero pero no en células pulmonares. Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
https://t.co/j1cAKvKw75
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. "Chloroquine failed to efficiently block Calu-3 (lung) cell infection with SARS-2-S-bearing pseudotypes and authentic #SARSCoV2" https://t.co/w6abUxcJpz via @nature
#Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 - chloroquine targets a pathway for viral activation that is not operative in lung cells and is unlikely to protect against SARS-CoV-2 spread in and between patients, finds new st…https://t.co/mKHh4Wz0tv
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.
El estudio muestra la cloroquina inhibe la actividad de la Catepsina-L renal, más no parece inhibir la TMPRSS2 producida por los pulmones en pctes Covid19.
https://t.co/KqnpoInIoy
https://t.co/78ZrlBmelE https://t.co/X7sjmeysrj
One more scientific evidence on the unusablility of #chloroquine as a might drug against #SARSCoV2. #molecular-biology and #DataScience usage on drug testing.
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2 | Nature https://t.co/s4Jdaq5dPw
#Chloroquine does not inhibit infection of human lung cells with #COVID19 https://t.co/mC7iedqd9n via
@debugliesnews #Health #healthcare #healthylifestyle #HealthyLife #COVIDー19 #coronavirus #Coronavid19 #COVID19Pandemic #CoronavirusOutbreak #CoronaLockdown #COVID2019
Hopefully, these two Nature articles will end the hydroxychloroquine controversy. 1/2:
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2
https://t.co/8OCW5K79eC
Scientists of the German Primate Center in Göttingen, together with colleagues at the @ChariteBerlin, were able to show that the malaria drug chloroquine does not inhibit #SARSCoV2 infection of lung cells: https://t.co/kqEDkZmLxk
https://t.co/wImmK96bZn
Wissenschaftler des Deutschen Primatenzentrums in Göttingen konnten zusammen mit Kollegen an der @ChariteBerlin zeigen, dass das Malaria-Medikament Chloroquin die #SARSCoV2-Infektion von Lungenzellen nicht blockiert: https://t.co/kqEDkZmLxk
https://t.co/mBVh0YVzG9
Artificial Intelligence in COVID 19 Drug Repurposi | PDF | Deep ...
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Corticosteroids: mechanisms org/10.1038/s41586-020-2575-3. of action in health and disease. Rheum Dis Clin North Am 2016; 69 Hou Y, Zhao J, Martin W, et al ...
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