Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.

Ching-Lin Hsieh, Jory A Goldsmith, Jeffrey M Schaub, Andrea M DiVenere, Hung-Che Kuo, Kamyab Javanmardi, Kevin C Le, Daniel Wrapp, Alison G Lee, Yutong Liu, Chia-Wei Chou, Patrick O Byrne, Christy K Hjorth, Nicole V Johnson, John Ludes-Meyers

September 2020 Science

Synopsis of Social media discussions

Several discussions highlight the significance of the prefusion-stabilized spikes, with users mentioning advancements like HexaPro being ten times more effective than previous models. Phrases like 'this technology has been used since 2013 without issues' and 'not the same as the spike protein in the virus' indicate a strong engagement with the scientific content and an attempt to clarify misconceptions around vaccine efficacy. The tone of support and curiosity, alongside scientific references, underscores a collective acknowledgment of the publication’s impacts.

A
Agreement
 Moderate agreement

Many participants express support for the findings in the publication and the benefits of the prefusion-stabilized spikes.

I
Interest
 High level of interest

There is a notable curiosity towards the implications of the research, as several posts reference specific scientific details and advancements.

E
Engagement
 High engagement

The discussions are deep, with users analyzing methods, implications, and different perspectives on spike protein structures and their relevance to vaccines.

I
Impact
 High level of impact

Most users believe the publication has a significant influence on vaccine design and therapeutic strategies, showcasing its importance in the ongoing pandemic response.

Social Mentions

YouTube

2 Videos

Twitter

116 Posts

Blogs

8 Articles

News

50 Articles

Reddit

4 Posts

Metrics

Video Views

56,037

Total Likes

2,616

Extended Reach

1,024,439

Social Features

180

Timeline: Posts about article

Top Social Media Posts

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  • triplekon
    @Navaraaa (Twitter)

    @RChabriet @SahabiaAli @pjd77420 @Titithebest4 @TristanHurieff @guillaumed2025 @Jeannemarie1309 @Alex49111 @Kevin_McKernan @QI_181 c'est vous qui faite un claim dans une discussion sur la sécurité des vaccins et vous etes pas capable de produire de sources ... des papiers sur la sub 2P ça manque pas https://t.co/xcdK5QIXKl https://t.co/B3dpY8tD6R
    view full post

    September 10, 2025

  • The GUT CLUB
    @club_gut (Twitter)

    @SolidEvidence @MdBreathe @X Intracellular bacteria may provide RT. Is 2P instability a problem in discerning mRNA-induced spike in wastewater detection? This mRNA spike may also be in our drinking water given poor sanitation where wastewater effluent is discharged in supply. https://t.co/wceLMN1Wpl
    view full post

    July 31, 2025

  • Graham Nigel
    @NigelHeal (Twitter)

    RT @AltenbergLee: It cites 2 prior studies of the proline substitutions in spike—both before the deployment of the COVID vaccines: "this mu…
    view full post

    April 5, 2025

    7

  • @marcusfitzsimons.bsky.social Woke Green Socialist
    @MarcusFitzsimon (Twitter)

    RT @AltenbergLee: It cites 2 prior studies of the proline substitutions in spike—both before the deployment of the COVID vaccines: "this mu…
    view full post

    April 5, 2025

    7

  • Michael Klein
    @Michael10415865 (Twitter)

    RT @RWittenbrink: enthaltene Spike-Protein eine Zellfusion verursacht!“ Weitere Details dazu hier in diesen Studien: https://t.co/N9w5bH4…
    view full post

    August 8, 2024

    5

  • RosaGrün
    @Rosamoonstar (Twitter)

    RT @RWittenbrink: enthaltene Spike-Protein eine Zellfusion verursacht!“ Weitere Details dazu hier in diesen Studien: https://t.co/N9w5bH4…
    view full post

    August 7, 2024

    5

  • Apocalypse IsNow
    @ApocalypseHere (Twitter)

    RT @AltenbergLee: It cites 2 prior studies of the proline substitutions in spike—both before the deployment of the COVID vaccines: "this mu…
    view full post

    August 7, 2024

    7

  • Berta Schodlok - @bertaschodlok.bsky.social
    @BSchodlok (Twitter)

    RT @RWittenbrink: enthaltene Spike-Protein eine Zellfusion verursacht!“ Weitere Details dazu hier in diesen Studien: https://t.co/N9w5bH4…
    view full post

    August 7, 2024

    5

  • Robuste Warnbake
    @RobusteW (Twitter)

    RT @RWittenbrink: enthaltene Spike-Protein eine Zellfusion verursacht!“ Weitere Details dazu hier in diesen Studien: https://t.co/N9w5bH4…
    view full post

    August 6, 2024

    5

  • Ralf Wittenbrink
    @RWittenbrink (Twitter)

    enthaltene Spike-Protein eine Zellfusion verursacht!“ Weitere Details dazu hier in diesen Studien: https://t.co/N9w5bH48T7 https://t.co/mMma7o4vGX #HeartDisease #LongCovid #COVID19 #Coronavirus #SARSCoV2 #ImpfenSchuetzt #CleanAir #MaskUp
    view full post

    August 6, 2024

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    5

  • Steve
    @EndCorpFascism (Twitter)

    RT @AltenbergLee: It cites 2 prior studies of the proline substitutions in spike—both before the deployment of the COVID vaccines: "this mu…
    view full post

    August 6, 2024

    7

  • #MrPaps #LordLibertarian #NumerOculto#Njosnavelin
    @AlbertCapine (Twitter)

    RT @AltenbergLee: It cites 2 prior studies of the proline substitutions in spike—both before the deployment of the COVID vaccines: "this mu…
    view full post

    August 6, 2024

    7

  • Noreen Pazderski
    @NoreenPaz87 (Twitter)

    RT @AltenbergLee: It cites 2 prior studies of the proline substitutions in spike—both before the deployment of the COVID vaccines: "this mu…
    view full post

    August 6, 2024

    7

  • Lee Altenberg, Ph.D.
    @AltenbergLee (Twitter)

    It cites 2 prior studies of the proline substitutions in spike—both before the deployment of the COVID vaccines: "this mutation greatly reduces cell fusion" 2017 MERS spike: https://t.co/qdT1mREr0h 2020-7 SARS2 spike: https://t.co/TtoVn8mIFu
    view full post

    August 6, 2024

    70

    7

  • C-A-G
    @C_A_G0101 (Twitter)

    @ShadowMike14 Ce serait bien de lire les articles
    view full post

    May 3, 2024

  • Byron
    @ByronHsu2 (Twitter)

    @Nomoretrust8 @maolesen Spike glycoproteins from SARS-CoV-2 are toxic to human cells. Spike glycoproteins translated by mRNA vaccines are stabilized in the prefusion conformation by 2P mutations and cannot bind ACE2 receptors. https://t.co/YIWTM3PF8w
    view full post

    February 13, 2024

  • Agnieszka Szuster-Ciesielska
    @AgnieszkaSzust3 (Twitter)

    białka kolca S-2P jako kontroli negatywnej, wykazując całkowity brak fuzogenności neuronów. To jasno wskazuje na bezpieczeństwo szczepionek mRNA. Źródła: https://t.co/gLsUYC70ri https://t.co/I5YWFwI45d https://t.co/kEp9ikeuUW End
    view full post

    January 14, 2024

    12


  • @ShaneAKAProp (Twitter)

    @jneill @cellestial1 @bjurrows @krebiozen @Scary7Dr @AphasiaAnomic @sduncanhealth @shinko_hadoken @Arkout3 @ASchifty @TakethatCt @Pouldeau61 @runhack @cappsie @JRNave @BB0941167867205 @AnnLove4All @raoulduke49 @crabb_vicki @taurusg333 @doritmi @RN_MSN_Snark @Kathmarval @mcfunny @Danny459673 @WendyOrent @DaveBla81093404 @MsTrixter @TonyBaduy @TheFrankmanMN @Hurriquake @MONTMAN9500 @StuWizzle @Golfergirl2018 @dann58638436 @AngryMouse23 @BigGuy4U86 @encyclopath @1_TMF_ @Fornowago @FUDyou2 @Catheri49917567 @RadioColor @tonymac5 @groin_hammer @CyclopsSeesAll @ScienceMonkey0 @Just4TheCause @janiesaysyay https://t.co/kFPVy7nixH But, you can believe whatever you want. Even though this was well known from the offset.
    view full post

    January 2, 2024

    5

  • Ryan Hisner
    @LongDesertTrain (Twitter)

    @AltenbergLee I don't know what the status is right now as far as the development of a vaccine, but @McLellan_Lab developed a version of spike with six prolines in S2 that's even more stable than the 2-proline version. Seems likely to be superior to current shots. https://t.co/Xniw3Lhr3A
    view full post

    December 7, 2023

    3

  • ของขวัญของMr.J.G.
    @KKwan_of702 (Twitter)

    RT @pokrath: นักวิทยาศาสตร์ที่ค้นพบว่าเรา สามารถ modify โปรตีนส่วนที่จับกับเซลลํก่อนไวรัสเข้าเซลล์ (pre-fusion spike) ให้โครงสร้างมันเสถียร…
    view full post

    November 11, 2023

    4

  • teejay
    @htongjai (Twitter)

    RT @pokrath: นักวิทยาศาสตร์ที่ค้นพบว่าเรา สามารถ modify โปรตีนส่วนที่จับกับเซลลํก่อนไวรัสเข้าเซลล์ (pre-fusion spike) ให้โครงสร้างมันเสถียร…
    view full post

    November 11, 2023

    4

  • Pokrath Hansasuta
    @pokrath (Twitter)

    นักวิทยาศาสตร์ที่ค้นพบว่าเรา สามารถ modify โปรตีนส่วนที่จับกับเซลลํก่อนไวรัสเข้าเซลล์ (pre-fusion spike) ให้โครงสร้างมันเสถียรจะสามารถกระตุ้นแอนติบอดีชนิด neutralising antibody ได้ดีขึ้น https://t.co/NWJRK5wHOK ซึ่งเป็นความรู้ต่อยอดมาตั้งแต่ก่อนโควิด 3/3
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    November 11, 2023

    6

    4

  • CeeBee
    @ceegarciabee (Twitter)

    @Novaxxjoker @DrSusanOliver1 My limited understanding is you’re confusing C19’s capabilities w/mRNA vax, & they’re not the same. “A version of the spike ectodomain that includes two proline substitutions (S-2P) and stabilizes the prefusion conformation” So locked in pre-fusion. https://t.co/MF8WY22z7H
    view full post

    October 29, 2023

    1

  • CeeBee
    @ceegarciabee (Twitter)

    @RickCaughell @tonymac5 @ichudov @DrSusanOliver1 The Spike Protein in Vax is not only not the same as Spike Protein in the virus. It cannot do the damage you think it can. Vax spike protein’s not connected to a virus, & locked in pre-fusion. ie stabilized in pre-fusion confirmation. https://t.co/MF8WY22z7H
    view full post

    September 25, 2023

    3

  • aura+
    @ALloiVERA (Twitter)

    RT @ANo1505: ⬆️ ⚡️☠️
    view full post

    September 19, 2023

    1

  • АлексАНдр
    @ANo1505 (Twitter)

    ⬆️ ⚡️☠️
    view full post

    September 19, 2023

    3

    1

  • Crystal
    @whitelotus888 (Twitter)

    RT @CartlandDavid: Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science https://t.co/eViPZY6gMi
    view full post

    September 4, 2023

    5

  • Ron Botterill
    @Ron36820436 (Twitter)

    RT @CartlandDavid: Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science https://t.co/eViPZY6gMi
    view full post

    September 4, 2023

    5

  • Rich Hoblyn 〓〓
    @itsrichhoblyn (Twitter)

    RT @CartlandDavid: Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science https://t.co/eViPZY6gMi
    view full post

    September 4, 2023

    5

  • Marion Steggles
    @marionste (Twitter)

    RT @CartlandDavid: Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science https://t.co/eViPZY6gMi
    view full post

    September 4, 2023

    5

  • Dr Dave Cartland BMedSc MBChB Ex-MRCGP
    @CartlandDavid (Twitter)

    Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science https://t.co/eViPZY6gMi
    view full post

    September 4, 2023

    6

    5

  • Matthew D
    @DopplerEffect93 (Twitter)

    @MNAmyJo This is what is used in the vaccines. It is just 2 additional proline amino acids to stabilize spike protein in a prefusion confirmation. https://t.co/2yyd32LTXi https://t.co/5EssF9BbK6
    view full post

    August 16, 2023

  • рауль рамзес
    @raulramesses (Twitter)

    @DulmaZavr @texanaloa Да потом хуйня эти переехавшие. UT всегда крутым был. Кто по-вашему структуру подробно описал структуру спайк-протеина SARS-CoV-2? https://t.co/a2WcMgBSsx
    view full post

    June 21, 2023

  • Andrew Tan
    @andrewtanyongyi (Twitter)

    @evly843 Not sure, but I think that's doable. Changing the sequence is easy, but the tricky thing is adapting it so the protein takes the right shape - which seems to have been worked out by @McLellan_Lab https://t.co/TGgY1jumr2: "we exclusively focused our efforts on stabilizing S2"
    view full post

    May 18, 2023

  • Charmet christophe
    @CharmetC (Twitter)

    @la_mesange_ @MartineRsx @CaudeHenrion https://t.co/zpb6SRo7cU "he published a new version in July called HexaPro (Science 2020, DOI: 10.1126/science.abd0826). It contains the original 2P mutation plus four additional prolines that further stabilize other regions of the protein." "Etudiant en biologie "
    view full post

    May 7, 2023

  • MrPfizerFormerly
    @shadowwarrioret (Twitter)

    @Decentr43423678 @DiamondandSilk If the mRNA code is installed, I'm not sure Dr. Patrick realizes what benefit Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes have... especially in non neutralizing anti bodies and miss matched T Cell Memory, in which shedding becomes a larger problem
    view full post

    January 31, 2023

  • BeeCo
    @ClubEffective (Twitter)

    @Chris__again @Just_Pamp_It @lgoshen @nytimes @CDCgov lol. The spike in vaxx is not the same as the spike in Covid. 100’s of articles on it. It’s 2022 almost 2023, time to wake up. Just like my dead cousin can’t do the same things my living cousin can. Get it. https://t.co/NYxvyXZxqF
    view full post

    November 1, 2022

  • Manolo Tabaiba
    @Manolotabaiba1 (Twitter)

    RT @PComentator: @BorregoUnadeca @Luis13104072 @disidente30 @berdole @thymocyte @CurrodelaTorre @CherenkovTNF @LeilaYLab @RAFUNKEL1 @Los_3c…
    view full post

    September 18, 2022

    1

  • ProfessionalInternetCommentator
    @PComentator (Twitter)

    @BorregoUnadeca @Luis13104072 @disidente30 @berdole @thymocyte @CurrodelaTorre @CherenkovTNF @LeilaYLab @RAFUNKEL1 @Los_3cerditos @Samuel13004969 @84DiegoQM @Manolotabaiba1 @Alex__AM @GPlandemiun @aliciacgviolin @IvanAle98358888 @BALDERDelNorte @Mirambella @AnaCabrera81200 @Jaque100cia @SdeSanty @Josekl2022 @LekLaial @ElRecogelatas @Anorcr1 @AI2BO4 @farmafilico El que llevan los viales tampoco lo invento malone. https://t.co/zcFeC3v4Xy
    view full post

    September 18, 2022

    2

    1

  • The Anti-VAXX Are Blooming Idiots
    @5shezz4IsAMoron (Twitter)

    @DanielHayes31 @TakethatCt @ShockTraumaRN @LunarDoggy @SwaledaleMutton @troydee @LyquidPirate @NathanaelYoung @JaydenUddoman @GBates76034889 @VikiLovesFACS @EricTopol @Dereklowe Mr. Hayes, get your butt in gear and read about : -- 2P mutation -- pre-fusion -- post-fusion -- Dr. Jason McLellan & Dr. Barney Graham -- mRNA RSV vaccines Because this technology has been used since 2013 without issues Vaccine Spike Proteins are safe https://t.co/x5bQr972A4
    view full post

    September 9, 2022

    1

  • Andrew Tan
    @andrewtanyongyi (Twitter)

    @ScottAMullin @tony_burnetti @jallepap @ENirenberg From popsci of @mclellan_lab's beautiful work: "However, even S-2P is unstable and difficult to produce in mammalian cells. Hsieh et al. ... HexaPro, that retains the prefusion conformation but shows higher expression than S-2P" https://t.co/TGgY1jcdcU
    view full post

    August 29, 2022

    1

  • Andrew Tan
    @andrewtanyongyi (Twitter)

    @mikechenwriter @ENirenberg Not sure, but as I understand this is just several substitutions in the mRNA sequence, so should be straightforward. The newer hexapro version studied in the OP paper and the 2P version currently in use both came out of beautiful work by @McLellan_Lab. https://t.co/TGgY1jumr2
    view full post

    August 29, 2022

    4

  • Kaitie Q., MSN, RN, MPH, ACNP
    @ImKatieRN (Twitter)

    @willywo06261169 @Mr_Magoo5 @JimeeLiberty @reacharoundu @JonathanHannah @anxiety_korma @AndrewLazarus4 @mpc_xetts @MsTrixter @carlsmythe @andylumm @LifeAfterWEF @JamesLynchGTC @FvckYourFear @krebiozen @JuliaHadley15 @whykeepitup @SkepticalMutant @The_Seeadler @FillmoreWhite @AngryFleas @mcfunny @DrGeniusGino @TonyBaduy @JuneCacao @BreezerGalway @RsprtryTracked @Willard1951 @PremierImproves @Turrialba27 @Jaytee116James @richykirsh @ghoppe @doom37455413 @Amber84280581 @CaeJak @djchicus @WalterTAllen @Dominos20076133 @FoolanderWorld @chimera414 @fadgesniffer @nuhope2022 @Alex_on_A14 @paramaniac9 @Theonew16516042 @TwitterSupport @TwitterSafety @AstraZeneca I'm STILL waiting for you to tell us what PRE-FUSION is for VACCINE Spike Proteins You know, the ones you said were "sharp" and "stuck" in organs
    view full post

    August 23, 2022

    1

  • Nicholas Wu
    @wchnicholas (Twitter)

    Although S-based immunogen design typically focuses on the mutations in the S2 domain (examples listed below), our results suggest that mutations in NTD may provide a complementary strategy. (5/6) https://t.co/Cr6s5z1F4D https://t.co/irvNfI41Jp https://t.co/QcQ1FuYv4p
    view full post

    June 22, 2022

    1

  • Le Biochimiste
    @c0v1d1984 (Twitter)

    @erikmartin99 @birb_k @Jikkyleaks @Parsifaler The 2 Prolines make this prefusion conformation more stable, but do not prevent rearrangement. It takes SIX Proline substitutions (and not 2, as read in Pfizer affiliated publications) to LOCK into a prefusion state confirmed by cryo–electron microscopy https://t.co/XKDFfdTFIs
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    May 16, 2022

    1

  • Edward Nirenberg
    @ENirenberg (Twitter)

    There are also other variations, including RBD-β and RBD-Hexapro which are the beta variant's receptor binding domain of the spike protein and the Hexapro version of spike respectively (https://t.co/Dr70pKr3fr).
    view full post

    March 22, 2022

    8

  • Jimmy John
    @SevereJury8 (Twitter)

    @aperfectstrange @jjcouey can you speak more on this topic? ive read the use of proline makes the spike inert and not bind to human ace-2. here's one study showing this to be true -> https://t.co/COmtd6BA0D
    view full post

    February 16, 2022

  • Marek Bogacki
    @documentavi (Twitter)

    RT @Clucky92864053: @JikkyKjj @MeltedJonSnow @ClownBasket @ChrisAn06367911 @SwaledaleMutton @tony_vandongen @PaulAsh98643549 Where I don't…
    view full post

    January 20, 2022

    1

  • Clucky
    @Clucky92864053 (Twitter)

    @JikkyKjj @MeltedJonSnow @ClownBasket @ChrisAn06367911 @SwaledaleMutton @tony_vandongen @PaulAsh98643549 Where I don't know. But the inventors did write about the rationale for the strategy. https://t.co/SCCdjoO6TS
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    January 20, 2022

    3

    1

  • Todd McKenzie
    @ToddEBear (Twitter)

    https://t.co/drKZWk5ay0
    view full post

    January 18, 2022

  • Etienne Balli
    @enneiteillab (Twitter)

    @JolivetRaphael @ArtMoon96162802 @renkatroussier https://t.co/3GC1o07jCU
    view full post

    January 16, 2022

  • JR
    @JR__8888 (Twitter)

    @Adamant07781306 @HotBrea58570647 @astynis @MikeStenel @dressing_code69 @DocAmine_ @Drmartyufml @Le___Doc @FXMoronval Mauvais lien, en effet : https://t.co/vSNMb1vzpy
    view full post

    January 10, 2022

    1

  • Rick Stievenart
    @RStievenart (Twitter)

    @laurenmill3r93 @ChrisBoozer7 @enoughalready93 @hbruckman15 @RealCandaceO I found the article on the design of the spike: https://t.co/p9wfWNDduA
    view full post

    January 3, 2022

  • Isatou Sarr
    @IsatouSarr4 (Twitter)

    Structure-based design of prefusion-stabilized SARS-CoV-2 spikes https://t.co/ZdXC3bfFWv
    view full post

    December 15, 2021

    1

  • Janieyaya, NIYY Director
    @janieyaya (Twitter)

    RT @jhillmd: @janieyaya @Lvvvcs @Fynnderella1 Those saying vax spike is stabilized in the prefusion state cite Hsieh’s paper, describing He…
    view full post

    October 20, 2021

    3

  • Sharons Sharings
    @SharonKNess1 (Twitter)

    RT @jhillmd: @janieyaya @Lvvvcs @Fynnderella1 Those saying vax spike is stabilized in the prefusion state cite Hsieh’s paper, describing He…
    view full post

    October 20, 2021

    3

  • James Hill, MD
    @jhillmd (Twitter)

    RT @jhillmd: @janieyaya @Lvvvcs @Fynnderella1 Those saying vax spike is stabilized in the prefusion state cite Hsieh’s paper, describing He…
    view full post

    October 20, 2021

    3

  • James Hill, MD
    @jhillmd (Twitter)

    @janieyaya @Lvvvcs @Fynnderella1 Those saying vax spike is stabilized in the prefusion state cite Hsieh’s paper, describing HexaPro, a spike version in this conformation for use as “a potential vaccine antigen or diagnostic reagent.” Haven’t seen evidence vaccines encode such a version. https://t.co/DaAtjxPk2l
    view full post

    October 20, 2021

    7

    3

  • Tryn2Laugh
    @gr8ful4God2 (Twitter)

    @slovborg @nellybee83 @CountryOTBlind @PierreKory And here's where they trash on the specific 2P tweak you originally referred me to. Is this why the vaxes are such a failure? I have more studies, including one from NIH that's 162 pages that discusses covid synthetic vaccines, and again, not great. https://t.co/cAbfB6mu0g
    view full post

    October 7, 2021

  • Moved to @cotton_dpad@meow.social
    @cottondpad (Twitter)

    @phoenixesrise @TheRenegadeOp @kevinfritzsche4 @Z410S @millbro82 @HumanistReport @hasanthehun But the S spike in vaccines don't even do that: it's modified to remain in it's pre-fusion conformation, So it doesn't really bind to ACE2. 2/2 https://t.co/gDuXnl7mXF
    view full post

    September 15, 2021

  • Phendran
    @phendran (Twitter)

    https://t.co/7NPuXlQTjU
    view full post

    September 15, 2021

  • laverbreadtangle
    @laverbreadtangl (Twitter)

    @AcousticKnights @di_jelle @RWMaloneMD https://t.co/SE2ol7MkjQ
    view full post

    September 11, 2021

  • Paul Langton
    @WALangProf (Twitter)

    Yes, Au Gov't (=tax payers) could spend many $$Ms to develop tech that might work in 3-4 yrs $$$ for those mRNA interests Or spend a fraction to develop a pre-fusion spike protein (eg 2P or Hexapro) on current tech => belt out jabs w ~90% VE in mths DOI: 10.1126/science.abd0826 https://t.co/fUBksCdIaQ
    view full post

    April 9, 2021

  • Dave Talltree, son of Wymo. Leilani is the ʻīlio.
    @unsc1325 (Twitter)

    @hjelle_brian @pen_is_mighty Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes https://t.co/GVQXY0Qhq6
    view full post

    April 6, 2021

  • Paul Langton
    @WALangProf (Twitter)

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Abstract Synopsis

  • The COVID-19 pandemic has spurred rapid development of therapeutics and vaccines, focusing on the challenge of producing the spike (S) protein effectively.
  • Researchers tested 100 designs for the spike protein and found 26 specific modifications that improved its yield and stability, leading to a notable variant called HexaPro.
  • HexaPro showed 10 times greater expression than previous models and maintained its structure under various stress conditions, paving the way for faster vaccine development for SARS-CoV-2.