medRxiv July 2020 PMID 32743600

Dynamics and significance of the antibody response to SARS-CoV-2 infection.

Anita S Iyer, Forrest K Jones, Ariana Nodoushani, Meagan Kelly, Margaret Becker, Damien Slater, Rachel Mills, Erica Teng, Mohammad Kamruzzaman, Wilfredo F Garcia-Beltran, Michael Astudillo, Diane Yang, Tyler E Miller, Elizabeth Oliver, Stephanie Fischinger

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Mentions

23
Peak: 6 in Jul 2020
across 4 sources since Jul 2020

Extended reach

38,182
potential audience

Total likes

87

Video views

755

Mentions per month

Jul 2020 – Mar 2021

Where it's discussed

  • X / Twitter12 posts
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  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions demonstrate high interest, with comments emphasizing the importance of IgG in long-term immunity and its potential as a protective marker, as shown when posts mention 'durable and effective immunity' and references to the specifics like antibody durations. The tone and choice of words reflect a serious, research-focused engagement, indicating that this publication is regarded as a meaningful contribution to understanding COVID-19 immunity that could impact future research and policy.

AgreementModerate agreement

Most discussions acknowledge the value of the study’s findings, with some expressing confidence in the implications for understanding immunity.

InterestHigh interest

Participants show high curiosity, referencing the technical aspects of antibody dynamics and their significance.

EngagementModerate engagement

Comments often include references to specific data and implications, indicating a moderate level of analysis and engagement.

ImpactModerate impact

The discussions suggest that the publication influences ongoing research and public health considerations, though perhaps not yet catalyzing widespread action.

Abstract in brief

  • The study measured the antibody responses to SARS-CoV-2 in symptomatic patients and found that IgG, IgA, and IgM antibodies to the spike protein's RBD region are highly accurate in identifying recent infection, with IgG lasting longer than IgA and IgM.
  • IgA and IgM antibodies tend to decline within about 47-51 days after symptom onset, while IgG antibodies can persist for at least 75 days, making IgG a more reliable marker for longer-term immunity.
  • The presence of RBD-targeted IgG antibodies correlates strongly with neutralizing antibodies, suggesting they could indicate protective immunity, and no cross-reactivity was observed with other common coronaviruses, highlighting the specificity of these immune responses.

Top posts

Most liked on X and Bluesky
medRxiv
@medrxivpreprint · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/doPmOYcULV #medRxiv

Jul 20, 2020 · 4 likes · 1 share · 17,454 followers View post →
MGH Pathology
@MGHPathology · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection ✏️ Wilfredo F Garcia-Beltran (4), @MikeGAstudillo (4), @TylerEMiller (4), A John Iafrate (4)

Aug 5, 2020 · 3 likes · 2 shares · 7,706 followers View post →
COVID-19_arXiv
@COVID19arXiv · X

Jul 20, 2020 · 4,510 followers View post →
Steven Goh
@crazygrape · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/yiPQCPHPWV

Jul 20, 2020 · 1,782 followers View post →
Ty Miller Lab
@TyMillerLab · X

RT @MGHPathology: Dynamics and significance of the antibody response to SARS-CoV-2 infection ✏️ Wilfredo F Garcia-Beltran (4), @MikeGAstud…

Aug 5, 2020 · 2 shares · 1,701 followers View post →
Outbreak Science
@outbreaksci · X

Contribute a rapid review or request one for "Dynamics and significance of the antibody response to SARS-CoV-2 infection" (https://t.co/Zy8t6KFq2m). "Add" or "Request" w/DOI (10.1101/2020.07.18.20155374) at https://t.co/RnurTL3DyM @outbreaksci @PREreview_

Jul 21, 2020 · 1,373 followers View post →

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SciScore Reports
@SciscoreReports · X

The preprint “Dynamics and significance of the antibody response…” (https://t.co/uvYjb5e7Ju) has been reviewed by automated tools, find results here: https://t.co/7Y8C2uOCwi. We detected 1 of 5 rigor criteria, 3 resources, open data, and open code.

Mar 11, 2021 · 328 followers View post →
Andrew Junkin, MD
@Dr_Junkin_MD · X

12/ A critical aside: based on the findings of Iyer et. al in @medrxivpreprint, it seems reasonable to assume, for the purposes of our discussion, that SARS-CoV-2 IgG seropositivity is in fact a good surrogate for durable and effective immunity. Study: https://t.co/zYIlkr2UdG https://t.co/cC9Txbno0F

Dec 2, 2020 · 237 followers View post →
Aleksander Shalshin
@asdsns · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/9N17DFN3Xe

Aug 19, 2020 · 85 followers View post →
Lenny Moise
@gen2vax · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/Cc1SqDsuj4

Aug 18, 2020 · 111 followers View post →
Ty Miller Lab
@TyMillerLab · X

RT @MGHPathology: Dynamics and significance of the antibody response to SARS-CoV-2 infection ✏️ Wilfredo F Garcia-Beltran (4), @MikeGAstud…

Aug 5, 2020 · 2 shares · 1,701 followers View post →
MGH Pathology
@MGHPathology · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection ✏️ Wilfredo F Garcia-Beltran (4), @MikeGAstudillo (4), @TylerEMiller (4), A John Iafrate (4)

Aug 5, 2020 · 3 likes · 2 shares · 7,706 followers View post →
Outbreak Science
@outbreaksci · X

Contribute a rapid review or request one for "Dynamics and significance of the antibody response to SARS-CoV-2 infection" (https://t.co/Zy8t6KFq2m). "Add" or "Request" w/DOI (10.1101/2020.07.18.20155374) at https://t.co/RnurTL3DyM @outbreaksci @PREreview_

Jul 21, 2020 · 1,373 followers View post →
Outbreak Science
@outbreaksci · X

New #SARSCoV preprint: Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/Zy8t6KFq2m

Jul 21, 2020 · 1,373 followers View post →
COVID-19_arXiv
@COVID19arXiv · X

Jul 20, 2020 · 4,510 followers View post →
Steven Goh
@crazygrape · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/yiPQCPHPWV

Jul 20, 2020 · 1,782 followers View post →
PLASTIC BRAZIL
@PROFESSOREUCIMA · X

RT @medrxivpreprint: Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/doPmOYcULV #medRxiv

Jul 20, 2020 · 1 share · 666 followers View post →
medRxiv
@medrxivpreprint · X

Dynamics and significance of the antibody response to SARS-CoV-2 infection https://t.co/doPmOYcULV #medRxiv

Jul 20, 2020 · 4 likes · 1 share · 17,454 followers View post →
David Crivello
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medRxiv (preprint) 2020.07.18.20155374: 5. Elizaldi SR, Lakshmanappa YS, Roh JW, et al. SARS-CoV-2 infection ...

Dec 14, 2025 View →
Foto a pagina intera
News

14 lyer, A. S. et al.: medRxiv (2020) doi:10.1101/2020.07.18.20155374. 15 Isho, B. et al.: Science Immunology 5, (2020). 16. Ripperger, T. J. et al ...

Dec 14, 2025 View →
Age groups that sustain resurging COVID-19 epidemics in the ...
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medRxiv 10.1101/2020.07.18.20155374 [Preprint]. 20 July 2020. https://doi.org/10.1101/2020.07.18.20155374. GO TO REFERENCE. Google Scholar. 45. I. Schulien, J ...

Dec 14, 2025 View →
Persistence of serum and saliva antibody responses to SARS-CoV-2 ...
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MedRxiv, https://www.medrxiv.org/content/10.1101/2020.07.18.20155374v1 (2020). Google Scholar. 9. A. Wajnberg et al., SARS-CoV-2 infection induces robust ...

Dec 14, 2025 View →
Age Groups Science - Abe8372.full | PDF | Infection
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medRxiv 10.1101/2020.07.18.20155374 [Preprint]. 20 July 2020. 69. Louisiana Department of Health, “Cases and Deaths by Age” (2020); https://doi.org/10.1101 ...

Dec 14, 2025 View →
Article-2021-COVID-19-Neutralizing Antibodies Predict Disease ...
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and Significance of the Antibody Response to SARS-CoV-2 Infection. medR- 101–106. xiv. https://doi.org/10.1101/2020.07.18.20155374. Pinto, D., Park, Y.

Dec 14, 2025 View →
SARS-CoV-2 Serology Testing in the Setting of Vaccination | Clinical ...
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DOI:10.1101/2020.07.18.20155374. 40. Figueiredo-Campos P, et al. Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and ...

Mar 25, 2021 View →
Age groups that sustain resurging COVID-19 epidemics in the ...
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A. S. Iyer et al., Dynamics and significance of the antibody response to SARS-CoV-. 2 infection. medRxiv 10.1101/2020.07.18.20155374 [Preprint].

Feb 2, 2021 View →
Ako dlho trvá imunita na COVID-19? https://vedator.space/ako-dlho ...
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... 10.1101/2020.07.18.20155374v1 [5] https://www.medrxiv.org/content/10.1101/2020.08.01.20166553v2 [6] https://www.medrxiv.org/content/10.1101 ...

Sep 11, 2020 View →