A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.

Torahiko L Higashi, Patrik Eickhoff, Joana S Sousa, Julia Locke, Andrea Nans, Helen R Flynn, Ambrosius P Snijders, George Papageorgiou, Nicola O'Reilly, Zhuo A Chen, Francis J O'Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann

September 2020 Mol Cell

Synopsis of Social media discussions

Several discussions highlight specific elements from the research, such as the role of ATP binding and the opening and closing of gates in the cohesin complex. The use of terms like ‘crucial findings’ and ‘breakthrough discovery’ indicates excitement and underscores the potential transformative impact on the field of molecular biology.

A
Agreement
 Moderate agreement

Many discussions reflect a general consensus about the importance of the mechanisms outlined in the publication.

I
Interest
 High level of interest

The posts express strong curiosity, showcasing that the topic resonates significantly with the audience.

E
Engagement
 Moderate level of engagement

While comments focus on the core findings, the conversation lacks deep analytical engagement with the methodologies.

I
Impact
 High level of impact

Participants perceive the findings as having substantial implications for further research in chromosome organization.

Social Mentions

YouTube

2 Videos

Twitter

71 Posts

Metrics

Video Views

600

Total Likes

189

Extended Reach

529,142

Social Features

73

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Architecture and Mechanism of SMC Complexes in Chromosome Organization

Architecture and Mechanism of SMC Complexes in Chromosome Organization

Jan Paleček presents his research on the architecture and evolution of SMC (Structural Maintenance of Chromosomes) complexes at the Nuclear architecture Function symposium. This work uncovers the DNA loading mechanism into cohesin rings, highlighting how ATP binding influences the loading process.

INC consortium

November 23, 2022

408 views

Mechanisms of Cohesin Loading onto DNA Explained

Mechanisms of Cohesin Loading onto DNA Explained

Nathalie Basti presents her research on mechanisms controlling cohesin's translocase activity, essential for establishing chromatin loops. The study uses biochemical methods and cryoelectron microscopy to reveal how DNA enters cohesin rings, highlighting the role of ATP and gate dynamics.

INC consortium

November 23, 2022

192 views

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Abstract Synopsis

  • The study investigates how cohesin rings are loaded onto DNA, a crucial process for sister chromatid cohesion and chromosome organization.
  • Researchers used biochemical methods and cryoelectron microscopy (cryoEM) to visualize a DNA-cohesin loading intermediate, uncovering the mechanism of DNA entry through specific gates in the cohesin structure.
  • The findings highlight that the process involves ATP binding, opening and closing of gates in the cohesin complex, and suggest that a conserved kleisin tail may influence whether DNA loading is successful or leads to further actions like loop extrusion.