Mol Cell September 2020 PMID 32755595

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.

Torahiko L Higashi, Patrik Eickhoff, Joana S Sousa, Julia Locke, Andrea Nans, Helen R Flynn, Ambrosius P Snijders, George Papageorgiou, Nicola O'Reilly, Zhuo A Chen, Francis J O'Reilly, Juri Rappsilber, Alessandro Costa, Frank Uhlmann

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Peak: 31 in Aug 2020

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Several discussions highlight specific elements from the research, such as the role of ATP binding and the opening and closing of gates in the cohesin complex. The use of terms like ‘crucial findings’ and ‘breakthrough discovery’ indicates excitement and underscores the potential transformative impact on the field of molecular biology.

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While comments focus on the core findings, the conversation lacks deep analytical engagement with the methodologies.

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Participants perceive the findings as having substantial implications for further research in chromosome organization.

Abstract in brief

The study investigates how cohesin rings are loaded onto DNA, a crucial process for sister chromatid cohesion and chromosome organization.
Researchers used biochemical methods and cryoelectron microscopy (cryoEM) to visualize a DNA-cohesin loading intermediate, uncovering the mechanism of DNA entry through specific gates in the cohesin structure.
The findings highlight that the process involves ATP binding, opening and closing of gates in the cohesin complex, and suggest that a conserved kleisin tail may influence whether DNA loading is successful or leads to further actions like loop extrusion.

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Architecture and Mechanism of SMC Complexes in Chromosome Organization

Jan Paleček presents his research on the architecture and evolution of SMC (Structural Maintenance of Chromosomes) complexes at the Nuclear architecture Function symposium. This work uncovers the DNA loading mechanism…

INC consortium · Nov 23, 2022 408 views

Mechanisms of Cohesin Loading onto DNA Explained

Nathalie Basti presents her research on mechanisms controlling cohesin's translocase activity, essential for establishing chromatin loops. The study uses biochemical methods and cryoelectron microscopy to reveal how DNA…

INC consortium · Nov 23, 2022 192 views

Victor V. Lobanenkov

@boris_ctcf · X

A Structure-Based Mechanism for DNA Entry into the Cohesin Ring https://t.co/QD4NdfQECE

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cryoEM Papers

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Molecular Cell

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Sofía Muñoz (@sofiamf24.bsky.social)

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Kala Nambiar, PhD MSCE

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Druse Labs

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https://t.co/zDX6POAWfo A Structure-Based Mechanism for DNA Entry into the Cohesin Ring by Torahiko Higashi Patrik Eickhoff (et al.) Alessandro Costa Frank Uhlmann fluorescence resonance energy transfer cryo-electron microscopy DNA-protein crosslink mass spectrometry https://t.co/V11gMUwVRT

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A Structure-Based Mechanism for DNA Entry into the Cohesin Ring.

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Abstract in brief

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Architecture and Mechanism of SMC Complexes in Chromosome Organization

Mechanisms of Cohesin Loading onto DNA Explained