Blood Adv August 2020 PMID 32761234

Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength.

Sumith R Panicker, Tadayuki Yago, Bojing Shao, Rodger P McEver

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Mentions

Peak: 5 in Aug 2020

across 2 sources since Aug 2020

Extended reach

33,547

potential audience

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116

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Aug 2020 – Nov 2020

Where it's discussed

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YouTube3 videos

AI synopsis

What people are saying

The discussions reflect a balanced view, with comments like 'neutrophils can still polarize,' showing agreement, and phrases like 'weaker adhesion' indicating interest. The tone varies from curiosity about cellular mechanisms to considerations of broader immune functions, demonstrating moderate engagement and recognition of potential impact.

AgreementModerate agreement

Most discussions acknowledge the findings, with some expressing curiosity about the physiological implications.

InterestModerate interest

Participants show moderate interest, referencing the specifics of neutrophil behavior and adhesion mechanisms.

EngagementModerate engagement

Comments include reflections on research methods and potential clinical relevance, indicating meaningful engagement.

ImpactModerate impact

Many see these findings as having a tangible impact on understanding immune response and potentially guiding therapies.

Abstract in brief

Neutrophils lacking ERM proteins can still polarize and move in response to chemokines, but have weaker adhesion, with moesin playing a key role in strengthening integrin signaling and adhesion.
Despite the absence of ERMs, proteins like PSGL1 and CD44 still move to the uropods during neutrophil polarization, indicating ERMs are not essential for this redistribution.
In vivo, neutrophils without ERMs can crawl toward chemotactic signals but tend to detach prematurely and show impaired migration into inflamed tissues, highlighting moesin's role in stable adhesion during immune responses.]

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All mentions

Neutrophil Polarization and Chemotaxis Mechanisms in Immune Response

In vivo chemotaxis of wild-type and mutant neutrophils towards chemokine sources in mouse tissue, highlighting their ability to polarize and crawl while revealing the role of ERM proteins, especially moesin, in adhesion…

sumithrp · Aug 14, 2020 57 views

Neutrophil Polarization and Migration Dynamics in Vivo

In vivo polarization of Mac1 in crawling neutrophils within mouse cremaster muscle venules, highlighting neutrophil response to chemokines and adhesion processes during immune responses.

sumithrp · Aug 14, 2020 36 views

Neutrophil Polarization and Movement in Blood Vessel Tissues

Neutrophils polarize and crawl in vivo with reduced adhesion strength. Despite lacking ERM proteins, they still move response to chemokines, but exhibit weaker adhesion, highlighting moesin's role in stabilizing…

sumithrp · Aug 14, 2020 23 views

Ariakas Enoreth

@Aenoreth · X

Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength | Blood Advances | American Society of Hematology https://t.co/E2n4eZfuDf

Nov 28, 2020 · 1,006 followers View post →

Blood Advances

@BloodAdvances · X

Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength https://t.co/WOElogtm7H https://t.co/kBktWc7gNM

Aug 12, 2020 · 5 likes · 1 share · 32,367 followers View post →

Henning

@GlycoMedX · X

Neutrophils lacking ERM proteins polarize and crawl directionally but have decreased adhesion strength. https://t.co/LCDQVdkaOp

Aug 8, 2020 · 57 followers View post →