Nat Rev Gastroenterol Hepatol November 2020 PMID 32855515

Brain-gut-microbiome interactions in obesity and food addiction.

Arpana Gupta, Vadim Osadchiy, Emeran A Mayer

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AI synopsis

What people are saying

In the discussions, various posts emphasize the complexity of food addiction, with one user mentioning 'the trap of regulating our mood with food.' Others highlight the necessity of understanding microbiome science, indicating that 'studies on the microbiome are being done more and more.' The language used, such as 'interesting development' and 'game changer,' illustrates both excitement and acknowledgment of the importance of these issues, contributing to the overall positive sentiment.

AgreementModerate agreement

The discussions show general support for the findings presented in the article, though some skepticism is observed.

InterestHigh interest

There is a high level of curiosity about the relationship between the brain, gut, and microbiome, as highlighted by multiple comments referencing their relevance to personal health.

EngagementModerate engagement

Many commenters engage with the content at a surface level, but a few individuals show a deeper understanding of the implications of the research.

ImpactHigh impact

There is a strong belief that the research could have significant implications for addressing obesity and food addiction issues.

Abstract in brief

The balance between homeostatic and hedonic mechanisms regulates normal eating behavior, while food addiction shows a shift towards hedonic mechanisms linked to brain-gut-microbiome interactions.
Early-life factors, including gut microbiome priming and antibiotic usage, can predispose individuals to food addiction, influenced further by marketing of unhealthy foods.
A systems biology model of brain-gut-microbiome interactions is presented, suggesting new treatment targets to address food addiction at various levels of this axis.

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