January 2021 PMID 32857334

Vitamin D supplementation: upper limit for safety revisited?

René Rizzoli

Mentions

39
Peak: 6 in Aug 2020
across 6 sources since Aug 2020

Extended reach

187,591
potential audience

Total likes

972

Video views

23,901

Mentions per month

Aug 2020 – Nov 2025

Where it's discussed

  • X / Twitter21 posts
  • Reddit9 posts
  • News4 articles
  • YouTube3 videos
  • Facebook1 posts
  • TikTok1 posts

AI synopsis

What people are saying

The group discusses the safety of vitamin D doses, citing studies that typically mention 4000 IU as a safe upper limit, but some posts question or suggest lower thresholds like 1000 IU, emphasizing the ongoing debate. The tone varies from scientific references to cautious paraphrasing, highlighting the importance of dosage management in health practices.

AgreementModerate agreement

Most discussions acknowledge that traditional safety limits like 4000 IU are being reconsidered, with some posts supporting the idea of lower or different upper limits based on recent studies.

InterestHigh interest

The discussions show high curiosity about dosage safety, new research findings, and clinical implications, indicated by questions and references to scientific studies.

EngagementModerate engagement

Participants refer to specific research, mention doses, and debate clinical practices, reflecting moderate depth of engagement.

ImpactModerate impact

The conversations suggest a recognition of the potential influence of this research on health recommendations and clinical guidelines, though some posts are more cautious, indicating moderate impact.

Abstract in brief

  • The traditionally accepted safe upper limit for vitamin D intake is 4000 IU daily, but recent research suggests that the risk of adverse effects may depend on factors such as dose, treatment plan, age, sex, and baseline vitamin D levels.
  • Excessive vitamin D intake can lead to health issues like hypercalcemia, hypercalciuria, and mineral deposits in soft tissues, and the therapeutic window might be narrower than previously thought.
  • For preventing or correcting deficiency, doses of 800-1000 IU daily or 10 micrograms of calcifediol are considered safe, while higher doses over the long term or in intermittent treatments could pose risks.]

Top posts

Most liked on X and Bluesky
Saúl Sánchez
@SaulNutri · X

Pero muchas veces no se presta atención a este valor, por lo que no se toman medidas para corregirlo.

Dec 9, 2022 · 17 likes · 2 shares · 108,083 followers View post →
John Tal
@JohnTal6 · X

@goddeketal The prevention and correction of vitamin D deficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected. https://t.co/AbMHHYT9el

Apr 15, 2023 · 10 likes · 672 followers View post →
David Scott
@DavidScottPhD · X

#VitaminD supplementation: upper limit for safety revisited? https://t.co/ifX9hJkFKC

Aug 29, 2020 · 5 likes · 5 shares · 2,945 followers View post →
Nutrition Detective
@NutriDetect · X

REFERENCE: Vitamin D supplementation: upper limit for safety revisited? https://t.co/NVUJqtNqKY

Sep 29, 2024 · 2 likes · 37,029 followers View post →
DENTRO_MADRID
@CER_OF_AUT · X

En éste otro estudio marcan el límite como 1000 ui. De lo que no habla ninguno de los dos estudios es de usarla con k2 para que no se produzcan depósitos de calcio. https://t.co/5L5RE21MgT

Oct 28, 2025 · 1 like · 1 share · 3,439 followers View post →
Robert Leponge
@jonpi39 · X

@MonsieurAlazon @ricB435183 @Tometprazole @NightHaunter on peut jouer la carte du scientiste mais mieux vaut avoir du fond. On donne des doses de 100 000 UI aux personnes âgées. 4000 UI par jour chez des adultes est considéré comme sûr chez springer. https://t.co/zl8Mb19Elv 7000 UI par jour pendant 12 mois, rendomisé avec placébo,

Jun 11, 2025 · 1 like · 606 followers View post →

All mentions

sandra
@sandra286076518 · X

RT @CER_OF_AUT: En éste otro estudio marcan el límite como 1000 ui. De lo que no habla ninguno de los dos estudios es de usarla con k2 par…

Oct 31, 2025 · 1 share · 185 followers View post →
DENTRO_MADRID
@CER_OF_AUT · X

En éste otro estudio marcan el límite como 1000 ui. De lo que no habla ninguno de los dos estudios es de usarla con k2 para que no se produzcan depósitos de calcio. https://t.co/5L5RE21MgT

Oct 28, 2025 · 1 like · 1 share · 3,439 followers View post →
Robert Leponge
@jonpi39 · X

@MonsieurAlazon @ricB435183 @Tometprazole @NightHaunter on peut jouer la carte du scientiste mais mieux vaut avoir du fond. On donne des doses de 100 000 UI aux personnes âgées. 4000 UI par jour chez des adultes est considéré comme sûr chez springer. https://t.co/zl8Mb19Elv 7000 UI par jour pendant 12 mois, rendomisé avec placébo,

Jun 11, 2025 · 1 like · 606 followers View post →
Nutrition Detective
@NutriDetect · X

REFERENCE: Vitamin D supplementation: upper limit for safety revisited? https://t.co/NVUJqtNqKY

Sep 29, 2024 · 2 likes · 37,029 followers View post →
John Tal
@JohnTal6 · X

@goddeketal The prevention and correction of vitamin D deficiency with 800-1000 IU/daily of vitamin D or 10 µg/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected. https://t.co/AbMHHYT9el

Apr 15, 2023 · 10 likes · 672 followers View post →
Elizabeth Eckert
@WordCures · X

I would also consider the amount of D I pound down. 7/ https://t.co/8femHPaunX

Jan 8, 2023 · 1,296 followers View post →
Elizabeth Eckert
@WordCures · X

@foodbeforepills @LowCarbCarla @SeedOilDsrspctr https://t.co/8femHPaunX

Jan 8, 2023 · 1,296 followers View post →
alicia colmenares
@alicolsi · X

RT @SaulNutri: Pero muchas veces no se presta atención a este valor, por lo que no se toman medidas para corregirlo.

Dec 9, 2022 · 2 shares · 120 followers View post →
Andres Martinez
@amart166 · X

RT @SaulNutri: Pero muchas veces no se presta atención a este valor, por lo que no se toman medidas para corregirlo.

Dec 9, 2022 · 2 shares · 2,450 followers View post →
Saúl Sánchez
@SaulNutri · X

Pero muchas veces no se presta atención a este valor, por lo que no se toman medidas para corregirlo.

Dec 9, 2022 · 17 likes · 2 shares · 108,083 followers View post →
Kai
@Koronomoa · X

@G73528023 @punktpreradovic @MeyerMeyer64 Ich würde mich eher auf wissenschaftliche Studien beziehen. Seriöse Wissenschaftler und Ärzte nennen ihre Quellen. Die folgende Studie nennt 4000 IE/Tag als maximale Tagesdosis. Selbst bei dieser Dosis gab es bei 9% negative Effekte (Kalziumeinlagerungen) https://t.co/I7pXuui3kB

Apr 4, 2022 · 4 followers View post →
Don Tidwell
@tidwell_don · X

RT @microRNAnoob: Health risks of high vitamin D supplementation (>1000 IU daily): “Vitamin D overdosing includes hypercalcemia, hypercalc…

Oct 10, 2021 · 1 share · 2,795 followers View post →
MagChad
@magnesiumchad · X

Health risks of high vitamin D supplementation (>1000 IU daily): “Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues” https://t.co/hwwrAIYQKq

Oct 10, 2021 · 1 like · 1 share · 127 followers View post →
Milgram
@milgramDr · X

@atalorico @AxelRollie @yerbs7 @foundmyfitness 1/ he did not have polycystic kidney, only his siblings. As it is a dominant mutation, he had 50% chance to have it and actually did not have it. 2/ it is not a receptor but a cytochrome CYP24a1. Find enclosed a review of the toxic doses https://t.co/Vok8xarMxK

Jan 2, 2021 · 1,567 followers View post →
originofoverweight
@originoverwght · X

Review of the dosing of vitamin D for bone health, fall risk, frailty, kidney stones and mortality. Some studies have found adverse effects when using very high doses, so should upper limit of 100 micrograms/4,000 IU per day be revised? https://t.co/96r4aoxWRb

Sep 18, 2020 · 194 followers View post →
Kineblasto
@Kineblasto · X

RT @DavidScottPhD: #VitaminD supplementation: upper limit for safety revisited? https://t.co/ifX9hJkFKC

Aug 30, 2020 · 5 shares · 111 followers View post →
Steven Phu
@phu_steven · X

RT @DavidScottPhD: #VitaminD supplementation: upper limit for safety revisited? https://t.co/ifX9hJkFKC

Aug 30, 2020 · 5 shares · 213 followers View post →
Claudio Chinaglia
@claudiochinagli · X

RT @DavidScottPhD: #VitaminD supplementation: upper limit for safety revisited? https://t.co/ifX9hJkFKC

Aug 29, 2020 · 5 shares · 119 followers View post →
Alan Hayes
@alan_hayes_vu · X

RT @DavidScottPhD: #VitaminD supplementation: upper limit for safety revisited? https://t.co/ifX9hJkFKC

Aug 29, 2020 · 5 shares · 205 followers View post →
Green Ginger
@GreenGinger19 · X

RT @DavidScottPhD: #VitaminD supplementation: upper limit for safety revisited? https://t.co/ifX9hJkFKC

Aug 29, 2020 · 5 shares · 4 followers View post →
David Scott
@DavidScottPhD · X

#VitaminD supplementation: upper limit for safety revisited? https://t.co/ifX9hJkFKC

Aug 29, 2020 · 5 likes · 5 shares · 2,945 followers View post →
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... 10.1007/s40520-020-01678-x. "Профилактика и/или коррекция дефицита/недостаточности витамина D с помощью 800–1000 МЕ/день витамина D или 10 ...

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... olds without deficiency showed hypercalcemia at 10k IU: https://link.springer.com/article/10.1007/s40520-020-01678-x. 1 more reply.

Aug 29, 2023 View →
왜 이렇게 많은 사람들이 비타민 D를 하루에 5000 IU씩 보충하는 걸까 ...
Reddit

... 없는 62세 노인 중 9%가 10k IU에서 고칼슘혈증을 보였어: https://link.springer.com/article/10.1007/s40520-020-01678-x. 답글 1 개 더 보기.

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... , 22 and 31% of the corresponding groups." https://link.springer.com/article/10.1007/s40520-020-01678-x. CC: u/12ealdeal · More replies.

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