Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation.
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Sep 2020 – Sep 2025Where it's discussed
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The discussions highlight the study's findings regarding the effectiveness of 15mg edoxaban in preventing stroke and systemic embolism in patients over 80, often referencing its lower risk of major bleeding compared to standard doses. Phrases like 'superior to placebo' and 'high-risk patients' illustrate the urgency and excitement within the discussions, reinforcing the transformative potential this research holds for elderly patient care.
The discussions largely express strong agreement with the findings of the study, emphasizing its relevance for treatment strategies in elderly patients.
Participants show a high level of curiosity about the implications of low-dose edoxaban for elderly patients, reflecting its significance in clinical practice.
While many participants engage with the content, the depth of discussion is somewhat moderate, often focusing on summarizing findings without delving deeper into methodology or broader implications.
There is a consensus among participants that the publication has significant implications for clinical practice, particularly in reducing stroke risk in high-risk elderly patients.
Abstract in brief
- The study assessed the effectiveness and safety of a low 15mg dose of edoxaban versus placebo in elderly patients (80+) with atrial fibrillation, focusing on those at risk of stroke but not suitable for standard anticoagulant doses.
- The primary goal was to compare rates of stroke or systemic embolism (efficacy) and major bleeding events (safety).
- Results showed that edoxaban significantly reduced stroke risk but was associated with higher gastrointestinal bleeding compared to placebo, while the overall mortality rates were similar in both groups.
Top posts
Most liked on X and Bluesky【定期】アピキサバン2.5mg1日1回にするくらいなら、エドキサバン15mg1日1回にしろって言ってるんだよォ! ※高齢、心房細動の方の話 https://t.co/eNsD9b415P
Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of stroke/SE/ mortality with no addl risk of ICH Higher risk of GI bleed https://t.co/Io1HZrthrB https://t.co/XcFro8q1G1 https://t.co/SHDqswmcqY
「超高齢者に抗凝固療法を行うべきか」については不明な点が多い。この研究で、低用量エドキサバン(15mg)は ✓80歳以上の日本人 ✓出血を増やさずに、脳梗塞を予防する ことがわかった。添付文章では許されていませんが、僕は高齢者にこの容量で処方することがあります https://t.co/PqmL5NJUqt https://t.co/sGwYhoNMHw
1/15 Since the publication of the ELDERCARE-AF in NEJM (https://t.co/bJtTZkPksc), I have seen a lot of residents and colleagues talking that “low dose” anticoagulation is the solution for older frail patients at high bleeding risk. That an “intermediate” dose would be the best
ELDERCARE-AF: In Pts >80 y.o. with non-valvular AF, CHADS2 >1, unable to take OAC at approved doses, edoxaban 15 mg/d ⬇️stroke/systemic embolism vs. placebo (ARR 4.4%/year). ⬆️Bleeding with edoxaban, esp. GI bleed (ARI 1.5%/year), CRNMB (ARI 5.6%/year). https://t.co/jpxIcayR6t https://t.co/QvuV3hOnjb
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超高齢者のAFに対する低用量エドキサバン(リクシアナ)の有効性について ・80歳以上、CHADS2スコア2点以上、かつ標準的な抗凝固療法(ワルファリンや通常量DOAC)が不適切とされた非弁膜症性AF患者984例が対象 ・介入群ではエドキサバン15mg/dayを投与 https://t.co/VR7gbgZHA4
@TT58852391 こちらの有名なリクシアナ15mgのRCTは平均年齢86歳のようでした
今日のモヤり そば先生とも会議。 これを脳梗塞の二次予防として外挿してよい? under dose案件? https://t.co/wrPnOioekC
RT @itraslan: @DrEmilyMcD Not that I use Edox often, but the dosing flexibility studied in RCTs is really helpful for shared decision makin…
@DrEmilyMcD Not that I use Edox often, but the dosing flexibility studied in RCTs is really helpful for shared decision making can even push down to 15mg https://t.co/Ro6w1Y85rE
@Ryu04196650Ryu 最近はその辺のアンテナ乏しいので僕も明確に答えれないのですが、低容量で質が高い予防効果を狙うとなるedoxabanが高位に上がってくる認識です。あとは総合的な選択をするしかないのでしょうね。あとは参考指標とて既報からNNHを自力で算出するしかないのかもです。 https://t.co/7cZt9xn7C2
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation https://t.co/DmgyixM5Xy
@michael22joseph @DHidlayVIR @EzraTeitelbaum Not a periop study, but recent study that gets at some of these questions is eldercare-af. Low dose doac vs placebo in patients generally considered not eligible for OAC. https://t.co/v0BqNBbJcm
RT @pharmax9: 【定期】アピキサバン2.5mg1日1回にするくらいなら、エドキサバン15mg1日1回にしろって言ってるんだよォ! ※高齢、心房細動の方の話 https://t.co/eNsD9b415P
【定期】アピキサバン2.5mg1日1回にするくらいなら、エドキサバン15mg1日1回にしろって言ってるんだよォ! ※高齢、心房細動の方の話 https://t.co/eNsD9b415P
『⽇本⼈超⾼齢者における⼼房細動に対する低⽤量エドキサバンの有⽤性』 https://t.co/k07i5FpTto https://t.co/cmSYpWQqca
RT @DrJasonAndrade: @RhythmHelp @drraviele @DrMarthaGulati @guroledip @cpgale3 @LuigiDiBiaseMD @TJaredBunch @SeguraCardio @PrashSanders @SA…
RT @DrJasonAndrade: @RhythmHelp @drraviele @DrMarthaGulati @guroledip @cpgale3 @LuigiDiBiaseMD @TJaredBunch @SeguraCardio @PrashSanders @SA…
@RhythmHelp @drraviele @DrMarthaGulati @guroledip @cpgale3 @LuigiDiBiaseMD @TJaredBunch @SeguraCardio @PrashSanders @SABOURETCardio @mmamas1973 @gonzaeperez @ShelleyZieroth @Dr_Santangeli @JonPicciniSr @GiuseppeGalati_ We have that with eldercare. Though that assumes 2.5 bud of Apixaban is similar to edoxaban 15 https://t.co/p0rALtn40l
RT @tororo__ph:
循環器メモ:超高齢者へのDOAC投与 結論:リクシアナ15は日本発のエビデンスあり ELDER-CARE AF試験はDOAC躊躇しがちな、80歳以上の患者にエドキサバンとプラセボを比較したもの。ワーファリンとの比較でなくプラセボとの比較なのが珍しい。 続 https://t.co/slhcLzxPfA
RT @Yohei_Kanzawa: そしてECSが盛り上がってるんですね。 超高齢者のAF、少量エドキサバン(リクシアナ)vsプラセボ。 日本から! #心房細動 #DOAC Low-Dose Edoxaban in Very Elderly Patients with Atr…
An interesting and relevant study population selection by the ELDERCARE-AF group Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/fx9e0qQTLc
RT @muddasir_ayazMD: GI is often asked about resumption of anticoagulation as a binary (yes/no) We owe it to our patients to be aware of e…
GI is often asked about resumption of anticoagulation as a binary (yes/no) We owe it to our patients to be aware of emerging data to make more nuanced recommendations Data like
the ELDERCARE-AF これ好きです。 ばあさん(享年95歳)はエドキサバン15mg飲んでました。 親父殿は、早々に筆頭著者に焼いてもらうべきでした。紹介状は持っていたのに... Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/YOVw9fxfeK
https://t.co/KLSOJ6icZd
@mackey_yo 高齢者に対してきめ細かく抗凝固薬を調整できないかとの試みも平行して検討されています。 あ、ASA+DOACは避けるべきです。同意です。しかし循環器疾患を合併している場合や高度症候性ICSの場合は本人と家族と相談して処方するしかないかと忸怩たる思いです https://t.co/BV877Cx4bS
RT @taora_bokujun: この話と思います 論文開きながら視聴できるのはWebのよさかも #22JCS https://t.co/dlXMhyYbfJ
RT @taora_bokujun: この話と思います 論文開きながら視聴できるのはWebのよさかも #22JCS https://t.co/dlXMhyYbfJ
この話と思います 論文開きながら視聴できるのはWebのよさかも #22JCS https://t.co/dlXMhyYbfJ
リクシアナ15mgで使えるようになって嬉しいけど、プラセボとの比較なんだな。 他のDOACが基本ワーファリンとの非劣勢だから戦っている相手が違うことは認識必要。リクシアナ15mgは飲まないよりはマシくらいの感じ。 https://t.co/9U7QVxuzka
RT @Fizz_DI: 80歳以上でCHADS2≧2のNVAFに対するエドキサバン15mg/日 vs プラセボ(n=984、日本) ・脳卒中or全身性塞栓症 2.3%/年 vs 6.7%/年 HR=0.34 [95%CI:0.19-0.61] ・大出血 3.3%/年 vs…
RT @Fizz_DI: 80歳以上でCHADS2≧2のNVAFに対するエドキサバン15mg/日 vs プラセボ(n=984、日本) ・脳卒中or全身性塞栓症 2.3%/年 vs 6.7%/年 HR=0.34 [95%CI:0.19-0.61] ・大出血 3.3%/年 vs…
RT @Fizz_DI: 80歳以上でCHADS2≧2のNVAFに対するエドキサバン15mg/日 vs プラセボ(n=984、日本) ・脳卒中or全身性塞栓症 2.3%/年 vs 6.7%/年 HR=0.34 [95%CI:0.19-0.61] ・大出血 3.3%/年 vs…
80歳以上でCHADS2≧2のNVAFに対するエドキサバン15mg/日 vs プラセボ(n=984、日本) ・脳卒中or全身性塞栓症 2.3%/年 vs 6.7%/年 HR=0.34 [95%CI:0.19-0.61] ・大出血 3.3%/年 vs 1.8%/年 HR=1.87 [95%CI:0.90-3.89] N Engl J Med.383(18):1735-45,(2020) PMID:32865374 https://t.co/7qNVepNNTF
@caperubono @Fosfolamban Mira así publican los japoneses a los que si les interesa la ciencia y la salud de los pacientes. https://t.co/zIkShcDpEP
RT @rahimkachra: Top 5 papers at #RMIM21 via Dr M Prystajecky. 4/5: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation @N…
Top 5 papers at #RMIM21 via Dr M Prystajecky. 4/5: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation @NEJM @RockyMtnIM https://t.co/i6bcsFNcvE
【S54-1】あとはエドキサバンの例の論文。https://t.co/PmA0d5beuI #jsphcs2021
エドキサバン15mgの承認が少し経ちますELDERCARE-AFって結構面白くて ①半分ぐらい抗血小板薬併用 ②これまでは渋々30mgを飲んでいたであろう患者群。 OAC単剤と+SAPT群で層別化して欲しい。 Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/nFFwj7kN05
memoとして貼っておく ELDERCARE-AF https://t.co/Hu4SugMwEV https://t.co/iTMyLfXkKi
#026 Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation N Engl J Med 2020; 383:1735-1745
RT @Fizz_DI: CHADS2スコア≧2、80歳以上の日本人高齢者に対するエドキサバン15mg/日の有効性と安全性。 (年間発生率) ・塞栓症の複合 2.3% vs 6.7%:HR=0.34 [95%CI:0.19-0.61] ・大出血 3.3% vs 1.8%:HR…
CHADS2スコア≧2、80歳以上の日本人高齢者に対するエドキサバン15mg/日の有効性と安全性。 (年間発生率) ・塞栓症の複合 2.3% vs 6.7%:HR=0.34 [95%CI:0.19-0.61] ・大出血 3.3% vs 1.8%:HR=1.87 [95%CI:0.90-3.89] N Engl J Med.383(18):1735-45,(2020) PMID:32865374 https://t.co/7qNVepvEFx
エドキサバンの15mg低用量の試験。 vsプラセボで、出血リスクHR1.87; 95%CI 0.90〜3.89; P = 0.09 リスクは上がらない可能性があるかもって感じ? 第一三共のかな? https://t.co/aM1oQ3gjes
やはり何度読み返しても、センスよいCQの論文だよなぁ。https://t.co/a0YJwLnIFK 確かに、標準⽤量のDOACが使⽤できない⾼齢者に対する抗凝固療法は、これまで臨床上未解決な問題であったと言ってもよい
80歳以上の心房細動患者に、エドキサバン低用量投与すると、プラセボと比べて脳卒中および全身塞栓症の発症が少なく、大出血は多い傾向にある。Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation https://t.co/ARWTw8nOLy
RT @Darbepoeti_n: 「超高齢者に抗凝固療法を行うべきか」については不明な点が多い。この研究で、低用量エドキサバン(15mg)は ✓80歳以上の日本人 ✓出血を増やさずに、脳梗塞を予防する ことがわかった。添付文章では許されていませんが、僕は高齢者にこの容量で…
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation https://t.co/GBjCXNFRlA
RT @Yohei_Kanzawa: そしてECSが盛り上がってるんですね。 超高齢者のAF、少量エドキサバン(リクシアナ)vsプラセボ。 日本から! #心房細動 #DOAC Low-Dose Edoxaban in Very Elderly Patients with Atr…
大往生した祖母を偲んで思い出した試験。婆さん、15mg飲んでてやっぱよかったペーぞ!!元気でな〜(あの世で) ELDERCARE-AF 試験 Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation The New England Journal of Medicine(日本国内版) https://t.co/2vvWezcsZi
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation Read more: https://t.co/FsbmD6385L #metabolicsyndrome #metabolichealthdigest #hypertension #hypertensionawerness #highbloodpressure #highbloodpressureproblems https://t.co/wPDTV6nxIJ
3) Edoxaban chez les patients > 80 ans en FA non valvulaire
Next up on #GeriMedJC, @NEJM Eldercare-AF Trial: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation https://t.co/GBeehYPZAq
RT @GeriMedJC: Tune into #GeriMedJC on Nov 27 at 08:00 AM ET via Zoom: https://t.co/10EKfkm5Cg Low-Dose Edoxaban in Very Elderly Patients w…
RT @GeriMedJC: Tune into #GeriMedJC on Nov 27 at 08:00 AM ET via Zoom: https://t.co/10EKfkm5Cg Low-Dose Edoxaban in Very Elderly Patients w…
Tune into #GeriMedJC on Nov 27 at 08:00 AM ET via Zoom: https://t.co/10EKfkm5Cg Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation. https://t.co/GBeehYPZAq
Full-dose anticoagulation is often used in a fib patients, but carries a risk of bleeding. This study shows that lower dose anticoagulation w/ edoxaban could accomplish the same stroke/heart attack prevention & lower the risk of bleeding for elderly pts https://t.co/7S46Y8RSir https://t.co/ubDbSdIfK5
RT @hichachu: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation 「超高齢心房細動患者における低用量エドキサバンの有効性と安全性の検討」 https://t.co/S44uTgt…
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation 「超高齢心房細動患者における低用量エドキサバンの有効性と安全性の検討」 https://t.co/S44uTgtOBS
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation https://t.co/fXEAu5lGsF
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/valwi1p0sD
Have you read our new Essential Knowledge Update Journal Watch? It offers the latest clinical knowledge on topics including heart failure with reduced ejection fraction and low-dose edoxaban in very elderly patients with atrial fibrillation: https://t.co/H9wer5OVOc https://t.co/BstHey1qY8
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
「超高齢者に抗凝固療法を行うべきか」については不明な点が多い。この研究で、低用量エドキサバン(15mg)は ✓80歳以上の日本人 ✓出血を増やさずに、脳梗塞を予防する ことがわかった。添付文章では許されていませんが、僕は高齢者にこの容量で処方することがあります https://t.co/PqmL5NJUqt https://t.co/sGwYhoNMHw
RT @RevistaMFSamfyc: Edoxaban a dosis bajas en pacientes muy mayores con fibrilación auricular https://t.co/FiPqi8Z4dp PMID 32865374
Edoxaban a dosis bajas en pacientes muy mayores con fibrilación auricular https://t.co/FiPqi8Z4dp PMID 32865374
https://t.co/VdV041Jj7D 80歳以上の日本人の非弁膜症性afに対するエドキサバンの効果を調べたRCT 結果は脳梗塞or全身性塞栓症の発生率は、介入群で2.3%、対照群で6.7%だった(HR:0.34[0.19-0.61])出血発生率は実質的に介入群で多かった(3.3%vs1.8%;HR:1.87[0.90-3.89]) #当麻_凝固
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @YoungGeris: Great to see research in over 80s in the @NEJM , albeit with the outdated phrase 'elderly' in the title. https://t.co/vZZI…
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/hFBj5GaJLO
Great to see research in over 80s in the @NEJM , albeit with the outdated phrase 'elderly' in the title. https://t.co/vZZI5ZijYS
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/g8eybBsgWb
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
En japoneses ≥80 años con fibrilación auricular no valvular no candidatos a anticoagulantes orales, 15 mg de edoxabán/día fue superior al placebo en la prevención de ACVs o embolia sistémica, sin aumento significativo hemorragia mayor vs. placebo. https://t.co/yIT1iW9BFP
RT @caiodeamtavares: 1/15 Since the publication of the ELDERCARE-AF in NEJM (https://t.co/bJtTZkPksc), I have seen a lot of residents and c…
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
Okumura K, Akao M, Yoshida T, et al.; ELDERCARE-AF Committees and Investigators. Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med. 2020; 383: 1735-45. #LowDose #Edoxaban #VeryElderlyJapanesePatients #NonValvularAtrialFibri…https://t.co/YMMYcYEtOV
RT @caiodeamtavares: 1/15 Since the publication of the ELDERCARE-AF in NEJM (https://t.co/bJtTZkPksc), I have seen a lot of residents and c…
5/5 Dans la fibrillation auriculaire du sujet âgé, l’edoxaban à faible dose est supérieur au placebo et ne provoque pas plus de saignement https://t.co/Aq4cACFzSQ
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
1/15 Since the publication of the ELDERCARE-AF in NEJM (https://t.co/bJtTZkPksc), I have seen a lot of residents and colleagues talking that “low dose” anticoagulation is the solution for older frail patients at high bleeding risk. That an “intermediate” dose would be the best
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
https://t.co/RwVimbUbXm
https://t.co/QeQFqQe9d0 https://t.co/7Ip36I8Wui
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @vic_pallares:
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @vic_pallares:
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @DhirajGuptaBHRS: Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of…
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
Practice changing study @NEJM In elderly AF pts with contraindications to OAC, Edoxaban 15mg reduces composite of stroke/SE/ mortality with no addl risk of ICH Higher risk of GI bleed https://t.co/Io1HZrthrB https://t.co/XcFro8q1G1 https://t.co/SHDqswmcqY
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
RT @NEJM: Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
Visual Abstract: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation
En pac muy ancianos c/FA no valv no candidatos para dosis estándar de ACO, una dosis de 15 mg una vez al día de edoxaban sería superior a placebo previniendo el ictus o el embolismo sistémico y no resultaría en una mayor incidencia de sangrado mayor https://t.co/aLJJqTuIyJ
A touch of Edox? In 80+ year olds with non-valvular Afib and at high-risk for anti-coagulation, half-dose Edoxaban cuts stroke risk by 2/3s with no change in mortality. Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/NgZuHmS8Q4
RT @drjohnmorley: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/X1RPWG5vqg
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/X1RPWG5vqg
RT @GiusepeBellelli: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/bxNmC8X9iE
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/bxNmC8X9iE
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/W5QufGsG5Q
【気になった論文】 NEJMより,80歳以上のNVAFに対するLow-Dose Edoxabanの二重盲検プラセボ比較試験.日本からの報告. いずれはNVAFに対するEdoxaban15mgも適応になるのだろうか… https://t.co/rP5pd7bDC6
CHADS2≧2で抗凝固薬の通常使用に不適切と考えられた80歳以上のAf患者をエドキサバン15mgとplaceboを比較した日本発のRCT. Stroke+全身塞栓は2.3% vs 6.7%(HR 0.34 CI 0.19-0.61)、major bleedingは3.3% vs 1.8%(HR 1.87 CI 0.90-3.89). https://t.co/WGcPWsplRP
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/yS2yfMcoHP
"...In very elderly Japanese patients with NVAF who were not appropriate candidates for standard doses of OAC, a once-daily 15-mg dose of edoxaban was superior to placebo in preventing stroke or systemic embolism, without more major bleedings..." https://t.co/LwU1BUA5TQ https://t.co/Fi4vUYYRXl
RT @rincondesisifo: (2 minute medicine) El edoxabán a dosis BAJAS previene los ACV en pac ancianos con FA https://t.co/rW3ibPHPa6 REC de E…
RT @RichardPollok: Also consider low dose Edoxaban in elderly with AF https://t.co/hic1jdQjvX
Also consider low dose Edoxaban in elderly with AF https://t.co/hic1jdQjvX https://t.co/697tb7Q6U1
心房細動の非常に高齢の患者における低用量エドキサバン-PubMed https://t.co/AjRt7XuJnd https://t.co/Z3haS2WkSZ
Étude japonaise de phase 3 concluant que l’edoxaban 15 mg par jour est >au placebo pour prévenir les incidents cardiovasculaires chez les 80 ans avec FA non-valvulaire, ayant des contre-indications aux doses usuelles d’anticoagulants en prévention de l’AVC https://t.co/dkABYUVpz8 https://t.co/V3xB8z5kX2
RT @rincondesisifo: (2 minute medicine) El edoxabán a dosis BAJAS previene los ACV en pac ancianos con FA https://t.co/rW3ibPHPa6 REC de E…
RT @rincondesisifo: (2 minute medicine) El edoxabán a dosis BAJAS previene los ACV en pac ancianos con FA https://t.co/rW3ibPHPa6 REC de E…
(2 minute medicine) El edoxabán a dosis BAJAS previene los ACV en pac ancianos con FA https://t.co/rW3ibPHPa6 REC de ECA https://t.co/S63WGiITpl Estudio original https://t.co/sVvuhEqeGY
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/CdR7mXwbGa
RT @StrokeAHA_ASA: Chaos About Treatment of Chaotic Heartbeat in Elderly Patients https://t.co/A8NOcuoQuj In this blog post, #BloggingStrok…
Chaos About Treatment of Chaotic Heartbeat in Elderly Patients https://t.co/A8NOcuoQuj In this blog post, #BloggingStroke contributor Nurose Karim discusses @NEJM article "Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation" #stroke https://t.co/FJR6hvoAK0
RT @MontefioreGeri: REMINDER: #Geriatrics fellows' #journalclub this afternoon at 2PM! See you there! DM for Zoom link. #GeriMed Low-Dose…
REMINDER: #Geriatrics fellows' #journalclub this afternoon at 2PM! See you there! DM for Zoom link. #GeriMed Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation @NEJM https://t.co/OraqKmCAN4
Once daily 15mg edoxaban superior to placebo in preventing stroke or systemic embolism in ELDERCARE-AF rial and incidence of major bleeding not significantly higher. https://t.co/b2kHj74fEq
Do you have older nonvalvular Afib >=80YO who can't take standard dose AC? @NEJM Try Edoxaban 15mg/day. Less stroke, no⬆️major bleeding vs placebo @TempleIM @aliachisty @PaulNWilliamz @JMAllenbaugh @jaimefine @LaReinaJay10 https://t.co/hR0SEfIyuC https://t.co/VXxvX5xQ3h
低用量エドキサバンのエビデンスって、これかな? https://t.co/zD0dCzrnRo
RT @NEJM: Original Article: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation #ESCCongress
Low-Dose Edoxaban in Very Elderly Patients With Atrial Fibrillation https://t.co/DI0s1k0vij #cardiology
RT @Derek_Leong_RPh: ELDERCARE-AF: In Pts >80 y.o. with non-valvular AF, CHADS2 >1, unable to take OAC at approved doses, edoxaban 15 mg/d…
“Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation - PubMed” https://t.co/hnykOLe3lS
RT @Derek_Leong_RPh: ELDERCARE-AF: In Pts >80 y.o. with non-valvular AF, CHADS2 >1, unable to take OAC at approved doses, edoxaban 15 mg/d…
RT @Derek_Leong_RPh: ELDERCARE-AF: In Pts >80 y.o. with non-valvular AF, CHADS2 >1, unable to take OAC at approved doses, edoxaban 15 mg/d…
ELDERCARE-AF: In Pts >80 y.o. with non-valvular AF, CHADS2 >1, unable to take OAC at approved doses, edoxaban 15 mg/d ⬇️stroke/systemic embolism vs. placebo (ARR 4.4%/year). ⬆️Bleeding with edoxaban, esp. GI bleed (ARI 1.5%/year), CRNMB (ARI 5.6%/year). https://t.co/jpxIcayR6t https://t.co/QvuV3hOnjb
Low-Dose Edoxaban in Very Elderly Patients With Atrial Fibrillation | comment: Peter Lin MD, CCFP https://t.co/IdzlpZn4sR via @practiceupdate
Low-Dose Edoxaban in Very Elderly Patients With Atrial Fibrillation https://t.co/GTEZh9nPvF #hematology
結論として、標準量の経口抗凝固薬が適応外の日本の超高齢非弁膜症性心房細動患者に対するエドキサバン15mg/日投与は、偽薬よりも脳卒中もしくは全身性塞栓症の予防効果に優れ大出血を増やしませんでした。 https://t.co/soriuCqKqe
RT @mencardio: Low-Dose Edoxaban in Very Elderly Patients With Atrial Fibrillation | comment: Peter Lin MD, CCFP https://t.co/Mx5y1drrhv vi…
Low-Dose Edoxaban in Very Elderly Patients With Atrial Fibrillation | comment: Peter Lin MD, CCFP https://t.co/Mx5y1drrhv via @practiceupdate
総合内科は毎日のアップデートを欠かしません!今日は研修医の先生とELDERCARE-AF試験を読みました。日本発の質の高いRCTです。https://t.co/TILPqOxvFX
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation https://t.co/N6YmKbdYCv
RT @ChaturvediNeuro: Getting clinicians to anticoagulate elderly patients with A FIB is challenging, esp. with previous falls/GI bleeds. EL…
https://t.co/9Jx6AYiYJv
RT @koureiigaku: 80歳以上の超高齢心房細動者に対する低用量のエドキサバンの有効性と安全性を評価したELDERCARE-AF試験の論文がNEJMに掲載されていたので抄訳します。 結果、エドキサバン15mg/日投与は偽薬より脳卒中や全身性塞栓症が少なく、大出血の発…
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/83dI9Qs0ce
RT @koureiigaku: 80歳以上の超高齢心房細動者に対する低用量のエドキサバンの有効性と安全性を評価したELDERCARE-AF試験の論文がNEJMに掲載されていたので抄訳します。 結果、エドキサバン15mg/日投与は偽薬より脳卒中や全身性塞栓症が少なく、大出血の発…
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/anGYl2Qiho
80歳以上の超高齢心房細動者に対する低用量のエドキサバンの有効性と安全性を評価したELDERCARE-AF試験の論文がNEJMに掲載されていたので抄訳します。 結果、エドキサバン15mg/日投与は偽薬より脳卒中や全身性塞栓症が少なく、大出血の発生も多くはありませんでした。 https://t.co/ERRfkQifDt
RT @bryanacotton1: Lemme fix conclusion by showing results...”rate of major bleeding was 3.3% in edoxaban group, 1.8% in placebo (P=0.09)..…
RT @juanjolopezn: In very elderly patients with nonvalvular #AF who were not appropriate candidates for standard doses of oral anticoagulan…
RT @juanjolopezn: In very elderly patients with nonvalvular #AF who were not appropriate candidates for standard doses of oral anticoagulan…
RT @syuichiao89: [文献]心房細動を有する超高齢者に低用量エドキサバンで脳卒中及び全身性塞栓症が少ないかもしれない(RCT DOI: 10.1056/NEJMoa2012883) : 薬剤師の地域医療日誌 https://t.co/A5qFXEkb21
RT @jsenior64: #ESCCongress #ESCCongress2020 @escardio siguió con el ELDERCARE AF, edoxaban en pacientes > 80 años con FA con resultados po…
[文献]心房細動を有する超高齢者に低用量エドキサバンで脳卒中及び全身性塞栓症が少ないかもしれない(RCT DOI: 10.1056/NEJMoa2012883) : 薬剤師の地域医療日誌 https://t.co/A5qFXEkb21
RT @jsenior64: #ESCCongress #ESCCongress2020 @escardio siguió con el ELDERCARE AF, edoxaban en pacientes > 80 años con FA con resultados po…
RT @NEJM: Original Article: Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation #ESCCongress
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/DmIb1ukl4z
RT @pinacol: 【RCT】脳卒中予防に承認された投与量での経口抗凝固薬治療が適切でないと考えられる高齢(≥80歳)の心房細動患者へのエドキサバン15mg/dayの投与は、プラセボと比較して、脳卒中/全身性塞栓症の年率を減少させ、大出血の年率に差はなかった(消化管出血は…
【RCT】脳卒中予防に承認された投与量での経口抗凝固薬治療が適切でないと考えられる高齢(≥80歳)の心房細動患者へのエドキサバン15mg/dayの投与は、プラセボと比較して、脳卒中/全身性塞栓症の年率を減少させ、大出血の年率に差はなかった(消化管出血は多かった)。 #ペ読 https://t.co/PmA0d5beuI
RT @VivienHLee: ELDERARE-AF. In elderly Japanese pts with Afib not appropriate for standard AC, low-dose edoxaban (15mg QD) was superior to…
周回遅れ。これ結果出てたんですね、エドキバン15mg。驚くような内容ではないが、有意差の付いていないmajor bleedingは症例数の問題だろう考察される。 Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/mtwHLyY32c
ELDERARE-AF. In elderly Japanese pts with Afib not appropriate for standard AC, low-dose edoxaban (15mg QD) was superior to placebo in preventing #stroke or systemic embolism. Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/qQ5xOVXbuN
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/rsXMhbWvEj
RT @NINDSdirector: More evidence that anticoagulants reduce #stroke in persons with Atrial Fibrillation; even those over 80 yrs old. Low-Do…
Low-Dose Edoxaban in Very Elderly Patients with Atrial Fibrillation | NEJM https://t.co/uSSxDCazSr
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