Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition.

Jia Yu, Xuan Yuan, Hang Chen, Shruti Chaturvedi, Evan M Braunstein, Robert A Brodsky

October 2020 Blood

Synopsis of Social media discussions

Several discussions mention the role of SARS-CoV-2 spike proteins in activating the alternative complement pathway, indicating a range of concerns surrounding vaccine safety and the mechanism of complement activation. Phrases like 'using pathogenic spike protein was one of the dumbest things' and 'could be a game changer' illustrate a polarized view, with some expressing alarm and others highlighting potential breakthroughs. The tone varies, reflecting both skepticism and guarded optimism.

A
Agreement
 Neither agree nor disagree

There is mixed sentiment regarding the findings, with posts showing skepticism and caution about the spike proteins' effects.

I
Interest
 Moderate level of interest

Participants display a moderate level of curiosity, referencing the study and asking for clarifications, but reactions vary widely.

E
Engagement
 Moderate level of engagement

While some posts indicate thoughtful engagement with the research, others reflect dismissiveness toward the implications or focus solely on sharing information.

I
Impact
 Moderate level of impact

The perceived impact of the findings seems modest, with some discussions labeling it as significant while others dismiss it as auxiliary.

Social Mentions

YouTube

2 Videos

Twitter

321 Posts

Blogs

5 Articles

News

15 Articles

Metrics

Video Views

288

Total Likes

491

Extended Reach

2,077,605

Social Features

343

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Inhibition of Complement Activation by SARS-CoV-2 Spike Proteins

Inhibition of Complement Activation by SARS-CoV-2 Spike Proteins

This week we explore the activation of the alternative complement pathway by SARS-CoV-2 spike proteins and how factor D inhibition can prevent complement-mediated damage. This research suggests targeting complement activation may offer therapeutic strategies for severe COVID-19 symptoms.

Youtube Microbiology Journal Club

February 1, 2021

149 views

Investigating SARS-CoV-2 Spike Protein and Complement Activation

Investigating SARS-CoV-2 Spike Protein and Complement Activation

This week we will analyze the impact of SARS-CoV-2 spike proteins on the alternative complement pathway. The discussion includes evidence that inhibiting factor D could mitigate complications in COVID-19, highlighting a potential therapeutic strategy for severe symptoms.

Youtube Microbiology Journal Club

January 24, 2021

140 views

  • MariaGutschi✝️
    @CanningPharm (Twitter)

    @HouseLyndseyRN Not so sure about that actually. There’s some evidence the spike protein itself can activate the alternative complement pathway so who knows. From 2020 https://t.co/OvQazqa6TG
    view full post

    July 4, 2025

    1

  • CLAUDINE GAUTIER
    @vicmahec (Twitter)

    RT @Thefish751855: Related study from 2020. Using pathogenic Spike protein was one of the dumbest, reckless, or malicious things you could…
    view full post

    May 7, 2025

    3

  • Pinsolle Typhaine
    @PinsolleT (Twitter)

    RT @Thefish751855: Related study from 2020. Using pathogenic Spike protein was one of the dumbest, reckless, or malicious things you could…
    view full post

    May 7, 2025

    3

  • Bocquet Annelise
    @AnneliseBocquet (Twitter)

    RT @Thefish751855: Related study from 2020. Using pathogenic Spike protein was one of the dumbest, reckless, or malicious things you could…
    view full post

    May 6, 2025

    3

  • Thefish
    @Thefish751855 (Twitter)

    Related study from 2020. Using pathogenic Spike protein was one of the dumbest, reckless, or malicious things you could do. Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition https://t.co/rM2VI3A2HP https://t.co/I5nzjfiAz1 https://t.co/x62dzaU9yj
    view full post

    May 5, 2025

    3

    3

  • ETERNAL
    @RWyoral (Twitter)

    RT @exosome: This is interesting....#covid19 activated complement https://t.co/hcVwCZ1oEn
    view full post

    June 2, 2023

    2

  • Frank Paul Mora
    @InTime_49 (Twitter)

    RT @exosome: This is interesting....#covid19 activated complement https://t.co/hcVwCZ1oEn
    view full post

    June 2, 2023

    2

  • Dr. Thomas Ichim
    @exosome (Twitter)

    This is interesting....#covid19 activated complement https://t.co/hcVwCZ1oEn
    view full post

    June 2, 2023

    3

    2

  • Lucciano Brazil
    @BrazilLucciano (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 26, 2023

    9

  • Suzana
    @euincognita (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9

  • Adão Santos
    @aasantos61 (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9


  • @Vanda_SEP (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9

  • fernando moraes
    @fernandomorae25 (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9

  • Vagner
    @vagnerdom (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9

  • Viviane,Recife
    @Vivianerecife (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9

  • Francielle Ferreira
    @franciellefg11 (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9

  • Nirdo P
    @nirdop (Twitter)

    RT @DaAcervo: 1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator…
    view full post

    April 19, 2023

    9

  • C.L.A.U.D.I.A
    @DaAcervo (Twitter)

    1- A ativação direta da via alternativa do complemento pelas proteínas spike do SARS-CoV-2 é bloqueada pela inibição do fator D https://t.co/JmZT2LITh1
    view full post

    April 19, 2023

    36

    9

  • Lisa Michelle
    @LisaMichelle195 (Twitter)

    RT @ResearcherNP: An oldie but interesting one re m: S1 protein and the complement pathway…to dysfunction https://t.co/CmPBhzo68P https://t…
    view full post

    February 15, 2023

    5

  • 48HDpanhead
    @48HDpanhead (Twitter)

    RT @ResearcherNP: An oldie but interesting one re m: S1 protein and the complement pathway…to dysfunction https://t.co/CmPBhzo68P https://t…
    view full post

    February 14, 2023

    5

  • T
    @Taylord_haird (Twitter)

    RT @ResearcherNP: An oldie but interesting one re m: S1 protein and the complement pathway…to dysfunction https://t.co/CmPBhzo68P https://t…
    view full post

    February 13, 2023

    5

  • Eva
    @redkryptonite_ (Twitter)

    RT @ResearcherNP: An oldie but interesting one re m: S1 protein and the complement pathway…to dysfunction https://t.co/CmPBhzo68P https://t…
    view full post

    February 12, 2023

    5

  • Shaun Barcavage, FNP-BC
    @ResearcherNP (Twitter)

    An oldie but interesting one re m: S1 protein and the complement pathway…to dysfunction https://t.co/CmPBhzo68P https://t.co/t6iWcoMyfp
    view full post

    February 12, 2023

    4

    5

  • Ann Morgan
    @AnnMorganInMD (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    December 4, 2022

    12

  • Gabor Erdosi
    @gerdosi (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    December 4, 2022

    12

  • Vatansever
    @asedl27 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 11, 2022

    120

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    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 11, 2022

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    @AltunalanKenan (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 10, 2022

    120

  • paradiselost
    @paradiselostmu (Twitter)

    RT @HarunCenkErman1: Şu size tekrar tekrar verdikleri spike protein ne yapabilirmiş?
    view full post

    August 10, 2022

    4

  • Sağlık Ⓜ️ Olsun Gönül Birliği,Fikir birliği
    @HarunCenkErman1 (Twitter)

    RT @HarunCenkErman1: Şu size tekrar tekrar verdikleri spike protein ne yapabilirmiş?
    view full post

    August 10, 2022

    4

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    @mtlgkr78 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 10, 2022

    120

  • Davut Korkmaz
    @negelegele38 (Twitter)

    RT @HarunCenkErman1: Şu size tekrar tekrar verdikleri spike protein ne yapabilirmiş?
    view full post

    August 9, 2022

    4

  • Sağlık Ⓜ️ Olsun Gönül Birliği,Fikir birliği
    @HarunCenkErman1 (Twitter)

    Şu size tekrar tekrar verdikleri spike protein ne yapabilirmiş?
    view full post

    August 9, 2022

    5

    4

  • mulaytr
    @mulaytr (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 9, 2022

    120

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    @tolunay_oya (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 9, 2022

    120

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    @serefcan527 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 8, 2022

    120

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    @OrmanNeriman (Twitter)

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    @MaznunY (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @n_ozengin (Twitter)

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    @yasince1978 (Twitter)

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    @adeemcoban19 (Twitter)

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    120

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    @mirupamerope (Twitter)

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    120

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    @Doa10079423 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @mariaangel4444 (Twitter)

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    @samisert62 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @Meryem1870 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @gunesdemirtas_ (Twitter)

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    @Hanife787838951 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 8, 2022

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    @sgtagaci (Twitter)

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    @ibrahimcpn (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @CemalEnsert (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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  • şeyda~
    @SheydaSe (Twitter)

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    @ayd_free_by_God (Twitter)

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    @MunganSelcuk (Twitter)

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    @NurSener6 (Twitter)

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    @Hopkins14223746 (Twitter)

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    @srplakdgn (Twitter)

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    August 7, 2022

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  • Human Rights
    @HumanRights_100 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @smmm_zkalkan (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @laliko08769085 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @gulbahar_ozacar (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    @Esra62287729 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 7, 2022

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    @YmetAkkas (Twitter)

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    @ig55999494 (Twitter)

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    August 7, 2022

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  • Ahmet Abi
    @Ahmet_Abi3428 (Twitter)

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    @777baloncuk (Twitter)

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    @babaninoglu6134 (Twitter)

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    @dervish85823619 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
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    August 7, 2022

    120

  • Emre YETEN
    @EmreYeten77 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Tuğba Koçpınar
    @TugbaKocp (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Bilgi arsızı
    @FadimeNeseAynur (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Meric Karasu
    @MDavetci (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • MEHMET DOĞAN HELVACIOĞLU
    @MEHMETDOANHELV2 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • ZEHRA TOSUN
    @zehratosun026 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • mabilmez (ZAG)
    @mabilmez (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • rerman namre
    @kimimbenonerede (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Mavi Vatan #ANDIMIZ
    @OzekSebehat (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Benimdilhocam
    @benimdilhocam (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Mehmet Kutlu Tank
    @tank_kutlu (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Okuyan-biz
    @OkuyanBiz (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Ahmet ÖZ
    @ahmetoz_ (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Lale
    @Lale47682789 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Zöhre Kanar
    @KanarZohre (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • memet
    @yesilvet1 (Twitter)

    @KSerefhanoglu Lütfen yanıtlayın ve aydınlatın bizi.Neden testislerimizden ya da böbrek üstünden ya da karaciğer ya da kalp hücrelerinden... .. .plasenta , pankreas . ... ..,Corona olmamak için ,patogen bir protein olan SPİKE PROTEİNİ salgılamak gerekiyor ? https://t.co/7teczsONrL
    view full post

    August 7, 2022

    5

  • Altay Tuna Orhun
    @AltaytunaOrhun1 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Cemaleddin Acar
    @cemaleddinacar (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • ramazan
    @rmznkeskin33 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Sağlık Ⓜ️ Olsun Gönül Birliği,Fikir birliği
    @HarunCenkErman1 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • meliha vatansever
    @melihav (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Neriman Tümer
    @tumer_neriman (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Ferruh BACANLI
    @FerruhBACANLI (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • bilal kocatürk
    @bllkctrk (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • eyüp eryılmaz
    @EryilmazEyp (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • hsyncvlk23
    @hsyncvlk23 (Twitter)

    RT @Ferhatarslandr: Demek bilime tapma noktasındasınız o zaman size hematoloji in en baba :) dergisinden haber veriyorum. Şu size tekrar te…
    view full post

    August 7, 2022

    120

  • Jacquesenboit
    @jacquesenboit (Twitter)

    @MelanieVInjured ...(Yu, ..., Brodsky, 2020). https://t.co/A0MJx3mwfE In the process, not only the skin becomes red & swollen, but platelets get activated & distributed microclots happen in capillaries. https://t.co/A0MJx3mwfE
    view full post

    February 25, 2022

    1

  • Jacquesenboit
    @jacquesenboit (Twitter)

    @MdBreathe ...on cell membrane by blocking factor H. Thus platelets should be easily activated (visible under
    view full post

    February 21, 2022

  • aspenbrz
    @aspenbrz (Twitter)

    RT @kakape: @GretchenVogel1 @steinarma @PEI_Germany We know that #covid19 leads to clotting disorders in some people. And this paper showe…
    view full post

    February 10, 2022

    31

  • Jacquesenboit
    @jacquesenboit (Twitter)

    @Clucky92864053 Robert Brodsky lab at JHU showed the spike blocks factor H on membrane surface, allowing terminal complement complex to assemble & puncture the membrane. https://t.co/A0MJx3EFtM
    view full post

    January 24, 2022

    2

  • Anisopterid
    @Anisopterid (Twitter)

    The alternative complement pathway is directly activated by SCV2 spike protein: https://t.co/hwiteP9su0
    view full post

    January 21, 2022

    2

  • Jacquesenboit
    @jacquesenboit (Twitter)

    @Undergroundcou1 This brief description sounds exactly like the paper from Robery Brodsky's lab at JHU. https://t.co/A0MJx3EFtM
    view full post

    January 12, 2022

    1

  • Naga Prawda
    @virridi (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    January 12, 2022

    12

  • Adam Pawlicki
    @AdamPawlicki2 (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 11, 2021

    10

  • Marek#Murem za mundurem!!Pl
    @Marek41032655 (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 11, 2021

    10

  • Arkadiusz Kopczyński
    @kopciusz (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 11, 2021

    10

  • Elżbieta Stańczuk
    @ElbietaStaczuk (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 11, 2021

    10

  • Krystyna Jańczak
    @Krychaprzybyl (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 10, 2021

    10

  • Wika
    @Wika06382713 (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 10, 2021

    10

  • Anna Garanin
    @annagaranin (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 10, 2021

    10

  • NOP
    @Doktul_Bapka (Twitter)

    RT @MariuszJagora: Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i z…
    view full post

    December 10, 2021

    10

  • Mariusz Jagóra
    @MariuszJagora (Twitter)

    Kiedy białko spike wiąże się z receptorami komórek gospodarza, może dojść do aktywacji układu dopełniacza, aktywacji i zlepiania płytek krwi, ekspresji białek odpowiedzialnych za śmierć komórek, https://t.co/KC7cUD8pz4 https://t.co/8RIBBTZ0Wa https://t.co/LAf9ZqHSjr
    view full post

    December 10, 2021

    25

    10

  • Jacquesenboit
    @jacquesenboit (Twitter)

    @heniek_htw Jia Yu, ..., Robert Brodsky (2020-Oct) : https://t.co/A0MJx3mwfE https://t.co/JFy4pQpA5s
    view full post

    December 10, 2021

    2

    1

  • Helena Torkkeli
    @HelenaTorkkeli (Twitter)

    @risto_kuosa Tarkoitin ed. twiitissä Adenovirusrokotetta ja piikiproteiinin tuotto trombosyyteissä. P-proteiini yksinään sitoutuu ACE2-reseptoreihin mistä aiheutuu mm.poikkeavia immunologisia reaktiomalleja elimistöön Tiedenäyttö: Yu J.. https://t.co/o1U5fgy2e5;2020; https://t.co/PEnTwYgK5o.
    view full post

    October 24, 2021

  • Miguel Ascon, MS, PhD
    @ascon_miguel (Twitter)

    Por qué las Vacunas Experimentales anti-Covid son toxicas y enferman??? https://t.co/G7PQg2GnOH Porque la Spike Protein producidas por estas vacunas, activa el Sistema Alternativo del Complemento - APC, el cual produce la Trombosis, y daño celular en los órganos del cuerpo! https://t.co/JuPk9LAjw3
    view full post

    September 10, 2021

    1

  • GiL_J316
    @GilJ316 (Twitter)

    @RWMaloneMD Could you please translate what this study is claiming? https://t.co/eKsM5tjcze
    view full post

    August 30, 2021

  • Fiore DiNotte
    @FiorediNotte33 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition "SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces." https://t.co/KxC79cUn8s
    view full post

    August 30, 2021

  • Jacquesenboit
    @jacquesenboit (Twitter)

    @kazmoo37 @veryvirology "SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces." https://t.co/A0MJx3mwfE RBC is most vulnerable bcoz w/o nucleus it cannot self repair the holes punched by MAC (membrane attack complex).
    view full post

    August 8, 2021

  • Isatou Sarr
    @IsatouSarr4 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibit… https://t.co/yl1Wwnsrto
    view full post

    July 28, 2021

    1

  • Jennifer Depew, RD
    @deNutrients (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    June 28, 2021

    12

  • JM
    @740205 (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    June 9, 2021

    12

  • Javi Ciborro
    @papayaykware (Twitter)

    https://t.co/DzUc1bxC40 "Efectos secundarios peligrosos de la producción inducida genéticamente de proteínas de espiga del CoV-2 del SARS Wolfgang Wodarg 15.3.2021 Ni los coronavirus ni sus picos entran en la sangre en las infecciones no complicadas. En más del 90% de las
    view full post

    May 4, 2021

    1

  • Jacquesenboit
    @jacquesenboit (Twitter)

    @richardursomd The Spike protein is known to activate complement system attack on host cells via the alternative pathway. Yu,..., Brodsky(2020). https://t.co/A0MJx3mwfE (preprint published online 2020/07)
    view full post

    April 30, 2021

  • Mark Stronge
    @markoftec (Twitter)

    @stone_skipping @vonbrauckmann @IUTruthtellers The vaccine is (part of) the virus. https://t.co/yjornNwuDT
    view full post

    April 28, 2021

  • Mark Stronge
    @markoftec (Twitter)

    @AlexBerenson All Vs based on spike
    view full post

    April 15, 2021

  • b_schaarschmidt
    @b_schaarschmidt (Twitter)

    @DrCWerner @LJohnsdorf Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins https://t.co/U7CK8CtulZ
    view full post

    April 5, 2021

  • b_schaarschmidt
    @b_schaarschmidt (Twitter)

    @LJohnsdorf @KriegelMartin Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins https://t.co/U7CK8CtulZ
    view full post

    April 5, 2021

  • b_schaarschmidt
    @b_schaarschmidt (Twitter)

    @CiesekSandra Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins https://t.co/U7CK8CtulZ
    view full post

    April 5, 2021

  • b_schaarschmidt
    @b_schaarschmidt (Twitter)

    @CiesekSandra Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins https://t.co/U7CK8CtulZ
    view full post

    April 5, 2021

  • b_schaarschmidt
    @b_schaarschmidt (Twitter)

    @kakape @GretchenVogel1 Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins https://t.co/U7CK8CtulZ
    view full post

    April 5, 2021

  • Austin Jeans
    @jeansdoc61 (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    March 23, 2021

    12

  • David M.
    @davidmanzode (Twitter)

    RT @kakape: @GretchenVogel1 @steinarma @PEI_Germany We know that #covid19 leads to clotting disorders in some people. And this paper showe…
    view full post

    March 21, 2021

    31

  • Carlos Julio Lemus
    @CarlosJulioLem3 (Twitter)

    RT @amandaasubiar: Sobre algunos mecanismos fisiopatológicos que NO producen las vacunas. Hilo.
    view full post

    March 21, 2021

    128

  • JWVELEZ
    @JhonWilliamVel1 (Twitter)

    RT @amandaasubiar: Sobre algunos mecanismos fisiopatológicos que NO producen las vacunas. Hilo.
    view full post

    March 21, 2021

    128

  • MattyMo
    @MattyMo61262503 (Twitter)

    RT @RealJoelSmalley: @flojack300 Study the potential mode of action. Here's a few papers to get you started. https://t.co/3qgvvNANpy https…
    view full post

    March 21, 2021

    2

  • MRS T
    @werrylettuce (Twitter)

    RT @RealJoelSmalley: @flojack300 Study the potential mode of action. Here's a few papers to get you started. https://t.co/3qgvvNANpy https…
    view full post

    March 21, 2021

    2

  • Joel
    @RealJoelSmalley (Twitter)

    @flojack300 Study the potential mode of action. Here's a few papers to get you started. https://t.co/3qgvvNANpy https://t.co/bjMVGeAe1Y https://t.co/cirJpSbPSN https://t.co/wpZPXEYXtw
    view full post

    March 21, 2021

    9

    2

  • Yoshifumi Murakami
    @Leo238umi (Twitter)

    ① Complement path. #SARSCoV2 S bind heparan sulfate and activate the alternative complement pathway on cell surfaces. HS interacts with many extracellular proteins, including FGF2, VEGF, TGFβ, HB-EGF, & ecSOD → a broad influence by the S? Thanks to https://t.co/xVQsL7zZPl
    view full post

    March 21, 2021

  • rubic3n
    @rubic3n (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    March 20, 2021

    12

  • Anthony M
    @AnthonyBmur (Twitter)

    @brodjustice @kimbones85 @SharkysTweet @ClareCraigPath Who is clarifying the facts? https://t.co/mdF0Hkh44Z
    view full post

    March 20, 2021

  • Cran75HW
    @Cran75H (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    March 19, 2021

    12

  • Kevin Toral Olivo
    @toral_olivo (Twitter)

    RT @amandaasubiar: Sobre algunos mecanismos fisiopatológicos que NO producen las vacunas. Hilo.
    view full post

    March 19, 2021

    128

  • Rob Soltysik
    @soltysik_rob (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    March 19, 2021

    12

  • Silvia de Dios
    @SilviadeDios12 (Twitter)

    RT @gerdosi: “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-C…
    view full post

    March 19, 2021

    12

  • Gabor Erdosi
    @gerdosi (Twitter)

    “SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces.” “the SARS-CoV-2 spike protein (subunit 1 and 2), but not the N protein, directly activates the alternative pathway of complement (APC).” https://t.co/gPOM9hcCNi
    view full post

    March 19, 2021

    57

    12

  • Joanna Kolenda
    @KolendaJoanna (Twitter)

    RT @HomeopathicRx: @BreesAnna Spiked. But it’s no use explaining... Experience is a harsh teacher. https://t.co/XbjsQXkPRR
    view full post

    March 19, 2021

    1

  • Ann Sorrell
    @HomeopathicRx (Twitter)

    @robinmonotti From Mike Yeadon with thanks: https://t.co/XbjsQXkPRR
    view full post

    March 19, 2021

    1

  • Ann Sorrell
    @HomeopathicRx (Twitter)

    @BreesAnna Spiked. But what’s the point. Experience is a harsh teacher. https://t.co/XbjsQXkPRR .
    view full post

    March 19, 2021

  • Ann Sorrell
    @HomeopathicRx (Twitter)

    @BreesAnna Spiked. But it’s no use explaining... Experience is a harsh teacher. https://t.co/XbjsQXkPRR
    view full post

    March 19, 2021

    1

    1

  • Ann Sorrell
    @HomeopathicRx (Twitter)

    Spiked? https://t.co/XbjsQXkPRR
    view full post

    March 19, 2021

  • Ann Sorrell
    @HomeopathicRx (Twitter)

    @ianmdallas @JuliaHB1 https://t.co/XbjsQXkPRR research
    view full post

    March 19, 2021

  • Janieyaya, NIYY Director
    @janieyaya (Twitter)

    of COVID-19 that are also observed in other complement-driven diseases" https://t.co/8ud90EorDo
    view full post

    March 19, 2021

  • Javi Ciborro
    @papayaykware (Twitter)

    https://t.co/DzUc1bxC40
    view full post

    March 19, 2021

    1

  • Joanne Hoggard
    @JoStardust (Twitter)

    RT @robinmonottibot: S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complem…
    view full post

    March 19, 2021

    8

  • Renegade mind
    @MoanyMr (Twitter)

    RT @robinmonottibot: S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complem…
    view full post

    March 19, 2021

    8

  • Pixty
    @Pixty3 (Twitter)

    RT @robinmonottibot: S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complem…
    view full post

    March 19, 2021

    8

  • normsaid ☝
    @normsaid (Twitter)

    RT @robinmonottibot: S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complem…
    view full post

    March 19, 2021

    8

  • Louis Paul Boon
    @louispaulboon (Twitter)

    RT @robinmonottibot: S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complem…
    view full post

    March 19, 2021

    8

  • Clara
    @Claramind (Twitter)

    RT @robinmonottibot: S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complem…
    view full post

    March 19, 2021

    8

  • Gooner2342 ❌
    @Refuse_Nick2342 (Twitter)

    RT @robinmonottibot: S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complem…
    view full post

    March 19, 2021

    8

  • Robin Monotti
    @robinmonotti2 (Twitter)

    S-PROTEIN: "The SARS-CoV-2 spike protein, but not the N protein, directly activates the alternative pathway of complement (APC)..activation may explain many of the clinical manifestations (microangiopathy, thrombocytopenia, renal injury, & thrombophilia)" https://t.co/ZrCKtanauD
    view full post

    March 19, 2021

    11

    8

  • ραтяι¢ισ яσмαη  帕特里克 
    @patoro33 (Twitter)

    RT @amandaasubiar: Sobre algunos mecanismos fisiopatológicos que NO producen las vacunas. Hilo.
    view full post

    March 19, 2021

    128

  • gillianthurston
    @gillianthurston (Twitter)

    RT @kakape: @GretchenVogel1 @steinarma @PEI_Germany We know that #covid19 leads to clotting disorders in some people. And this paper showe…
    view full post

    March 19, 2021

    31

  • Dan Torba (i)
    @dtorbay (Twitter)

    RT @amandaasubiar: Sobre algunos mecanismos fisiopatológicos que NO producen las vacunas. Hilo.
    view full post

    March 19, 2021

    128

  • Free Speech
    @IgnoraMaanush (Twitter)

    RT @kakape: @GretchenVogel1 @steinarma @PEI_Germany We know that #covid19 leads to clotting disorders in some people. And this paper showe…
    view full post

    March 19, 2021

    31

  • Amber
    @NYCdeb8tr (Twitter)

    RT @kakape: @GretchenVogel1 @steinarma @PEI_Germany We know that #covid19 leads to clotting disorders in some people. And this paper showe…
    view full post

    March 18, 2021

    31

  • (((Dorit Reiss)))
    @doritmi (Twitter)

    RT @kakape: @GretchenVogel1 @steinarma @PEI_Germany We know that #covid19 leads to clotting disorders in some people. And this paper showe…
    view full post

    March 18, 2021

    31

  • Dr AusCanDoc⚡️
    @auscandoc (Twitter)

    @NiamthC @kakape @EMA_News Tricky to tease out the biological trigger isn’t it. Could it be adenovirus? Could it be spike protein? Both have plausibility https://t.co/K5Dri4aBQK
    view full post

    March 18, 2021

    1

  • Caro
    @gabrielaacrb (Twitter)

    RT @amandaasubiar: Sobre algunos mecanismos fisiopatológicos que NO producen las vacunas. Hilo.
    view full post

    March 18, 2021

    128

  • Danny Elizalde
    @DannyElizalde23 (Twitter)

    RT @amandaasubiar: Sobre algunos mecanismos fisiopatológicos que NO producen las vacunas. Hilo.
    view full post

    March 18, 2021

    128

  • stephen o'rahilly (its pronounced O-RA-hill-EEE)
    @StephenORahilly (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/lNp1e3fbHr
    view full post

    March 18, 2021

  • hirokisuyama
    @hirokisuyama1 (Twitter)

    RT @LaurenceLuu: Stumbled across this pretty neat YouTube channel (@microtwjc), an open online microbiology journal club with @DefectiveBr…
    view full post

    January 31, 2021

    3

  • Dr. Rebekah Henry
    @Black_Beaker (Twitter)

    RT @LaurenceLuu: Stumbled across this pretty neat YouTube channel (@microtwjc), an open online microbiology journal club with @DefectiveBr…
    view full post

    January 28, 2021

    3

  • Faz Alam
    @DefectiveBrayne (Twitter)

    RT @LaurenceLuu: Stumbled across this pretty neat YouTube channel (@microtwjc), an open online microbiology journal club with @DefectiveBr…
    view full post

    January 28, 2021

    3

  • Laurence Luu
    @LaurenceLuu (Twitter)

    Stumbled across this pretty neat YouTube channel (@microtwjc), an open online microbiology journal club with @DefectiveBrayne and @id_EATER discussing recent papers (mostly COVID-19 at the moment) #microtwjc https://t.co/4vC9QmUg4K
    view full post

    January 28, 2021

    6

    3

  • Biotech without Borders
    @BioWOborders (Twitter)

    RT @microtwjc: Tune in next sunday for our discussion on "Direct activation of the alternative complement pathway by SARS-CoV-2 spike prote…
    view full post

    January 27, 2021

    2

  • @danwchan@scholar.social
    @id_EATER (Twitter)

    RT @microtwjc: Tune in next sunday for our discussion on "Direct activation of the alternative complement pathway by SARS-CoV-2 spike prote…
    view full post

    January 25, 2021

    2

  • @MicrobioJC@scicomm.xyz
    @microtwjc (Twitter)

    Tune in next sunday for our discussion on "Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition" https://t.co/bpPdp6Z0Yq
    view full post

    January 24, 2021

    1

    2

  • ONE
    @YuZhu4 (Twitter)

    RT @JamesEKrause: Parking this interesting pub from Brodsky lab on "Direct activation of the alternative complement pathway by SARS-CoV-2 s…
    view full post

    January 20, 2021

    3

  • zipjet
    @zipjet (Twitter)

    RT @JamesEKrause: Parking this interesting pub from Brodsky lab on "Direct activation of the alternative complement pathway by SARS-CoV-2 s…
    view full post

    January 19, 2021

    3

  • 7leafclover7
    @7leafclover7 (Twitter)

    RT @JamesEKrause: Parking this interesting pub from Brodsky lab on "Direct activation of the alternative complement pathway by SARS-CoV-2 s…
    view full post

    January 19, 2021

    3

  • Biotech Jim
    @JamesEKrause (Twitter)

    Parking this interesting pub from Brodsky lab on "Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition". Free pdf... Spike and/or N-protein activation of complement? https://t.co/pxPJfYKgmX https://t.co/r8cL8tfiIs
    view full post

    January 19, 2021

    8

    3

  • Krishna M
    @maringanti (Twitter)

    Could be a game changer! Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/INdzialAns
    view full post

    November 18, 2020

  • Eddine Kerboua
    @KerbouaKheir (Twitter)

    RT @roumenina: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blo…
    view full post

    November 13, 2020

    2

  • JuanaSe
    @juanitatolea_se (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 6, 2020

    12

  • Linfocita NK
    @LinfocitaNK_ (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 6, 2020

    12

  • Khalil El Karoui
    @KElKaroui (Twitter)

    RT @roumenina: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blo…
    view full post

    November 6, 2020

    2

  • Lubka Roumenina
    @roumenina (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/BHBSkDwPUY
    view full post

    November 6, 2020

    7

    2

  • Aida
    @dudidubidubidu (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • Noelia Pérez
    @Aileonpg76 (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • Khalid Alharbi
    @HarbyKhalid (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • Erin Mulvey
    @ECMulvey (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • labclinorg
    @labclinorg (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • sophie susen
    @sophie_susen (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • Danny Fletcher
    @Dfletcher1983 (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • jeanette impia ♪♫ ♪♫
    @jeanetteimpia (Twitter)

    RT @BloodJournal: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition ht…
    view full post

    November 5, 2020

    12

  • Blood Journals Portfolio
    @BloodPortfolio (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition https://t.co/lCVNttp5jC #COVID19 https://t.co/SSy2lV3rAQ
    view full post

    November 5, 2020

    39

    12

  • Snob_order
    @snob_order (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by #factorD inhibition (#BCRX #BIOCRYST #BCX9930) https://t.co/XkHKL3bgaD https://t.co/bE7WHiQYAU
    view full post

    October 27, 2020

    2

  • Marita Alfaro
    @maritaAS27 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 27, 2020

    72

  • Rodrigo Nunes Cal
    @CalZole (Twitter)

    RT @DrChoueiri: Direct activation of the complement pathway by #SARSspikeproteins is blocked by factor D inhibition ⁦@BloodJournal⁩. These…
    view full post

    October 26, 2020

    4

  • Annals of Cardiovascular and Thoracic Surgery
    @AndThoracic (Twitter)

    RT @HanCardiomd: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition htt…
    view full post

    October 26, 2020

    1

  • Daniel Jarovsky
    @djarovsky (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 26, 2020

    72

  • BS Science
    @BSsciencenews (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/zaC9QTR6Dt
    view full post

    October 25, 2020

  • Diane Dewhirst
    @NJdoc (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • A_S(ヤドカリ：釣り餌にしないで下さい)
    @zzz_as_zzz (Twitter)

    @__ice9 @farid__jalali @gstanchev Cell surface HSPG is not just attachment receptor but Sarscov-2 retainer inducing APC activation, more epithelial cell damage, & thrombosis et al. Not much virus detected from serum probably because of HSPG retention? https://t.co/dMnza5sa7h
    view full post

    October 25, 2020

    1

  • A_S(ヤドカリ：釣り餌にしないで下さい)
    @zzz_as_zzz (Twitter)

    これらの対策としてFactor D阻害剤のACH145951と補体のC5に対する抗体が（試験管では）役に立つとのこと。 詳しくは、原文でご確認ください。 https://t.co/dMnza5sa7h
    view full post

    October 25, 2020

    1

  • Andrea N.A.
    @ANAguero383 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • SpaceAix
    @cathcoste (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • BS Science
    @BSsciencenews (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • ニューロドクター乱夢
    @hichachu (Twitter)

    SARS-CoV-2 spike proteins bind heparan sulfate and activate the alternative complement pathway on cell surfaces. Factor D inhibitor (ACH-145951) blocks the complement activation induced by SARS-CoV-2 spike proteins. https://t.co/iqd4PdQpDh
    view full post

    October 25, 2020

  • Henry Han
    @HanCardiomd (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition https://t.co/Ypf20V1o2s @VirusesImmunity @allnick @YaleMed @virologist_atu @AmerSocVirol @BloodJournal @BloodAdvances @EricTopol @DrJennHaythe @Leo_ReapDO https://t.co/VkqmQF8wke
    view full post

    October 25, 2020

    3

    1

  • Mrs. Berger
    @Caroll_Berger (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • meilinvia cahyadi
    @meilinvia (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • @vic_bioinfo@genomic.social
    @Vic_Bioinfo (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • Libert Nicolas
    @dr_Libert_N (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • MedChem & ONCo&
    @MedChem314 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • Anne Miller
    @millerinanne (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • Susy Parada
    @susy_parada (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • PharmaDecisions LLC
    @PharmaDecisions (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • Saied Froghi
    @SFroghi (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • susi
    @susi38532167 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 25, 2020

    72

  • satish rath
    @DrSatishRath (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Hocine Remini, Ph.D "ⵃoⵛⵉⵏⴻ ⵕⴻⵎⵉⵏⵉ"
    @HocineRemini (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Kevin Goheen
    @Mrkalman (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Eilonwy24
    @Eilonwy24 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Ravi Ratna
    @medical91 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Rodrigo Nunes Cal
    @CalZole (Twitter)

    RT @DrChoueiri: Direct activation of the complement pathway by #SARSspikeproteins is blocked by factor D inhibition ⁦@BloodJournal⁩. These…
    view full post

    October 24, 2020

    4

  • Ruda Mohaweche, MD, MBA
    @rudmoha (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • ノリオ
    @norioNY (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/w3q0Yy8chm
    view full post

    October 24, 2020

  • Queenie Maquilang
    @qmmaquilang (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Chris Labaki
    @Chrislabaki1 (Twitter)

    RT @DrChoueiri: Direct activation of the complement pathway by #SARSspikeproteins is blocked by factor D inhibition ⁦@BloodJournal⁩. These…
    view full post

    October 24, 2020

    4

  • Ghazwan Butrous
    @gbutrous (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Sylvie DeLacroixSainTJacques compte de secours
    @SissiPalla (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • A_Tangle ☮️
    @A_Tangle (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • amrojasm@bsky.social
    @amrojasmendoza (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Sean
    @smhanlon (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • ASTS
    @ASTS1972 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Romain Martin
    @RomainMartinIO (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • BlueEdit
    @MargieSchulz (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Rapid Covid Labs
    @RapidCovidLabs (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Ying
    @ysha_168 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Rapid Covid Labs, LLC
    @CovidLabs (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Karuna Jain
    @karunajain21 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Aha?
    @Aha_31X3 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Brenda
    @worldcatlover (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Gary Marcus
    @GaryMarcus (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Tina de Toetterbeck7jabs
    @Toetterbeck (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Vangrunderbeeck
    @gretav5 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Martin Correa
    @martinrafco (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Andy Smith
    @PredatorDiaries (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Ziad Bakouny, MD, MSc
    @ZiadBakouny (Twitter)

    RT @DrChoueiri: Direct activation of the complement pathway by #SARSspikeproteins is blocked by factor D inhibition ⁦@BloodJournal⁩. These…
    view full post

    October 24, 2020

    4

  • enlightenbio
    @enlightenbio (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Toni Choueiri, MD
    @DrChoueiri (Twitter)

    Direct activation of the complement pathway by #SARSspikeproteins is blocked by factor D inhibition ⁦@BloodJournal⁩. These proteins bind heparan sulfate on cell surface. This may explain catastrophic thrombosis with #COVID19 ⁦@COVID19nCCC⁩ https://t.co/gYgQl15Lyf
    view full post

    October 24, 2020

    7

    4

  • John P Erwin III MD MBA MACC (#BigPoppy )
    @HeartOTXHeartMD (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Edward Allan McPhail
    @EdMcPhail (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • MEJIA MD
    @mejia_bf (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Marcin Czerwinski
    @CzerwinsMarcin (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • #JusticaParaVitimasCovid
    @SalvaSocial (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Andree Kurniawan MD, PhD, FINASIM
    @a125ee (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • COVID-19 HQ
    @covid19hq1 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Carolien Hamming
    @carolienhamming (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • brennan. ophelia
    @brennanophelia3 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Mathias Bourke
    @Orfeu_Negro_ (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • talking to computer
    @AlTag (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Peter Persyn
    @peter_persyn (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Meral Beksac
    @mbeksac56 (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Juka - Risikogruppe - hockt viel am Fenster
    @_Juka_BB (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Jan SMH Harper
    @SmhJan (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Kevin Kirwin
    @kevinsonline (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72


  • @Lob_developing (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • SaludHEALTHinfo
    @SaludHEALTHinfo (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Krishna M
    @maringanti (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Zhan Li
    @thezhanly (Twitter)

    RT @EricTopol: This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complemen…
    view full post

    October 24, 2020

    72

  • Eric Topol
    @EricTopol (Twitter)

    This important study reinforces the heparan sulfate cofactor for #SARSCoV2-ACE2 binding, the role of the alternate complement pathway, and potential to block it https://t.co/oRzxRh4L0W @HopkinsMedicine @BloodJournal Thanks Molly! https://t.co/MbRwzMGzNB https://t.co/hBFQSw4fv2
    view full post

    October 24, 2020

    198

    72

  • Prof. Dr. Sanjeev Bagai
    @BagaiDr (Twitter)

    Direct activatn:alternative complement pathway(ACP)by SARSCoV2,Sproteins,blocked by factor D inh.Sproteins bind heparan sulfate-activate ACP.Factor D inh.(ACH145951)block ACP activatn by S(S1,2),⬆️APC.C3,C5b-9 deposit on TF1PIGAnull target cell,CBb⬆️ https://t.co/8qcB2a9v8c
    view full post

    October 23, 2020

    1

  • Guillermo Alarcon
    @Gmo_1965 (Twitter)

    https://t.co/OoEKMowAU4
    view full post

    October 22, 2020

  • Ramcés Falfán-Valencia
    @RFalfanV (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/nLmp5JdUkn
    view full post

    October 20, 2020

  • 101stmonk3y ◼️
    @101stmonk3y (Twitter)

    Direct activation of the alternative complement pathway by #SARSCoV2 spike proteins is blocked by factor D inhibition https://t.co/BC9niCSiyP
    view full post

    October 20, 2020

  • Dr Anthony Martin
    @AMAinsight (Twitter)

    https://t.co/QKTyJXYgZC https://t.co/TOznRfiFAD
    view full post

    October 20, 2020

  • Dr Anthony Martin
    @AMAinsight (Twitter)

    https://t.co/QWP9jt2YTc
    view full post

    October 20, 2020

  • Sallby
    @slickferret (Twitter)

    Important discovery about how #COVID19 activates in the body Link to technical article https://t.co/ClzNDmPXoP Link to overview article https://t.co/nng75kQOqI
    view full post

    October 19, 2020

  • anarcho
    @anarcho (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/0wAVygI3yU
    view full post

    October 19, 2020

  • Aureliano Stingi PhD
    @AurelianoStingi (Twitter)

    @Doom3Gloom @bicidiario https://t.co/sl7VrpgWW6
    view full post

    October 19, 2020

    2

  • Sriganesh Srihari | Biomedical Data Science
    @srigsri23 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition https://t.co/vRa350hv42
    view full post

    October 18, 2020

    2

  • Ivan Slatinski
    @ISlatinski (Twitter)

    https://t.co/qc8H0RFGZx
    view full post

    October 18, 2020

  • Ruben Kenny Briceno
    @rubskenny (Twitter)

    This is it!!!!! Great work. https://t.co/NwMicqy7Wq
    view full post

    October 18, 2020

  • Helen Ong
    @Lin_ling_88 (Twitter)

    #JohnsHopkins Researchers Identify #ImmuneSystem #Pathway That May Stop #COVID_19 Infection ▪️Original article published in Blood: https://t.co/BGeKFb9eYN https://t.co/bS7x7zPmzh
    view full post

    October 18, 2020

    2

    1

  • Helen Ong
    @Lin_ling_88 (Twitter)

    #Johns_Hopkins Researchers Identify #ImmuneSystem #Pathway That May Stop #COVID_ 19 Infection (10/17) ▪️Original article published in Blood: https://t.co/BGeKFb9eYN https://t.co/bS7x7zPmzh
    view full post

    October 18, 2020

  • Dr. Irene Salinas Remiro
    @DrSalinasLab (Twitter)

    https://t.co/s0Ncf869Wc
    view full post

    October 18, 2020

    4

  • Snob_order
    @snob_order (Twitter)

    https://t.co/XkHKL3bgaD #factorD #Covid19 #BioCryst #Bcrx #bcx9930 #Galidesivir #Antiviral https://t.co/5L9DkIyP9T
    view full post

    October 18, 2020

  • Jennifer Depew, RD
    @deNutrients (Twitter)

    Research article about the surface protein system that can cause cell membrane breakdown #COVID19 re Factor H and Factor D, Complement system https://t.co/2RpL1tFk11
    view full post

    October 18, 2020

  • fj
    @gecko39 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition https://t.co/TSGxK0bFX3 https://t.co/dzARBXgER2
    view full post

    October 18, 2020

    1

  • fj
    @gecko39 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition https://t.co/TSGxK0bFX3
    view full post

    October 18, 2020

    2

  • fj
    @gecko39 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition https://t.co/TSGxK0bFX3 https://t.co/Z6jfYMnDY0
    view full post

    October 18, 2020

    1

  • Victoria Chernyakhovsky
    @VChernyakhovsky (Twitter)

    #COVID19 "Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology" https://t.co/NKBQc1YOC0
    view full post

    October 18, 2020

  • Dr. M. Bernardo
    @mbernardo321 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/lbzuzdYvHq
    view full post

    October 18, 2020

  • gys de jongh
    @gysdejongh (Twitter)

    @EricTopol @NatGeo @LoisParshley @MoNscience https://t.co/sWThMHC2r1 Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
    view full post

    October 17, 2020

  • Dr. Santosh
    @SS45749994 (Twitter)

    Morning reads Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology @JohnsHopkins⁩ ⁦@ASH_hematology⁩ ⁦@JoeBiden⁩ https://t.co/Y3saNmKIyx
    view full post

    October 15, 2020

  • Kathy Grant
    @KathyGrants (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/hh3H1M3JK3
    view full post

    October 14, 2020

  • Heather K
    @hkl1323 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/r9OjPDjKja
    view full post

    October 14, 2020

  • charlieandy
    @cvbow (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/7hmSOCRxys
    view full post

    October 14, 2020

  • kai
    @kai958531911 (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | Blood | American Society of Hematology https://t.co/fM023ieIlT
    view full post

    October 11, 2020

    1

  • @thevelvetmeow.bsky.social
    @thevelvetmeow (Twitter)

    RT @gysdejongh: @EricTopol @CellCellPress https://t.co/sWThMHC2r1 Direct activation of the alternative complement pathway by SARS-CoV-2 spi…
    view full post

    October 9, 2020

    1

  • gys de jongh
    @gysdejongh (Twitter)

    @EricTopol @CellCellPress https://t.co/sWThMHC2r1 Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition The spike itself contains super antigen https://t.co/wepgT21kSB
    view full post

    October 9, 2020

    1

    1

  • R8Plus
    @AAABiotech (Twitter)

    $BCRX $ALXN “Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition” #COVID19 Johns Hopkins researchers invitro data thread very impressive https://t.co/kbKXC98sEV https://t.co/WmpJ1I7ZVR
    view full post

    September 6, 2020

    13

  • Complement Kidney TMA UK
    @aHUSUKvoice (Twitter)

    RT @dmastellos: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | @B…
    view full post

    September 5, 2020

    3

  • Panagiotis Skendros
    @PSkendros (Twitter)

    RT @dmastellos: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | @B…
    view full post

    September 4, 2020

    3

  • Richard Burwick, MD, MPH
    @RichardBurwick (Twitter)

    RT @dmastellos: Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | @B…
    view full post

    September 4, 2020

    3

  • Dimitris Mastellos
    @dmastellos (Twitter)

    Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition | @BloodJournal #complementbiology #therapeutics #COVID19 https://t.co/KPaDpvsC8O
    view full post

    September 4, 2020

    6

    3

Abstract Synopsis

  • SARS-CoV-2 spike proteins directly activate the alternative complement pathway, which might contribute to various complications like thrombosis and organ damage in COVID-19 patients.
  • Inhibition of factor D can effectively block this activation, preventing complement-mediated damage, whereas C5 inhibition only partially mitigates the effects.
  • These findings suggest that targeting complement activation could be a potential therapeutic strategy for managing severe COVID-19 symptoms and related conditions.