February 2021 PMID 32882250

Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use.

Patrick M Wieruszewski, Erica D Wittwer, Kianoush B Kashani, Daniel R Brown, Simona O Butler, Angela M Clark, Craig J Cooper, Danielle L Davison, Ognjen Gajic, Kyle J Gunnerson, Rachel Tendler, Kristin C Mara, Erin F Barreto

Mentions

17
Peak: 14 in Feb 2021
across 3 sources since Sep 2020

Extended reach

29,734
potential audience

Total likes

99

Video views

3,557

Mentions per month

Sep 2020 – Feb 2021

Where it's discussed

  • X / Twitter13 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Discussions emphasize the promising response rate of 67% and mention factors like lower lactate levels and vasopressin use as predictors of response, indicating a constructive, data-driven conversation. The tone varies from cautious optimism to calls for further collaboration, reflecting both interest and engagement in understanding and applying the findings.

AgreementModerate agreement

Most discussions recognize the main findings, especially the 67% response rate and the potential benefits of Angiotensin II, indicating agreement or positive acknowledgment.

InterestHigh interest

The focus on new research findings and implications for treatment shows high interest among the posters.

EngagementModerate engagement

Posts reference specific data points, such as response rates and factors like lactate levels, demonstrating a moderate level of engagement.

ImpactModerate impact

The discussions highlight potential clinical impact and the importance of collaborative research, suggesting a perception of moderate to high influence.

Abstract in brief

  • The study investigated the safety and effectiveness of synthetic angiotensin II in treating patients with vasodilatory shock unresponsive to other vasopressors, finding that 67% of patients responded with improved blood pressure and reduced vasopressor needs.
  • Responders showed significant increases in mean arterial pressure and decreased vasopressor use, and they had lower lactate levels and more often received vasopressin, which were associated with better responses.
  • Overall, patients who responded to angiotensin II had a lower 30-day mortality rate, although some adverse effects like arrhythmias and VTE occurred during treatment.]

Top posts

Most liked on X and Bluesky
ACCP CRIT PRN
@accpcritprn · X

#JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory shock, 67% of angiotensin II recipients [had] a favorable hemodynamic response.” #critPRN #PharmICU @pwierusz @erin_barreto https://t.co/yE6FZxAXHo

Feb 24, 2021 · 30 likes · 7 shares · 7,506 followers View post →
MayoPCCM
@MayoPCCM · X

@pwierusz @erin_barreto @EricaWittwer @kianoushbk @ogi_gajic et al found that 67% of angio II recipients had favorable hemodynamic response and mortality. Pts w/ lower lactate and those receiving vasopressin were more likely to respond to angio II. https://t.co/ACLlmVXyhb

Feb 13, 2021 · 13 likes · 2 shares · 3,803 followers View post →
Ayman Soubani, MD
@PagingDrAyman · X

Post-marketing use for vasopressor-refractory shock, 67% of angiotensin II recipients experienced favorable hemodynamic response. Pts w/ lower lactate or on vasopressin were more likely to respond. Angio II responders had lower mortality @SCCM @accpchest https://t.co/meRN3ROs01

Sep 8, 2020 · 3 likes · 158 followers View post →
Alice Gallo, MD
@GallodeMoraesMD · X

RT @MayoPCCM: @pwierusz @erin_barreto @EricaWittwer @kianoushbk @ogi_gajic et al found that 67% of angio II recipients had favorable hemody…

Feb 13, 2021 · 2 shares · 8,986 followers View post →
Erin Barreto
@erin_barreto · X

RT @MayoPCCM: @pwierusz @erin_barreto @EricaWittwer @kianoushbk @ogi_gajic et al found that 67% of angio II recipients had favorable hemody…

Feb 13, 2021 · 2 shares · 2,706 followers View post →
EM/CCC
@EMCCC2 · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 25, 2021 · 7 shares · 885 followers View post →

All mentions

dr-pharmnadiaferguson
@drnadiaferguson · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 26, 2021 · 7 shares · 41 followers View post →
EM/CCC
@EMCCC2 · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 25, 2021 · 7 shares · 885 followers View post →
Velliyur Viswesh, PharmD, BCIDP
@VisweshPharmD · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 25, 2021 · 7 shares · 273 followers View post →
Brent C. Beckner PharmD, BCPS, BCCCP
@BCB_PharmD · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 25, 2021 · 7 shares · 844 followers View post →
krsrml0
@krsrml0 · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 24, 2021 · 7 shares · 205 followers View post →
Seumsack Somtakoune
@ssomtakoune · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 24, 2021 · 7 shares · 15 followers View post →
Kelly Gentry
@Kgentry23 · X

RT @accpcritprn: #JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory…

Feb 24, 2021 · 7 shares · 560 followers View post →
ACCP CRIT PRN
@accpcritprn · X

#JournalWatch Angiotensin II Infusion for Shock: A Multicenter Study of Postmarketing Use “...for vasopressor-refractory shock, 67% of angiotensin II recipients [had] a favorable hemodynamic response.” #critPRN #PharmICU @pwierusz @erin_barreto https://t.co/yE6FZxAXHo

Feb 24, 2021 · 30 likes · 7 shares · 7,506 followers View post →
Angela Clark (she/her)
@amclark726 · X

Collaboration is KEY to learning more about the role of AngII in refractory shock @KyleGunnerson @umichCVC @UMichPharmacy READ more

Feb 13, 2021 · 72 followers View post →
Erin Barreto
@erin_barreto · X

RT @MayoPCCM: @pwierusz @erin_barreto @EricaWittwer @kianoushbk @ogi_gajic et al found that 67% of angio II recipients had favorable hemody…

Feb 13, 2021 · 2 shares · 2,706 followers View post →
Alice Gallo, MD
@GallodeMoraesMD · X

RT @MayoPCCM: @pwierusz @erin_barreto @EricaWittwer @kianoushbk @ogi_gajic et al found that 67% of angio II recipients had favorable hemody…

Feb 13, 2021 · 2 shares · 8,986 followers View post →
MayoPCCM
@MayoPCCM · X

@pwierusz @erin_barreto @EricaWittwer @kianoushbk @ogi_gajic et al found that 67% of angio II recipients had favorable hemodynamic response and mortality. Pts w/ lower lactate and those receiving vasopressin were more likely to respond to angio II. https://t.co/ACLlmVXyhb

Feb 13, 2021 · 13 likes · 2 shares · 3,803 followers View post →
Ayman Soubani, MD
@PagingDrAyman · X

Post-marketing use for vasopressor-refractory shock, 67% of angiotensin II recipients experienced favorable hemodynamic response. Pts w/ lower lactate or on vasopressin were more likely to respond. Angio II responders had lower mortality @SCCM @accpchest https://t.co/meRN3ROs01

Sep 8, 2020 · 3 likes · 158 followers View post →