Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states.

Akiyo Natsubori, Tomomi Tsunematsu, Akihiro Karashima, Hiromi Imamura, Naoya Kabe, Andrea Trevisiol, Johannes Hirrlinger, Tohru Kodama, Tomomi Sanagi, Kazuto Masamoto, Norio Takata, Klaus-Armin Nave, Ko Matsui, Kenji F Tanaka, Makoto Honda

September 2020

Synopsis of Social media discussions

The community shows a strong interest in the biological implications of ATP fluctuations, with comments noting that ATP levels decrease during REM sleep, which highlights an intriguing paradox given increased blood flow at that stage. The tone varies from analytical, referencing specific experimental methods, to more general appreciation of the research's significance, reflecting both curiosity and recognition of its relevance for neuroscience.

A
Agreement
 Moderate agreement

Most posts acknowledge the significance of the findings, with some explicitly supporting the conclusion that ATP levels fluctuate with sleep-wake states, such as emphasizing the drop during REM sleep.

I
Interest
 High level of interest

The discussions demonstrate high curiosity, particularly with mentions of methods and implications, like the use of sensors and relevance to sleep research.

E
Engagement
 Moderate level of engagement

Posts vary from high engagement, citing specific details like ATP decrease during REM sleep and the use of stimulation, to more superficial mentions in discussion of general findings.

I
Impact
 Moderate level of impact

Perceptions of impact are moderate, with some posts describing the research as a potentially important discovery in understanding brain energy dynamics, though not universally emphasizing its broader influence.

Social Mentions

YouTube

2 Videos

Facebook

2 Posts

Twitter

26 Posts

Blogs

2 Articles

News

6 Articles

Metrics

Video Views

123

Total Likes

97

Extended Reach

217,351

Social Features

38

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Neuron Energy Levels Vary with Sleep and Wake States in Mice

Neuron Energy Levels Vary with Sleep and Wake States in Mice

This study used a special sensor to measure ATP levels inside brain cells of live mice. Find that ATP levels change with sleep-wake states, decreasing during REM sleep despite increased blood flow, indicating neurons may be in negative energy balance during different states.

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July 30, 2025

98 views

Intracellular ATP Levels in Neurons Vary with Sleep-Wake States

Intracellular ATP Levels in Neurons Vary with Sleep-Wake States

This study measures ATP levels inside mouse cortical neurons, showing fluctuations during wakefulness, slow-wave sleep, and REM sleep, with the lowest ATP during REM sleep, indicating neurons may experience negative energy balance at this stage.

オシポッド

June 14, 2025

26 views

  • Dieter
    @Wuhle (Twitter)

    RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…
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    October 30, 2020

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  • Dr Anthony Martin
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    RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…
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    October 28, 2020

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    RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…
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    October 27, 2020

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    RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…
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    Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neuroscience from @CommsBio https://t.co/Ha08ekxMku
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    October 16, 2020

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    RT @GulcinPekkurnaz: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez
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    October 14, 2020

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  • Fiona Hollis
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    RT @GulcinPekkurnaz: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez
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    RT @NatureJapan: 【日本からの研究成果】Communications Biology 夏堀 晃世 / 東京都医学総合研究所「Intracellular ATP levels in mouse cortical excitatory neurons varies…
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    RT @NatureJapan: 【日本からの研究成果】Communications Biology 夏堀 晃世 / 東京都医学総合研究所「Intracellular ATP levels in mouse cortical excitatory neurons varies…
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    RT @NatureJapan: 【日本からの研究成果】Communications Biology 夏堀 晃世 / 東京都医学総合研究所「Intracellular ATP levels in mouse cortical excitatory neurons varies…
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    【日本からの研究成果】Communications Biology 夏堀 晃世 / 東京都医学総合研究所「Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states｣ https://t.co/94929YLC8N @CommsBio
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    【日本からの研究成果】Communications Biology 夏堀 晃世 / 東京都医学総合研究所「Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states｣ https://t.co/o9ExjcfPZu @CommsBio
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    September 23, 2020

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  • Hiroshi Yamaguchi
    @HYamagu23443318 (Twitter)

    Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/BKy8uuqN8i
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    September 23, 2020

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  • BrainEnergyMetabolism
    @BrainMetabolism (Twitter)

    Using intracellular sensor @JohHirrlinger @KlausNave et al showed stimulation frequency dependent decrease in [ATP] with longer recovery time than Ca2+ and blood flow. 1/2 https://t.co/0WRPXlrMzx https://t.co/BSlCL6Pvyv
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    September 13, 2020

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    September 12, 2020

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    September 8, 2020

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  • Shuntaro Izawa
    @IzawaShuntaro (Twitter)

    Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states #communicationsbiology led by Akiyo Natsubori "ATP levels profoundly decreased during REM sleep" https://t.co/73CWQECJxz
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    September 8, 2020

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  • Akiyo Natsubori
    @ms_kameko (Twitter)

    RT @ryotaiino: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/wZUchohz5e https://…
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    September 7, 2020

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  • Ryota IINO 飯野亮太
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    Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/wZUchohz5e https://t.co/KEEHWLkM39
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    September 7, 2020

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Abstract Synopsis

  • The study used a special sensor to measure ATP levels inside brain cells of live mice and found that these levels change depending on whether the mouse is awake, in slow-wave sleep, or REM sleep, with the lowest ATP during REM sleep.
  • During REM sleep, even though blood flow and energy supply to the brain increase, the ATP inside neurons still drops, implying neurons may be in a negative energy balance at that time.
  • When neurons are activated by electrical stimulation, ATP levels decrease while blood flow still increases, suggesting that brain energy supply sometimes doesn't fully match the neurons' energy needs, leading to natural fluctuations in ATP levels.