September 2020 PMID 32895482

Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states.

Akiyo Natsubori, Tomomi Tsunematsu, Akihiro Karashima, Hiromi Imamura, Naoya Kabe, Andrea Trevisiol, Johannes Hirrlinger, Tohru Kodama, Tomomi Sanagi, Kazuto Masamoto, Norio Takata, Klaus-Armin Nave, Ko Matsui, Kenji F Tanaka, Makoto Honda

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Mentions

Peak: 14 in Sep 2020

across 5 sources since Sep 2020

Extended reach

217,351

potential audience

Total likes

Video views

123

Mentions per month

Sep 2020 – Jul 2025

Where it's discussed

X / Twitter26 posts
News6 articles
YouTube2 videos
Facebook2 posts
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AI synopsis

What people are saying

The community shows a strong interest in the biological implications of ATP fluctuations, with comments noting that ATP levels decrease during REM sleep, which highlights an intriguing paradox given increased blood flow at that stage. The tone varies from analytical, referencing specific experimental methods, to more general appreciation of the research's significance, reflecting both curiosity and recognition of its relevance for neuroscience.

AgreementModerate agreement

Most posts acknowledge the significance of the findings, with some explicitly supporting the conclusion that ATP levels fluctuate with sleep-wake states, such as emphasizing the drop during REM sleep.

InterestHigh interest

The discussions demonstrate high curiosity, particularly with mentions of methods and implications, like the use of sensors and relevance to sleep research.

EngagementModerate engagement

Posts vary from high engagement, citing specific details like ATP decrease during REM sleep and the use of stimulation, to more superficial mentions in discussion of general findings.

ImpactModerate impact

Perceptions of impact are moderate, with some posts describing the research as a potentially important discovery in understanding brain energy dynamics, though not universally emphasizing its broader influence.

Abstract in brief

The study used a special sensor to measure ATP levels inside brain cells of live mice and found that these levels change depending on whether the mouse is awake, in slow-wave sleep, or REM sleep, with the lowest ATP during REM sleep.
During REM sleep, even though blood flow and energy supply to the brain increase, the ATP inside neurons still drops, implying neurons may be in a negative energy balance at that time.
When neurons are activated by electrical stimulation, ATP levels decrease while blood flow still increases, suggesting that brain energy supply sometimes doesn't fully match the neurons' energy needs, leading to natural fluctuations in ATP levels.

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All mentions

Neuron Energy Levels Vary with Sleep and Wake States in Mice

This study used a special sensor to measure ATP levels inside brain cells of live mice. Find that ATP levels change with sleep-wake states, decreasing during REM sleep despite increased blood flow, indicating neurons…

医療法人社団健整会 · Jul 30, 2025 98 views

Intracellular ATP Levels in Neurons Vary with Sleep-Wake States

This study measures ATP levels inside mouse cortical neurons, showing fluctuations during wakefulness, slow-wave sleep, and REM sleep, with the lowest ATP during REM sleep, indicating neurons may experience negative…

オシポッド · Jun 14, 2025 26 views

Dieter

@Wuhle · X

RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…

Oct 30, 2020 · 3 shares · 510 followers View post →

Dr Anthony Martin

@AMAinsight · X

RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…

Oct 28, 2020 · 3 shares · 914 followers View post →

Amol Bhandare

@bhandaream · X

RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…

Oct 27, 2020 · 3 shares · 339 followers View post →

umptemp

@Umptemping · X

RT @CommsBio: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neurosci…

Oct 23, 2020 · 3 shares · 40 followers View post →

Communications Biology

@CommsBio · X

Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states The latest research in #neuroscience from @CommsBio https://t.co/Ha08ekxMku

Oct 16, 2020 · 28 likes · 3 shares · 11,256 followers View post →

Indian Society of Developmental Biologists

@InSDB_79 · X

RT @GulcinPekkurnaz: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez

Oct 14, 2020 · 5 shares · 2,758 followers View post →

Fiona Hollis

@fiona_hollis · X

RT @GulcinPekkurnaz: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez

Oct 13, 2020 · 5 shares · 641 followers View post →

Saudou Frédéric

@SaudouLab · X

RT @GulcinPekkurnaz: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez

Oct 13, 2020 · 5 shares · 690 followers View post →

Dane M. Wolf

@DaneMWolf · X

RT @GulcinPekkurnaz: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez

Oct 12, 2020 · 5 shares · 369 followers View post →

Cahir O'Kane

@OKaneCahir · X

RT @GulcinPekkurnaz: Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez

Oct 12, 2020 · 5 shares · 1,656 followers View post →

PekkurnazLab

@GulcinPekkurnaz · X

Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states https://t.co/jYKpajv3Ez

Oct 12, 2020 · 14 likes · 5 shares · 1,117 followers View post →