October 2020 PMID 32907861

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.

Longxing Cao, Inna Goreshnik, Brian Coventry, James Brett Case, Lauren Miller, Lisa Kozodoy, Rita E Chen, Lauren Carter, Alexandra C Walls, Young-Jun Park, Eva-Maria Strauch, Lance Stewart, Michael S Diamond, David Veesler, David Baker

Mentions

248
Peak: 61 in Sep 2020
across 6 sources since Sep 2020

Extended reach

502,828
potential audience

Total likes

4,250

Video views

101,387

Mentions per month

Sep 2020 – Feb 2025

Where it's discussed

  • X / Twitter125 posts
  • News100 articles
  • Blogs14 articles
  • Facebook4 posts
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions highlight the innovative nature of the research, such as references to the effectiveness of the miniprotein inhibitors against the spike protein of the virus and the collaboration involved with notable researchers like David Baker. Phrases like 'game changer' and comments on 'exciting work in the fight against COVID-19' reflect a positive and hopeful tone, indicating that contributors recognize the high potential impact and relevance of this research in contemporary biomedical science.

AgreementModerate agreement

Many discussions express general support for the findings and the potential of the inhibitors, though some voices raise minor concerns about their application.

InterestHigh interest

The topic of SARS-CoV-2 and miniprotein inhibitors clearly captures a high level of interest, reflecting ongoing relevance in the fight against COVID-19.

EngagementModerate engagement

While many posts share further information and research references, a few show deep engagement by discussing potential challenges and implications.

ImpactHigh impact

Most contributors perceive the work as having significant potential for therapeutic advancements against COVID-19.

Abstract in brief

  • Researchers have developed miniprotein inhibitors targeting the interaction between the SARS-CoV-2 spike protein and the ACE2 receptor, a potential therapeutic approach.
  • The design process involved computer-generated scaffolds that were based on an ACE2 helix or docked against the spike's receptor-binding domain (RBD), resulting in ten inhibitors with strong binding affinities.
  • The most effective inhibitors blocked SARS-CoV-2 infection in cell tests and their structures confirmed by cryo-electron microscopy closely matched the computational models, indicating their potential as hyperstable therapeutic candidates.

Top posts

Most liked on X and Bluesky
BryanRoth
@zenbrainest · X

Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of a general response strategy." INDEED!! De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/3I6zwmP8nV

Sep 10, 2020 · 28 likes · 5 shares · 17,055 followers View post →
Kato
@oxkawaka · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh

Oct 22, 2020 · 25 likes · 6 shares · 5,815 followers View post →
YOshiki
@Y0shiki_2019 · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意分野だとは思うけど、ほんと仕事早い…

Oct 22, 2020 · 14 likes · 10 shares · 992 followers View post →
叢雲くすり (創薬ちゃん)
@souyakuchan · X

☎は Baker 氏。 Congrats!

Oct 9, 2024 · 12 likes · 7 shares · 10,233 followers View post →
Rosetta@Home
@RosettaAtHome · X

To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://t.co/qi5ksHKSUw COVID-19 Antivirals: https://t.co/yEDvpOL7tI

Jun 25, 2021 · 12 likes · 5 shares · 5,014 followers View post →
EMDB - EMPIAR @EBI
@EMDB_EMPIAR · X

Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper: https://t.co/LrdHgBh4oV 2/3

Sep 23, 2020 · 10 likes · 4 shares · 6,122 followers View post →

All mentions

Lucas Nivon
@lucas_nivon · X

@nimivashi15 @SynBio1 There is a lot of data on this, nothing systematic.should scale w SASA. This paper good example. AFAIK these are as specific as spike mAbs. https://t.co/kDziCQcUmj

Feb 12, 2025 · 2 likes · 565 followers View post →
Przemysław G. Czyryca (d. Tajemniczy don Pedro)
@TajemniczyDon · X

@loscharlos October 2020: https://t.co/BotshAmiXT

Jan 25, 2025 · 4 likes · 3,134 followers View post →
adhara_mathphys
@adhara_mathphys · X

RT @souyakuchan: ☎は Baker 氏。 Congrats!

Oct 9, 2024 · 7 shares · 8,609 followers View post →
輝竜司 | Tsukasa Kiryu
@citrocube · X

RT @souyakuchan: ☎は Baker 氏。 Congrats!

Oct 9, 2024 · 7 shares · 28,961 followers View post →
Masakazu Sekijima
@m_sekijima · X

RT @souyakuchan: ☎は Baker 氏。 Congrats!

Oct 9, 2024 · 7 shares · 6,364 followers View post →
フルチン中年男性
@otakutokkai · X

RT @souyakuchan: ☎は Baker 氏。 Congrats!

Oct 9, 2024 · 7 shares · 1,653 followers View post →
りおかんぽす
@riocampos · X

RT @souyakuchan: ☎は Baker 氏。 Congrats!

Oct 9, 2024 · 7 shares · 2,676 followers View post →
いつくしみお
@rdmasud · X

RT @souyakuchan: ☎は Baker 氏。 Congrats!

Oct 9, 2024 · 7 shares · 690 followers View post →
叢雲くすり (創薬ちゃん)
@souyakuchan · X

☎は Baker 氏。 Congrats!

Oct 9, 2024 · 12 likes · 7 shares · 10,233 followers View post →
Shinsuke Segawa (Maitotoxin)
@MaitotoxicPhD · X

好きなタンパク質きかれて、これ答えるの流石やぁ https://t.co/hJTr0peXFL

Oct 9, 2024 · 1,121 followers View post →
The Veesler Lab
@veeslerlab · X

We previously described computationally designed potent miniprotein inhibitors of SARS-CoV-2 targeting the spike (S) receptor-binding domain (RBD) in collaboration with the Baker lab @UWproteindesign 2/10 https://t.co/cnegagnv97

Aug 12, 2024 · 7 likes · 6,222 followers View post →
Wolvverine
@wolvverinepld · X

RT @TajemniczyDon: @normanpie @RomualdTomaszew @k_pyrc @BujumburaMike @wojtek1425 @docent_ws Trzeba tylko sprawdzić, czy nie zakłóci się en…

Nov 25, 2023 · 1 share · 639 followers View post →
Przemysław G. Czyryca (d. Tajemniczy don Pedro)
@TajemniczyDon · X

@normanpie @RomualdTomaszew @k_pyrc @BujumburaMike @wojtek1425 @docent_ws Trzeba tylko sprawdzić, czy nie zakłóci się enzymatycznej funkcji ACE2 i można jechać. Oprócz zespołu z MIT, podobny kierunek badań rozwinął zespół Davida Bakera https://t.co/BotshAmiXT A takie indywiduum teraz twierdzi, że to ja jemu czas i pieniądze zmarnowałem...

Nov 25, 2023 · 7 likes · 1 share · 3,134 followers View post →
Valda Vinson
@ValdaVinson · X

In 2020 2 papers in @ScienceMagazine described how ACE2 mimics might fight Covid https://t.co/7YY9WXVBs9 and https://t.co/Pn4HDVYCyd a News story reports on progress. https://t.co/m8WA6sSOCJ

Jan 27, 2023 · 1 like · 1,298 followers View post →
♕Buratino♕
@Buratino76 · X

https://t.co/oO5GMY0uRi

Jan 20, 2023 · 3,419 followers View post →
Robuś Miauczyński
@Pacanow · X

RT @TajemniczyDon: @Pacanow Brad Pentelute (MIT) i David Baker (U. Washington) zrobili już coś po tej linii. Praca Bakera okazała się wysta…

Oct 25, 2022 · 1 share · 1,347 followers View post →
Przemysław G. Czyryca (d. Tajemniczy don Pedro)
@TajemniczyDon · X

@Pacanow Brad Pentelute (MIT) i David Baker (U. Washington) zrobili już coś po tej linii. Praca Bakera okazała się wystarczająco dobra na publikację w Science. https://t.co/RhlOELa4da

Oct 25, 2022 · 2 likes · 1 share · 3,134 followers View post →
Yoshifumi Murakami
@Leo238umi · X

*N-glycans at N165 & N234 influence the open/closed conformation states of the #SARSCoV2 RBD. * at N331 & N343 have more of a shielding role of the RBD itself, regardless of state. (Nov 7, 2021) https://t.co/DJNjkpM01i ⬇️ miniprotein-① https://t.co/h1JAOEV55b Just for ref. https://t.co/NQJx4SvSeP

Aug 28, 2022 · 53 followers View post →
Robert Kremer NYC
@kremer_robert · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/M48AOtgvtS

Apr 20, 2022 · 247 followers View post →
Showboat7
@Showboat7 · X

RT @veeslerlab: We describe multivalent minibinders designed to simultaneously engage multiple RBDs on a single spike trimer (to increase a…

Apr 13, 2022 · 1 share · 1,495 followers View post →
The Veesler Lab
@veeslerlab · X

We describe multivalent minibinders designed to simultaneously engage multiple RBDs on a single spike trimer (to increase avidity) using the ultrapotent minibinder modules we previously described as building blocks. 2/13 https://t.co/cnegagmXjz

Apr 12, 2022 · 4 likes · 1 share · 6,222 followers View post →
John Timmer
@j_timmer · X

@KenGoldsholl Details here: https://t.co/gPstdyuOZx

Mar 25, 2022 · 8,706 followers View post →
銀松
@Fk_Ginsan · X

RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…

Mar 17, 2022 · 5 shares · 139 followers View post →
Michael Retchin
@MichaelRetchin · X

More on their miniprotein inhibitor work against SARS-CoV-2 Spike https://t.co/4bg4HzuY57

Sep 5, 2021 · 3 likes · 9,684 followers View post →
The Scritcher
@UnknownOutrider · X

RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…

Aug 18, 2021 · 5 shares · 1,421 followers View post →
Breno Zanchetta
@BrenoZanchetta1 · X

RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…

Jun 27, 2021 · 5 shares · 5 followers View post →
Rosario Strano
@Rosario_Strano · X

RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…

Jun 25, 2021 · 5 shares · 6,982 followers View post →
Sid Celery
@sidcelery · X

RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…

Jun 25, 2021 · 5 shares · 9,253 followers View post →
Rosetta@Home
@RosettaAtHome · X

To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://t.co/qi5ksHKSUw COVID-19 Antivirals: https://t.co/yEDvpOL7tI

Jun 25, 2021 · 12 likes · 5 shares · 5,014 followers View post →
C V A Marosa
@cvamarosa · X

RT @SeqComplete: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/MsOJRWegnj #bioinformatics

Dec 20, 2020 · 1 share · 2,551 followers View post →
Roger D. Jones, PhD
@RogerDJones1 · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/1iDYch0yU8 #bioinformatics

Nov 30, 2020 · 1,528 followers View post →
Fabrice Leclerc
@rnomics · X

Top #tweeted story in #bioscience: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/FedNDKSf6J, see more https://t.co/kME3G1o122

Nov 29, 2020 · 2,759 followers View post →
SeqComplete
@SeqComplete · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/MsOJRWegnj #bioinformatics

Nov 29, 2020 · 4,404 followers View post →
minnlab_litbot
@MLitbot · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. https://t.co/4V2KCcsp12 https://t.co/E3Zq7Sf7B9

Nov 18, 2020 · 72 followers View post →
AI X BIO
@AIXBIO · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/IjO4NIekSV

Nov 6, 2020 · 882 followers View post →
UGA College of Pharmacy
@UGAPharmacy · X

Dr. Eva-Maria Strauch, Assistant Professor in PBS, was published in Science with the article, “De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.” https://t.co/4OEvLrPKWt https://t.co/hS1LxFK3x1

Nov 5, 2020 · 5 likes · 2,414 followers View post →
Jean P. Gelinas
@JeanPGelinas · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/MlNlNRPeZp

Oct 30, 2020 · 879 followers View post →
Cell Signaling Group
@CellSignalGroup · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/GNmBPIDryc

Oct 30, 2020 · 235 followers View post →
Cutez Brayz
@climaxnewsroom · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/qEvwHFJ1md

Oct 29, 2020 · 18 followers View post →
Craig TX
@AntiAgingN · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/dElQWRj7AX

Oct 28, 2020 · 866 followers View post →
Serpell Lab Reads
@SerpellLabReads · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ejKRmOQc57

Oct 27, 2020 · 823 followers View post →
Suman Chakrabarty
@SumanPhysChem · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/i9CMPVmdSF

Oct 26, 2020 · 2 likes · 2,193 followers View post →
Takeshi
@QM_MM · X

RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…

Oct 25, 2020 · 10 shares · 244 followers View post →
Klaus Riede
@KlausRiede · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/WHiLOziE7l Miniproteins against #SARSCoV2 #gehtdoch

Oct 24, 2020 · 2 likes · 4,564 followers View post →
@severud@social.seattle.wa.us
@severuduw · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Oct 24, 2020 · 46 shares · 1,503 followers View post →
BWFUND
@BWFUND · X

From @ScienceMagazine - De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/jSF2jYlP39 #bwfpath https://t.co/A1SSohOdJi

Oct 24, 2020 · 1 like · 7,114 followers View post →
Emma Parkes
@emmafparkes · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors - Science Magazine https://t.co/vWZMPZeWEy

Oct 24, 2020 · 514 followers View post →
Lori L. Burrows
@Dr_Lori_Burrows · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/muq6sFklEk

Oct 23, 2020 · 2 likes · 4,705 followers View post →
eScience
@ScienceVaccine · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/IDxuy1UFlK

Oct 23, 2020 · 27 followers View post →
のじまんぼうや
@nojimang · X

RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…

Oct 23, 2020 · 10 shares · 243 followers View post →
圧到的に成長したヌー卜リアは力ピバラと区別できないですわ(極悪令嬢・圧ヌ一ちゃん)
@piyota0 · X

RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…

Oct 23, 2020 · 10 shares · 2,775 followers View post →
RxInsilico
@RxInsilico · X

Computational protein design of novel therapeutics. Check out this recent use of Rosetta to rapidly find a novel Covid treatment in Science this week... De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/vDeVfKqOXy

Oct 23, 2020 · 171 followers View post →
ポスドク
@nil_leiden · X

RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh

Oct 23, 2020 · 6 shares · 337 followers View post →
Kawano Lab. (東京農工大学 川野研究室)
@KawanoLab__tuat · X

RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…

Oct 22, 2020 · 10 shares · 1,198 followers View post →
Naoaki ONO
@naono_twt · X

RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…

Oct 22, 2020 · 10 shares · 425 followers View post →
叢雲くすり (創薬ちゃん)
@souyakuchan · X

RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…

Oct 22, 2020 · 10 shares · 10,233 followers View post →
ねごねごはにわ
@phai_bica · X

RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…

Oct 22, 2020 · 10 shares · 1,005 followers View post →
YOshiki
@Y0shiki_2019 · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意分野だとは思うけど、ほんと仕事早い…

Oct 22, 2020 · 14 likes · 10 shares · 992 followers View post →
弐代目うしごや:: ver. KH
@urakiyonobu · X

RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh

Oct 22, 2020 · 6 shares · 711 followers View post →
naka-take
@Yuhki_Nakatake · X

RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh

Oct 22, 2020 · 6 shares · 3,434 followers View post →
サクセスリバーコーテシーinエイトプリンス
@rei_nari · X

RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh

Oct 22, 2020 · 6 shares · 13,968 followers View post →
Kato
@oxkawaka · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh

Oct 22, 2020 · 25 likes · 6 shares · 5,815 followers View post →
Scott Leibrand
@scottleibrand · X

RT @RMBurckhardt: Miniprotein inhibitors as possible therapeutics against SARS-CoV-2, more exciting work in the fight against #COVID19 foun…

Oct 8, 2020 · 1 share · 3,580 followers View post →
なおずめ(無料のおじさん)
@naozume · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/YjsZQz9hDT 分散コンピューティングのrosetta@home がピコモラーSARS-CoV-2ミニタンパク質阻害剤のデノボ設計で一定の成果を出したみたい

Oct 7, 2020 · 290 followers View post →
Wagner Pontel
@wpontel · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 29, 2020 · 46 shares · 75 followers View post →
かぴばら
@kapibara19 · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/BviUcLE12b

Sep 25, 2020 · 499 followers View post →
Andrej Drozdov
@AndrejDrozdov · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/MsORc9tDsW

Sep 25, 2020 · 9 followers View post →
CRISP_SCIENCE
@ScienceCrisp · X

"De novo design of picomolar SARS-CoV-2 miniprotein inhibitors" Cao L [..] Baker D. Science 2020-09-09 (bioRxiv 08-03) https://t.co/q9JmMpMift EMDB: 22532, 22574, 22534, 22533, 22535 Vero E6 cells #COVID19

Sep 24, 2020 · 1,928 followers View post →
Ashutosh Kumar Pandey
@asrayagiriraj · X

RT @EMDB_EMPIAR: Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper:…

Sep 24, 2020 · 4 shares · 1,105 followers View post →
Dana
@millerlab · X

RT @EMDB_EMPIAR: Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper:…

Sep 23, 2020 · 4 shares · 2,710 followers View post →
AurelG
@AurelG7 · X

De novo design of picomolar SARS-CoV-2 miniprotein #inhibitors | #drugdesign #SARSCoV2 https://t.co/hvDlXnjNCv

Sep 23, 2020 · 30 followers View post →
Ajasja
@AjasjaLjubetic · X

RT @EMDB_EMPIAR: Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper:…

Sep 23, 2020 · 4 shares · 1,655 followers View post →
EMDB - EMPIAR @EBI
@EMDB_EMPIAR · X

Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper: https://t.co/LrdHgBh4oV 2/3

Sep 23, 2020 · 10 likes · 4 shares · 6,122 followers View post →
CovidSalon
@CovidSalon · X

9-09 De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/j11EuCCyS9 https://t.co/HTlPcyGfRi

Sep 21, 2020 · 40 followers View post →
Robert Coplin
@r_coplin · X

RT @UWproteindesign: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/mJWbrL5guH | @biorxivpreprint https://t.co/…

Sep 21, 2020 · 41 shares · 799 followers View post →
culver
@culverindiana · X

RT @COVID19arXiv:

Sep 20, 2020 · 1 share · 914 followers View post →
Esteban Engel
@engelbio · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/malk5Mz6n4

Sep 19, 2020 · 1,270 followers View post →
MarkQuarter
@MarkQuarter · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 17, 2020 · 46 shares · 1,611 followers View post →
Volodymyr Nechyporuk-Zloy
@vnzloy · X

"De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao et al. https://t.co/4kjqt6APkL" https://t.co/HWTEjc9P6D

Sep 16, 2020 · 1,279 followers View post →
Prof. Nilesh Kumar Sharma (Ph.D. FRSB., FMASc.)
@nksharmaiitr · X

'Diamond cuts diamond" is truly applicable to CONTROL #SARSCoV2 infected #COVID19. Why? #SARSCoV2, learned the tricks to infect lung epithelial cells during evolution by mimicking. In fact, humans start MIMICKING OF #SARSCoV2 to develop DRUGS. https://t.co/dm408kGbYO

Sep 15, 2020 · 1 like · 52 followers View post →
Rachel Burckhardt, Ph.D.
@RMBurckhardt · X

Miniprotein inhibitors as possible therapeutics against SARS-CoV-2, more exciting work in the fight against #COVID19 found in @ScienceMagazine "De novo design of picomolar SARS-CoV-2 miniprotein inhibitors" https://t.co/WRTHG0vyu9

Sep 14, 2020 · 1 share · 468 followers View post →
Robert Coplin
@r_coplin · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 14, 2020 · 46 shares · 799 followers View post →
Can Cao
@CanCao_Natural · X

RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…

Sep 13, 2020 · 5 shares · 375 followers View post →
Olivier Elemento
@ElementoLab · X

Very cool - De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/eER1uGPiAl

Sep 13, 2020 · 2 likes · 6,250 followers View post →
binaya rana
@binu_binaya · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 12, 2020 · 46 shares · 98 followers View post →
NG20194
@NG20194 · X

@abledoc @__ice9 De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. https://t.co/foVyJYWJFz

Sep 12, 2020 · 1 like · 185 followers View post →
gmopundit (David Tribe Ph.D.) Vinceremo
@gmopundit · X

RT @AusVirologySoc: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/KbZMXEhNaA

Sep 12, 2020 · 2 shares · 5,093 followers View post →
Stephen Turner
@sjturn · X

RT @AusVirologySoc: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/KbZMXEhNaA

Sep 12, 2020 · 2 shares · 3,248 followers View post →
minnlab_litbot
@MLitbot · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. https://t.co/KoP4ohLYYU https://t.co/kimmv9RaHt

Sep 12, 2020 · 72 followers View post →
Aust'asian Virology
@AusVirologySoc · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/KbZMXEhNaA

Sep 11, 2020 · 3 likes · 2 shares · 3,215 followers View post →
Fred Barry Hetrick Jr.
@HetrickBarry · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/iCSpXMm2fv

Sep 11, 2020 · 328 followers View post →
puey
@PueyLab · X

RT @cryoEM_Papers: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/bPPho4JZIW

Sep 11, 2020 · 14 shares · 492 followers View post →
快速渡り烏@禍津己【喪中】
@AzureReises · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 11, 2020 · 46 shares · 165 followers View post →
BoincNetwork
@BOINCNetwork · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 11, 2020 · 46 shares · 1,778 followers View post →
dxbarradas
@dxbarradas · X

RT @Al__Perez: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/XxBXcXP0s3

Sep 11, 2020 · 1 share · 573 followers View post →
Shota Suzuki
@structure_bio36 · X

RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…

Sep 10, 2020 · 5 shares · 797 followers View post →
Norio Nakatsuji
@norionakatsuji · X

RT @norionakatsuji: “De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science“ https://t.co/BoQzVIUhy0

Sep 10, 2020 · 1 share · 15,691 followers View post →
Alberto Perez
@Al__Perez · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/XxBXcXP0s3

Sep 10, 2020 · 2 likes · 1 share · 1,324 followers View post →
Collins lab
@collins_lab · X

RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…

Sep 10, 2020 · 5 shares · 398 followers View post →
Terry Hébert
@THebertMcGill · X

RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…

Sep 10, 2020 · 5 shares · 2,189 followers View post →
Pedro Beltrao
@pedrobeltrao · X

RT @ShorterLab: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB

Sep 10, 2020 · 3 shares · 6,755 followers View post →
Claes Andréasson
@ClaesAndreasson · X

RT @ShorterLab: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB

Sep 10, 2020 · 3 shares · 452 followers View post →
Rafael Schulman
@RafaelSchulman · X

RT @ShorterLab: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB

Sep 10, 2020 · 3 shares · 214 followers View post →
ShorterLab
@ShorterLab · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB

Sep 10, 2020 · 7 likes · 3 shares · 12,108 followers View post →
BryanRoth
@zenbrainest · X

Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of a general response strategy." INDEED!! De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/3I6zwmP8nV

Sep 10, 2020 · 28 likes · 5 shares · 17,055 followers View post →
Alena Khmelinskaia
@khmelinskaia · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 10, 2020 · 46 shares · 522 followers View post →
Sebastian Pomplun
@PomplunSeb · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 10, 2020 · 46 shares · 1,389 followers View post →
Alexander Zlobin
@zlobin_as · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 10, 2020 · 46 shares · 121 followers View post →
Carolyn Newsom
@CarolynNewsom · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/u9JCpDvMtR

Sep 10, 2020 · 33,517 followers View post →
UW Biochemistry
@UWBiochemistry · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 10, 2020 · 46 shares · 5,561 followers View post →
です
@__DesertInn__ · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/FPAiFiepLP

Sep 10, 2020 · 5,975 followers View post →
Norio Nakatsuji
@norionakatsuji · X

“De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science“ https://t.co/BoQzVIUhy0

Sep 10, 2020 · 1 share · 15,691 followers View post →
Mark McCaskill, AICP
@McCaskillMark · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 10, 2020 · 46 shares · 514 followers View post →
Juan José Manclús
@jmanclus60 · X

Se abre una nueva ventana de antivirales frente a la #covid19 @BlasIgnacio De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/55YWKjwZpc

Sep 10, 2020 · 1 like · 1,111 followers View post →
Max Maletta
@MalettaMax · X

RT @cryoEM_Papers: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/bPPho4JZIW

Sep 10, 2020 · 14 shares · 521 followers View post →
たかとー
@takatoh1 · X

RT @nob_mai: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/tfN91zRLVw

Sep 10, 2020 · 3 shares · 606 followers View post →
Jonny Walker
@JonnyWalker0806 · X

RT @nob_mai: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/tfN91zRLVw

Sep 10, 2020 · 3 shares · 48 followers View post →
Mel Markoski
@melmarkoski · X

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/cfJeJwzTEi

Sep 10, 2020 · 6,936 followers View post →
Rajeev Ranjan Roy
@rajeevroy09 · X

RT @cryoEM_Papers: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/bPPho4JZIW

Sep 10, 2020 · 14 shares · 151 followers View post →
Dr Onisha Patel
@dr_opatel · X

RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…

Sep 10, 2020 · 46 shares · 2,222 followers View post →
ttk_235
@ttk_235 · X

RT @m_sekijima: Bakerやるなぁ。Sars-CoV-2のS蛋白質のreceptor binding domain (RBD)に結合するミニ蛋白質をde novoで設計。/ De novo design of picomolar SARS-CoV-2 minip…

Sep 10, 2020 · 3 shares · 272 followers View post →
Valentín Estévez-Souto
@Exosomita · X

RT @scipak_es: Utilizando enfoques innovadores basados ​​en computación, los investigadores han desarrollado inhibidores de proteínas que b…

Sep 9, 2020 · 2 shares · 661 followers View post →
Meagan Phelan
@MeaganPhelan · X

Researchers at @UW have designed inhibitors that block the interaction between #SARS-CoV-2 and human cell receptor ACE2, paving the way for therapeutics that could be delivered more easily than antibodies https://t.co/aWPgd4PVSW

Sep 9, 2020 · 1,961 followers View post →
José L. Moreno-Garvayo  (afanporsaber)
@jlmgarvayo · X

RT @scipak_es: Utilizando enfoques innovadores basados ​​en computación, los investigadores han desarrollado inhibidores de proteínas que b…

Sep 9, 2020 · 2 shares · 3,128 followers View post →
@scipak_es
@scipak_es · X

Utilizando enfoques innovadores basados ​​en computación, los investigadores han desarrollado inhibidores de proteínas que bloquean la interacción entre el virus #SARS-CoV-2 y el receptor de células humanas ACE2. @UWMedicine https://t.co/ktnuffedKu https://t.co/v7gt0sFUHA

Sep 9, 2020 · 2 likes · 2 shares · 2,507 followers View post →