Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of a general response strategy." INDEED!! De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/3I6zwmP8nV
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
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Sep 2020 – Feb 2025Where it's discussed
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X / Twitter125 posts
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News100 articles
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What people are saying
The discussions highlight the innovative nature of the research, such as references to the effectiveness of the miniprotein inhibitors against the spike protein of the virus and the collaboration involved with notable researchers like David Baker. Phrases like 'game changer' and comments on 'exciting work in the fight against COVID-19' reflect a positive and hopeful tone, indicating that contributors recognize the high potential impact and relevance of this research in contemporary biomedical science.
Many discussions express general support for the findings and the potential of the inhibitors, though some voices raise minor concerns about their application.
The topic of SARS-CoV-2 and miniprotein inhibitors clearly captures a high level of interest, reflecting ongoing relevance in the fight against COVID-19.
While many posts share further information and research references, a few show deep engagement by discussing potential challenges and implications.
Most contributors perceive the work as having significant potential for therapeutic advancements against COVID-19.
Abstract in brief
- Researchers have developed miniprotein inhibitors targeting the interaction between the SARS-CoV-2 spike protein and the ACE2 receptor, a potential therapeutic approach.
- The design process involved computer-generated scaffolds that were based on an ACE2 helix or docked against the spike's receptor-binding domain (RBD), resulting in ten inhibitors with strong binding affinities.
- The most effective inhibitors blocked SARS-CoV-2 infection in cell tests and their structures confirmed by cryo-electron microscopy closely matched the computational models, indicating their potential as hyperstable therapeutic candidates.
Top posts
Most liked on X and BlueskyDe novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意分野だとは思うけど、ほんと仕事早い…
☎は Baker 氏。 Congrats!
To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://t.co/qi5ksHKSUw COVID-19 Antivirals: https://t.co/yEDvpOL7tI
Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper: https://t.co/LrdHgBh4oV 2/3
All mentions
"Antibodies" of the Future: Smaller, Better, Faster, Stronger | History of Antibodies
Molecular Structure and Dynamics of SARS-CoV-2 Envelope Revealed by Modeling
Researchers utilize advanced computational modeling to analyze the dynamic interactions of SARS-CoV-2's envelope, revealing how M proteins form filament-like structures and confirming envelope stability through…
@nimivashi15 @SynBio1 There is a lot of data on this, nothing systematic.should scale w SASA. This paper good example. AFAIK these are as specific as spike mAbs. https://t.co/kDziCQcUmj
@loscharlos October 2020: https://t.co/BotshAmiXT
RT @souyakuchan: ☎は Baker 氏。 Congrats!
RT @souyakuchan: ☎は Baker 氏。 Congrats!
RT @souyakuchan: ☎は Baker 氏。 Congrats!
RT @souyakuchan: ☎は Baker 氏。 Congrats!
RT @souyakuchan: ☎は Baker 氏。 Congrats!
RT @souyakuchan: ☎は Baker 氏。 Congrats!
☎は Baker 氏。 Congrats!
好きなタンパク質きかれて、これ答えるの流石やぁ https://t.co/hJTr0peXFL
We previously described computationally designed potent miniprotein inhibitors of SARS-CoV-2 targeting the spike (S) receptor-binding domain (RBD) in collaboration with the Baker lab @UWproteindesign 2/10 https://t.co/cnegagnv97
RT @TajemniczyDon: @normanpie @RomualdTomaszew @k_pyrc @BujumburaMike @wojtek1425 @docent_ws Trzeba tylko sprawdzić, czy nie zakłóci się en…
@normanpie @RomualdTomaszew @k_pyrc @BujumburaMike @wojtek1425 @docent_ws Trzeba tylko sprawdzić, czy nie zakłóci się enzymatycznej funkcji ACE2 i można jechać. Oprócz zespołu z MIT, podobny kierunek badań rozwinął zespół Davida Bakera https://t.co/BotshAmiXT A takie indywiduum teraz twierdzi, że to ja jemu czas i pieniądze zmarnowałem...
In 2020 2 papers in @ScienceMagazine described how ACE2 mimics might fight Covid https://t.co/7YY9WXVBs9 and https://t.co/Pn4HDVYCyd a News story reports on progress. https://t.co/m8WA6sSOCJ
https://t.co/oO5GMY0uRi
RT @TajemniczyDon: @Pacanow Brad Pentelute (MIT) i David Baker (U. Washington) zrobili już coś po tej linii. Praca Bakera okazała się wysta…
@Pacanow Brad Pentelute (MIT) i David Baker (U. Washington) zrobili już coś po tej linii. Praca Bakera okazała się wystarczająco dobra na publikację w Science. https://t.co/RhlOELa4da
*N-glycans at N165 & N234 influence the open/closed conformation states of the #SARSCoV2 RBD. * at N331 & N343 have more of a shielding role of the RBD itself, regardless of state. (Nov 7, 2021) https://t.co/DJNjkpM01i ⬇️ miniprotein-① https://t.co/h1JAOEV55b Just for ref. https://t.co/NQJx4SvSeP
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/M48AOtgvtS
RT @veeslerlab: We describe multivalent minibinders designed to simultaneously engage multiple RBDs on a single spike trimer (to increase a…
We describe multivalent minibinders designed to simultaneously engage multiple RBDs on a single spike trimer (to increase avidity) using the ultrapotent minibinder modules we previously described as building blocks. 2/13 https://t.co/cnegagmXjz
@KenGoldsholl Details here: https://t.co/gPstdyuOZx
RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…
More on their miniprotein inhibitor work against SARS-CoV-2 Spike https://t.co/4bg4HzuY57
RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…
RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…
RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…
RT @RosettaAtHome: To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://…
To learn more about this coronavirus #proteindesign research, visit https://t.co/zpTQfh32R8 COVID-19 Vaccines: https://t.co/qi5ksHKSUw COVID-19 Antivirals: https://t.co/yEDvpOL7tI
RT @SeqComplete: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/MsOJRWegnj #bioinformatics
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/1iDYch0yU8 #bioinformatics
Top #tweeted story in #bioscience: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/FedNDKSf6J, see more https://t.co/kME3G1o122
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/MsOJRWegnj #bioinformatics
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. https://t.co/4V2KCcsp12 https://t.co/E3Zq7Sf7B9
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/IjO4NIekSV
Dr. Eva-Maria Strauch, Assistant Professor in PBS, was published in Science with the article, “De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.” https://t.co/4OEvLrPKWt https://t.co/hS1LxFK3x1
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/MlNlNRPeZp
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/GNmBPIDryc
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/qEvwHFJ1md
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/dElQWRj7AX
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ejKRmOQc57
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/i9CMPVmdSF
RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/WHiLOziE7l Miniproteins against #SARSCoV2 #gehtdoch
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
From @ScienceMagazine - De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/jSF2jYlP39 #bwfpath https://t.co/A1SSohOdJi
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors - Science Magazine https://t.co/vWZMPZeWEy
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/muq6sFklEk
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/IDxuy1UFlK
RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…
RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…
Computational protein design of novel therapeutics. Check out this recent use of Rosetta to rapidly find a novel Covid treatment in Science this week... De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/vDeVfKqOXy
RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh
RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…
RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…
RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…
RT @Y0ist_2019: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意…
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/KWE1JcNawI レセプター結合ドメインに結合するデノボタンパク質の設計。Bakerらの得意分野だとは思うけど、ほんと仕事早い…
RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh
RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh
RT @oxkawa: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors タンパク質のデザインと言ったら、、、、見参です https://t.co/YHyYTOSrAh
RT @RMBurckhardt: Miniprotein inhibitors as possible therapeutics against SARS-CoV-2, more exciting work in the fight against #COVID19 foun…
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/YjsZQz9hDT 分散コンピューティングのrosetta@home がピコモラーSARS-CoV-2ミニタンパク質阻害剤のデノボ設計で一定の成果を出したみたい
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/BviUcLE12b
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/MsORc9tDsW
"De novo design of picomolar SARS-CoV-2 miniprotein inhibitors" Cao L [..] Baker D. Science 2020-09-09 (bioRxiv 08-03) https://t.co/q9JmMpMift EMDB: 22532, 22574, 22534, 22533, 22535 Vero E6 cells #COVID19
RT @EMDB_EMPIAR: Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper:…
RT @EMDB_EMPIAR: Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper:…
De novo design of picomolar SARS-CoV-2 miniprotein #inhibitors | #drugdesign #SARSCoV2 https://t.co/hvDlXnjNCv
RT @EMDB_EMPIAR: Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper:…
Study by Cao et al. from @veeslerlab @UWproteindesign @WashUID @UW @UWMedicine @WUSTLmed @UGAPharmacy & @HHMINEWS. Paper: https://t.co/LrdHgBh4oV 2/3
9-09 De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/j11EuCCyS9 https://t.co/HTlPcyGfRi
RT @UWproteindesign: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/mJWbrL5guH | @biorxivpreprint https://t.co/…
RT @COVID19arXiv:
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/malk5Mz6n4
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
"De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao et al. https://t.co/4kjqt6APkL" https://t.co/HWTEjc9P6D
'Diamond cuts diamond" is truly applicable to CONTROL #SARSCoV2 infected #COVID19. Why? #SARSCoV2, learned the tricks to infect lung epithelial cells during evolution by mimicking. In fact, humans start MIMICKING OF #SARSCoV2 to develop DRUGS. https://t.co/dm408kGbYO
Miniprotein inhibitors as possible therapeutics against SARS-CoV-2, more exciting work in the fight against #COVID19 found in @ScienceMagazine "De novo design of picomolar SARS-CoV-2 miniprotein inhibitors" https://t.co/WRTHG0vyu9
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…
Very cool - De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/eER1uGPiAl
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
@abledoc @__ice9 De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. https://t.co/foVyJYWJFz
RT @AusVirologySoc: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/KbZMXEhNaA
RT @AusVirologySoc: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/KbZMXEhNaA
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors. https://t.co/KoP4ohLYYU https://t.co/kimmv9RaHt
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science https://t.co/KbZMXEhNaA
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/iCSpXMm2fv
RT @cryoEM_Papers: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/bPPho4JZIW
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
RT @Al__Perez: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/XxBXcXP0s3
RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…
RT @norionakatsuji: “De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science“ https://t.co/BoQzVIUhy0
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/XxBXcXP0s3
RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…
RT @zenbrainest: Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of…
RT @ShorterLab: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB
RT @ShorterLab: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB
RT @ShorterLab: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/ZYq3rVQYRB
Wow^3! "Preparing against unknown future pandemics is difficult, and such a capability could be an important component of a general response strategy." INDEED!! De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/3I6zwmP8nV
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/u9JCpDvMtR
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/FPAiFiepLP
“De novo design of picomolar SARS-CoV-2 miniprotein inhibitors | Science“ https://t.co/BoQzVIUhy0
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
Se abre una nueva ventana de antivirales frente a la #covid19 @BlasIgnacio De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/55YWKjwZpc
RT @cryoEM_Papers: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/bPPho4JZIW
RT @nob_mai: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/tfN91zRLVw
RT @nob_mai: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/tfN91zRLVw
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/cfJeJwzTEi
RT @cryoEM_Papers: De novo design of picomolar SARS-CoV-2 miniprotein inhibitors https://t.co/bPPho4JZIW
RT @UWproteindesign: New: Synthetic proteins designed to bind Spike on SARS-CoV-2 provide starting points for COVID-19 therapeutics. @UWMed…
RT @m_sekijima: Bakerやるなぁ。Sars-CoV-2のS蛋白質のreceptor binding domain (RBD)に結合するミニ蛋白質をde novoで設計。/ De novo design of picomolar SARS-CoV-2 minip…
RT @scipak_es: Utilizando enfoques innovadores basados en computación, los investigadores han desarrollado inhibidores de proteínas que b…
Researchers at @UW have designed inhibitors that block the interaction between #SARS-CoV-2 and human cell receptor ACE2, paving the way for therapeutics that could be delivered more easily than antibodies https://t.co/aWPgd4PVSW
RT @scipak_es: Utilizando enfoques innovadores basados en computación, los investigadores han desarrollado inhibidores de proteínas que b…
Utilizando enfoques innovadores basados en computación, los investigadores han desarrollado inhibidores de proteínas que bloquean la interacción entre el virus #SARS-CoV-2 y el receptor de células humanas ACE2. @UWMedicine https://t.co/ktnuffedKu https://t.co/v7gt0sFUHA
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