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BMC Biol September 2020 PMID 32912212

Mechanical force-induced morphology changes in a human fungal pathogen.

Charles Puerner, Nino Kukhaleishvili, Darren Thomson, Sebastien Schaub, Xavier Noblin, Agnese Seminara, Martine Bassilana, Robert A Arkowitz

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Mentions

18
Peak: 10 in Sep 2020
across 2 sources since Sep 2020

Extended reach

365,873
potential audience

Total likes

60

Video views

242

Mentions per month

Sep 2020 – Jun 2024

Where it's discussed

  • X / Twitter16 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions generally reflect a positive interest in the research, with comments such as 'Amazing work!' and references to how the biophysical forces change fungal morphology. The tone varies from enthusiastic praise to scientific curiosity, indicating recognition of both the study’s significance and its potential influence on understanding pathogen behavior.

AgreementModerate agreement

Most discussions express support or acknowledgment of the study’s importance, indicating general agreement with its findings.

InterestHigh interest

The discussions highlight genuine curiosity about the biophysical mechanisms and implications for fungal invasion, showing high interest.

EngagementModerate engagement

Postings include specific references to experimental methods and results, demonstrating moderate engagement.

ImpactModerate impact

Several discussions suggest that this research could influence future studies or medical approaches, implying a meaningful impact.

Abstract in brief

  • The study investigates how the fungal pathogen Candida albicans physically penetrates and invades host tissues, focusing on how substrate stiffness affects its ability to enter.
  • Researchers used a microfabrication method to test penetration in materials of different stiffness and found that the fungus can only effectively invade substrates with a stiffness below 200 kPa, displaying changes like filament buckling and reduced extension speed in stiffer environments.
  • The fungus's cell shape changes during invasion are driven by mechanical compression, causing increased activity of some growth regulators (Cdc42) at the tips, while others (Rho1) become less active, showing that environmental stiffness influences fungal invasion strategies.]
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Top posts

Most liked on X and Bluesky
CNRS Biologie
@CNRSbiologie · X

#ResultatScientifique

Sep 29, 2020 · 11 likes · 3 shares · 17,978 followers View post →
BMC Biology
@BMCBiology · X

New #openaccess research from Robert Arkowitz and colleagues: Mechanical force-induced morphology changes in a human fungal pathogen Read it here: https://t.co/X4ospbWJKc https://t.co/tcbcDMpwKm

Sep 11, 2020 · 11 likes · 6 shares · 9,013 followers View post →
Hung-Ji Tsai
@HJTsai · X

#Candida2021 Charles Puerner from Arkowitz lab is talking about how biophysical force in C. albicans changes morphology and invasion https://t.co/9aAJIjdgvA Amazing work!

Mar 23, 2021 · 4 likes · 2 shares · 1,010 followers View post →
Steve Marek
@stephenmarek2 · X

Mechanical force-induced morphology changes in a human fungal pathogen https://t.co/t7ZeqRuPVa https://t.co/Iajphwhy6M

Oct 12, 2020 · 2 likes · 1 share · 5,458 followers View post →
Darren Thomson
@fungalhyphae · X

@mgblango 'WT' hyphae undergo compartment length change during invasive growth; another (shameless!) plug here: https://t.co/uO7lMZD41n But although the septa/compartment 'distance' changed, I think the volume is the constant clock for cell division.

Oct 28, 2020 · 2 likes · 1,937 followers View post →
CNRS
@CNRS · X

RT @INSB_CNRS: #ResultatScientifique

Oct 1, 2020 · 3 shares · 224,188 followers View post →

All mentions

Hung-Ji Tsai
@HJTsai · X

#Candida2021 Charles Puerner from Arkowitz lab is talking about how biophysical force in C. albicans changes morphology and invasion https://t.co/9aAJIjdgvA Amazing work!

Mar 23, 2021 · 4 likes · 2 shares · 1,010 followers View post →
Darren Thomson
@fungalhyphae · X

RT @INSB_CNRS: #ResultatScientifique

Mar 11, 2021 · 3 shares · 1,937 followers View post →
Darren Thomson
@fungalhyphae · X

@mgblango 'WT' hyphae undergo compartment length change during invasive growth; another (shameless!) plug here: https://t.co/uO7lMZD41n But although the septa/compartment 'distance' changed, I think the volume is the constant clock for cell division.

Oct 28, 2020 · 2 likes · 1,937 followers View post →
Leopoldo Naranjo-Briceño
@Leorange69 · X

RT @stephenmarek2: Mechanical force-induced morphology changes in a human fungal pathogen https://t.co/t7ZeqRuPVa https://t.co/Iajphwhy6M

Oct 12, 2020 · 1 share · 379 followers View post →
Steve Marek
@stephenmarek2 · X

Mechanical force-induced morphology changes in a human fungal pathogen https://t.co/t7ZeqRuPVa https://t.co/Iajphwhy6M

Oct 12, 2020 · 2 likes · 1 share · 5,458 followers View post →
CNRS
@CNRS · X

RT @INSB_CNRS: #ResultatScientifique

Oct 1, 2020 · 3 shares · 224,188 followers View post →
Rachid de B
@mounibtayeb · X

RT @INSB_CNRS: #ResultatScientifique

Sep 29, 2020 · 3 shares · 928 followers View post →
CNRS Biologie
@CNRSbiologie · X

#ResultatScientifique

Sep 29, 2020 · 11 likes · 3 shares · 17,978 followers View post →
Rohan Wakade
@rohan_wakade · X

RT @BMCBiology: New #openaccess research from Robert Arkowitz and colleagues: Mechanical force-induced morphology changes in a human fungal…

Sep 15, 2020 · 6 shares · 172 followers View post →
Antonio Serrano
@Antonio_Serr90 · X

RT @BMCBiology: New #openaccess research from Robert Arkowitz and colleagues: Mechanical force-induced morphology changes in a human fungal…

Sep 15, 2020 · 6 shares · 393 followers View post →
Sam D, Ph. D
@DrSam_D · X

RT @BMCBiology: New #openaccess research from Robert Arkowitz and colleagues: Mechanical force-induced morphology changes in a human fungal…

Sep 15, 2020 · 6 shares · 1,707 followers View post →
Genome Biology
@GenomeBiology · X

RT @BMCBiology: New #openaccess research from Robert Arkowitz and colleagues: Mechanical force-induced morphology changes in a human fungal…

Sep 14, 2020 · 6 shares · 89,947 followers View post →
Himender Bharti
@adubharti · X

Mechanical force-induced morphology changes in a human fungal pathogen | BMC Biology | Full Text https://t.co/7JThXAyuc2

Sep 14, 2020 · 1,326 followers View post →
BMC Biology
@BMCBiology · X

RT @BMCBiology: New #openaccess research from Robert Arkowitz and colleagues: Mechanical force-induced morphology changes in a human fungal…

Sep 14, 2020 · 6 shares · 9,013 followers View post →
Candida Papers
@Candida_papers · X

Mechanical force-induced morphology changes in a human fungal pathogen. https://t.co/CBohSQJYbX

Sep 13, 2020 · 142 followers View post →
BMC Biology
@BMCBiology · X

New #openaccess research from Robert Arkowitz and colleagues: Mechanical force-induced morphology changes in a human fungal pathogen Read it here: https://t.co/X4ospbWJKc https://t.co/tcbcDMpwKm

Sep 11, 2020 · 11 likes · 6 shares · 9,013 followers View post →