Front Cell Infect Microbiol June 2021 PMID 32923412

Block and Lock HIV Cure Strategies to Control the Latent Reservoir.

Chantelle L Ahlenstiel, Geoff Symonds, Stephen J Kent, Anthony D Kelleher

Mentions

16
Peak: 7 in Sep 2020
across 4 sources since Aug 2020

Extended reach

16,624
potential audience

Total likes

60

Video views

222

Mentions per month

Aug 2020 – Nov 2024

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos
  • Facebook2 posts
  • News2 articles

AI synopsis

What people are saying

Discussions reflect a positive outlook toward the potential of 'block and lock' strategies, with posts emphasizing mechanisms like epigenetic modifications and the importance of recent publications. Words like 'seek to control,' 'deep latent state,' and references to research articles indicate active engagement and recognition of the strategy's significance in ongoing HIV cure efforts.

AgreementModerate agreement

Most discussions express support or neutral acceptance of the block and lock strategies, recognizing their potential benefit in HIV cure research.

InterestHigh interest

Participants show high interest, with multiple posts highlighting recent publications and specific mechanisms like epigenetic modifications.

EngagementModerate engagement

Posts involve some depth, referencing specific processes like transcription blocking and deep silencing, but mostly serve to acknowledge the strategy rather than critique or deeply analyze.

ImpactModerate impact

The overall tone suggests a noteworthy impact on the scientific community's outlook on HIV cure strategies, though broader clinical implications remain to be seen.

Abstract in brief

  • The HIV latent reservoir in resting CD4 T cells and myeloid cells presents a major challenge for curing HIV because it isn’t eliminated by ART and can reactivate virus production when treatment stops.
  • Current cure strategies include stem cell transplants with HIV-resistant CCR5 cells, gene editing techniques like CRISPR, and two main methods: shock and kill (reactivating and destroying the virus) and block and lock (deeply silencing the virus to prevent reactivation).
  • While shock and kill is a focus now, researchers believe block and lock might be more effective for achieving long-term remission without ART by epigenetically locking the virus in a deep latent state, though there are still challenges to bringing these approaches into clinical practice.

Top posts

Most liked on X and Bluesky
defeatHIV
@defeatHIV · X

The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking” the #HIV promoter in a deep latent state via epigenetic modifications. https://t.co/zo3qkon96Y https://t.co/RyOghDSDyA

Sep 21, 2020 · 45 likes · 22 shares · 6,998 followers View post →
Frontiers - Infectious Disease
@FrontInfectDis · X

Block and Lock HIV Cure Strategies to Control the Latent Reservoir https://t.co/QHytVg48V4 #cellinfect

Aug 14, 2020 · 6 likes · 2 shares · 3,839 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R

Sep 15, 2020 · 4 likes · 3 shares · 621 followers View post →
Robert Paulino-Ramirez, MD, DTM&H, MA, HIVS
@PaulinoRobert · X

Este caso es un ejemplo de las estrategias “block and lock” con células primordiales. (3/3) https://t.co/gif4aGs0Tb

Feb 16, 2022 · 3 likes · 2,914 followers View post →
(◍•ᴗ•◍)✧기대/hope/ความหวัง
@backtoblack6666 · X

RT @Epigenetica: New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R

Sep 15, 2020 · 3 shares · 991 followers View post →
Yves Gebhardt
@YvesGebhardt · X

RT @defeatHIV: The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking”…

Sep 21, 2020 · 22 shares · 552 followers View post →

All mentions

Robert Paulino-Ramirez, MD, DTM&H, MA, HIVS
@PaulinoRobert · X

Este caso es un ejemplo de las estrategias “block and lock” con células primordiales. (3/3) https://t.co/gif4aGs0Tb

Feb 16, 2022 · 3 likes · 2,914 followers View post →
Yves Gebhardt
@YvesGebhardt · X

RT @defeatHIV: The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking”…

Sep 21, 2020 · 22 shares · 552 followers View post →
defeatHIV
@defeatHIV · X

The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking” the #HIV promoter in a deep latent state via epigenetic modifications. https://t.co/zo3qkon96Y https://t.co/RyOghDSDyA

Sep 21, 2020 · 45 likes · 22 shares · 6,998 followers View post →
Prometheus
@PrometheusClstr · X

New article: Block and Lock HIV Cure Strategies to Control the Latent Reservoir. https://t.co/nAXgGGsQvu

Sep 16, 2020 · 31 followers View post →
iamnunee
@iamnunee1 · X

RT @Epigenetica: New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R

Sep 15, 2020 · 3 shares · 70 followers View post →
(◍•ᴗ•◍)✧기대/hope/ความหวัง
@backtoblack6666 · X

RT @Epigenetica: New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R

Sep 15, 2020 · 3 shares · 991 followers View post →
Phages & Crisprs
@CrisprPhages · X

Block and Lock HIV Cure Strategies to Control the Latent Reservoir. https://t.co/C7niuRoH8o

Sep 15, 2020 · 185 followers View post →
Epigenética
@Epigenetica · X

New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R

Sep 15, 2020 · 4 likes · 3 shares · 621 followers View post →
Tcake
@A_Little_Nurse · X

RT @FrontCellInfect: Block and Lock HIV Cure Strategies to Control the Latent Reservoir https://t.co/QHytVg48V4 #cellinfect

Aug 15, 2020 · 2 shares · 87 followers View post →
Frontiers - Infectious Disease
@FrontInfectDis · X

Block and Lock HIV Cure Strategies to Control the Latent Reservoir https://t.co/QHytVg48V4 #cellinfect

Aug 14, 2020 · 6 likes · 2 shares · 3,839 followers View post →