The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking” the #HIV promoter in a deep latent state via epigenetic modifications. https://t.co/zo3qkon96Y https://t.co/RyOghDSDyA
Block and Lock HIV Cure Strategies to Control the Latent Reservoir.
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Aug 2020 – Nov 2024Where it's discussed
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X / Twitter10 posts
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YouTube2 videos
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Facebook2 posts
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News2 articles
AI synopsis
What people are saying
Discussions reflect a positive outlook toward the potential of 'block and lock' strategies, with posts emphasizing mechanisms like epigenetic modifications and the importance of recent publications. Words like 'seek to control,' 'deep latent state,' and references to research articles indicate active engagement and recognition of the strategy's significance in ongoing HIV cure efforts.
Most discussions express support or neutral acceptance of the block and lock strategies, recognizing their potential benefit in HIV cure research.
Participants show high interest, with multiple posts highlighting recent publications and specific mechanisms like epigenetic modifications.
Posts involve some depth, referencing specific processes like transcription blocking and deep silencing, but mostly serve to acknowledge the strategy rather than critique or deeply analyze.
The overall tone suggests a noteworthy impact on the scientific community's outlook on HIV cure strategies, though broader clinical implications remain to be seen.
Abstract in brief
- The HIV latent reservoir in resting CD4 T cells and myeloid cells presents a major challenge for curing HIV because it isn’t eliminated by ART and can reactivate virus production when treatment stops.
- Current cure strategies include stem cell transplants with HIV-resistant CCR5 cells, gene editing techniques like CRISPR, and two main methods: shock and kill (reactivating and destroying the virus) and block and lock (deeply silencing the virus to prevent reactivation).
- While shock and kill is a focus now, researchers believe block and lock might be more effective for achieving long-term remission without ART by epigenetically locking the virus in a deep latent state, though there are still challenges to bringing these approaches into clinical practice.
Top posts
Most liked on X and BlueskyBlock and Lock HIV Cure Strategies to Control the Latent Reservoir https://t.co/QHytVg48V4 #cellinfect
New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R
Este caso es un ejemplo de las estrategias “block and lock” con células primordiales. (3/3) https://t.co/gif4aGs0Tb
RT @Epigenetica: New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R
RT @defeatHIV: The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking”…
All mentions
Understanding HIV Replication and Emerging Cure Strategies
This video explores how HIV replicates in the body and innovative strategies scientists are developing to cure it, including gene therapies and approaches to silence the virus to prevent reactivation.
Advances in HIV Cure Strategies: Block and Lock Approaches Explained
HIV cure strategies include stem cell transplants, gene editing like CRISPR, and approaches to control the latent reservoir. The block and lock method aims to silence the virus long-term, offering potential for ART-free…
Este caso es un ejemplo de las estrategias “block and lock” con células primordiales. (3/3) https://t.co/gif4aGs0Tb
RT @defeatHIV: The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking”…
The "block and lock" #hivcure strategies seek to control the latent reservoir by “blocking” HIV transcription and “locking” the #HIV promoter in a deep latent state via epigenetic modifications. https://t.co/zo3qkon96Y https://t.co/RyOghDSDyA
New article: Block and Lock HIV Cure Strategies to Control the Latent Reservoir. https://t.co/nAXgGGsQvu
RT @Epigenetica: New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R
RT @Epigenetica: New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R
Block and Lock HIV Cure Strategies to Control the Latent Reservoir. https://t.co/C7niuRoH8o
New in Pubmed: "Block and Lock HIV Cure Strategies to Control the Latent Reservoir." https://t.co/BHsBNkFT3R
RT @FrontCellInfect: Block and Lock HIV Cure Strategies to Control the Latent Reservoir https://t.co/QHytVg48V4 #cellinfect
Block and Lock HIV Cure Strategies to Control the Latent Reservoir https://t.co/QHytVg48V4 #cellinfect
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