Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
Underlying features of epigenetic aging clocks in vivo and in vitro.
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Sep 2020 – Jun 2024Where it's discussed
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AI synopsis
What people are saying
The discussions prominently highlight various aspects of the article, such as the potential of epigenetic clocks to offer insights into biological age, with one participant stating, 'the Meta-clock approach holds great promise for predicting mortality.' Another contributor emphasizes the need to shift focus from traditional health markers to biological age, saying, 'Eventually, the field will move past glucose, BP, and cholesterol.' Such phrases illustrate the enthusiasm and optimism surrounding the research, creating a collective sense of urgency and importance in exploring biological aging.
Many discussions reflect a general acceptance of the article's findings, with users expressing validation of the research.
There is a high level of curiosity, as participants frequently reference linked topics and suggest watching videos related to the publication.
While there are several insightful comments, a portion of the dialogue emphasizes shared resources without delving deeply into more complex analyses.
Several participants strongly believe that the insights from the publication may significantly influence ongoing research and understanding of biological aging.
Abstract in brief
- Epigenetic clocks based on DNA methylation measure biological aging across various tissues but often show weak correlations, indicating they may reflect different biological processes.
- Analysis of multiomics data revealed that five clocks (Horvath1, Horvath2, Levine, Hannum, and Lin) share conserved transcriptional associations that link epigenetic aging to metabolism, immunity, and autophagy in specific human tissues.
- In vitro experiments indicated that two of these clocks (Levine and Lin) correlated with aging hallmarks like cellular senescence and mitochondrial dysfunction, leading to the development of a "metaclock" that more accurately predicts mortality and aligns better with aging characteristics compared to individual clocks.
Top posts
Most liked on X and BlueskyWhen we think of age we typically think of our chronological age. This is starting to change... Biological age may become more important. But what is it and how is it measured? Let me introduce aging clocks --> https://t.co/MBWzInonsr @LongevityTech #scicomm #AcademicYouTube https://t.co/6xsbWeTwlT
Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/8njm92M74g
Here's my latest video! https://t.co/tISWal6jcz
Having above-average RHR and HRV(for my age) may be contributing to a relatively youthful biological age: https://t.co/FEyGVxYmha https://t.co/4930U4ySTq
Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/tor7oZ0KXj https://t.co/8hGZdBIUNu
All mentions
Innovative Aging Clocks: Understanding Biological Age Measurement
In this video, we will discuss aging clocks, which measure not just chronological age but biological age derived from various biomarkers. We will explore methods like the BiT age clock that enhance accuracy in…
Impact of Niacin and NAD on Epigenetic Aging Dynamics
Explore the implications of niacin and NAD levels on the pace of epigenetic aging. This video discusses how various epigenetic clocks can reflect different biological aging processes, linking metabolism, immunity, and…
Understanding Biological Age Through Advanced Blood Testing Techniques
This video explores the quantification of biological age, leveraging advanced blood tests and innovative epigenetic clocks. Discover how multiomics data connects aging processes with metabolism and immunity, offering…
Understanding the Epigenetic Age and Its Implications
Explore the underlying features of epigenetic aging clocks, which measure biological aging across various tissues. Despite weak correlations, analysis reveals connections between these clocks and metabolism, immunity…
Understanding Epigenetic Aging Clocks and Metaclock Insights
Join us as we explore what epigenetic clocks reveal about biological aging across different tissues. Our analysis discusses how these clocks correlate with metabolism, immunity, and autophagy, and introduces the concept…
New Insights on Epigenetic Aging and NMN Supplementation
We have found that there is a lot of information on longevity and healthspan being published. This newsletter explores the underlying features of epigenetic aging clocks and their links to metabolism and immunity…
Resisting An Increased Epigenetic Speed Of Aging (14-Test Results) https://t.co/paW4fBJpFl via @YouTube
RT @mike_lustgarten: I agree, and the only way to know is to test! 14-test analysis posted yesterday... https://t.co/uF6F1I7o3l
I agree, and the only way to know is to test! 14-test analysis posted yesterday... https://t.co/uF6F1I7o3l https://t.co/ns5Fu2c2wG
My latest video is live on YT! Link: https://t.co/uF6F1I6QdN https://t.co/u9x1Ff1Pxa
@B_gudenas The idea that these clocks haven't been proven is inaccurate. See the published data in this video: https://t.co/yUxyS8LNRu
@drmarkhyman Eventually, the field will move past glucose, BP, and cholesterol to include other markers of health, including the kidneys, immune cells, inflammation, and more! https://t.co/CSOAbN6Ay8
@nutrition_facts A high vegetable diet is a part of my approach for slowing biological age: https://t.co/yUxyS8LNRu
@nutrition_facts Relatedly, https://t.co/3WrJE4LP7T
Already working on it! https://t.co/yUxyS8LNRu https://t.co/GHTYTIS75O
RT @mike_lustgarten: Here's my latest video! https://t.co/tISWal6jcz
@richroll @SergeyYoung200 A good start for living to 150 would be quantifying and optimizing biological age: https://t.co/yUxyS8LNRu
@GWelch_1 Thanks Geoff Welch. I haven't, because most of my blood biomarkers are good (https://t.co/O9NjSKCiwf). Should that change, and if I can't alter it with my current approach, I may try it.
|・ω・`)フムフム "Aging clocks - how to measure biological age." on YouTube - https://t.co/bnpWLmLLgx
RT @mike_lustgarten: @andy_d_lee @realNathanCheng @beondeck @adanguyenx @michellebkwok Biological age can definitely be optimized: https:/…
@andy_d_lee @realNathanCheng @beondeck @adanguyenx @michellebkwok Biological age can definitely be optimized: https://t.co/yUxyS8LNRu
@drmarkhyman Exercise is a big part of my approach for optimizing biological age: https://t.co/yUxyS8LNRu
@metapredict @DrMorganLevine @CharlesMBrenner Several studies have used them across time for dynamics + most are generally reliable across tech reps and that can be further improved (https://t.co/6Im8yBy3nW). Clocks more associated with mortality also generally predict higher age acc for tumors (https://t.co/hU3VK35zk2).
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @weissiam: Solid overview of aging clocks by @EleanorSheekey - https://t.co/H3fmAsnklA
Solid overview of aging clocks by @EleanorSheekey - https://t.co/H3fmAsnklA
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @mike_lustgarten: Having above-average RHR and HRV(for my age) may be contributing to a relatively youthful biological age: https://t.c…
RT @mike_lustgarten: Having above-average RHR and HRV(for my age) may be contributing to a relatively youthful biological age: https://t.c…
RT @mike_lustgarten: Having above-average RHR and HRV(for my age) may be contributing to a relatively youthful biological age: https://t.c…
RT @mike_lustgarten: Having above-average RHR and HRV(for my age) may be contributing to a relatively youthful biological age: https://t.c…
Having above-average RHR and HRV(for my age) may be contributing to a relatively youthful biological age: https://t.co/FEyGVxYmha https://t.co/4930U4ySTq
@whoop Having above-average RHR and HRV(for my age) may be contributing to a relatively youthful biological age: https://t.co/FEyGVxYmha
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
RT @EleanorSheekey: When we think of age we typically think of our chronological age. This is starting to change... Biological age may b…
When we think of age we typically think of our chronological age. This is starting to change... Biological age may become more important. But what is it and how is it measured? Let me introduce aging clocks --> https://t.co/MBWzInonsr @LongevityTech #scicomm #AcademicYouTube https://t.co/6xsbWeTwlT
Quantifying Biological Age: Blood Test #3 in 2021 https://t.co/4DL8QAjZMv https://t.co/wEM1pMF5Xp
Here's my latest video! https://t.co/tISWal6jcz
#RaviVisvesvarayaSharadaPrasad. https://t.co/8FW0BBAXmH Quantifying Biological Age: Blood Test #3 in 2021 Michael Lustgarten, Ph.D.
New video coming tomorrow! Quantifying Biological Age: Blood Test #3 in 2021 https://t.co/tISWal6jcz
RT @agingdoc1: @foundmyfitness GrimmAge esp. (Horvath pub) shows promise: https://t.co/1o2JVX1nF3 but the best clock will depend on precise…
@foundmyfitness GrimmAge esp. (Horvath pub) shows promise: https://t.co/1o2JVX1nF3 but the best clock will depend on precisely what this surrogate variable is targeting. @DrMorganLevine is doing some great comparative work here as well: https://t.co/yg4kslhS9C https://t.co/gHH7SSbjha -@agingdoc1
Underlying features of epigenetic aging clocks in vivo and in vitro - Liu @agingdoc1 —This Meta-clock approach holds great promise & potential for ⬆️robustly predicting mortality & tracking targeted indices of hallmarks of aging➡️
RT @AgeingUK: Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/tor7oZ0KXj https://t.co/8hGZdBIUNu
RT @AgeingUK: Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/tor7oZ0KXj https://t.co/8hGZdBIUNu
RT @AgeingUK: Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/tor7oZ0KXj https://t.co/8hGZdBIUNu
Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/tor7oZ0KXj https://t.co/8hGZdBIUNu
@AndrewMerle Epigenetic clocks, pioneered by Steve Horvath show great promise as a biomarkers of biological age. That reversing them can reverse aging is more controversial but epigenetic reprogramming results and iPSC provide favorable POC evidence. Deep dive here: https://t.co/Sfgce7foHT
RT @AdamsBioAging: Thoughtful article from Morgan Levine and co. Underlying features of epigenetic aging clocks in vivo and in vitro - Li…
RT @AdamsBioAging: Thoughtful article from Morgan Levine and co. Underlying features of epigenetic aging clocks in vivo and in vitro - Li…
RT @AdamsBioAging: Thoughtful article from Morgan Levine and co. Underlying features of epigenetic aging clocks in vivo and in vitro - Li…
Thoughtful article from Morgan Levine and co. Underlying features of epigenetic aging clocks in vivo and in vitro - Liu - - Aging Cell - Wiley Online Library https://t.co/cAnLqfo2dT
"we developed a meta‐clock that demonstrated improved prediction for mortality and robustly related to hallmarks of aging in vitro than single clocks." Underlying features of #epigenetic #aging #clocks in vivo and in vitro https://t.co/KdgMp4i8IP
RT @AgingBiology: Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/8njm92M74g
RT @AgingBiology: Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/8njm92M74g
Underlying features of epigenetic aging clocks in vivo and in vitro - Liu - - Aging Cell - Wiley Online Library https://t.co/2oKQHp2mrl
RT @AgingBiology: Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/8njm92M74g
RT @AgingBiology: Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/8njm92M74g
Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/8njm92M74g
Underlying features of #epigenetic #aging #clocks in vivo and in vitro - Two clocks (#Levine and #Lin) were accelerated in accordance with two #hallmarks of #aging-#cellular #senescence and #mitochondrial #dysfunction. https://t.co/yg4kslhS9C
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
Underlying features of epigenetic aging clocks in vivo and in vitro - Liu - - Aging Cell - Wiley Online Library https://t.co/r7u8VComuH
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
Our collaborator @DrMorganLevine + team examine 11 different epigenetic clocks https://t.co/zyhre5KbkY in tissues and cells. @AgingCell
RT @DrMorganLevine: Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
Our new paper is now out in @AgingCell discussing features of different #epigeneticclocks https://t.co/pFsxpavZ5r
Underlying features of epigenetic aging clocks in vivo and in vitro https://t.co/AWMm0npsDb https://t.co/JN78slfifq
They found the Levine & Lin #epigenetic #clocks “accelerated” cellular #senescence & #mitochondrial dysfunction hallmarks & therefore developed a meta‐clock that improved #mortality & related #hallmarks of #aging in vitro. https://t.co/KHxxiGwqBs