Biol Rev Camb Philos Soc February 2021 PMID 32965076

The biology of human hair greying.

James D B O'Sullivan, Carina Nicu, Martin Picard, Jérémy Chéret, Barbara Bedogni, Desmond J Tobin, Ralf Paus

Mentions

80
Peak: 6 in Aug 2025
across 8 sources since Nov 2020

Extended reach

223,073
potential audience

Total likes

2,354

Video views

191,813

Mentions per month

Nov 2020 – Dec 2025

Where it's discussed

  • TikTok42 posts
  • Facebook10 posts
  • News9 articles
  • X / Twitter8 posts
  • Instagram4 posts
  • Reddit4 posts
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

The discussions include comments like dismissing the link between long-term pigmentation loss and systemic aging and mentions of possible natural interventions such as calcium pantothenate and antioxidants, with phrases like 'awesome review' indicating appreciation. The tone is casual and somewhat speculative, leading to an overall neutral impact assessment.

AgreementNeither agree nor disagree

The discussions show mixed opinions; some users dismiss the connection between hair greying and systemic aging, while others acknowledge certain factors involved.

InterestModerate interest

Most users find the topic somewhat interesting, especially those mentioning potential interventions like calcium pantothenate and melatonin.

EngagementNeutral engagement

The conversations are relatively superficial, with users referencing the publication broadly without deep analysis or critique.

ImpactNeutral impact

Overall, these discussions seem to have limited influence on changing opinions or driving further research, reflecting a moderate recognition of the topic's importance.

Abstract in brief

  • Human hair greying begins with a decline in melanin production within hair follicle pigment cells, driven by factors like reduced tyrosinase activity and cell death, with irreversible greying occurring after the depletion of melanocyte stem cells in the hair follicle.
  • Oxidative damage plays a key role in the process, disrupting melanocyte survival, stem cell maintenance, and enzymatic functions necessary for pigment production, while genetic and hormonal factors also influence greying, though their exact roles are still being researched.
  • The complex molecular mechanisms underlying greying involve neuroendocrine factors such as hormones and transcription factors that regulate melanocyte activity; however, a definitive model explaining how these factors modulate greying remains undeveloped.]

Top posts

Most liked on X and Bluesky
Julia B.
@JuliaB_fitness · X

@celinehalioua + Calcium pantothenate (and likely melatonin + high dose #omega3 (TNF etc inhibition). Awesome review: The biology of human hair greying. 2020 https://t.co/tCu7LN7N4t https://t.co/fE8Serw3k0

Nov 27, 2020 · 22 likes · 2 shares · 2,262 followers View post →
Madam Mitochondria
@Madam_Mito · X

@yeeseak Check this; “The study of long-term pigmentation loss is likely to promote our understanding of other systemic ageing controls” (This isn’t true at all )

Dec 13, 2023 · 3 likes · 10,665 followers View post →
Cambridge Philosophical Society
@CamPhilSoc · X

Worried about going grey? Don't be, many underlying factors contribute to hair greying and not all are age related. Read: "The biology of human hair greying" in Biological Reviews, Volume 96, Issue 1, February 2021: https://t.co/qtTYTe0Obr https://t.co/86zECnkNxB

Aug 26, 2021 · 2 likes · 1,686 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @JuliaB_fitness: @celinehalioua + Calcium pantothenate (and likely melatonin + high dose #omega3 (TNF etc inhibition). Awesome review: T…

Feb 13, 2024 · 2 shares · 10,665 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

The biology of human hair greying https://t.co/bttfppfkgX #Basically

Jan 26, 2023 · 2,239 followers View post →
Science and Dogs
@ScienceOfDogs · X

On going grey https://t.co/65GaHBX8Vy

Feb 21, 2021 · 1,694 followers View post →

All mentions

Jonas Rangel
@JonasRangel20 · X

RT @JuliaB_fitness: @celinehalioua + Calcium pantothenate (and likely melatonin + high dose #omega3 (TNF etc inhibition). Awesome review: T…

Feb 13, 2024 · 2 shares · 15 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @JuliaB_fitness: @celinehalioua + Calcium pantothenate (and likely melatonin + high dose #omega3 (TNF etc inhibition). Awesome review: T…

Feb 13, 2024 · 2 shares · 10,665 followers View post →
Madam Mitochondria
@Madam_Mito · X

@yeeseak Check this; “The study of long-term pigmentation loss is likely to promote our understanding of other systemic ageing controls” (This isn’t true at all )

Dec 13, 2023 · 3 likes · 10,665 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

The biology of human hair greying https://t.co/bttfppfkgX #Basically

Jan 26, 2023 · 2,239 followers View post →
|| AOL Tarun ||
@tarundsnaol · X

RT @CamPhilSoc: Worried about going grey? Don't be, many underlying factors contribute to hair greying and not all are age related. Read: "…

Feb 21, 2022 · 1,323 followers View post →
Cambridge Philosophical Society
@CamPhilSoc · X

Worried about going grey? Don't be, many underlying factors contribute to hair greying and not all are age related. Read: "The biology of human hair greying" in Biological Reviews, Volume 96, Issue 1, February 2021: https://t.co/qtTYTe0Obr https://t.co/86zECnkNxB

Aug 26, 2021 · 2 likes · 1,686 followers View post →
Science and Dogs
@ScienceOfDogs · X

On going grey https://t.co/65GaHBX8Vy

Feb 21, 2021 · 1,694 followers View post →
Julia B.
@JuliaB_fitness · X

@celinehalioua + Calcium pantothenate (and likely melatonin + high dose #omega3 (TNF etc inhibition). Awesome review: The biology of human hair greying. 2020 https://t.co/tCu7LN7N4t https://t.co/fE8Serw3k0

Nov 27, 2020 · 22 likes · 2 shares · 2,262 followers View post →
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