November 2020 PMID 32989322

The mutational signature profile of known and suspected human carcinogens in mice.

Laura Riva, Arun R Pandiri, Yun Rose Li, Alastair Droop, James Hewinson, Michael A Quail, Vivek Iyer, Rebecca Shepherd, Ronald A Herbert, Peter J Campbell, Robert C Sills, Ludmil B Alexandrov, Allan Balmain, David J Adams

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Mentions

71
Peak: 22 in Sep 2020
across 5 sources since Sep 2020

Extended reach

201,647
potential audience

Total likes

121

Video views

500

Mentions per month

Sep 2020 – May 2025

Where it's discussed

  • X / Twitter51 posts
  • News12 articles
  • YouTube4 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions reflect strong interest and moderate engagement, with many posts citing specific mutational signatures like SBS19 and SBS42 to illustrate key findings, using technically precise language that emphasizes the study’s relevance to understanding environmental carcinogens and their genetic impacts.

AgreementModerate agreement

Most discussions support the significance of the study, emphasizing its contribution to understanding carcinogens and their genetic effects.

InterestHigh interest

The posts show high interest, with many highlighting specific mutational signatures and their links to environmental pollutants.

EngagementModerate engagement

Participants reference detailed aspects of the research, such as mutational signatures SBS19 and SBS42, indicating moderate engagement with the scientific content.

ImpactModerate impact

Posts suggest that the findings could influence future research on cancer and environmental health, though some focus more on acknowledging the study's importance than on immediate applications.

Abstract in brief

  • This study analyzed how various known and suspected carcinogens affect tumor genomes in mice, finding that most do not produce unique mutational signatures or increase overall mutation levels, as many mutations come from natural tissue-specific processes.
  • Researchers identified specific mutational signatures caused by exposure to cobalt, vinylidene chloride, and 1,3-trichloropropane, and linked some of these signatures (SBS19 and SBS42) to human tumors associated with environmental pollutants.
  • The findings help map the genetic effects of different carcinogens across species, enhancing our understanding of how environmental agents contribute to cancer development in humans.]

Top posts

Most liked on X and Bluesky
Nature Genetics
@NatureGenet · X

The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh https://t.co/MAPCsbf84M

Sep 28, 2020 · 46 likes · 19 shares · 128,343 followers View post →
Safia Danovi
@SafiaDanovi · X

Still pondering the recent @NatureGenet paper on the mutational signature profile of known and suspected human carcinogens in mice by @David_J_Adams + colleagues? Need another hit? Check out this News and Views article by @nlbigas . Yes, we spoil you. https://t.co/reiSsXWDjX

Nov 2, 2020 · 18 likes · 4 shares · 2,010 followers View post →
DavideChicco.it
@DavideChicco_it · X

Great article by @LauraRiva, @David_J_Adams, and their team just published on Nature Genetics @NatureGenet: "The mutational signature profile of known and suspected human carcinogens in mice" >>> https://t.co/OJXxDudlvF

Oct 9, 2020 · 6 likes · 1 share · 428 followers View post →
For health-promoting environments
@SilkeLeFay · X

#water #oncology Mutational signatures SBS19 and SBS42 are associated with exposure to 1,2,3-trichloropropane, a haloalkane and pollutant of drinking water. The mutational signature profile of known and suspected human carcinogens in mice https://t.co/PsONGLr1Q6

Jan 27, 2023 · 5 likes · 1 share · 4,601 followers View post →
EllisLab_
@EllisLab_ · X

The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics | great work from ⁦@David_J_Adams⁩ https://t.co/txket08sSd

Sep 28, 2020 · 4 likes · 2 shares · 3,951 followers View post →
mutational signatures twitbot
@mutSignatures · X

The mutational signature profile of known and suspected human carcinogens in mice. https://t.co/g6fW5u22Ef

Nov 21, 2020 · 2 likes · 252 followers View post →

All mentions

TANIMA
@sahatanima · X

https://t.co/WtPsALQQ62

May 28, 2025 · 10 followers View post →
TANIMA
@sahatanima · X

‘ENVIRONMENTAL EXPOSURE & CANCER CONNECTION’ XV METALS CARCINOGEN, MUTAG... https://t.co/szZs4S4ORG via @YouTube

May 28, 2025 · 10 followers View post →
TANIMA
@sahatanima · X

‘ENVIRONMENTAL EXPOSURE & CANCER CONNECTION’ XIV METALS: CARCINOGEN, MUT... https://t.co/Iw66qUpU1M via @YouTube

May 21, 2025 · 10 followers View post →
TANIMA
@sahatanima · X

‘ENVIRONMENTAL EXPOSURE & CANCER CONNECTION’ IV THE CASE FOR ENVIRONMENT... https://t.co/ObfsEwiEEH via @YouTube

Mar 7, 2025 · 10 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @SilkeLeFay: #water #oncology Mutational signatures SBS19 and SBS42 are associated with exposure to 1,2,3-trichloropropane, a haloalka…

Jan 29, 2023 · 1 share · 252 followers View post →
For health-promoting environments
@SilkeLeFay · X

#water #oncology Mutational signatures SBS19 and SBS42 are associated with exposure to 1,2,3-trichloropropane, a haloalkane and pollutant of drinking water. The mutational signature profile of known and suspected human carcinogens in mice https://t.co/PsONGLr1Q6

Jan 27, 2023 · 5 likes · 1 share · 4,601 followers View post →
Ariel Afek
@Afek7Afek · X

RT @MarsPioneer: The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics https://t.co/I9cIef8ZQC

Sep 10, 2022 · 2 shares · 1,474 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @MarsPioneer: The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics https://t.co/I9cIef8ZQC

Sep 10, 2022 · 2 shares · 252 followers View post →
Mars Pioneer
@MarsPioneer · X

The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics https://t.co/I9cIef8ZQC

Sep 10, 2022 · 1 like · 2 shares · 1,483 followers View post →
biotech archives
@bot_biotech · X

The mutational signature profile of known and suspected human carcinogens in mice https://t.co/YlXUMZgwzT

Apr 29, 2022 · 162 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @scsongcao: The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics https://t.co/E9ukGNykvH

May 5, 2021 · 1 share · 252 followers View post →
OncoPapers
@sccancerres · X

The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics https://t.co/E9ukGNykvH

May 5, 2021 · 1 share · 310 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @LiteratureFeed: Mutational Signatures: The mutational signature profile of known and suspected human carcinogens in mice. https://t.co/…

Dec 30, 2020 · 1 share · 252 followers View post →
LiteratureFeed
@LiteratureFeed · X

Mutational Signatures: The mutational signature profile of known and suspected human carcinogens in mice. https://t.co/RaJ1VAPnrW https://t.co/XCm1I7Bu0Q

Dec 30, 2020 · 2 likes · 1 share · 156 followers View post →
mutational signatures twitbot
@mutSignatures · X

The mutational signature profile of known and suspected human carcinogens in mice. https://t.co/g6fW5tKrfF

Dec 13, 2020 · 1 like · 252 followers View post →
mutational signatures twitbot
@mutSignatures · X

The mutational signature profile of known and suspected human carcinogens in mice. https://t.co/g6fW5u22Ef

Nov 21, 2020 · 2 likes · 252 followers View post →
Ian Green
@oncohistone · X

RT @SafiaDanovi: Still pondering the recent @NatureGenet paper on the mutational signature profile of known and suspected human carcinogens…

Nov 3, 2020 · 4 shares · 731 followers View post →
mutational signatures twitbot
@mutSignatures · X

The mutational signature profile of known and suspected human carcinogens in mice. https://t.co/g6fW5tKrfF

Nov 3, 2020 · 252 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @SafiaDanovi: Still pondering the recent @NatureGenet paper on the mutational signature profile of known and suspected human carcinogens…

Nov 2, 2020 · 4 shares · 252 followers View post →
Samir Amin
@SBAmin · X

RT @SafiaDanovi: Still pondering the recent @NatureGenet paper on the mutational signature profile of known and suspected human carcinogens…

Nov 2, 2020 · 4 shares · 887 followers View post →
Sandy Anderson
@ara_anderson · X

RT @SafiaDanovi: Still pondering the recent @NatureGenet paper on the mutational signature profile of known and suspected human carcinogens…

Nov 2, 2020 · 4 shares · 5,371 followers View post →
Safia Danovi
@SafiaDanovi · X

Still pondering the recent @NatureGenet paper on the mutational signature profile of known and suspected human carcinogens in mice by @David_J_Adams + colleagues? Need another hit? Check out this News and Views article by @nlbigas . Yes, we spoil you. https://t.co/reiSsXWDjX

Nov 2, 2020 · 18 likes · 4 shares · 2,010 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @BioDecoded: The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics https://t.co/qj2N9sG7ny…

Oct 10, 2020 · 1 share · 252 followers View post →
BioDecoded
@BioDecoded · X

The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics https://t.co/qj2N9sG7ny #Genomics

Oct 10, 2020 · 1 share · 8,904 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @DavideChicco_it: Great article by @LauraRiva, @David_J_Adams, and their team just published on Nature Genetics @NatureGenet: "The mutat…

Oct 9, 2020 · 1 share · 252 followers View post →
DavideChicco.it
@DavideChicco_it · X

Great article by @LauraRiva, @David_J_Adams, and their team just published on Nature Genetics @NatureGenet: "The mutational signature profile of known and suspected human carcinogens in mice" >>> https://t.co/OJXxDudlvF

Oct 9, 2020 · 6 likes · 1 share · 428 followers View post →
b_hring_m
@b_hring_m · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Oct 6, 2020 · 19 shares · 125 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @AndresFCardonaZ: The mutational signature profile of known and suspected human carcinogens in mice https://t.co/cd17rXaEQA

Oct 1, 2020 · 1 share · 252 followers View post →
Andres F. Cardona
@AndresFCardonaZ · X

The mutational signature profile of known and suspected human carcinogens in mice https://t.co/cd17rXaEQA

Oct 1, 2020 · 1 like · 1 share · 8,810 followers View post →
Understanding Animal Research
@animalresearch · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 30, 2020 · 19 shares · 8,043 followers View post →
Gemma Balmer-Kemp
@gem_424 · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 29, 2020 · 19 shares · 185 followers View post →
LabAnimal
@LA_NatRes · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 29, 2020 · 19 shares · 1,889 followers View post →
Doruk Beyter
@dbeyter · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 29, 2020 · 19 shares · 199 followers View post →
Inês Sequeira
@InesSequeira7 · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 29, 2020 · 19 shares · 942 followers View post →
Stefano de Pretis
@ilDepoMI · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 29, 2020 · 19 shares · 109 followers View post →
Aedin Culhane (@AedinCulhane@genomic.social)
@AedinCulhane · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 3,786 followers View post →
Roel Verhaak
@roelverhaak · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 5,041 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 252 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @EllisLab_: The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics | great work from ⁦@Davi…

Sep 28, 2020 · 2 shares · 252 followers View post →
mutational signatures twitbot
@mutSignatures · X

RT @LupinCambridge: The mutational signature profile of known and suspected human carcinogens in mice https://t.co/SUmkULGZiZ

Sep 28, 2020 · 1 share · 252 followers View post →
Heer Lab
@Heer_Lab · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 1,616 followers View post →
Mattia Pelizzola
@MattiaPelizzola · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 397 followers View post →
Safia Danovi
@SafiaDanovi · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 2,010 followers View post →
Eduardo Maury, MD, PhD
@emauryg · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 668 followers View post →
David F. Antoran
@LupinCambridge · X

The mutational signature profile of known and suspected human carcinogens in mice https://t.co/SUmkULGZiZ

Sep 28, 2020 · 1 share · 702 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @EllisLab_: The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics | great work from ⁦@Davi…

Sep 28, 2020 · 2 shares · 1,318 followers View post →
EllisLab_
@EllisLab_ · X

The mutational signature profile of known and suspected human carcinogens in mice | Nature Genetics | great work from ⁦@David_J_Adams⁩ https://t.co/txket08sSd

Sep 28, 2020 · 4 likes · 2 shares · 3,951 followers View post →
Victoria Hendry
@HendryVictoria · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 1,318 followers View post →
Nicolas Alcala
@nl_alcala · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 288 followers View post →
Laura Riva
@IauraRiVA · X

RT @NatureGenet: The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh ht…

Sep 28, 2020 · 19 shares · 548 followers View post →
Nature Genetics
@NatureGenet · X

The mutational signature profile of known and suspected human carcinogens in mice (Riva et al.) https://t.co/CbZjuYqoCh https://t.co/MAPCsbf84M

Sep 28, 2020 · 46 likes · 19 shares · 128,343 followers View post →