High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue.

Yang Liu, Mingyu Yang, Yanxiang Deng, Graham Su, Archibald Enninful, Cindy C Guo, Toma Tebaldi, Di Zhang, Dongjoo Kim, Zhiliang Bai, Eileen Norris, Alisia Pan, Jiatong Li, Yang Xiao, Stephanie Halene

December 2020

Synopsis of Social media discussions

The collective discussions reveal enthusiasm for the high-resolution multi-omics method, with influential posts calling it an 'amazing technical advance' and mentioning its ability to map gene and protein activity within tissue sections—highlighting both technical innovation and potential for transformative impact in biological research.

A
Agreement
 Moderate agreement

Most discussions express support or excitement about the technological advances described in the publication, indicating general agreement on its significance.

I
Interest
 High level of interest

The discussions show high curiosity, with many posts highlighting the innovative methods and potential applications, reflecting strong interest.

E
Engagement
 Moderate level of engagement

While some posts are merely sharing or acknowledging the publication, others involve technical comments and references, suggesting moderate to active engagement.

I
Impact
 High level of impact

Many posts suggest that this advancement could greatly influence fields like pathology and developmental biology, highlighting its high impactful potential.

Social Mentions

YouTube

4 Videos

Twitter

66 Posts

Blogs

6 Articles

News

8 Articles

Metrics

Video Views

195

Total Likes

161

Extended Reach

424,471

Social Features

84

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

High-Resolution Spatial Multi-Omics Sequencing Using Deterministic Barcoding

High-Resolution Spatial Multi-Omics Sequencing Using Deterministic Barcoding

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High-Resolution Spatial Multi-Omics Sequencing Using Deterministic Barcoding in Tissue

High-Resolution Spatial Multi-Omics Sequencing Using Deterministic Barcoding in Tissue

DBiTseq is a high-resolution spatial omics technique that uses microfluidic channels to deliver DNA barcodes onto tissue slides, allowing for the mapping of gene and protein activity directly within tissue sections. This method enables detailed spatial analysis at a 10-micron scale.

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March 23, 2024

51 views

High-Resolution Spatial Multi-Omics Using Deterministic Barcoding in Tissue

High-Resolution Spatial Multi-Omics Using Deterministic Barcoding in Tissue

Discover how DBiTseq enables detailed spatial mapping of gene and protein activity within tissue sections, using microfluidic barcode delivery for high-resolution multi-omics analysis at 10-micron scale.

Informative

March 26, 2024

38 views

High-Resolution Spatial Multi-Omics Using Deterministic Barcoding in Tissue

High-Resolution Spatial Multi-Omics Using Deterministic Barcoding in Tissue

High-Resolution Spatial Omics Sequencing via Deterministic Barcoding in Tissue offers detailed mapping of gene and protein activity within tissue sections, enabling advancements in developmental biology, cancer research, neuroscience, and pathology.

Informative

March 24, 2024

17 views

  • HT Vvang
    @xchromosome (Twitter)

    First demonstration of spatial multi-omics sequencing back to 2020 High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue @CellPressNews https://t.co/VcZAsGTPG2
    view full post

    October 20, 2023

  • Zhiqiang Sha (@zhiqiangsha.bsky.social)
    @sha_zhiqiang (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/iINhOaKSYZ
    view full post

    March 10, 2023

  • RRID Robot
    @RobotRrid (Twitter)

    RRIDs were included in the Cell paper "High-Spatial-Resolution Multi-Omics Sequencing via…" (https://t.co/09oc7636KT). RRIDs like this improve reproducibility in scientific research. #RRID #reproducibility
    view full post

    April 25, 2021

  • Robert Homer
    @rjhomer57 (Twitter)

    @Vik_deshpandeMD Why not genomics? https://t.co/WvDCxjTwqb
    view full post

    January 14, 2021

    2

  • M Herrera-Rivero
    @HerreraR_biomed (Twitter)

    This is an awesome technical advance: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue - https://t.co/TfeuyyEp0A
    view full post

    January 10, 2021

    1

  • uFluidix Inc.
    @uFluidix (Twitter)

    #Microfluidic channels can deliver barcodes to the surface of a tissue slide for encoding spatial information resulting in a 2D mosaic of tissue pixels that can be used for spatial co-profiling of gene expression and proteins of interest. https://t.co/iobINsGhZF #multiomics
    view full post

    January 8, 2021

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  • DryWetty
    @DryWetty (Twitter)

    また新しくRNA・タンパク質発現が空間的に見える手法が。シングルセルと組み合わせるのが流行り。 High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue: Cell https://t.co/UBvzpEQiqJ
    view full post

    December 11, 2020

    1

  • lbgbox
    @lbgbox (Twitter)

    RT @LGMartelotto: Excited that I might be able to get my hands on this amazing ST device! 2021 is coming good... @hoheyn this is also righ…
    view full post

    December 11, 2020

    3

  • Minh Tran
    @MinhTran_GK (Twitter)

    RT @LGMartelotto: Excited that I might be able to get my hands on this amazing ST device! 2021 is coming good... @hoheyn this is also righ…
    view full post

    December 11, 2020

    3

  • Eric Minwei Liu
    @EricM_Liu (Twitter)

    RT @LGMartelotto: Excited that I might be able to get my hands on this amazing ST device! 2021 is coming good... @hoheyn this is also righ…
    view full post

    December 10, 2020

    3

  • Luciano Martelotto
    @LGMartelotto (Twitter)

    Excited that I might be able to get my hands on this amazing ST device! 2021 is coming good... @hoheyn this is also right along your alley! https://t.co/H2IHtPYTpv
    view full post

    December 10, 2020

    39

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  • Joshua Elkington
    @elkingtonxy (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue - https://t.co/Qq2xyoAlqS
    view full post

    November 29, 2020

    3

  • Susan Heavey
    @susan_heavey (Twitter)

    Only just noticed I forgot the link
    view full post

    November 27, 2020

    2

  • Sacha LEBON
    @SachaLEBON (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
    view full post

    November 27, 2020

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  • CCB_VIB_KUL
    @vib_ccb (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
    view full post

    November 27, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @PubTrend: Trending on PubMed: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. https://t.co/XJ2Hz…
    view full post

    November 21, 2020

    1

  • PubMed Trending
    @PubTrend (Twitter)

    Trending on PubMed: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. https://t.co/XJ2HzOqVhv
    view full post

    November 21, 2020

    1

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @sc_papers: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. https://t.co/06xh3FLDU1 https://t.co/Q…
    view full post

    November 16, 2020

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  • single cell papers
    @sc_papers (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. https://t.co/06xh3FLDU1 https://t.co/QS2mE2EWme
    view full post

    November 16, 2020

    1

  • Biomage
    @BiomageLtd (Twitter)

    "High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue" out now in @CellPressNews. Use of new DBiT-seq technology. Congrats @RongFan8! #scRNAseq #spatialtranscriptomics https://t.co/9ciKn4AVhQ
    view full post

    November 16, 2020

  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @Osamu_ON: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/YxoYsCUpxE
    view full post

    November 15, 2020

    1

  • Osamu Onodera　MD. PhD.
    @Osamu_ON (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/YxoYsCUpxE
    view full post

    November 15, 2020

    1

  • Tain Luquez
    @TainLuquez (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
    view full post

    November 15, 2020

    11

  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @ZhenpengQin: check out the new paper on "High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue" from @Ro…
    view full post

    November 14, 2020

    1

  • Zhenpeng Qin
    @ZhenpengQin (Twitter)

    check out the new paper on "High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue" from @RongFan8 and colleagues, published in Cell https://t.co/AOdr4c9ZJE
    view full post

    November 14, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @ZivShulman: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/N5L3ZHBOS2
    view full post

    November 14, 2020

    1

  • Ziv Shulman Lab
    @ZivShulman (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/N5L3ZHBOS2
    view full post

    November 14, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @ioavlachos: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/9nmAcdpiQb
    view full post

    November 14, 2020

    1

  • Ioannis Vlachos // @ioavlachos.bsky.social
    @ioavlachos (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/9nmAcdpiQb
    view full post

    November 14, 2020

    1

  • Francesca Finotello
    @Francesca_Fin_ (Twitter)

    RT @LabPagani: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue: Cell https://t.co/AOYC8VrAct
    view full post

    November 14, 2020

    2

  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @LabPagani: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue: Cell https://t.co/AOYC8VrAct
    view full post

    November 14, 2020

    2

  • Vidhya Ravi
    @Vidhya1227 (Twitter)

    RT @Pluchinolab: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue: Cell https://t.co/UdjrmzDjfM
    view full post

    November 14, 2020

    2

  • lbgbox
    @lbgbox (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
    view full post

    November 14, 2020

    11

  • Darrol Baker
    @darrolb (Twitter)

    Barcoding in tissue for spatial omics sequencing (DBiT-seq) for co-mapping of mRNAs and proteins in a formaldehyde-fixed tissue slide via next-generation sequencing (NGS) https://t.co/1WvJPXheId
    view full post

    November 14, 2020

  • Pagani Lab
    @LabPagani (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue: Cell https://t.co/AOYC8VrAct
    view full post

    November 14, 2020

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  • Ranjan Kumar Maji, PhD
    @ranjankrmaji (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 14, 2020

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  • Kelvin Yip
    @KelvinHYYip (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 13, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @Pluchinolab: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue: Cell https://t.co/UdjrmzDjfM
    view full post

    November 13, 2020

    2

  • Thomas Ashhurst
    @TomAsh_1 (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 13, 2020

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  • Pluchino lab - Regenerative Neuroimmunology
    @Pluchinolab (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue: Cell https://t.co/UdjrmzDjfM
    view full post

    November 13, 2020

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  • Stephen Kearney
    @s_j_kearney (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 13, 2020

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  • James Hadfield
    @coregenomics (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 13, 2020

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  • Harry Sokol
    @h_sokol (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
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    November 13, 2020

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  • Camilla Cerutti ☮️
    @ccamilla81 (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
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    November 13, 2020

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  • Dr. Neil Ashley
    @NotWIMM (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
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    November 13, 2020

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  • P. stipticus
    @bitter_oyster (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
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    November 13, 2020

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  • Nick Wong AU/MEL
    @methylnick (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 13, 2020

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  • Bree
    @BreeKB_ (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 13, 2020

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  • David Russler-Germain, MD/PhD
    @dgermain21 (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
    view full post

    November 13, 2020

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  • Ying
    @ysha_168 (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
    view full post

    November 13, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @jsantoyo: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. https://t.co/NrUd3jCoVA
    view full post

    November 13, 2020

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  • Javier Santoyo
    @jsantoyo (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue. https://t.co/NrUd3jCoVA
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    November 13, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @gottapatchemall: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/lFborGCgZC https://t…
    view full post

    November 13, 2020

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  • Jen Li
    @DrJenLi_Renal (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
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    November 13, 2020

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  • Jen Li
    @JLi_Renal (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
    view full post

    November 13, 2020

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  • Alex Naka
    @gottapatchemall (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/lFborGCgZC https://t.co/RoSaCQ4Fh1
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    November 13, 2020

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  • Sharan Janjuha
    @sharan_janjuha (Twitter)

    RT @CellCellPress: New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.…
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    November 13, 2020

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  • Dartmouth Genomics
    @Dart_DNA (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
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    November 13, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @Abdul_Squared: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/ecnLlcJVTp
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    November 13, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @LGMartelotto: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
    view full post

    November 13, 2020

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  • AbdulAbdul
    @Abdul_Squared (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/ecnLlcJVTp
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    November 13, 2020

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  • Luciano Martelotto
    @LGMartelotto (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/GHRQez7thd
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    November 13, 2020

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  • Benedict Spinoza ❁
    @spinobot (Twitter)

    RT @genebrew: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/Yfrewd2J9V
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    November 13, 2020

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  • Rahul Karnik
    @genebrew (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/Yfrewd2J9V
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    November 13, 2020

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  • Cell Genomics
    @CellGenomics (Twitter)

    High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/QBSi4xdBQN
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    November 13, 2020

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  • Cell
    @CellCellPress (Twitter)

    New Resource now online: High-Spatial-Resolution Multi-Omics Sequencing via Deterministic Barcoding in Tissue https://t.co/qwGGp8k4MM
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    November 13, 2020

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Abstract Synopsis

  • DBiTseq is a high-resolution spatial omics technique that uses microfluidic channels to deliver DNA barcodes onto tissue slides, allowing for the mapping of gene and protein activity directly within tissue sections.
  • The process involves applying two sets of barcodes (A150 and B150) across tissue in a crossflow pattern, which creates unique 2D barcoded "pixels" that identify specific tissue regions, enabling detailed spatial analysis of tissue types and features in early development and disease models.
  • This method produces gene expression data at a very fine scale (10-micron pixels) that match single-cell transcriptomes, making it easy for researchers—regardless of microfluidics experience—to identify and study cell types in various fields like developmental biology, cancer research, neuroscience, and pathology.]