Pharmacol Ther May 2021 PMID 33189715

Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine.

S Kohtala, O Alitalo, M Rosenholm, S Rozov, T Rantamäki

Mentions

17
Peak: 5 in Dec 2020
across 2 sources since Nov 2020

Extended reach

16,210
potential audience

Total likes

204

Video views

3,894

Mentions per month

Nov 2020 – Oct 2023

Where it's discussed

  • X / Twitter15 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone and choice of words reflect genuine enthusiasm and acknowledgment of the publication's significance, with phrases like 'important' and 'highlighting the shared ground' emphasizing the article's potential to influence future research. Posts referencing the review as 'very interesting' or calling it a 'must consider' demonstrate active engagement, especially among researchers and clinicians interested in rapid-acting antidepressants and neurobiology.

AgreementModerate agreement

Most discussions recognize the importance of integrating sleep and circadian biology with ketamine's antidepressant effects, showing general support.

InterestHigh interest

The discussion demonstrates high interest, especially among those involved in neuropharmacology and neuroscience, with references to specific mechanisms and potential therapeutic advancements.

EngagementModerate engagement

Posts include sharing links, emphasizing shared ground between sleep and circadian rhythms, and highlighting the significance of the review, indicating moderate but genuine engagement.

ImpactModerate impact

The discussions underscore the relevance of this research for advancing treatment strategies in depression, though some posts emphasize its preliminary or theoretical nature, suggesting moderate perceived impact.

Abstract in brief

  • This article discusses how ketamine is effective in quickly reducing depression and suicidal thoughts but highlights the slow progress in turning research into new treatments due to limited understanding of how circadian rhythms and sleep influence its effects.
  • It emphasizes that while ketamine's immediate effects last only hours, its antidepressant benefits peak after about a day and last for several days, suggesting that daily biological processes like sleep and circadian cycles are crucial to understanding its full impact.
  • The authors review new hypotheses connecting sleep, circadian regulation, and ketamine's neurobiological effects, arguing that considering these factors may be key to developing better treatments for depression.]

Top posts

Most liked on X and Bluesky
Samuel Kohtala
@samuelkohtala · X

Article in press! I consider this work important for highlighting the shared ground between #sleep, #circadianrhythm and rapid #antidepressant mechanisms. Time is of the essence: Coupling sleep-wake and circadian neurobiology. https://t.co/Fd5J2x00yE #ketamine @TomiRantamki

Nov 13, 2020 · 8 likes · 2 shares · 571 followers View post →
Jari Yli-Kauhaluoma
@JYK_Viikki · X

⏳Time is of the essence: Coupling sleep-wake and circadian neurobiology... https://t.co/WOFDv1EdvC A new paper by @samuelkohtala #OkkoAlitalo #MarkoRosenholm #StanislavRozov & @TomiRantamki #DrugResearchProgram #FTDK #viikkicampus @LifeSciHelsinki

May 6, 2021 · 7 likes · 4 shares · 1,307 followers View post →
Tomi Rantamäki
@TomiRantamki · X

Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine. Final version out at! Thanks Okko, Stan, Marko and Samuel. https://t.co/3wh0fQXJey

Dec 7, 2020 · 6 likes · 3 shares · 211 followers View post →
Samuel Kohtala
@samuelkohtala · X

I want to highlight our latest review: "Time is of the essence: Coupling sleep-wake and circadian neurobiology" https://t.co/Fd5J2x00yE Very interesting stuff for anyone working with rapid-acting antidepressant treatments, #neuropharmacology or #neuroscience

Dec 9, 2020 · 3 likes · 1 share · 571 followers View post →
Palva Lab
@PalvaLab · X

RT @samuelkohtala: Article in press! I consider this work important for highlighting the shared ground between #sleep, #circadianrhythm and…

Nov 15, 2020 · 2 shares · 2,421 followers View post →
Life Sciences University of Helsinki
@LifeSciHelsinki · X

RT @JYK_Viikki: ⏳Time is of the essence: Coupling sleep-wake and circadian neurobiology... https://t.co/WOFDv1EdvC A new paper by @samuelk…

May 6, 2021 · 4 shares · 2,342 followers View post →

All mentions

Gweet Toesan
@Kiltagroomer133 · X

https://t.co/UUhTfS4e8g

Oct 16, 2023 · 774 followers View post →
Sleepwell
@SleepwellPrgm · X

RT @JYK_Viikki: ⏳Time is of the essence: Coupling sleep-wake and circadian neurobiology... https://t.co/WOFDv1EdvC A new paper by @samuelk…

May 18, 2021 · 4 shares · 57 followers View post →
Tomi Rantamäki
@TomiRantamki · X

RT @JYK_Viikki: ⏳Time is of the essence: Coupling sleep-wake and circadian neurobiology... https://t.co/WOFDv1EdvC A new paper by @samuelk…

May 7, 2021 · 4 shares · 211 followers View post →
Samuel Kohtala
@samuelkohtala · X

RT @JYK_Viikki: ⏳Time is of the essence: Coupling sleep-wake and circadian neurobiology... https://t.co/WOFDv1EdvC A new paper by @samuelk…

May 6, 2021 · 4 shares · 571 followers View post →
Life Sciences University of Helsinki
@LifeSciHelsinki · X

RT @JYK_Viikki: ⏳Time is of the essence: Coupling sleep-wake and circadian neurobiology... https://t.co/WOFDv1EdvC A new paper by @samuelk…

May 6, 2021 · 4 shares · 2,342 followers View post →
Jari Yli-Kauhaluoma
@JYK_Viikki · X

⏳Time is of the essence: Coupling sleep-wake and circadian neurobiology... https://t.co/WOFDv1EdvC A new paper by @samuelkohtala #OkkoAlitalo #MarkoRosenholm #StanislavRozov & @TomiRantamki #DrugResearchProgram #FTDK #viikkicampus @LifeSciHelsinki

May 6, 2021 · 7 likes · 4 shares · 1,307 followers View post →
Katja K
@katjaviivi · X

RT @TomiRantamki: Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine. Final v…

Jan 5, 2021 · 3 shares · 441 followers View post →
Sleepwell
@SleepwellPrgm · X

RT @TomiRantamki: Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine. Final v…

Dec 14, 2020 · 3 shares · 57 followers View post →
Poppy Douglas
@PoppyDouglas4 · X

RT @samuelkohtala: I want to highlight our latest review: "Time is of the essence: Coupling sleep-wake and circadian neurobiology" https://…

Dec 9, 2020 · 1 share · 75 followers View post →
Samuel Kohtala
@samuelkohtala · X

I want to highlight our latest review: "Time is of the essence: Coupling sleep-wake and circadian neurobiology" https://t.co/Fd5J2x00yE Very interesting stuff for anyone working with rapid-acting antidepressant treatments, #neuropharmacology or #neuroscience

Dec 9, 2020 · 3 likes · 1 share · 571 followers View post →
Samuel Kohtala
@samuelkohtala · X

RT @TomiRantamki: Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine. Final v…

Dec 8, 2020 · 3 shares · 571 followers View post →
Tomi Rantamäki
@TomiRantamki · X

Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine. Final version out at! Thanks Okko, Stan, Marko and Samuel. https://t.co/3wh0fQXJey

Dec 7, 2020 · 6 likes · 3 shares · 211 followers View post →
NeurocenterFI
@NeurocenterFI · X

RT @samuelkohtala: Article in press! I consider this work important for highlighting the shared ground between #sleep, #circadianrhythm and…

Nov 16, 2020 · 2 shares · 2,056 followers View post →
Palva Lab
@PalvaLab · X

RT @samuelkohtala: Article in press! I consider this work important for highlighting the shared ground between #sleep, #circadianrhythm and…

Nov 15, 2020 · 2 shares · 2,421 followers View post →
Samuel Kohtala
@samuelkohtala · X

Article in press! I consider this work important for highlighting the shared ground between #sleep, #circadianrhythm and rapid #antidepressant mechanisms. Time is of the essence: Coupling sleep-wake and circadian neurobiology. https://t.co/Fd5J2x00yE #ketamine @TomiRantamki

Nov 13, 2020 · 8 likes · 2 shares · 571 followers View post →