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Physiol Genomics January 2021 PMID 33197228

A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project.

Tarek M El-Achkar, Michael T Eadon, Rajasree Menon, Blue B Lake, Tara K Sigdel, Theodore Alexandrov, Samir Parikh, Guanshi Zhang, Dejan Dobi, Kenneth W Dunn, Edgar A Otto, Christopher R Anderton, Jonas M Carson, Jinghui Luo, Chris Park

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Mentions

23
Peak: 6 in Jan 2021
across 3 sources since Nov 2019

Extended reach

198,808
potential audience

Total likes

31

Video views

1,146

Mentions per month

Nov 2019 – Apr 2022

Where it's discussed

  • X / Twitter20 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

The discussions consistently praise the article's comprehensive approach to kidney tissue analysis, with phrases like 'rigor and reproducibility' and references to advanced 'transcriptomics' and 'metabolomics' methods indicating high engagement and perceived importance. The tone is enthusiastic, reflecting a strong consensus on its potential to influence future kidney disease research.

AgreementStrong agreement

Most discussions strongly support the importance and relevance of the publication, emphasizing its role in advancing kidney research.

InterestHigh interest

The discussions show high interest, referencing multiple aspects such as multimodal techniques, reproducibility, and clinical implications.

EngagementHigh engagement

Participants critically engage with the content, mentioning specific technologies and advocating for the standardization discussed in the article.

ImpactHigh impact

Many comments highlight the significant potential impact on kidney disease diagnosis and research, referring to innovations and future applications.

Abstract in brief

  • The Kidney Precision Medicine Project (KPMP) aims to create detailed 3D molecular maps of healthy and diseased human kidney tissues using advanced imaging and multiomics technologies, highlighting the importance of spatial and cellular resolution for understanding kidney diseases.
  • The project emphasizes a rigorous and standardized "follow the tissue" pipeline that ensures quality control, validation, and reproducibility across various technologies and institutions, including pilot experiments and peer review processes to maintain data integrity.
  • This integrated approach optimizes the use of scarce biopsy material, ensuring reliable and reproducible results, and provides a model for similar precision medicine initiatives by promoting collaboration, standardization, and rigorous validation across different research laboratories.]
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Top posts

Most liked on X and Bluesky
bioRxiv
@biorxivpreprint · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project https://t.co/IAJhkZ3wd8 #bioRxiv

Nov 6, 2019 · 9 likes · 2 shares · 138,527 followers View post →
American Physiological Society
@APSPhysiology · X

.@PhysiologicalG study discusses rigor & reproducibility guidelines from the Kidney Precision Medicine Project: #APSselect https://t.co/3xXBhNCbKj CC: @KPMProject, @AshkarLab @emblm @anderplants @azeloglu @beckysteckUM @BradRovin @MiKTMC @AlpersCharles https://t.co/ljTsvY6zi2

Jan 11, 2021 · 8 likes · 3 shares · 13,989 followers View post →
Physiological Genomics
@PhysiologicalG · X

#SuggestedRead "A multimodal & integrated approach to interrogate human kidney biopsies with rigor & reproducibility: guidelines from the Kidney Precision Medicine Project" by Tarek M. El-Achkar, et al https://t.co/B2Th3ZbLQC #KidneyDisease #Transcriptomics Fig 1

Apr 6, 2022 · 4 likes · 2 shares · 636 followers View post →
APS Publications
@APSPublications · X

A multimodal and integrated approach to interrogate human #kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project - new in @PhysiolGenomics https://t.co/ph8KCvcGy2 #KidneyDisease #metabolomics #proteomics https://t.co/cVEUHlOFSu

Jan 12, 2021 · 3 likes · 1 share · 7,400 followers View post →
APS Publications
@APSPublications · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project - new research in @PhysiologicalG https://t.co/NQu9e8gWig #transcriptomics #kidneydisease #proteomics #metabolomics https://t.co/yJA6mYS0TG

Nov 17, 2020 · 3 likes · 2 shares · 7,400 followers View post →
Liz Worthey
@lizworthey · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project https://t.co/sarh6Y7C8Y

Sep 27, 2020 · 2 likes · 5,517 followers View post →

All mentions

Hilary Coller
@CollerHilary · X

RT @PhysiologicalG: #SuggestedRead "A multimodal & integrated approach to interrogate human kidney biopsies with rigor & reproducibility: g…

Apr 6, 2022 · 2 shares · 74 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @PhysiologicalG: #SuggestedRead "A multimodal & integrated approach to interrogate human kidney biopsies with rigor & reproducibility: g…

Apr 6, 2022 · 2 shares · 8,215 followers View post →
Physiological Genomics
@PhysiologicalG · X

#SuggestedRead "A multimodal & integrated approach to interrogate human kidney biopsies with rigor & reproducibility: guidelines from the Kidney Precision Medicine Project" by Tarek M. El-Achkar, et al https://t.co/B2Th3ZbLQC #KidneyDisease #Transcriptomics Fig 1

Apr 6, 2022 · 4 likes · 2 shares · 636 followers View post →
Physiological Genomics
@PhysiologicalG · X

In honor of #KidneyWk 2021

Nov 2, 2021 · 636 followers View post →
Physiological Genomics
@PhysiologicalG · X

Research Article: "Precision Medicine and Complex Disease A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project." https://t.co/w3MXCzT3Vr

Feb 19, 2021 · 636 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @APSPublications: A multimodal and integrated approach to interrogate human #kidney biopsies with rigor and reproducibility: guidelines…

Jan 12, 2021 · 1 share · 8,215 followers View post →
APS Publications
@APSPublications · X

A multimodal and integrated approach to interrogate human #kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project - new in @PhysiolGenomics https://t.co/ph8KCvcGy2 #KidneyDisease #metabolomics #proteomics https://t.co/cVEUHlOFSu

Jan 12, 2021 · 3 likes · 1 share · 7,400 followers View post →
Evren U. Azeloglu
@azeloglu · X

RT @APSPhysiology: .@PhysiologicalG study discusses rigor & reproducibility guidelines from the Kidney Precision Medicine Project: #APSsele…

Jan 11, 2021 · 3 shares · 1,217 followers View post →
Tarek M. Ashkar (El-Achkar)
@AshkarLab · X

RT @APSPhysiology: .@PhysiologicalG study discusses rigor & reproducibility guidelines from the Kidney Precision Medicine Project: #APSsele…

Jan 11, 2021 · 3 shares · 652 followers View post →
Kidney Precision Medicine Project
@KPMProject · X

RT @APSPhysiology: .@PhysiologicalG study discusses rigor & reproducibility guidelines from the Kidney Precision Medicine Project: #APSsele…

Jan 11, 2021 · 3 shares · 1,386 followers View post →
American Physiological Society
@APSPhysiology · X

.@PhysiologicalG study discusses rigor & reproducibility guidelines from the Kidney Precision Medicine Project: #APSselect https://t.co/3xXBhNCbKj CC: @KPMProject, @AshkarLab @emblm @anderplants @azeloglu @beckysteckUM @BradRovin @MiKTMC @AlpersCharles https://t.co/ljTsvY6zi2

Jan 11, 2021 · 8 likes · 3 shares · 13,989 followers View post →
Mark Tomilo
@MTomilo · X

RT @APSPublications: A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines f…

Nov 18, 2020 · 2 shares · 58 followers View post →
Becky Steck
@beckysteckUM · X

RT @APSPublications: A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines f…

Nov 18, 2020 · 2 shares · 73 followers View post →
SingleCellHD
@sccHeidelberg · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project. https://t.co/FP4znjv1p8

Nov 18, 2020 · 921 followers View post →
APS Publications
@APSPublications · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project - new research in @PhysiologicalG https://t.co/NQu9e8gWig #transcriptomics #kidneydisease #proteomics #metabolomics https://t.co/yJA6mYS0TG

Nov 17, 2020 · 3 likes · 2 shares · 7,400 followers View post →
Liz Worthey
@lizworthey · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project https://t.co/sarh6Y7C8Y

Sep 27, 2020 · 2 likes · 5,517 followers View post →
Michigan Kidney Translational Med. Center (MiKTMC)
@MiKTMC · X

RT @biorxivpreprint: A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney P…

Nov 7, 2019 · 2 shares · 418 followers View post →
University of Michigan - Division of Nephrology
@UMichKidney · X

RT @biorxivpreprint: A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney P…

Nov 7, 2019 · 2 shares · 1,540 followers View post →
Scientific communication & education Papers
@Science_comedu · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project https://t.co/hK6ApHKg2y

Nov 6, 2019 · 78 followers View post →
bioRxiv
@biorxivpreprint · X

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project https://t.co/IAJhkZ3wd8 #bioRxiv

Nov 6, 2019 · 9 likes · 2 shares · 138,527 followers View post →
The Kidney Precision Medicine Project (KPMP). An Update and ...
News

Physiol Genomics 2021; 53:1–11. doi: 10.1152/physiolgenomics.00104.2020. PubMed. El-Achkar TM , A multimodal and integrated approach to interrogate human ...

Jan 3, 2026 View →