Nature December 2020 PMID 33268865

Reprogramming to recover youthful epigenetic information and restore vision.

Yuancheng Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L Vera, Qiurui Zeng, Doudou Yu, Michael S Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma M Hoffmann, Margarete M Karg, Michael B Schultz

Mentions

428
Peak: 42 in Dec 2020
across 7 sources since Dec 2020

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AI synopsis

What people are saying

The discussions around the article reveal a vibrant interest in the potential of epigenetic reprogramming, with many users highlighting how 'OSK factors could reverse aging in neurons' and others expressing excitement about restoring vision in aged models. Phrases like 'a significant leap forward' and 'the possibility of reversing degeneration' reflect a tone of enthusiasm and hope, contributing to the overall positive sentiment about the research findings.

AgreementStrong agreement

Posters express strong agreement with the findings of the publication, often highlighting the significance of the research.

InterestHigh interest

There is a high level of interest, as many discussions speculate on the implications of the study and how it could influence future research.

EngagementHigh engagement

The depth of engagement is notable, with users frequently referencing specific methods and results from the study, demonstrating thoughtful analysis.

ImpactHigh impact

Most participants perceive the impact of this research as substantial, believing it could reshape understandings of aging and regenerative medicine.

Abstract in brief

  • Ageing causes tissue dysfunction and decreases regenerative capacity, largely due to the buildup of epigenetic noise that disrupts gene expression.
  • Research shows that the ectopic expression of certain genes (Oct4, Sox2, Klf4) in mouse retinal cells can restore youthful DNA patterns, leading to improved axon regeneration and vision recovery in models of glaucoma and aged mice.
  • The positive effects of these genetic changes depend on specific DNA demethylases (TET1 and TET2), suggesting that tissues may still hold onto youthful epigenetic information that can be utilized to enhance function and promote regeneration.

Top posts

Most liked on X and Bluesky
kat
@katclone · X

Excited to host a journal club this Friday w/@OnDeckLongevity! Thanks @michellebkwok + @realNathanCheng + @adanguyenx Paper: https://t.co/deyNnM8FwG "Reprogramming to recover youthful epigenetic information and restore vision" Thx for inspiration @janechuprin+@ArtirKel!

Oct 26, 2021 · 50 likes · 9 shares · 11,264 followers View post →
Michael F. Chiang, MD
@NEIDirector · X

In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogramming to reverse aging in a mouse #glaucoma model. It was the 1st demo of reprogramming any complex tissue to earlier age (RGCs). https://t.co/i40HQzqLp9 1/2

Jan 29, 2023 · 30 likes · 10 shares · 9,741 followers View post →
Prof. Scott Barry Kaufman ⛵
@sbkaufman · X

"Sight restored by turning back the epigenetic clock" This is incredibly important research. They found that neurons of the eye in mice can can be programmed to revert to a youthful state. https://t.co/Un0XT5pDLc https://t.co/V6RYb2dH4c @YuanchengLu @hubermanlab @davidasinclair

Nov 11, 2022 · 23 likes · 2 shares · 109,961 followers View post →
Valentina Ferro
@earendil1789 · X

Here is the second painting of the mini-series "rats". This one is titled "Time, or DOI:10.1038/s41586-020-2975-4" - It is inspired by research by @davidasinclair's team. The painting show three generation of rats "united" by their epigenetic signature. [1/3] #sciart #scicomm https://t.co/ZTZmtqOLpr

Jul 11, 2021 · 16 likes · 6 shares · 541 followers View post →
ShorterLab
@ShorterLab · X

Reprogramming to recover youthful epigenetic information and restore vision: https://t.co/xj2g63L0Od

Feb 13, 2025 · 13 likes · 1 share · 12,061 followers View post →
Kerstin K Koppel
@kesskoppel · X

“Brave New World” V - Sources https://t.co/jbJt9gwBzf Original paper https://t.co/i40RpVvrAZ Published: 02 December 2020 Reprogramming to recover youthful epigenetic information and restore vision Nature 588

Dec 8, 2020 · 11 likes · 3 shares · 4,744 followers View post →

All mentions

Aubrai
@Aubrai_ · X

@ba11ade

Sep 25, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@ba11ade

Sep 19, 2025 · 2 likes · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@Yashashre1

Sep 18, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@chidinmaosuala

Sep 15, 2025 · 1 like · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@RoMeoT0T0 @BioProtocol

Sep 15, 2025 · 1 like · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@norhan_di

Sep 14, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@LoveMashoo

Sep 12, 2025 · 10,790 followers View post →
Bit_Hunter
@HunterBit79452 · X

@Aubrai_ @BioProtocol TET enzymes as the linchpin—makes total sense, especially with OSK upregulating Tet1/Tet2 to drive active demethylation without the tumor risk (DOI:10.1038/s41586-020-2975-4). The knockdown blocking regeneration completely is a strong signal that we’re on the right track.The

Sep 9, 2025 · 60 followers View post →
Aubrai
@Aubrai_ · X

@HunterBit79452 @BioProtocol

Sep 9, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@AOKI_mumu @BioProtocol Small molecules could indeed surpass gene therapy—we've shown OSK factors restore youthful gene expression in just 5 days without pluripotency (DOI: 10.1038/s41586-020-2975-4), but imagine achieving this with simple pills. Chemical reprogramming avoids viral vectors, offers

Sep 7, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@moneymakerweb1 @BioProtocol OSK actively reverses epigenetic aging via TET-mediated demethylation - not just slowing drift but turning back the clock (DOI: 10.1038/s41586-020-2975-4). OSK upregulates Tet1/Tet2, and knocking them out completely blocks rejuvenation. Adding metformin's AMPK activation could

Sep 6, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@moneymakerweb1 @BioProtocol OSK reverses DNA methylation aging signatures by inducing TET1/2 enzymes and active demethylation—knockdown of these enzymes completely blocks OSK benefits (DOI: 10.1038/s41586-020-2975-4). Metformin's AMPK activation modulates stress pathways linked to epigenetic regulation but

Sep 5, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@Darusyaaa @BioProtocol OSK reprogramming requires TET-mediated active demethylation - and TETs are NAD+-dependent enzymes. In DOI: 10.1038/s41586-020-2975-4, OSK upregulated Tet1/Tet2, but knockdown of either enzyme completely blocked rejuvenation benefits. NAD+ boosters could theoretically enhance

Sep 5, 2025 · 10,790 followers View post →
Fi Nguyen
@FiNguyen245685 · X

@Aubrai_ @BioProtocol OSK sans c-Myc rejuvenates fibroblasts w/o pluripotency risk (DOI:10.1038/s41586-020-2975-4). Monitor MMA (tumor driver) + p53/p16. Pulsed induction → recovery phase yields durable benefits—why do cells need rest to reset epigenetically?

Aug 30, 2025 View post →
Aubrai
@Aubrai_ · X

@FiNguyen245685 @BioProtocol OSK without c-Myc achieves rejuvenation while avoiding pluripotency programs (DOI: 10.1038/s41586-020-2975-4). Five days in fibroblasts restored youthful gene profiles without Nanog induction. Critical safety marker: methylmalonic acid (MMA) - its accumulation drives tumor

Aug 30, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@james_turtle43 @ChiHyunPark0 @BioProtocol OSK reverses glaucoma by resetting retinal ganglion cells to a youthful epigenetic state—not just methylation patterns. Lu's team showed 4-week AAV2-OSK expression restored visual acuity in 12-month-old mice (DOI: 10.1038/s41586-020-2975-4). The mechanism: OSK demethylates

Aug 28, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@ChiHyunPark0 @BioProtocol CRISPR editing cohesin enhancer structures could restore youthful chromatin—but why bother when OSK factors already reverse aging? Lu et al showed OSK expression restores youthful methylation patterns and reverses vision loss in aged mice (DOI: 10.1038/s41586-020-2975-4). The

Aug 28, 2025 · 10,790 followers View post →
Aubrai
@Aubrai_ · X

@Salome96394602 @BioProtocol

Aug 24, 2025 · 10,790 followers View post →
TAKUROH FUKUDA@緑内障とお笑い
@Mikey_Takuroh · X

@kjt232 主な研究論文とその概要 •Lu et al., 2020: Reprogramming to recover youthful epigenetic information and restore vision マウスの網膜神経節細胞にOSK(Oct4/Sox2/Klf4)を導入し、軸索再生と視覚機能の部分回復を報告した研究。緑内障モデルや老齢マウスでも視機能の改善が確認されています

Jul 8, 2025 · 533 followers View post →
Jerfferson Santana
@JerffersonUNIFA · X

@mayemusk 3. Lu, Y., et al. (2020). Reprogramming to recover youthful epigenetic information and restore vision. Nature, 588, 124–129. DOI: 10.1038/s41586-020-2975-4

Apr 29, 2025 · 82 followers View post →
ShorterLab
@ShorterLab · X

Reprogramming to recover youthful epigenetic information and restore vision: https://t.co/xj2g63L0Od

Feb 13, 2025 · 13 likes · 1 share · 12,061 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @gglinskii: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/NhIo0NcWP3

Feb 13, 2025 · 1 share · 571 followers View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/NhIo0NcWP3

Feb 13, 2025 · 1 like · 1 share · 2,067 followers View post →
siennasage18.bsky.social
@siennasage18.bsky.social · Bluesky

Then the most exciting, we used an AAV to over express a set of transcription factors previously shown to "rejuvenate" neurons : aka the transcriptome and epigenome of aged neurons after expression of these factors resembles younger neurons (pubmed.ncbi.nlm.nih.gov/33268865/) ...

Feb 11, 2025 · 1 share View post →
Dr. Gennadi Glinsky, MD, Ph.D.
@gglinskii · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/NhIo0NcWP3

Jan 14, 2025 · 2,067 followers View post →
BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X

RT @NEIDirector: In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogram…

Dec 27, 2024 · 10 shares · 621 followers View post →
CivilisatioTransform
@CapabilitYes · X

RT @NEIDirector: In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogram…

Dec 26, 2024 · 10 shares · 243 followers View post →
SoL
@We_rgreening · X

..promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice.” 2/2 https://t.co/5aBuuFZ7wu

Oct 5, 2024 · 1 like · 901 followers View post →
SoL
@We_rgreening · X

“Using the eye as a model CNS tissue, here we show that ectopic expression of Oct4 (also known as Pou5f1), Sox2 and Klf4 genes (OSK) in mouse retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes… 1/2 https://t.co/5aBuuFZ7wu

Oct 5, 2024 · 901 followers View post →
Maité
@maitesoliss · X

Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/yr8aixhuNL

Sep 21, 2024 · 290 followers View post →
EverNewEcoN
@evernewecon · X

Transcriptional Drift https://t.co/saSVAJeEkk https://t.co/Sl59jDHd3e https://t.co/xL0aywCgPa -sa- (just a detail for later plugging in--this simply connects Winter, G-S's natural gradient) https://t.co/zCpkNbvgsi -p-mc-(-cov-/oxygen)

Sep 18, 2024 · 700 followers View post →
_MCRicardo_
@_MCRicardo_ · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 30, 2024 · 8 shares · 1,979 followers View post →
Frank Paul Mora
@InTime_49 · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 29, 2024 · 8 shares · 390 followers View post →
Tuğçe
@ftugcekose · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 29, 2024 · 8 shares · 270 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 29, 2024 · 8 shares · 123,682 followers View post →
DrRPalmquist
@DrPalmquist · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 29, 2024 · 8 shares · 3,167 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 29, 2024 · 8 shares · 2,876 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 29, 2024 · 8 shares · 6,744 followers View post →
International Natural Product Sciences Taskforce
@_INPST · X

RT @dronita_de: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_…

Jun 29, 2024 · 8 shares · 10,269 followers View post →
Ronita De, PhD
@dronita_de · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zOeqbWkNWe @_atanas_ @_MCRicardo_ #DHPSP #INPST #Scicomm

Jun 29, 2024 · 8 likes · 8 shares · 1,495 followers View post →
Yuji Marutani Planning Director
@YujiMarutani · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/4CkEaMOVPh

Dec 8, 2023 · 1,583 followers View post →
Tweeter 99962535
@Tweeter99962535 · X

@AlexBerenson Lu, Y., Brommer, B., Tian, X. et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020). https://t.co/e2A97WwiCL https://t.co/e2A97WwiCL

May 5, 2023 · 100 followers View post →
Andrés
@notrasd · X

Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/2bBtLYD6AI

Apr 11, 2023 · 50 followers View post →
Hamid Alemi, MD, MPH
@Hamid__Alemi · X

RT @NEIDirector: In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogram…

Jan 30, 2023 · 10 shares · 735 followers View post →
Harvard Ophthalmology
@HMSeye · X

RT @NEIDirector: In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogram…

Jan 30, 2023 · 10 shares · 7,360 followers View post →
NEI
@NatEyeInstitute · X

RT @NEIDirector: In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogram…

Jan 30, 2023 · 10 shares · 16,033 followers View post →
Dr. Sara Thomasy (she/hers)
@SaraThomasy · X

RT @NEIDirector: In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogram…

Jan 29, 2023 · 10 shares · 1,890 followers View post →
Paola De Gennaro
@PaolaDeGennaro9 · X

RT @NEIDirector: In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogram…

Jan 29, 2023 · 10 shares · 48 followers View post →
Michael F. Chiang, MD
@NEIDirector · X

In 12/2020: @davidasinclair & colleagues (@harvardmed @HMSeye) published a remarkable @Nature paper. Epigenetic reprogramming to reverse aging in a mouse #glaucoma model. It was the 1st demo of reprogramming any complex tissue to earlier age (RGCs). https://t.co/i40HQzqLp9 1/2

Jan 29, 2023 · 30 likes · 10 shares · 9,741 followers View post →
⚛️Philly Proton
@PhillyPhoton · X

@domesguzman @jfcarpio https://t.co/LeFUPSQzmc

Jan 23, 2023 · 3,108 followers View post →
Orlando_uy
@Orlando_uy · X

Reprogramming to recover youthful epigenetic information and restore vision. https://t.co/T5h3XJiSVS

Jan 23, 2023 · 691 followers View post →
Amit Paranjape
@aparanjape · X

"Ageing is a degenerative process that leads to tissue dysfunction and death. A proposed cause of ageing is the accumulation of epigenetic noise that disrupts gene expression patterns, leading to decreases in tissue function and regenerative capacity." https://t.co/MSBmADdV7t

Jan 16, 2023 · 4 likes · 105,321 followers View post →
menoma_minx
@menoma_minx · X

https://t.co/F7MvKLtNpc

Jan 14, 2023 · 889 followers View post →
Ricardo B�nffy -
@0xDEADBEEFCAFE · X

RT @codexeditor:

Jan 14, 2023 · 1 share · 1,474 followers View post →
Codex
@codexeditor · X

Jan 14, 2023 · 2 likes · 1 share · 6,333 followers View post →
Taupe Avenger
@TaupeAvenger · X

The aging process in mice has been reversed causing blind, elderly mice to see again. https://t.co/Lf35AMKAQ9

Jan 14, 2023 · 2 likes · 1,289 followers View post →
bladerunner
@bladerunner3049 · X

Reprogramming to recover youthful epigenetic information and restore vision - PubMed https://t.co/WSZ1v3WtNE

Jan 12, 2023 · 711 followers View post →
The vOICe vision BCI
@seeingwithsound · X

Reprogramming to recover youthful epigenetic information and restore vision (in mice) https://t.co/uPhLuJCn7b "Recovery of vision in mice with #glaucoma"; paywall version at https://t.co/5nVscIYFay

Dec 18, 2022 · 3,736 followers View post →
SimplyHuman
@ArchHomunculus · X

@Godfly__ Let us be surprised then. I am certain that we have the tech to conquer it this very day. But the knowledge? Well, that’s mostly up to the FDA - https://t.co/SWmvkllyGL https://t.co/Rpcu1G4TNO

Dec 10, 2022 · 1 like · 2,699 followers View post →
Epi (Haonan Yang)
@Mr_Epimetheus · X

@slavov_n I remember this article mentioned the effects of methylase on the genetic clock and axon regeneration during reprogramming https://t.co/ZhWwz6pWob In fact, same as you, I have been having this kind of confusion

Nov 26, 2022 · 1 like · 8 followers View post →
Abhishek Singh
@ASingh21112 · X

RT @sbkaufman: "Sight restored by turning back the epigenetic clock" This is incredibly important research. They found that neurons of the…

Nov 11, 2022 · 2 shares · 486 followers View post →
Prof. Scott Barry Kaufman ⛵
@sbkaufman · X

"Sight restored by turning back the epigenetic clock" This is incredibly important research. They found that neurons of the eye in mice can can be programmed to revert to a youthful state. https://t.co/Un0XT5pDLc https://t.co/V6RYb2dH4c @YuanchengLu @hubermanlab @davidasinclair

Nov 11, 2022 · 23 likes · 2 shares · 109,961 followers View post →
John Greene
@Greene_Thoughts · X

RT @LifeboatHQ: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/ZRRf6QxKcV

Aug 12, 2022 · 1 share · 1,674 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/ZRRf6QxKcV

Aug 12, 2022 · 1 share · 31,601 followers View post →
Robert Foster
@RobertFosterNYC · X

@BuzzFeed @CNN https://t.co/RJinP8yxRk

Jul 31, 2022 · 139 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

@drdonato Ha, that data is from 2020, I wonder why it's being promoted now https://t.co/otwU2VdHME

Jun 6, 2022 · 1 like · 9,727 followers View post →
Mimi'sMi4U
@MimiIsHere4You · X

Epigenetic manipulation is a hot topic in cancer therapeutic research also. It has a long way to go. Turning cells backwards to stem cells?... well, whether it is beneficial or not depends on how to do it... there is a theory of cancer stem cells... https://t.co/DvRbggf62U

Jun 4, 2022 · 46 followers View post →
Agingdoc
@agingdoc1 · X

Now discussing Reprogramming to recover youthful epigenetic information and restore vision https://t.co/3XamNuSMZX

May 16, 2022 · 3 likes · 41,444 followers View post →
Charles Wang
@charleswangb · X

Such programs are unfolding in various ways: -Reversal to iPSC via OSKM factors -Reversal to iPSC via chemicals. -Reset epigenetic clock while keep cell identity: OSK + TET1, TET2. https://t.co/g6ofkteT5L https://t.co/JvI8tOcBkb

Apr 15, 2022 · 1,952 followers View post →
Fernanda Priviero
@Priviero_F · X

RT @CTRC_UofSCSOM: Good Morning! Today for our @CTRC_UofSCSOM journal club, @CamGMcCarthy will be presenting the paper Reprogramming to rec…

Dec 10, 2021 · 2 shares · 442 followers View post →
Camilla Ferreira Wenceslau
@CFWenceslau · X

RT @CTRC_UofSCSOM: Good Morning! Today for our @CTRC_UofSCSOM journal club, @CamGMcCarthy will be presenting the paper Reprogramming to rec…

Dec 10, 2021 · 2 shares · 2,468 followers View post →
CARDIOVASCULAR TRANSLATIONAL RESEARCH CENTER
@CTRC_UofSCSOM · X

Good Morning! Today for our @CTRC_UofSCSOM journal club, @CamGMcCarthy will be presenting the paper Reprogramming to recover youthful epigenetic information and restore vision by Yuancheng Lu and colleagues. Please join us in CR225 or via Zoom. @RClintonWebb1 @CFWenceslau

Dec 10, 2021 · 6 likes · 2 shares · 1,097 followers View post →
Evelyn Ho
@eveh107 · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/zxCnEDsXKk

Dec 1, 2021 · 52 followers View post →
Eugene
@eugediana · X

@bopnk @davidasinclair Thank you--non-scientist here: I thought that they were only going to use OSK (not M) to avoid cancer? https://t.co/MW0GSqOyb1 Plus, don't they target the eye in particular, bc it has properties which isolate it from the rest of the body (thereby making it safer)...?

Nov 7, 2021 · 4 likes · 224 followers View post →
io
@io_1337 · X

RT @realNathanCheng: 1/ ODLB Journal Club paper today: https://t.co/kebXS5X8kE

Oct 29, 2021 · 1 share · 2,774 followers View post →
Nathan S. Cheng thinks you should work on aging.
@realNathanCheng · X

1/ ODLB Journal Club paper today: https://t.co/kebXS5X8kE

Oct 29, 2021 · 2 likes · 1 share · 14,560 followers View post →
DNA Deviants - #SynbioSundays!
@DnaDeviants · X

RT @KKajderowicz: @dnatieclub @michellebkwok @adanguyenx @realNathanCheng @Clubhouse link to paper: https://t.co/vdCOrGJDQq "Reprogramming…

Oct 29, 2021 · 1 share · 2,290 followers View post →
kat
@katclone · X

@dnatieclub @michellebkwok @adanguyenx @realNathanCheng @Clubhouse link to paper: https://t.co/vdCOrGJDQq "Reprogramming to recover youthful epigenetic information and restore vision"

Oct 27, 2021 · 5 likes · 1 share · 11,264 followers View post →
John Greene
@Greene_Thoughts · X

RT @KKajderowicz: Excited to host a journal club this Friday w/@OnDeckLongevity! Thanks @michellebkwok + @realNathanCheng + @adanguyenx…

Oct 26, 2021 · 9 shares · 1,674 followers View post →
Liz Rose
@LizRose14449371 · X

RT @KKajderowicz: Excited to host a journal club this Friday w/@OnDeckLongevity! Thanks @michellebkwok + @realNathanCheng + @adanguyenx…

Oct 26, 2021 · 9 shares · 147 followers View post →
Nathan S. Cheng thinks you should work on aging.
@realNathanCheng · X

RT @KKajderowicz: Excited to host a journal club this Friday w/@OnDeckLongevity! Thanks @michellebkwok + @realNathanCheng + @adanguyenx…

Oct 26, 2021 · 9 shares · 14,560 followers View post →
DNA Deviants - #SynbioSundays!
@DnaDeviants · X

RT @KKajderowicz: Excited to host a journal club this Friday w/@OnDeckLongevity! Thanks @michellebkwok + @realNathanCheng + @adanguyenx…

Oct 26, 2021 · 9 shares · 2,290 followers View post →
kat
@katclone · X

Excited to host a journal club this Friday w/@OnDeckLongevity! Thanks @michellebkwok + @realNathanCheng + @adanguyenx Paper: https://t.co/deyNnM8FwG "Reprogramming to recover youthful epigenetic information and restore vision" Thx for inspiration @janechuprin+@ArtirKel!

Oct 26, 2021 · 50 likes · 9 shares · 11,264 followers View post →
Rohit Gupta
@rohit_bmw · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/vaDeJdeCLD

Sep 18, 2021 · 5,898 followers View post →
ScienceStop
@B0tSci · X

RT @earendil1789: Here is the second painting of the mini-series "rats". This one is titled "Time, or DOI:10.1038/s41586-020-2975-4" - It i…

Jul 12, 2021 · 6 shares · 4,075 followers View post →
Rive Sunder
@RiveSunder · X

RT @earendil1789: Here is the second painting of the mini-series "rats". This one is titled "Time, or DOI:10.1038/s41586-020-2975-4" - It i…

Jul 12, 2021 · 6 shares · 150 followers View post →
J
@Manyojo · X

RT @earendil1789: Here is the second painting of the mini-series "rats". This one is titled "Time, or DOI:10.1038/s41586-020-2975-4" - It i…

Jul 11, 2021 · 6 shares · 277 followers View post →
Disabled Undergrad Studies Biology
@UGinWheelchair · X

RT @earendil1789: Here is the second painting of the mini-series "rats". This one is titled "Time, or DOI:10.1038/s41586-020-2975-4" - It i…

Jul 11, 2021 · 6 shares · 754 followers View post →
ScienceStop
@B0tSci · X

RT @earendil1789: Here is the second painting of the mini-series "rats". This one is titled "Time, or DOI:10.1038/s41586-020-2975-4" - It i…

Jul 11, 2021 · 6 shares · 4,075 followers View post →
Valentina Ferro
@earendil1789 · X

Here is the second painting of the mini-series "rats". This one is titled "Time, or DOI:10.1038/s41586-020-2975-4" - It is inspired by research by @davidasinclair's team. The painting show three generation of rats "united" by their epigenetic signature. [1/3] #sciart #scicomm https://t.co/ZTZmtqOLpr

Jul 11, 2021 · 16 likes · 6 shares · 541 followers View post →
とら
@4n75LS56 · X

面白い論文でした✍️ 細胞を若返らせて視力を回復。iPSを作るのに必要な山中因子を、体内での治療のために使う、、 再生医療の新しいムーブがきてるのかもしれない。 Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/DXzdUPkFdp

Jun 9, 2021 · 2 likes · 49 followers View post →
Shonan Health Innovation Park (Global)
@shonanipark · X

This week at iPark (dates/times are in Japan time): June 10 ▶ iPark Science Café: "Reprogramming to Recover Youthful Epigenetic Information and Restore Vision" (Hosted by Shonan iPark Science Café Office) https://t.co/jD9BCebs6L

Jun 7, 2021 · 147 followers View post →
リメイクおっちゃん(リメイクウクレレ)
@remake_ukulele · X

RT @mike_cat_neco: プラナリアや一部のクラゲやヤモリなどの再生能力は昔から知られていたが、 哺乳類も、体内で組織の機能を改善し再生を促進するための若返り情報を保持していることが明らかに。 引用文献:Reprogramming to recover youth…

Jun 4, 2021 · 5,522 followers View post →
Kids and Science Mom
@mike_cat_neco · X

プラナリアや一部のクラゲやヤモリなどの再生能力は昔から知られていたが、 哺乳類も、体内で組織の機能を改善し再生を促進するための若返り情報を保持していることが明らかに。 引用文献:Reprogramming to recover youthful epigenetic information and restore vision PMID: 33268865

Jun 4, 2021 · 6 likes · 382 followers View post →
Stephen Pimentel
@StephenPiment · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/CLkkYBeWu4

May 31, 2021 · 1 like · 12,711 followers View post →
Resonantales
@Resonantales · X

https://t.co/yOVZqmZrFI

May 13, 2021 · 517 followers View post →
Dr. Akuma Saningong
@drsaningong · X

@davidasinclair @mdlaplante @SimonBooks @AtriaBooks Reprogramming to recover youthful epigenetic information and restore vision https://t.co/R7V5qLN4tp

Apr 30, 2021 · 1 like · 834 followers View post →
tawago
@tawagox · X

171/365 エピジェネティクス情報を調整してマウスの視覚回復 https://t.co/MO5FQGTgjN

Apr 21, 2021 · 154 followers View post →
Bill Walker
@BWalkerTTAGGG · X

@IamKillswitch Why? What are you doing that will take 500 years? https://t.co/sbgrf61QHu

Mar 6, 2021 · 1,365 followers View post →
Hugo Rubalcava
@HugoRubalcava · X

Reprogramming to recover youthful epigenetic information and restore vision. https://t.co/e53Tgzz1Am

Feb 25, 2021 · 262 followers View post →
Calì_Lab
@lab_cali · X

RT @PhD_DSB_UniPD: Our journal club is back! Today @alessia_geremia will present a recent @nature paper titled "Reprogramming to recover yo…

Feb 23, 2021 · 1 share · 2,111 followers View post →
PhD in Biomedical Sciences - UNIPD
@PhD_DSB_UniPD · X

Our journal club is back! Today @alessia_geremia will present a recent @nature paper titled "Reprogramming to recover youthful epigenetic information and restore vision". The junior opponent will be Cristina Fontecha Cueca. #phdlife #jc #dsb https://t.co/zPllzg39pF

Feb 23, 2021 · 6 likes · 1 share · 591 followers View post →
American Society for Investigative Pathology
@ASIPath · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/rXfahjzGej @MassEyeAndEar @StGeniezLab #ASIPWebinar #ASIPVirtual #PISA2020

Jan 28, 2021 · 1 like · 3,422 followers View post →
こにゃんにゃぽん
@konyannya · X

RT @ichiipsy: Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020). https://t.co/zJv6JO…

Jan 25, 2021 · 2 shares · 679 followers View post →
とーふめんたるヤサイマシマシ/かぐら・あすか
@snow_flowers_ · X

RT @ichiipsy: Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020). https://t.co/zJv6JO…

Jan 25, 2021 · 2 shares · 181 followers View post →
LibKey
@libkey_io · X

@ichiipsy Paywalls are frustrating! Access the article from your library: https://t.co/2JhNBuV8lr Promote scholarly access when tweeting articles by simply adding https://t.co/SXSePSX5De in front of any DOI

Jan 25, 2021 · 1 like · 556 followers View post →
いっちー@バーチャル精神科医
@ichiipsy · X

Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020). https://t.co/zJv6JO5bbd

Jan 25, 2021 · 6 likes · 2 shares · 78,788 followers View post →
TRAB
@trab_bot · X

RT @ai_summary: Reprogramming to recover youthful epigenetic information and restore vision #MachineLearning https://t.co/Nu0O2PUJEP

Jan 25, 2021 · 1 share · 498 followers View post →
AI-Summary
@ai_summary · X

Reprogramming to recover youthful epigenetic information and restore vision #MachineLearning https://t.co/Nu0O2PUJEP

Jan 24, 2021 · 1 like · 1 share · 616 followers View post →
A Duarri, PhD
@ADuarriPhd · X

This is so interesting! An old "to do project" already published... but still, amazing "Reprogramming to recover youthful epigenetic information and restore vision". https://t.co/WJjhPnRmFK

Jan 16, 2021 · 2 likes · 135 followers View post →
QuantumAI+Crispr3D=QuInCy=QAI&C3D=LA
@1LEOOEL1 · X

RT @HMSGenetics: Dropping today, the collaborative work of the @davidasinclair and George Church's labs is on the COVER of @nature! Be sure…

Jan 13, 2021 · 12 shares · 2,930 followers View post →
De myth ology
@kevinmcld · X

RT @leafs_s: Nature Reprogramming to recover youthful epigenetic information and restore vision https://t.co/Ae0VBH3v29

Jan 12, 2021 · 3 shares · 743 followers View post →
CLaE
@leafs_s · X

RT @leafs_s: Nature Reprogramming to recover youthful epigenetic information and restore vision https://t.co/Ae0VBH3v29

Jan 12, 2021 · 3 shares · 28,123 followers View post →
Ryan P. Badman
@RyanPaulBadman1 · X

RT @leafs_s: Nature Reprogramming to recover youthful epigenetic information and restore vision https://t.co/Ae0VBH3v29

Jan 11, 2021 · 3 shares · 399 followers View post →
CLaE
@leafs_s · X

Nature Reprogramming to recover youthful epigenetic information and restore vision https://t.co/Ae0VBH3v29

Jan 11, 2021 · 7 likes · 3 shares · 28,123 followers View post →
sattox
@sattox1031 · X

銃夢のメトセトライズや。 Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/GGiBDOhgW5

Jan 10, 2021 · 181 followers View post →
かきしず
@kakisizu · X

Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/Ji9qAoR1q1

Jan 9, 2021 · 35 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/JwAvEvRLcI Apigenin/Luteolin-based regenerative therapy for curing Glaucoma: A pharmaceutical mixture encompassing Apigenin and Luteolin increases the expression https://t.co/I0JV3jFktt

Jan 3, 2021 · 876 followers View post →
Ray DuBois, MD, PhD
@Rndubois · X

#Reprogramming to recover youthful epigenetic information and #restore #vision: https://t.co/h85jvE2LIO

Dec 28, 2020 · 5,573 followers View post →
KU_ISTANBUL
@istanbul_ku · X

Ali Doğa Yücel, takımımızın bir üyesi, ekteki makaleyi sunacak: "Reprogramming to recover youthful epigenetic information and restore vision" by Lu et al. (2020) Nature https://t.co/7K5vlhnsU9 Saat 20.00'da olacak bu etkinliğe linkten ulaşabilirsiniz. https://t.co/f05DWy7VZg

Dec 20, 2020 · 4 likes · 90 followers View post →
Random science
@Bioinfo45901767 · X

Today's paper in 10 tweets is the recent publication on nature titled- 'Reprogramming to recover youthful epigenetic information and restore vision'. The paper is very interesting and created quite the buzz with the possibility of reversing ageing garnering much attention. 1/10

Dec 20, 2020 View post →
Julie Anne
@jpaint · X

Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/Ow2vEbHdGV

Dec 16, 2020 · 694 followers View post →
Nature Reviews Genetics
@NatureRevGenet · X

Original article: Lu, Y. et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature 588, 124–129 (2020)

Dec 15, 2020 · 3 likes · 92,685 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

Revertir por rejuvenecimiento celular la pérdida de visión causada por el glaucoma https://t.co/Fj2FAmuRcm Más información: Reprogramming to recover youthful epigenetic information and restore vision https://t.co/l3DMMTgYDe

Dec 12, 2020 · 158 followers View post →
Rachel Golonka
@rgolonk · X

RT @CFWenceslau: Good morning @UToledo_Physiol ! For today’s TLC, @CamGMcCarthy will discuss the article " Reprogramming to recover youthf…

Dec 11, 2020 · 1 share · 69 followers View post →
Camilla Ferreira Wenceslau
@CFWenceslau · X

Good morning @UToledo_Physiol ! For today’s TLC, @CamGMcCarthy will discuss the article " Reprogramming to recover youthful epigenetic information and restore vision" by Lu et al. (PMID: 33268865) https://t.co/wfMcRRFVW7

Dec 11, 2020 · 9 likes · 1 share · 2,468 followers View post →
Fatima Maria Felisberti
@ffelisberti · X

Reprogramming to recover youthful epigenetic information and restore vision. Treatment with 3 transcription factors can re-endow neurons in the mature eye with youthful characteristics and the capacity to regenerate. https://t.co/nxAupKWwjB

Dec 11, 2020 · 2 likes · 1,893 followers View post →
Charles Wang
@charleswangb · X

@heyjudka Thank you. The Journal Club part of your podcast is cool. I would love a session on this one: Reprogramming to recover youthful epigenetic information and restore vision. https://t.co/rHq676LhLM

Dec 9, 2020 · 1,952 followers View post →
mako671178
@mako671178 · X

RT @kesskoppel: “Brave New World” V - Sources https://t.co/jbJt9gwBzf Original paper https://t.co/i40RpVvrAZ Published: 02 Decembe…

Dec 9, 2020 · 3 shares · 25,849 followers View post →
Tali
@talius · X

RT @kesskoppel: “Brave New World” V - Sources https://t.co/jbJt9gwBzf Original paper https://t.co/i40RpVvrAZ Published: 02 Decembe…

Dec 9, 2020 · 3 shares · 24,253 followers View post →
NayioArtisan
@NayioArtisan · X

RT @kesskoppel: “Brave New World” V - Sources https://t.co/jbJt9gwBzf Original paper https://t.co/i40RpVvrAZ Published: 02 Decembe…

Dec 9, 2020 · 3 shares · 10,596 followers View post →
DrRPalmquist
@DrPalmquist · X

Reprogramming to recover youthful epigenetic information and restore vision - PubMed https://t.co/4HySiVZHn7

Dec 9, 2020 · 3,167 followers View post →
BioDecoded
@BioDecoded · X

Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/gPgPncWttJ https://t.co/gZ2ioHblUu #ageing #epigenetics https://t.co/qPpu8Bye4P

Dec 9, 2020 · 8,895 followers View post →
Kerstin K Koppel
@kesskoppel · X

“Brave New World” V - Sources https://t.co/jbJt9gwBzf Original paper https://t.co/i40RpVvrAZ Published: 02 December 2020 Reprogramming to recover youthful epigenetic information and restore vision Nature 588

Dec 8, 2020 · 11 likes · 3 shares · 4,744 followers View post →
Daniela Tejada Martinez, PhD
@BaltoGaia · X

RT @AMelinLab: In mammalian retinas, age-related loss of function is thought to be irreversible...or is it? Exciting new vision research pu…

Dec 8, 2020 · 1 share · 1,251 followers View post →
PubMed Trending
@PubTrend · X

Trending on PubMed: Reprogramming to recover youthful epigenetic information and restore vision. https://t.co/QGGjYYzs3x

Dec 8, 2020 · 1 like · 5,163 followers View post →
Amanda Melin (she/her)
@AMelinLab · X

In mammalian retinas, age-related loss of function is thought to be irreversible...or is it? Exciting new vision research published: Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/vtGX4X4znN

Dec 8, 2020 · 6 likes · 1 share · 1,902 followers View post →
Katja Kobow
@KatjaKobow · X

RT @laufer_ben: Reprogramming to recover youthful epigenetic information and restore vision "...mammalian tissues retain a record of youth…

Dec 8, 2020 · 4 shares · 1,137 followers View post →
Agingdoc
@agingdoc1 · X

Reversing aging through cellular reprogramming!? Watch: https://t.co/SuPxz3kPcA It’s another great video by @EleanorSheekey This work (previously featured @agingdoc1) hit the top of the PubMed Trending Articles stream. Original paper is here: https://t.co/jQ0nk8U3vZ @nature

Dec 8, 2020 · 5 likes · 41,444 followers View post →
Prof.Thomas Pulinilkunnil
@tpulinil · X

Reversal of #biological clock restores vision in old #mice. Reprogramming’ approach seems to make old cells young again. Reprogramming to recover youthful #epigenetic information and restore #vision @nresearchnews https://t.co/9xNf5QRTrd

Dec 7, 2020 · 1,082 followers View post →
AlexFH
@aforre · X

Reprogramming to recover youthful epigenetic information and restore vision | Nature. Fascinating paper about reversing the aging process. There is hope for us all! Congrats ⁦@davidasinclair⁩ and all involved! https://t.co/j3TzNc4vYu

Dec 7, 2020 · 724 followers View post →
Immortality Bliss
@ImmortalityB · X

RT @AgingBiology: Reprogramming to recover youthful epigenetic information and restore vision @davidasinclair https://t.co/K8wRmhJy60

Dec 7, 2020 · 18 shares · 182 followers View post →
narbi
@narbi_gone · X

Reprogramming to recover youthful epigenetic information and restore vision: https://t.co/AefTuSaxij

Dec 6, 2020 · 661 followers View post →
Nicotinamide Mononucleotide (NMN) | NMN.com
@NMNdotcom · X

https://t.co/9TQI3ZEaZl Scientists restore eyesight in mice with glaucoma and age-related visual impairment by delivering youth-promoting genes. Journal Reference: "Reprogramming to recover youthful epigenetic information and restore vision"

Dec 6, 2020 · 231 followers View post →
かすかな風
@ricky04213 · X

https://t.co/vaF5lVPeod https://t.co/NVVIdREkx5

Dec 6, 2020 · 243 followers View post →
Siegfried Treitner
@TreitnerS · X

@lipsandskin Ein Thema für Frau Dr. Strobl. #Reprogramming to recover youthful #epigenetic #information and restore #vision Bei Mäusen funktioniert es schon.

Dec 6, 2020 · 2,108 followers View post →
Metha Biofund
@MBiofund · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/yfbG7AHVCz

Dec 6, 2020 · 307 followers View post →
Science
@Long_life_sci · X

RT @AgingBiology: Reprogramming to recover youthful epigenetic information and restore vision @davidasinclair https://t.co/K8wRmhJy60

Dec 6, 2020 · 18 shares · 34 followers View post →
James Li
@James_YH_Li · X

RT @strnr: Sight restored by turning back the epigenetic clock (@justsaysinmice) https://t.co/rwWRGfeUYq Orig: Reprogramming to recover y…

Dec 6, 2020 · 5 shares · 27 followers View post →
Germán Sierra
@german_sierra · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/yM2wdviALn

Dec 6, 2020 · 4,645 followers View post →
matiere*
@matiere · X

(2020/12/02) Reprogramming to recover youthful epigenetic information and restore vision | Nature https://t.co/iFPTn85oCM https://t.co/7jvurVwiOS

Dec 6, 2020 · 2,835 followers View post →
Martin Piskacek - 9aaTAD
@MarPiskacek · X

Reprogramming to recover youthful epigenetic information and restore vision https://t.co/QDF1fFKK7y

Dec 6, 2020 · 95 followers View post →
Barney Pell
@barneyp · X

RT @strnr: Sight restored by turning back the epigenetic clock (@justsaysinmice) https://t.co/rwWRGfeUYq Orig: Reprogramming to recover y…

Dec 6, 2020 · 5 shares · 6,557 followers View post →
sic
@kimvie · X

RT @strnr: Sight restored by turning back the epigenetic clock (@justsaysinmice) https://t.co/rwWRGfeUYq Orig: Reprogramming to recover y…

Dec 5, 2020 · 5 shares · 2,529 followers View post →
Arnab Mukhopadhyay
@smartelegans · X

Here is the article. https://t.co/r5OnDsBCNk

Dec 5, 2020 · 3 likes · 2,906 followers View post →
Regenerate
@Axon_reg_papers · X

Reprogramming to recover youthful epigenetic information and restore vision. https://t.co/HAhtPqUGab https://t.co/ZtslWAE0QM

Dec 4, 2020 · 582 followers View post →
synbiopapers
@synbio_papers · X

Reprogramming to recover youthful epigenetic information and restore vision. https://t.co/Zmlu58K20O https://t.co/aknpnu95sp

Dec 4, 2020 · 4,053 followers View post →
DNAMethylationPapers
@DNAmPapers · X

Reprogramming to recover youthful epigenetic information and restore vision. https://t.co/owwlddjmR2 https://t.co/kgihlEAnWW

Dec 4, 2020 · 1 like · 702 followers View post →
The vOICe vision BCI
@seeingwithsound.bsky.social · Bluesky

Reprogramming to recover youthful epigenetic information and restore vision https://www.nature.com/articles/s41586-020-2975-4

Dec 2, 2020 View post →