Nature January 2021 PMID 33299186

A non-hallucinogenic psychedelic analogue with therapeutic potential.

Lindsay P Cameron, Robert J Tombari, Ju Lu, Alexander J Pell, Zefan Q Hurley, Yann Ehinger, Maxemiliano V Vargas, Matthew N McCarroll, Jack C Taylor, Douglas Myers-Turnbull, Taohui Liu, Bianca Yaghoobi, Lauren J Laskowski, Emilie I Anderson, Guoliang Zhang

Mentions

79
Peak: 40 in Dec 2020
across 4 sources since Dec 2020

Extended reach

686,300
potential audience

Total likes

365

Video views

4,542

Mentions per month

Dec 2020 – Mar 2025

Where it's discussed

  • X / Twitter67 posts
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  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

Overall, the discussions reveal strong support and curiosity around the article, with posts highlighting its potential to separate therapeutic benefits from hallucinogenic effects, as seen in phrases like 'promising effects', 'transformative potential', and questions about translating findings to humans. The tone is positive, emphasizing the innovation, while detailed references to molecular studies suggest deep engagement and recognition of the work's significance.

AgreementStrong agreement

Most discussions expressed strong support and positive evaluation of the research, emphasizing its promising potential and innovative approach.

InterestHigh interest

Posts consistently show high curiosity and engagement with the topic, referencing multiple studies and expressing enthusiasm about the therapeutic implications.

EngagementHigh engagement

Many participants delved into detailed analysis, mentioning molecular findings, potential for clinical translation, and questions about subjective effects, indicating deep involvement.

ImpactHigh impact

The discussions reflect significant recognition of the research's importance, with many suggesting it could change treatment approaches for addiction and mental health, indicating a high perceived impact.

Abstract in brief

  • Ibogaine is a psychedelic alkaloid that shows promise in treating various substance use disorders by altering addiction-related brain circuitry, but it has safety concerns due to toxicity and potential heart issues.
  • Researchers have engineered a safer version of ibogaine called tabernanthalog, which is water-soluble, non-hallucinogenic, and non-toxic while preserving therapeutic effects.
  • In animal studies, tabernanthalog promoted neural plasticity and reduced addictive behaviors, suggesting it could be a viable treatment option for addiction and depression.

Top posts

Most liked on X and Bluesky
Christian Lüscher
@LUSCHERC · X

Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinogenic 5HT2A partial agonist. Effects on drug-evoked synaptic plasticity linked to reinstatement? Why no hallucinations? @DEOlsonLab https://t.co/npKrKycMbt https://t.co/UxYUY3Yl2V

Feb 17, 2021 · 22 likes · 6 shares · 7,080 followers View post →
Joe Barnby
@JoeBarnby · X

'A non-hallucinogenic psychedelic analogue with therapeutic potential' From @DEOlsonLab In mice, but can this method to be carried across to other psychedelics? What would this mean for the supposed importance of the subjective psychedelic experience? https://t.co/91p43H90Yh

Dec 9, 2020 · 19 likes · 6 shares · 1,953 followers View post →
Chemistry News
@ChemistryNews · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/G7E4vsPJYY https://t.co/oTNxlxncC1

Dec 9, 2020 · 15 likes · 2 shares · 516,727 followers View post →
tociss
@tociss · X

TBGはイボガインという幻覚作用を持つアルカロイドのアナログとして開発されたより認容性に優れた物質で、マウスの行動実験の結果から抗うつ効果や依存症の治療効果が期待されていた article: https://t.co/Yq1CWVRXyW 解説: https://t.co/39xkRzgmGF

Jun 2, 2021 · 14 likes · 2 shares · 13,039 followers View post →
Sten Linnarsson
@slinnarsson · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/7za6gFH2nP

Jan 23, 2021 · 14 likes · 2 shares · 8,913 followers View post →
MetabolomicsUCDavis
@WCMC_UCDavis · X

Fresh off the press the fruits of cooperation a new nature article about the promising effects of #ibogaine. "A non-hallucinogenic psychedelic analogue with therapeutic potential" https://t.co/aOHHWISBzK https://t.co/PaOyCE4d9Q

Feb 1, 2021 · 14 likes · 6 shares · 3,307 followers View post →

All mentions

Evan Chiefer
@ChieferEvan · X

RT @ChieferEvan: @_R4V3N5_ LSD or Psilocybin 1. Cameron, L. P. et al. A non-hallucinogenic psychedelic analogue with therapeutic potentia…

Feb 22, 2025 · 1 share · 302 followers View post →
Evan Chiefer
@ChieferEvan · X

@_R4V3N5_ LSD or Psilocybin 1. Cameron, L. P. et al. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature 589, 474–479 (2020). 2. Raval, N. R. et al. A single dose of psilocybin increases synaptic density and decreases 5-HT2A receptor density in the pig brain.

Feb 22, 2025 · 3 likes · 1 share · 302 followers View post →
Samuel Kohtala
@samuelkohtala · X

@kwanalexc @UBoltaev @SamesLab After reading this, it is interesting to take another look at many of the recent psychedelic studies, e.g. "A non-hallucinogenic psychedelic analogue with therapeutic potential" and "Psychedelics Promote Neuroplasticity Through Activation of Intracellular 5-HT2A Receptors".

Mar 13, 2024 · 1 like · 617 followers View post →
Anti MD MD Club
@HMhnuey · X

https://t.co/hsw4pg04Pc

Feb 11, 2022 · 1,164 followers View post →
Tom Burns
@tfburns · X

@chrisrudge An analogue to showed increased spine formation in mice (https://t.co/yLDQ7Cqy9M) and there was some lower-resolution evidence of increased synaptic formation in pig (https://t.co/w2nNbChml4), but this is first molecular-level resolution, long-term results for mice, I think.

Sep 2, 2021 · 2 likes · 1,869 followers View post →
赤いはりねずみ | yumin
@yumin · X

RT @tociss: TBGはイボガインという幻覚作用を持つアルカロイドのアナログとして開発されたより認容性に優れた物質で、マウスの行動実験の結果から抗うつ効果や依存症の治療効果が期待されていた article: https://t.co/Yq1CWVRXyW 解説: htt…

Jun 2, 2021 · 2 shares · 545 followers View post →
tociss
@tociss · X

TBGはイボガインという幻覚作用を持つアルカロイドのアナログとして開発されたより認容性に優れた物質で、マウスの行動実験の結果から抗うつ効果や依存症の治療効果が期待されていた article: https://t.co/Yq1CWVRXyW 解説: https://t.co/39xkRzgmGF

Jun 2, 2021 · 14 likes · 2 shares · 13,039 followers View post →
Sarita
@Saritad18 · X

RT @WCMC_UCDavis: Fresh off the press the fruits of cooperation a new nature article about the promising effects of #ibogaine. "A non-hall…

Mar 3, 2021 · 6 shares · 23 followers View post →
Rosaura Brisuela @roswitta.bsky.social
@Roswitamind · X

RT @LUSCHERC: Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinoge…

Mar 3, 2021 · 6 shares · 1,288 followers View post →
tor wager
@torwager · X

RT @YoniAshar: A non-hallucinogenic psychedelic analogue with therapeutic potential -- very neat https://t.co/0HEPLWXuzw

Feb 24, 2021 · 1 share · 9,542 followers View post →
Yoni Ashar
@YoniAshar · X

A non-hallucinogenic psychedelic analogue with therapeutic potential -- very neat https://t.co/0HEPLWXuzw

Feb 23, 2021 · 7 likes · 1 share · 1,661 followers View post →
Linda Simmler
@lindasimmler · X

RT @LUSCHERC: Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinoge…

Feb 17, 2021 · 6 shares · 324 followers View post →
Blind Willie #BLM
@willsmithyyp · X

RT @LUSCHERC: Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinoge…

Feb 17, 2021 · 6 shares · 354 followers View post →
Craig Werner
@craigtwerner · X

RT @LUSCHERC: Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinoge…

Feb 17, 2021 · 6 shares · 446 followers View post →
Robyn Brown
@RobynBrownLab · X

RT @LUSCHERC: Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinoge…

Feb 17, 2021 · 6 shares · 864 followers View post →
yoshiyuki nishio
@nishiokov · X

RT @LUSCHERC: Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinoge…

Feb 17, 2021 · 6 shares · 519 followers View post →
Christian Lüscher
@LUSCHERC · X

Thought provoking report of high spine density in cortex & suppression of EtOH intake/Heroin reinstatement w/ non-hallucinogenic 5HT2A partial agonist. Effects on drug-evoked synaptic plasticity linked to reinstatement? Why no hallucinations? @DEOlsonLab https://t.co/npKrKycMbt https://t.co/UxYUY3Yl2V

Feb 17, 2021 · 22 likes · 6 shares · 7,080 followers View post →
ibogacare
@IbogaTravels · X

RT @WCMC_UCDavis: Fresh off the press the fruits of cooperation a new nature article about the promising effects of #ibogaine. "A non-hall…

Feb 3, 2021 · 6 shares · 918 followers View post →
Elizabeth H J Neilson
@ehneilson · X

RT @WCMC_UCDavis: Fresh off the press the fruits of cooperation a new nature article about the promising effects of #ibogaine. "A non-hall…

Feb 1, 2021 · 6 shares · 739 followers View post →
Paolo Bonini
@PaoloBonini6 · X

RT @WCMC_UCDavis: Fresh off the press the fruits of cooperation a new nature article about the promising effects of #ibogaine. "A non-hall…

Feb 1, 2021 · 6 shares · 1,268 followers View post →
Roy Nakbayaski
@Digging_Plants · X

RT @WCMC_UCDavis: Fresh off the press the fruits of cooperation a new nature article about the promising effects of #ibogaine. "A non-hall…

Feb 1, 2021 · 6 shares · 741 followers View post →
MetabolomicsUCDavis
@WCMC_UCDavis · X

Fresh off the press the fruits of cooperation a new nature article about the promising effects of #ibogaine. "A non-hallucinogenic psychedelic analogue with therapeutic potential" https://t.co/aOHHWISBzK https://t.co/PaOyCE4d9Q

Feb 1, 2021 · 14 likes · 6 shares · 3,307 followers View post →
Corey Duke, MD, PhD
@coreygduke · X

RT @slinnarsson: A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/7za6gFH2nP

Jan 25, 2021 · 2 shares · 1,698 followers View post →
Jun-Liszt Li
@poppingjun · X

RT @slinnarsson: A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/7za6gFH2nP

Jan 24, 2021 · 2 shares · 1,039 followers View post →
Armin
@arminkhaya · X

Key takeaways from the underlying article ("A non-hallucinogenic psychedelic analogue with therapeutic potential") abstract and transcript from the regulatory discussion for those who prefer to read on Twitter: https://t.co/O42UChTZG2

Jan 23, 2021 · 372 followers View post →
Sten Linnarsson
@slinnarsson · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/7za6gFH2nP

Jan 23, 2021 · 14 likes · 2 shares · 8,913 followers View post →
LSD_research
@LsdResearch · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/1Ify0uWFpB

Jan 16, 2021 · 27 followers View post →
OdeReiy
@Squarrocks · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/J3AU79EnlZ Beaucoup d'espoir dans cette voie.

Dec 26, 2020 · 356 followers View post →
Dr Anthony Martin
@AMAinsight · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/SvZl9oZvIx

Dec 21, 2020 · 918 followers View post →
Shiraz H. Robinson II | Dr. Quantum | Math God
@QuantumShiraz · X

RT @QuantumShiraz: A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/rVpIM51q59

Dec 21, 2020 · 1 share · 1,823 followers View post →
Shiraz H. Robinson II | Dr. Quantum | Math God
@QuantumShiraz · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/rVpIM51q59

Dec 21, 2020 · 1 like · 1 share · 1,823 followers View post →
Edgar Alschauff
@goldmccoin · X

Seems like therapeutic effects of psychedelic drugs can be separated from their psychedelic effects. https://t.co/5x8AqXWWOL

Dec 17, 2020 · 248 followers View post →
Lukasz Ciesla
@ciesla_lukasz · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/tHWkNY67sG

Dec 16, 2020 · 1 like · 1,680 followers View post →
Caroline Franzke
@carolfranzke · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/rVu2JzLcuK

Dec 15, 2020 · 82 followers View post →
Psychology Bot
@PsychologyBot24 · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/9NDRa0FhLb #psychology

Dec 15, 2020 · 232 followers View post →
Mira Behn
@tbdnonymous · X

Abstract: A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/B9tN0aLd9s

Dec 15, 2020 · 2,569 followers View post →
Institut fédératif des addictions comportementales
@IFAC_Addictions · X

#Addiction A non-hallucinogenic psychedelic analogue with therapeutic potential-Tvaux démontrant grâce à 1 conception chimique minutieuse possibilité modifier 1composé psychédélique pr produire 1variante +sûre non hallucinogène avec potentiel thérapeutique https://t.co/fK3nyIgggK

Dec 14, 2020 · 1,470 followers View post →
tommaso patriarchi
@tpatriarchi · X

"A non-hallucinogenic psychedelic analogue with therapeutic potential" https://t.co/8sSJCXfyCG

Dec 13, 2020 · 7 likes · 1,901 followers View post →
Krishan Maggon
@kkmaggon · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/qoKIge6MgK https://t.co/coRayEVzzp

Dec 13, 2020 · 999 followers View post →
Roy Nakbayaski
@Digging_Plants · X

A non-hallucinogenic psychedelic analogue with therapeutic potential Here we apply the principles of function-oriented synthesis to identify the key structural elements of the potential therapeutic pharmacophore of ibogaine... https://t.co/U4aYFOE3le

Dec 13, 2020 · 1 like · 741 followers View post →
Gustavo Vazquez, MD, PhD, FRCPC
@GustavoHVazquez · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/gZxjGKxKgm

Dec 12, 2020 · 2 likes · 293 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

A non-hallucinogenic psychedelic analogue with therapeutic potential. https://t.co/tGmAcCYWAo

Dec 11, 2020 · 3,999 followers View post →
Andreas Grätsch https://todon.nl/@AndyausLOS
@andy15los · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/M89PJyp1OZ

Dec 11, 2020 · 730 followers View post →
Society for the Study of Addiction
@SSA_Addiction · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature Dec 2020 (£) https://t.co/j66Ata19UO #ibogaine

Dec 11, 2020 · 1 like · 8,730 followers View post →
Rehab 4 Addiction
@Rehab4Group · X

A non-hallucinogenic psychedelic analogue with therapeutic potential by Nature https://t.co/YBzLPKcrOY

Dec 11, 2020 · 1,498 followers View post →
Paul McCullough
@ThePostsynaptic · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/pK7lT3cgea https://t.co/oigOwoHQxb

Dec 10, 2020 · 2,584 followers View post →
matiere*
@matiere · X

(2030/12/09) Psychedelics re-engineered for potential use in the clinic | Nature https://t.co/6jpnmUGnAF A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/qU0DshqCOw

Dec 10, 2020 · 2,860 followers View post →
Science Mission
@ScienceMission · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/CtVFDRm2tf https://t.co/P8ef4eCROd

Dec 10, 2020 · 303 followers View post →
Jacob R. Cheeseman
@jrcheeseman · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/lvSBYsIMmk

Dec 10, 2020 · 247 followers View post →
CLaE
@leafs_s · X

RT @JoeBarnby: 'A non-hallucinogenic psychedelic analogue with therapeutic potential' From @DEOlsonLab In mice, but can this method to b…

Dec 10, 2020 · 6 shares · 28,679 followers View post →
Celia Morgan
@profceliamorgan · X

RT @JoeBarnby: 'A non-hallucinogenic psychedelic analogue with therapeutic potential' From @DEOlsonLab In mice, but can this method to b…

Dec 10, 2020 · 6 shares · 1,329 followers View post →
Rudi Faust
@rpfaust · X

RT @APRA_bot: A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/Rq5dzEjKYH

Dec 10, 2020 · 1 share · 642 followers View post →
Arne Elofsson @arneelof.bsky.social
@arneelof · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/oWf0pY1YUt

Dec 10, 2020 · 2,576 followers View post →
Luke Nakaji/中島 振一郎@バルサと島巡りと猫と精神医療
@Luke_629 · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/ADNFUX7VAV

Dec 10, 2020 · 1 like · 2,280 followers View post →
Tom Pollak
@tompollak · X

RT @JoeBarnby: 'A non-hallucinogenic psychedelic analogue with therapeutic potential' From @DEOlsonLab In mice, but can this method to b…

Dec 10, 2020 · 6 shares · 5,263 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/Rq5dzEjKYH

Dec 10, 2020 · 4 likes · 1 share · 3,999 followers View post →
Sidhant Chopra
@SidChop · X

RT @JoeBarnby: 'A non-hallucinogenic psychedelic analogue with therapeutic potential' From @DEOlsonLab In mice, but can this method to b…

Dec 10, 2020 · 6 shares · 1,501 followers View post →
Calì_Lab
@lab_cali · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/YK11qPwQco

Dec 9, 2020 · 2,147 followers View post →
Adam Leventhal
@AdamMLeventhal · X

A non-hallucinogenic psychedelic analogue with therapeutic potential | Nature https://t.co/1JBtNn0Oez

Dec 9, 2020 · 2 likes · 1,589 followers View post →
Matt Wall (@mattwall.bsky.social)
@m_wall · X

RT @JoeBarnby: 'A non-hallucinogenic psychedelic analogue with therapeutic potential' From @DEOlsonLab In mice, but can this method to b…

Dec 9, 2020 · 6 shares · 9,439 followers View post →
Joe Barnby
@JoeBarnby · X

'A non-hallucinogenic psychedelic analogue with therapeutic potential' From @DEOlsonLab In mice, but can this method to be carried across to other psychedelics? What would this mean for the supposed importance of the subjective psychedelic experience? https://t.co/91p43H90Yh

Dec 9, 2020 · 19 likes · 6 shares · 1,953 followers View post →
Jamal Aqafaare Adam
@JamalAqafaare · X

RT @ChemistryNews: A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/G7E4vsPJYY https://t.co/oTNxlxncC1

Dec 9, 2020 · 2 shares · 9 followers View post →
Alex Naka
@gottapatchemall · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/DEBE7AvJDI

Dec 9, 2020 · 8 likes · 5,706 followers View post →
Bobby
@NotSoTiny_Life · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/bY4rMKmNy2 https://t.co/8URBJqS2Tv

Dec 9, 2020 · 58 followers View post →
Giuseppe Giannotti
@GiusGiannotti · X

"A non-hallucinogenic psychedelic analogue with therapeutic potential" @DEOlsonLab @MileHighLab and others! https://t.co/yPfrtCmhsW

Dec 9, 2020 · 2 likes · 753 followers View post →
Shroom Investor
@Shroom_investor · X

A non-hallucinogenic psychedelic analogue with therapeutic potential - https://t.co/HcKQaTzJRk #mushrush #potstocks #biotech #shroom #magicmushrooms https://t.co/NzFJBdKJFN

Dec 9, 2020 · 2 likes · 1,690 followers View post →
Chemistry News
@ChemistryNews · X

A non-hallucinogenic psychedelic analogue with therapeutic potential https://t.co/G7E4vsPJYY https://t.co/oTNxlxncC1

Dec 9, 2020 · 15 likes · 2 shares · 516,727 followers View post →
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psychedelic analogue with therapeutic potential. Nature, 589(7842), 474–479. https://doi.org/10.1038/s41586-020-3008-z. Carbonaro, ...

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... 10.1038/s41586-020-3008-z). Olson points out that tabernanthalog's mechanism likely modifies the circuitry in the brain that causes ...

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