December 2020 PMID 33322246

Retinoic Acid and Its Derivatives in Skin.

Łukasz Szymański, Rafał Skopek, Małgorzata Palusińska, Tino Schenk, Sven Stengel, Sławomir Lewicki, Leszek Kraj, Paweł Kamiński, Arthur Zelent

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Mentions

Peak: 3 in Oct 2022

across 3 sources since Dec 2020

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3,223,839

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63,244

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Dec 2020 – Apr 2024

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AI synopsis

What people are saying

This discussion shows a positive outlook on retinoids, with phrases like 'highly recommended' and references to dermatological expertise that suggest confidence in the publication's findings. The tone is informative and personal, highlighting the therapeutic potential of retinoids in skincare based on empirical evidence.

AgreementModerate agreement

The post strongly endorses the efficacy of retinoids based on empirical evidence, aligning with the publication's positive view of retinoids' benefits in skin health.

InterestModerate interest

The discussion indicates a moderate level of interest, with the poster sharing personal recommendations and emphasizing dermatological insights.

EngagementModerate engagement

The post engages by referencing specific products and a knowledgeable dermatologist, sparking curiosity about retinoids' practical applications.

ImpactNeutral impact

The post's impact is subtle; while supportive, it mainly serves to inform and recommend, rather than provoke significant change or debate.

Abstract in brief

Retinoids, including vitamin A and all-trans retinoic acid (ATRA), are important compounds that regulate cell growth, differentiation, and immune function across different organs, especially in skin health.
ATRA is used both in cancer treatment, notably for acute promyelocytic leukemia, and in dermatology to treat conditions such as skin cancer, psoriasis, acne, and ichthyosis, by modulating skin cell functions through retinoic acid receptors (RARs) and rexinoid receptors (RXRs).
Recent research using genetic models highlights the therapeutic potential of retinoids in treating serious skin disorders and certain malignant conditions by affecting dermal cell behavior through complex receptor interactions.

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