J Neurodev Disord December 2020 PMID 33327939

Early life stress and development: potential mechanisms for adverse outcomes.

Karen E Smith, Seth D Pollak

Mentions

104
Peak: 14 in Nov 2025
across 7 sources since Dec 2020

Extended reach

156,981
potential audience

Total likes

105

Video views

732

Mentions per month

Dec 2020 – Dec 2025

Where it's discussed

  • Facebook50 posts
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  • X / Twitter20 posts
  • News5 articles
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AI synopsis

What people are saying

Overall, the discussions reflect strong engagement and interest, highlighted by mentions of neurobiological effects such as hippocampal volume and connectivity, as well as concerns over the long-term mental health impacts of childhood stress. For example, remarks like 'fear for the long-term sequelae' and references to neurodevelopmental mechanisms underscore the perceived importance of the publication, while the tone varies from analytical to concerned, emphasizing both scientific interest and societal implications.

AgreementModerate agreement

Most posts acknowledge the article's importance and agree with the relevance of early life stress to development but some express reservations or skepticism about specific claims.

InterestHigh interest

Posts show high curiosity, with comments expressing excitement about learning and referencing ongoing discussions of the neurobiological impacts.

EngagementHigh engagement

Several discussions delve into complex concepts like hippocampal volume and connectivity, indicating deep engagement with the material.

ImpactHigh impact

The conversations suggest the research has significant implications for understanding long-term effects on mental health and child development, emphasizing concerns over chronic stress and its consequences.

Abstract in brief

  • Early life stress, such as childhood trauma, is linked to negative impacts on brain development, especially in areas like the prefrontal cortex, hypothalamus, amygdala, and dopamine systems, often through changes in the hypothalamic-pituitary-adrenal (HPA) axis.
  • However, current research mainly focuses on stressful events themselves, and less on how children interpret or perceive these stressors, which could help explain why some children are more affected than others.
  • Understanding both the neurobiological effects and the children's perceptions of stress could lead to better insights into how early adversity increases the risk of mental health issues and other health problems later in life.]

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@ScientistaBRG · X

@ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m gone, they’ll be paying the price in physical & mental health. https://t.co/vnSk2b3acG https://t.co/zh1zgtPko8

Aug 3, 2022 · 35 likes · 9 shares · 877 followers View post →
Karen Smith
@smith_ke · X

New review with @childemotionlab "Early life stress and development: potential mechanisms for adverse outcomes" @NeuroPsychBMC https://t.co/DNmiJeQlKw

Dec 20, 2020 · 18 likes · 3 shares · 563 followers View post →
BMC
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A Review published in the Journal of Neurodevelopmental Disorders evaluates the existing literature on the neurobiological effects of early life stress in children’s psychological and behavioural development. https://t.co/BruEG8h0od

Dec 28, 2020 · 3 likes · 75,107 followers View post →
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RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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Shamez Ladhani
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RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

Aug 3, 2022 · 9 shares · 9,373 followers View post →
Dylan Gee, PhD
@dylanggee · X

RT @smith_ke: New review with @childemotionlab "Early life stress and development: potential mechanisms for adverse outcomes" @NeuroPsychB…

Dec 20, 2020 · 3 shares · 7,932 followers View post →

All mentions

נינה
@nina_kulic_herz · X

@ArrestFauxi @QuoteJung https://t.co/nhG10g4jxK yeah don't think you can chose to have reduced hippocampal volume and a reduced connectivity between the amygdala and pre-frontal cortex. although its a lie, its a good thing for you to believe that, though.

Oct 21, 2025 · 762 followers View post →
Cyanna
@Cyanna_Banana · X

@H_SG_A @Halalcoholism Poverty isn't the only life factor that can induce stress, overall environment for children matter. Early life stress and development: potential mechanisms for adverse outcomes - PMC https://t.co/1mprHz0Wvx

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Childhood amygdala development is associated with stressful/non-stressful circumstances https://t.co/ouve1sMLQT https://t.co/TdZSnBEKdM

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What are you reading/learning today? https://t.co/c3VZCOOq4G This is something that I have been excited about for a while now! Let the learning begin!!

Aug 29, 2022 · 403 followers View post →
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RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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Jane
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RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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ronnocm
@ronnocm2 · X

RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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FUNacceptable Views
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RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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UsForThemUK
@UsforThemUK · X

RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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Luise Froehlich
@FroehlichLuise · X

RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

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Angela
@Madame_Angela_ · X

@MissJenHell1 @BVKJ https://t.co/mEv4FQqNHQ

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Shamez Ladhani
@ShamezLadhani · X

RT @MYC_Beth: @ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m g…

Aug 3, 2022 · 9 shares · 9,373 followers View post →
Scientista
@ScientistaBRG · X

@ShamezLadhani I fear for the long-term sequelae of inducing fear in children (the chronic stress response). Long after I’m gone, they’ll be paying the price in physical & mental health. https://t.co/vnSk2b3acG https://t.co/zh1zgtPko8

Aug 3, 2022 · 35 likes · 9 shares · 877 followers View post →
Neuropediatrics®️
@NeuroInfanti · X

Early life stress and development: potential mechanisms for adverse outcomes https://t.co/Y6TiMFeeVV

Aug 27, 2021 · 2,065 followers View post →
BMC
@BioMedCentral · X

A Review published in the Journal of Neurodevelopmental Disorders evaluates the existing literature on the neurobiological effects of early life stress in children’s psychological and behavioural development. https://t.co/BruEG8h0od

Dec 28, 2020 · 3 likes · 75,107 followers View post →
Dylan Gee, PhD
@dylanggee · X

RT @smith_ke: New review with @childemotionlab "Early life stress and development: potential mechanisms for adverse outcomes" @NeuroPsychB…

Dec 20, 2020 · 3 shares · 7,932 followers View post →
Seth Pollak Child Emotion Research Lab
@childemotionlab · X

RT @smith_ke: New review with @childemotionlab "Early life stress and development: potential mechanisms for adverse outcomes" @NeuroPsychB…

Dec 20, 2020 · 3 shares · 2,136 followers View post →
Karen Smith
@smith_ke · X

New review with @childemotionlab "Early life stress and development: potential mechanisms for adverse outcomes" @NeuroPsychBMC https://t.co/DNmiJeQlKw

Dec 20, 2020 · 18 likes · 3 shares · 563 followers View post →
NeuroPsychBMC
@NeuroPsychBMC · X

Early life stress and development: potential mechanisms for adverse outcomes https://t.co/j5MoKUnRc0

Dec 18, 2020 · 1 share · 1,584 followers View post →
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