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ACS Chem Neurosci February 2021 PMID 33438398

Classics in Chemical Neuroscience: Amitriptyline.

Elliot W McClure, R Nathan Daniels

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AgreementNeither agree nor disagree

The discussions do not strongly agree or disagree with the publication, simply referencing or exploring the topic.

InterestModerate interest

There is a slight interest in the medication or its use, but not high engagement with its details.

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The overall influence of these discussions appears limited, not highlighting significant changes or insights.

Abstract in brief

  • Amitriptyline, marketed as Elavil since 1961, is the second tricyclic antidepressant and has proven effective for major depressive disorder while raising concerns about cardiotoxicity.
  • It works by inhibiting the reuptake of serotonin and norepinephrine, impacting various receptors and contributing to the understanding of mood disorders through the monoamine theory.
  • The review covers amitriptyline's synthesis, manufacturing, metabolism, pharmacology, adverse effects, and its significance in therapy, highlighting its status in chemical neuroscience.
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Amitriptilina: Descubra se é o Remédio Certo para Você | Dr Diego de Cas... https://t.co/LKtlASTayY via @YouTube

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Dr Diego de Castro dos Santos
@DNeurologista · X

Amitriptilina: Descubra se é o Remédio Certo para Você | Dr Diego de Cas... https://t.co/LKtlASTayY via @YouTube

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