The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress.

Ester Méndez, Mercè Gomar-Alba, M Carmen Bañó, Manuel Mendoza, Inma Quilis, J Carlos Igual

December 2020

Synopsis of Social media discussions

Discussions highlight the key distinction that Whi7 acts as a major cell cycle brake during stress, with mentions of its regulation and localization, reflecting curiosity and recognition of its biological importance, using phrases like 'fundamentals in survival' and 'emerging as a major brake' to emphasize significance.

A
Agreement
 Neither agree nor disagree

Discussions acknowledge the importance of the proteins Whi7 and Whi5 and their roles as cell cycle regulators, but there's no strong consensus on the novelty or significance of the findings.

I
Interest
 Moderate level of interest

There is a mild interest in understanding the differences in regulation, especially regarding stress responses, which is reflected in the focus on cellular survival mechanisms.

E
Engagement
 Moderate level of engagement

Participants are actively comparing the proteins and their functions, indicating moderate engagement with the research details.

I
Impact
 Moderate level of impact

The discussions suggest that understanding Whi7's role could influence broader research in cell cycle regulation and stress response, hinting at moderate potential impact.

Social Mentions

YouTube

1 Videos

Facebook

2 Posts

Twitter

1 Posts

News

3 Articles

Metrics

Video Views

2,417

Total Likes

250

Extended Reach

2,574

Social Features

7

Timeline: Posts about article

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2,417 views

  • Miguel Ángel Sogorb
    @MASogorb (Twitter)

    Comparan las proteínas Whi5 y Whi7, fundamentales en la supervivencia celular https://t.co/GgSruTQ53Q Más información: The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress https://t.co/T9l5qkqenK
    view full post

    May 1, 2021

Abstract Synopsis

  • The study highlights that in budding yeast, the proteins Whi7 and Whi5 both act as repressors of the cell cycle, but they are regulated differently and have distinct roles, especially under stress conditions.
  • Whi7 differs from Whi5 in its regulation, subcellular localization, and ability to bind to gene promoters, making it more responsive to specific stresses like cell wall damage.
  • The results suggest that Whi7, rather than Whi5, is the primary inhibitor of the Start transition during certain stress responses, highlighting the complex regulation of cell cycle control in yeast.]