December 2020 PMID 33443080

The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress.

Ester Méndez, Mercè Gomar-Alba, M Carmen Bañó, Manuel Mendoza, Inma Quilis, J Carlos Igual

Mentions

7
Peak: 1 in May 2021
across 4 sources since May 2021

Extended reach

2,574
potential audience

Total likes

250

Video views

2,417

Mentions per month

May 2021 – Feb 2024

Where it's discussed

  • News3 articles
  • Facebook2 posts
  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions highlight the key distinction that Whi7 acts as a major cell cycle brake during stress, with mentions of its regulation and localization, reflecting curiosity and recognition of its biological importance, using phrases like 'fundamentals in survival' and 'emerging as a major brake' to emphasize significance.

AgreementNeither agree nor disagree

Discussions acknowledge the importance of the proteins Whi7 and Whi5 and their roles as cell cycle regulators, but there's no strong consensus on the novelty or significance of the findings.

InterestModerate interest

There is a mild interest in understanding the differences in regulation, especially regarding stress responses, which is reflected in the focus on cellular survival mechanisms.

EngagementModerate engagement

Participants are actively comparing the proteins and their functions, indicating moderate engagement with the research details.

ImpactModerate impact

The discussions suggest that understanding Whi7's role could influence broader research in cell cycle regulation and stress response, hinting at moderate potential impact.

Abstract in brief

  • The study highlights that in budding yeast, the proteins Whi7 and Whi5 both act as repressors of the cell cycle, but they are regulated differently and have distinct roles, especially under stress conditions.
  • Whi7 differs from Whi5 in its regulation, subcellular localization, and ability to bind to gene promoters, making it more responsive to specific stresses like cell wall damage.
  • The results suggest that Whi7, rather than Whi5, is the primary inhibitor of the Start transition during certain stress responses, highlighting the complex regulation of cell cycle control in yeast.]

Top posts

Most liked on X and Bluesky
Miguel Ángel Sogorb
@MASogorb · X

Comparan las proteínas Whi5 y Whi7, fundamentales en la supervivencia celular https://t.co/GgSruTQ53Q Más información: The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress https://t.co/T9l5qkqenK

May 1, 2021 · 158 followers View post →

All mentions

Miguel Ángel Sogorb
@MASogorb · X

Comparan las proteínas Whi5 y Whi7, fundamentales en la supervivencia celular https://t.co/GgSruTQ53Q Más información: The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress https://t.co/T9l5qkqenK

May 1, 2021 · 158 followers View post →