Blood January 2021 PMID 33443552

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma.

Sarah Gooding, Naser Ansari-Pour, Fadi Towfic, María Ortiz Estévez, Philip P Chamberlain, Kao-Tai Tsai, Erin Flynt, Marissa Hirst, Dan Rozelle, Paula Dhiman, Paola Neri, Karthik Ramasamy, Nizar Bahlis, Paresh Vyas, Anjan Thakurta

Mentions

65
Peak: 37 in Jan 2021
across 2 sources since Aug 2020

Extended reach

253,243
potential audience

Total likes

505

Video views

3,102

Mentions per month

Aug 2020 – Mar 2023

Where it's discussed

  • X / Twitter63 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions frequently emphasize the identification of genetic markers linked to drug resistance in multiple myeloma, with contributors describing the work as revolutionary and aiming to personalize treatment. Phrases like "better clinical outcomes for patients" and references to ongoing research efforts contribute to a tone of enthusiasm and urgency, illustrating the importance of this research in the fight against cancer.

AgreementStrong agreement

The majority of discussions highlight a consensus on the significance of the findings, with many participants expressing strong support for the research outcomes.

InterestHigh interest

Both the excitement and curiosity surrounding the genetic findings indicate a high level of interest in the topic, especially among those directly involved in cancer research.

EngagementHigh engagement

Posters engage deeply with the content, frequently referencing specific methodologies and implications, which indicates a thorough comprehension and commitment to the subject matter.

ImpactHigh impact

Commenters perceive this research as having a substantial positive impact on treatment strategies for multiple myeloma patients, emphasizing its potential to improve clinical outcomes.

Abstract in brief

  • The emergence of drug resistance poses a significant challenge for improving survival rates in myeloma patients.
  • A study analyzed genetic data from hundreds of patients and discovered that specific alterations in the CRBN protein increased with exposure to immunomodulatory drugs, impacting treatment outcomes.
  • This research provides the largest dataset on CRBN alterations in myeloma, which could aid in selecting patients for therapies targeting this protein.

Top posts

Most liked on X and Bluesky
Science Animated
@Sci_Ani · X

Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable clinicians to spot drug resistance and tailor treatment, resulting in better clinical outcomes for patients. Watch now: https://t.co/iwpBem6pIf

Dec 23, 2022 · 341 likes · 14 shares · 5,905 followers View post →
Sarah Gooding
@DrSarahGooding · X

Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequent regimen choice in relapsed/refractory myeloma #mmsm https://t.co/0cgB0AcjfM https://t.co/a23w4qPF9C

Jan 14, 2021 · 125 likes · 24 shares · 410 followers View post →
Naser Ansari-Pour
@NaserAnsariPour · X

Finding genomic aberrations responsible for relapse/refractory multiple myeloma. Our WGS-based CRBN paper is out! Congratulations to @DrSarahGooding for leading this study. https://t.co/tbXsCHPKlY

Aug 5, 2020 · 17 likes · 5 shares · 117 followers View post →
MRC WIMM
@MRC_WIMM · X

Discover more about how researchers at the MRC WIMM are investigating the genetic causes of drug resistant Multiple myeloma in this new animation. https://t.co/ZviBX7FUhV #multiplemyeloma #cancer #dna

Jan 30, 2023 · 5 likes · 2 shares · 3,562 followers View post →
Oxford Centre for Haematology
@OxfordHaem · X

Multiple cereblon genetic changes are associated with acquired #resistance to lenalidomide or pomalidomide in #MultipleMyeloma. @DrSarahGooding @NaserAnsariPour @pauladhiman @NBahlis @pvyas_oxford @OxfordBRC @bdi_oxford @MRC_WIMM #IMiD #haematology https://t.co/OCPkKNvX4z https://t.co/dfYs0ubsFk

Jan 22, 2021 · 5 likes · 2 shares · 3,559 followers View post →
MRC MHU
@MRC_MHU · X

Research from the @SarahGooding @Chapman_lab_UK has shown that drug resistant multiple myeloma is driven by clonal evolution. Find out more in a new animation. @OxfordHaem @MRC_WIMM https://t.co/piASPRjfGT

Jan 30, 2023 · 4 likes · 1 share · 905 followers View post →

All mentions

Science Animated
@Sci_Ani · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Mar 22, 2023 · 14 shares · 5,905 followers View post →
jill brown
@jill_mca_brown · X

RT @MRC_MHU: Research from the @SarahGooding @Chapman_lab_UK has shown that drug resistant multiple myeloma is driven by clonal evolution.…

Jan 31, 2023 · 1 share · 79 followers View post →
Medical Sciences
@OxfordMedSci · X

RT @MRC_WIMM: Discover more about how researchers at the MRC WIMM are investigating the genetic causes of drug resistant Multiple myeloma i…

Jan 30, 2023 · 2 shares · 23,331 followers View post →
Oxford Cancer
@OxfordCancer · X

RT @MRC_WIMM: Discover more about how researchers at the MRC WIMM are investigating the genetic causes of drug resistant Multiple myeloma i…

Jan 30, 2023 · 2 shares · 2,622 followers View post →
MRC WIMM
@MRC_WIMM · X

Discover more about how researchers at the MRC WIMM are investigating the genetic causes of drug resistant Multiple myeloma in this new animation. https://t.co/ZviBX7FUhV #multiplemyeloma #cancer #dna

Jan 30, 2023 · 5 likes · 2 shares · 3,562 followers View post →
MRC MHU
@MRC_MHU · X

Research from the @SarahGooding @Chapman_lab_UK has shown that drug resistant multiple myeloma is driven by clonal evolution. Find out more in a new animation. @OxfordHaem @MRC_WIMM https://t.co/piASPRjfGT

Jan 30, 2023 · 4 likes · 1 share · 905 followers View post →
naeem quyoum
@NQuyoum · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 28, 2022 · 14 shares · 1,589 followers View post →
Chris Wallace Brandon
@hdpr2016 · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 28, 2022 · 14 shares · 4,811 followers View post →
Emine Büber
@EmineBber8 · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 25, 2022 · 14 shares · 149 followers View post →
Parlhad Singh
@singh_parlhad · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 25, 2022 · 14 shares · 87 followers View post →
naeem quyoum
@NQuyoum · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 25, 2022 · 14 shares · 1,589 followers View post →
Rob Wilson
@roblwilson · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 25, 2022 · 14 shares · 4,681 followers View post →
دموع صامته
@swsw_ali1 · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 24, 2022 · 14 shares · 21,867 followers View post →
الانيق.
@aodaahmed26 · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 24, 2022 · 14 shares · 12,959 followers View post →
Timothy Cook
@timdcook4 · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 23, 2022 · 14 shares · 340 followers View post →
John Hyde
@Mollys1Daddy · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 23, 2022 · 14 shares · 246 followers View post →
سيد.عالمي
@ElDokshe · X

RT @Sci_Ani: Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable c…

Dec 23, 2022 · 14 shares · 14,745 followers View post →
Science Animated
@Sci_Ani · X

Researchers at Oxford University have identified #genetic markers in #drug-resistant multiple #myeloma. These markers enable clinicians to spot drug resistance and tailor treatment, resulting in better clinical outcomes for patients. Watch now: https://t.co/iwpBem6pIf

Dec 23, 2022 · 341 likes · 14 shares · 5,905 followers View post →
VJHemOnc
@VJHemOnc · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Mar 17, 2021 · 24 shares · 21,472 followers View post →
MRC WIMM
@MRC_WIMM · X

RT @OxfordHaem: Multiple cereblon genetic changes are associated with acquired #resistance to lenalidomide or pomalidomide in #MultipleMye…

Jan 26, 2021 · 2 shares · 3,563 followers View post →
Filip Garbicz
@FilipGarbicz · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 24, 2021 · 9 shares · 538 followers View post →
Transfusion Library
@TransfusionLib · X

RT @OxfordHaem: Multiple cereblon genetic changes are associated with acquired #resistance to lenalidomide or pomalidomide in #MultipleMye…

Jan 22, 2021 · 2 shares · 3,320 followers View post →
Oxford Centre for Haematology
@OxfordHaem · X

Multiple cereblon genetic changes are associated with acquired #resistance to lenalidomide or pomalidomide in #MultipleMyeloma. @DrSarahGooding @NaserAnsariPour @pauladhiman @NBahlis @pvyas_oxford @OxfordBRC @bdi_oxford @MRC_WIMM #IMiD #haematology https://t.co/OCPkKNvX4z https://t.co/dfYs0ubsFk

Jan 22, 2021 · 5 likes · 2 shares · 3,559 followers View post →
awechalekar
@awechalekar · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 21, 2021 · 9 shares · 1,219 followers View post →
Dr Ayan Santra,M.D.
@ayansantra · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 21, 2021 · 9 shares · 645 followers View post →
Sakshi Jasra
@sjasraMD · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 21, 2021 · 9 shares · 346 followers View post →
Hematology Media Center (HMC)
@US_HMC · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 20, 2021 · 9 shares · 270 followers View post →
BigNige
@BigNige73593282 · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 20, 2021 · 9 shares · 235 followers View post →
Graham jackson
@profghjackson · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 20, 2021 · 9 shares · 4,026 followers View post →
DAMH
@DanielM89741574 · X

RT @BloodJournal: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple mye…

Jan 20, 2021 · 9 shares · 27 followers View post →
Pashna N. Munshi MD
@MunshiPashnaMD · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 19, 2021 · 24 shares · 483 followers View post →
Myeloma Patients
@Myeloma_Patient · X

RT @Transplant_Doc: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple m…

Jan 18, 2021 · 1 share · 214 followers View post →
Georgia McCaughan
@gjmccaughan · X

Cereblon genetic alterations detected using WGS sequencing and RNASeq data in newly diagnosed, lenalidomide refractory & pomalidomide refractory multiple myeloma and association with poorer clinical outcomes #mmsm https://t.co/CUs6JDQn6g https://t.co/G87hV8iiYw

Jan 17, 2021 · 2 likes · 885 followers View post →
Muzaffar Qazilbash
@Transplant_Doc · X

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma @BloodJournal #mmsm #MYELOMA https://t.co/I6K019iDdK

Jan 17, 2021 · 1 like · 1 share · 7,401 followers View post →
gmcrotty.bsky.social
@gmcrotty · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 16, 2021 · 24 shares · 27,001 followers View post →
Dhananjay Suresh
@DhananjayAtomic · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 16, 2021 · 24 shares · 558 followers View post →
Tom Milne
@milnetom68 · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 16, 2021 · 24 shares · 717 followers View post →
NDMPapers
@NDM_Papers · X

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma. https://t.co/QVh48QJVHO

Jan 15, 2021 · 345 followers View post →
Joe Frost
@JoeNFrost · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 15, 2021 · 24 shares · 282 followers View post →
Paperbirds_Hematology
@PaperbirdsM · X

New article: Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma. https://t.co/ILs7fIXOnJ #MMSM #MultipleMyeloma #hematology https://t.co/e6TzZIHv2L

Jan 15, 2021 · 910 followers View post →
David Russler-Germain, MD/PhD
@dgermain21 · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 15, 2021 · 24 shares · 3,666 followers View post →
medstudy
@medstudy9 · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 37 followers View post →
Karen Sweiss
@KarenSweiss · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 1,441 followers View post →
Hematology Media Center (HMC)
@US_HMC · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 270 followers View post →
Eleni Louka
@el_louka26 · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 312 followers View post →
Robert Chen MD PhD
@PerceptronMD · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 423 followers View post →
Lucja Grajkowska, PhD
@LucjaG_PhD · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 457 followers View post →
Daniel Auclair
@AuclairDan · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 4,402 followers View post →
Philip McCarthy
@PLMcCarthyMD · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 4,394 followers View post →
jdavieslab
@jdavieslab · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 343 followers View post →
Oppermann Lab
@LabOppermann · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 216 followers View post →
Oni Chowdhury
@OniChowdhury2 · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 83 followers View post →
Mark Bustoros
@MarkBustoros · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 1,424 followers View post →
Amit Sud
@amit_sud · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 666 followers View post →
Adam Mead
@AdamMead_Oxford · X

RT @DrSarahGooding: Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequ…

Jan 14, 2021 · 24 shares · 1,362 followers View post →
Sarah Gooding
@DrSarahGooding · X

Our paper is out in Blood today! Genetic cereblon changes are frequent at IMiD resistance and could help inform subsequent regimen choice in relapsed/refractory myeloma #mmsm https://t.co/0cgB0AcjfM https://t.co/a23w4qPF9C

Jan 14, 2021 · 125 likes · 24 shares · 410 followers View post →
Neil Rodrigues
@NRodriguesLab · X

RT @NaserAnsariPour: Finding genomic aberrations responsible for relapse/refractory multiple myeloma. Our WGS-based CRBN paper is out! Cong…

Oct 29, 2020 · 5 shares · 544 followers View post →
NatureRevClinOncol
@NatRevClinOncol · X

SRBN point mutations, copy loss/structural variation and a specific variant transcript (exon 10-spliced) associated with inferior responses increase with progressive IMiD exposure in pts with MM, eventually occurring in up to 1/3rd of them: https://t.co/xOqR2SQnCt #MMSM #hemeonc

Aug 12, 2020 · 41,564 followers View post →
Oni Chowdhury
@OniChowdhury2 · X

RT @NaserAnsariPour: Finding genomic aberrations responsible for relapse/refractory multiple myeloma. Our WGS-based CRBN paper is out! Cong…

Aug 8, 2020 · 5 shares · 83 followers View post →
Mike Bogetofte Barnkob
@mikebarnkob · X

RT @NaserAnsariPour: Finding genomic aberrations responsible for relapse/refractory multiple myeloma. Our WGS-based CRBN paper is out! Cong…

Aug 7, 2020 · 5 shares · 2,316 followers View post →
David Cruz Hernandez
@d_dcruzh · X

RT @NaserAnsariPour: Finding genomic aberrations responsible for relapse/refractory multiple myeloma. Our WGS-based CRBN paper is out! Cong…

Aug 6, 2020 · 5 shares · 157 followers View post →
Sarah Gooding
@DrSarahGooding · X

RT @NaserAnsariPour: Finding genomic aberrations responsible for relapse/refractory multiple myeloma. Our WGS-based CRBN paper is out! Cong…

Aug 6, 2020 · 5 shares · 410 followers View post →
Naser Ansari-Pour
@NaserAnsariPour · X

Finding genomic aberrations responsible for relapse/refractory multiple myeloma. Our WGS-based CRBN paper is out! Congratulations to @DrSarahGooding for leading this study. https://t.co/tbXsCHPKlY

Aug 5, 2020 · 17 likes · 5 shares · 117 followers View post →